Cysteine Protease

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1115

Odanacatib (MK-0822)

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.

S7379

E-64

E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.

S3025

PMSF

PMSF is an irreversible serine/cysteine protease inhibitor.

S7393

Aloxistatin

Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor.

S7420New

CA-074 methyl ester (CA-074 Me)

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.

S2847

Cathepsin Inhibitor 1

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

S7396

Calpeptin

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.

S7386

MG-101 (ALLN)

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

S7391

Z-FA-FMK

Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.

S7380

Leupeptin Hemisulfate

Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases.

S7392

Loxistatin Acid (E-64C)

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

S7424

PD 151746

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.

Catalog No. Information Product Use Citations Product Validations
S1115

Odanacatib (MK-0822)

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.

S7379

E-64

E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain.

S3025

PMSF

PMSF is an irreversible serine/cysteine protease inhibitor.

S7393

Aloxistatin

Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor.

S7420New

CA-074 methyl ester (CA-074 Me)

CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.

S2847

Cathepsin Inhibitor 1

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

S7396

Calpeptin

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.

S7386

MG-101 (ALLN)

MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.

S7391

Z-FA-FMK

Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.

S7380

Leupeptin Hemisulfate

Leupeptin Hemisulfate is a reversible inhibitor of serine and cysteine proteases.

S7392

Loxistatin Acid (E-64C)

Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

S7424

PD 151746

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.