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DNA alkylator Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S4447 Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958 Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. This compound is potently cytotoxic against pancreatic cancer cell lines.
E1454New Phosphoramide mustard cyclohexanamine Phosphoramide mustard cyclohexanamine is the stabilized and biologically active cytotoxic metabolite of the prodrug cyclophosphamide that acts as a potent DNA alkylator. It selectively binds the N-7 position of guanine residues to generate cytotoxic mono- and bi-functional DNA adducts. These cross-links physically stall replication forks and trigger the ATM/gammaH2AX DNA damage response pathway, effectively driving malignant cells into apoptosis.