SGC-CBP30

Catalog No.S7256

SGC-CBP30 Chemical Structure

Molecular Weight(MW): 509.04

SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.

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1 Customer Review

  • Immuno-blot analysis of protein crotonylation after NaCr treatment in the absence or presence of p300/CBP inhibitors.

    J Proteome Res, 2017, 16:1743−1752. SGC-CBP30 purchased from Selleck.

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Choose Selective Epigenetic Reader Domain Inhibitors

Biological Activity

Description SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM in cell-free assays, respectively. Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively.
Features CREBBP/EP300-selective chemical probe.
Targets
CREBBP [1]
(Cell-free assay)
EP300 [1]
(Cell-free assay)
21 nM 38 nM
In vitro

As a CREBBP/EP300-selective chemical probe, SGC-CBP30 shows moderate cytotoxicity in U2OS cells and HeLa cells. [1]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (196.44 mM)
Ethanol 100 mg/mL (196.44 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 509.04
Formula

C28H33ClN4O3

CAS No. 1613695-14-9
Storage powder
Synonyms N/A

Bio Calculators

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C2=C1/X C2: LOG(C2):
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    C4=C3/X C4: LOG(C4):
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    The recommend formulation of SGC-CBP30 (Cat S7256) for in vivo studies on your website is “2% DMSO+30% PEG 300+5% Tween 80+ddH2O”. Is this a suspension or clear solution?

  • Answer:

    S7256 SGC-CBP30 in 2% DMSO+30% PEG 300+5% Tween 80+ddH2O at 5mg/ml is a clear solution.

Related Antibodies

Epigenetic Reader Domain Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID