Flubendazole

Catalog No.S1837 Synonyms: Flumoxanal, NSC 313680

Flubendazole Chemical Structure

Molecular Weight(MW): 313.28

Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.

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Biological Activity

Description Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.
Targets
Atg4B [1]
In vitro

Flubendazole results in morphological changes included contraction of the soma region, formation of blebs on the tegument, rostellar disorganization, loss of hooks and destruction of microtriches in Echinococcus granulosus. [1] Flubendazole have a bicyclic ring system in which a benzene has been fused to the -4 and -5 positions of the heterocycle (imidazole). [2] Flubendazole and Albendazole shows similar potency in affecting rat embryonic development in vitro, inducing retardation of growth and dysmorphogenic effects at concentrations ≥0.5 μg/mL. [3]

In vivo Flubendazole (6.32 mg/kg/day) initially induces an arrest of embryonic development followed by a generalized cell death that leads to 100% embryolethality by gestation day (GD) 12.5. Flubendazole (3.46 mg/kg/day) markedly reduces embryonic development by GD 12.5 without causing cell death. [4] Flubendazole in olive oil causes a statistically significant increase in embryolethality at doses of 7.83 mg/kg per day and higher, with complete resorption in all dams at 31.33 mg/kg per day in rats. [5] Flubendazole treatment causes a slight increase of metyrapone and daunorubicin activities in hepatic as well as intestinal cytosol in birds. Flubendazole treatment leads to statistically significant inhibition of intestinal GST activity. Flubendazole treatment leads to slight but significant inhibition (decrease to 69%) of 7-ethoxyresorufin activity in hepatic microsomes. [6]

Protocol

Solubility (25°C)

In vitro DMSO 3 mg/mL warmed (9.57 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 313.28
Formula

C16H12FN3O3

CAS No. 31430-15-6
Storage powder
Synonyms Flumoxanal, NSC 313680

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Related Antibodies

Autophagy Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID