Loxistatin Acid (E-64C)
Catalog No.S7392 Synonyms: NSC 694279, EP 475
Molecular Weight(MW): 314.38
Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
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|Description||Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.|
Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. 
|In vivo||In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H.  E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. |
|In vitro||DMSO||62 mg/mL (197.21 mM)|
|Ethanol||62 mg/mL (197.21 mM)|
|Water||2 mg/mL (6.36 mM)|
|In vivo||Add solvents individually and in order:
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
C15H26 N2 O5
|Synonyms||NSC 694279, EP 475|
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