Molecular Weight(MW): 357.41
E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM.
Purity & Quality Control
Choose Selective Cysteine Protease Inhibitors
|Description||E-64 is an irreversible and selective cysteine protease inhibitor, and also inhibits papain, calpain, and cathepsins B and H, but not serine proteases or aspartic proteases. The IC50 for papain is 9 nM.|
E-64 rapidly inhibits the activities of the cysteine proteinases cathepsins B, H and L and papain, while has no effect on the serine proteinases or the metalloproteinases.  E-64, as a specific inhibitor os cysteine proteases, effectively blocks in vitro ovarian cancer cell invasion.  In addition, E-64 also shows antiparasitic activity against Giardia lamblia excystation in vitro.  E-64 improves the preimplantation development of bovine somatic cell nuclear transfer embryos, which indicates another important implication of E-64. 
|In vivo||E-64 induces a marked decrease in the number of spontaneous metastasis in M5076 tumor bearing mice, while has no effect on the formation of experimental metastasis.  E-64 also shows antiparasitic activity against Giardia lamblia excystation in infected mice. |
-  Matsumoto K, et al. Biopolymers. 1999, 51(1), 99-107.
-  Barrett AJ, et al. Biochem J. 1982, 201(1), 189-198.
-  Kobayashi H, et al. Cancer Res. 1992, 52(13), 3610-3614.
|In vitro||DMSO||71 mg/mL warmed (198.65 mM)|
|Water||11 mg/mL warmed (30.77 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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