DNA alkylator Chemicals

Cat.No.	Product Name	Information	Product Use Citations
S8266	Melphalan	Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Cell, 2025, S0092-8674(25)00572-0 J Exp Clin Cancer Res, 2025, 44(1):125 J Transl Med, 2025, 23(1):917
S1278	Altretamine	Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.	iScience, 2024, 27(10):110862 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
E0609	Methyl methanesulfonate	Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.	J Adv Res, 2025, S2090-1232(25)00934-8 Int J Biol Sci, 2024, 20(11):4513-4531 Cell Death Dis, 2024, 15(12):898
S8880	Lobaplatin (D-19466)	Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	United Eur Gastroent, 2025, 13(7):1328-1342 Int J Nanomedicine, 2024, 19:9503-9547 Biochem Pharmacol, 2020, 12:114023
S5840	Palifosfamide	Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.	Oncotarget, April 27, 2018, 22571-22585 bioRxiv, April 21, 2025, nan
S7829	Tretazicar (CB1954)	Tretazicar (CB1954) is an anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.	Biochem J, 2024, 481(6):405-422
S6984	Dianhydrogalactitol (VAL-083)	Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. It shows antitumor activity.
E4754	Semustine	Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.
S1224	Oxaliplatin	Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.	Nature, 2025, 10.1038/s41586-025-08974-4 Cancer Cell, 2025, S1535-6108(25)00223-5 Signal Transduct Target Ther, 2025, 10(1):341
S1312	Streptozotocin (STZ)	Streptozotocin (STZ) is a glucosamine-nitrosourea compound derived from Streptomyces achromogenes, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. It induces autophagy and apoptosis. This compound can be used to induce animal models of diabetes. Solutions are unstable and should be fresh-prepared.	Cell Rep Med, 2025, 6(8):102249 J Nanobiotechnology, 2025, 23(1):588 Int J Biol Macromol, 2025, 321(Pt 2):146174