OF-1

Catalog No.S7681

OF-1 Chemical Structure

Molecular Weight(MW): 440.31

OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.

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Biological Activity

Description OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain with Kd of 100 nM and 500 nM, respectively.
Targets
BRPF1B [1]
()
BRPF2 [1]
()
100 nM(Kd) 500 nM(Kd)
In vitro

As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity. [1]

Protocol

Solubility (25°C)

In vitro DMSO 76 mg/mL warmed (172.6 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 440.31
Formula

C17H18BrN3O4S

CAS No. 919973-83-4
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02995083 Not yet recruiting Symptomatic Osteoarthritis of the Knee Rush University Medical Center January 2017 --
NCT02868021 Recruiting Osteoarthritis, Knee University of Florida|University of Florida Clinical and Translational Science Institute (CTSI) December 2016 --
NCT02290886 Recruiting Amyotrophic Lateral Sclerosis Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud|Iniciativa Andaluza en Terapias Avanzadas July 2014 Phase 1|Phase 2
NCT02065973 Unknown status Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of PDS0101 in Female Subjects With High-risk HPV Infection and Biopsy-proven CIN1. PDS Biotechnology Corp. February 2014 Phase 1
NCT01996111 Terminated Plantar Fasciitis MiMedx Group, Inc. September 2013 --
NCT02121314 Completed Tuberculosis University Medical Center Groningen|University of Groningen|Gadjah Mada University July 2013 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Epigenetic Reader Domain Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID