Calpeptin

Catalog No.S7396

Calpeptin Chemical Structure

Molecular Weight(MW): 362.46

Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.

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Biological Activity

Description Calpeptin is a potent, cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively.
Targets
Calpain II (porcine kidney) [1] Calpain I (human platelets) [1] Calpain I (porcine erythrocytes) [1] Papainb [1]
34 nM(ID50) 40 nM(ID50) 52 nM(ID50) 138 nM(ID50)
In vitro

Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. [1] In differentiating PC12 cells, Calpeptin promotes neurite elongation via inhibition of Calpain activity. [2] In rat retinal ganglion cells, Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential, and thus provides functional neuroprotection. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COS7 cells NYq3XZpvTnWwY4Tpc44h[XO|YYm= M33hblUxKM7:TR?= MYiyOEBp NX\nO|JJUW6mdXP0bY9vKG:oIHH1eI9xcGGpeTDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCFT2O3JINmdGy|IHHzd4V{e2WmIHHzJIlv[3KnYYPlJIlvKGG3dH;wbIFod3OxbXWgZZQhPTBidV2gZYZ1\XJiMkSgbJJ{KGK7IHXs[YN1em:wIH3pZ5Jwe2OxcIm= MnHDNVg{QTF7NEm=
HeLa cells MmHhSpVv[3Srb36gZZN{[Xl? NWf1OVl3PTBizszN NG\BSphKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJIh2dWGwIFjlUIEh[2WubIOg[ZhxemW|c3nu[{BGT0[SLVzDN{Bie3Onc4Pl[EBieyCrbnPy[YF{\SCrbjDMR|MuOiCuZY\lcEBifCB3MDD1UUBqdiCycnXz[Y5k\SCxZjC0NFAhdk1iYnHmbYxwdXmlaX6gRVE> MVqxPFM6OTl2OR?=
PC12 cells NFPKWFNHfW6ldHnvckBie3OjeR?= M4PwR|ExKM7:TR?= NF7XeHQ6PiCq NILiS3lKdmS3Y4Tpc44hd2ZiYYX0c5Bp[We7IHnuJJVv\GmoZnXy[Y51cWG2ZXSgdoF1KHO2YXLs[UBqdmS3Y3nicIUhWENzMjDj[YxteyCneIDy[ZN{cW6pIFG1N3Qh[WyyaHGtd5lvfWOuZXnuJIF{e2W|c3XkJIF{KEF3M2SgZYxxcGFvc4nueYNt\WmwIHPs[YFz[W6lZTDheEAyOCC3TTDh[pRmeiB7NjDodpMh[nliY3HsdIFqdiCjY4TpeoF1cW:wIHHzd4F6 NGD6WGoyQDN7MUm0PS=>

... Click to View More Cell Line Experimental Data

In vivo In a feline right ventricular (RV) PO (RVPO) model, calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3, cleavage of their substrates, and cardiomyocyte programmed cell death. [4] In a rat focal cerebral ischemia–reperfusion injury model, Calpeptin reduces the neuronal apoptosis in hippocampal CA1 sector via inhibition of the expression of Caspase-3. [5]

Protocol

Animal Research:[4]
+ Expand
  • Animal Models: Feline right ventricular (RV) PO (RVPO) model
  • Formulation: 1% DMSO in saline
  • Dosages: 0.6 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 72 mg/mL (198.64 mM)
Ethanol 72 mg/mL (198.64 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.46
Formula

C20H30N2O4

CAS No. 117591-20-5
Storage powder
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID