Loxistatin Acid (E-64C)

Catalog No.S7392 Synonyms: NSC 694279, EP 475

Loxistatin Acid (E-64C) Chemical Structure

Molecular Weight(MW): 314.38

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

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2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
cysteine protease [1]
In vitro

Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4]

In vivo In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3]


Animal Research:[3]
+ Expand
  • Animal Models: Male Sprague-Dawley rats.
  • Formulation: Dissolved in a small amount of saturated bicarbonate solution and then diluted with 0.9% NaCl saline.
  • Dosages: ~400 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 62 mg/mL (197.21 mM)
Ethanol 62 mg/mL (197.21 mM)
Water 2 mg/mL (6.36 mM)
In vivo saline 2mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 314.38

C15H26 N2 O5

CAS No. 76684-89-4
Storage powder
in solvent
Synonyms NSC 694279, EP 475

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID