COVID-19

Other Microbiology Related Inhibitors

Integrase Reverse Transcriptase Anti-infection Ribosomal Peptidyl Transferase 3C-Like Protease β-lactamase Parasite Neuraminidase CMV Fungal

Cat.No.	Product Name	Information	Product Use Citations
S1538	Telaprevir	Telaprevir is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.	JHEP Rep, 2025, 7(5):101328 J Virol, 2024, e0192123. bioRxiv, 2023, 2023.11.22.568224
S2851	Baricitinib (LY3009104)	Baricitinib (LY3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. It is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.	Cell Rep Med, 2025, 6(3):102027 Cell Rep, 2025, 44(3):115403 Cell Rep, 2025, S2211-1247(25)00781-8
S2853	PR-171 (Carfilzomib)	Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.	Nat Genet, 2025, 57(10):2468-2481 Nat Commun, 2025, 16(1):765 Acta Biomater, 2025, S1742-7061(25)00677-4
S1322	Dexamethasone	Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects. Dexamethasone induces autophagy and mitophagy. Dexamethasone is tested in hospitalized patients with COVID-19 and is found to have benefits for critically ill patients.	Signal Transduct Target Ther, 2025, 10(1):230 Signal Transduct Target Ther, 2025, 10(1):394 Gut, 2025, gutjnl-2025-336105
S1759	Pitavastatin (NK-104) Calcium	Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis.	bioRxiv, 2025, 2025.08.10.669191 Nat Commun, 2024, 15(1):4099 J Immunother Cancer, 2024, 12(11)e009805
S8969	Molnupiravir (EIDD-2801)	Molnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N⁴-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19.	Antioxidants (Basel), 2025, 14(8)945 Biomed Res, 2025, 46(2):37-50 Antiviral Res, 2024, 225:105840
S4430	HCQ (Hydroxychloroquine) Sulfate	Hydroxychloroquine (HCQ) Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.	EMBO J, 2025, 10.1038/s44318-025-00581-3 iScience, 2025, 28(4):112054 Int J Mol Sci, 2025, 26(2)588
S1680	Tetraethylthiuram disulfide (Disulfiram)	Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).	Nat Commun, 2025, 16(1):8083 Cell Rep Med, 2025, 6(9):102328 Leukemia, 2025, 39(9):2152-2162
S9731	PF-00835231	PF-00835231 is a 3CL^pro (M^pro) inhibitor that may targets SARS-CoV-2 protease 3CL^pro as a potential new treatment for COVID-19.	Mol Cell, 2022, S1097-2765(22)00433-6 Bioorg Med Chem Lett, 2022, 66:128732 Nat Commun, 2021, 12(1):6786
S2071	Prulifloxacin (NM441)	Prulifloxacin (NM441, AF 3013), the prodrug of ulifloxacin, is a broad-spectrum oral fluoroquinolone antibacterial agent.	J Cell Biochem, 2022, 10.1002/jcb.30213 J Virol, 2021, JVI0177821
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