BI-9564

Catalog No.S8113

BI-9564 Chemical Structure

Molecular Weight(MW): 353.41

BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains with the IC50 of 75 nM and 3.4 µM, respectively.

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Biological Activity

Description BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains with the IC50 of 75 nM and 3.4 µM, respectively.
Targets
BRD9 [1]
(Cell-free assay)
BRD7 [1]
(Cell-free assay)
CECR2 [1]
(Cell-free assay)
5.9 nM(Kd) 73 nM(Kd) 77 nM(Kd)
In vitro

Treatment of the panel with BI-9564 results in selective growth inhibition of a significant proportion of AML cell lines tested[1].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: MV-4-11 cells
  • Concentrations: various concentrations(10 nM-100 μM)
  • Incubation Time: 2 h
  • Method: To 750,000 MV-4-11 cells in 250 µl growth medium (in IMDM, 10 % FBS, GlutaMAX, 25 mM HEPES and 0,1% 2-Mercaptoethanol) per well compound is added at the desired concentration from a 10 mM stock solution using the HP D300 Digital Dispenser. After 2 hours of incubation with the compound, cells are collected by centrifugation, washed in ice cold PBS and lysed in 15 µl of cell extraction buffer. After 30 minutes on ice, nucleic acids are disrupted by sonication. cMYC levels are measured using the human c-Myc (Total) ELISA Kit.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female CIEA-NOG mice
  • Formulation: 0.5% Natrosol
  • Dosages: 10 mL/kg
  • Administration: Oral administration
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 16 mg/mL (45.27 mM)
DMSO 3 mg/mL (8.48 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 353.41
Formula

C20H23N3O3

CAS No. 1883429-22-8
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Related Antibodies

Epigenetic Reader Domain Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID