Catalog No.S1837

Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.

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Flubendazole Chemical Structure

Flubendazole Chemical Structure
Molecular Weight: 313.28

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Flubendazole is available in the following compound libraries:

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Product Description

Biological Activity

Description Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.
Targets Atg4B [1]
In vitro Flubendazole results in morphological changes included contraction of the soma region, formation of blebs on the tegument, rostellar disorganization, loss of hooks and destruction of microtriches in Echinococcus granulosus. [1] Flubendazole have a bicyclic ring system in which a benzene has been fused to the -4 and -5 positions of the heterocycle (imidazole). [2] Flubendazole and Albendazole shows similar potency in affecting rat embryonic development in vitro, inducing retardation of growth and dysmorphogenic effects at concentrations ≥0.5 μg/mL. [3]
In vivo Flubendazole (6.32 mg/kg/day) initially induces an arrest of embryonic development followed by a generalized cell death that leads to 100% embryolethality by gestation day (GD) 12.5. Flubendazole (3.46 mg/kg/day) markedly reduces embryonic development by GD 12.5 without causing cell death. [4] Flubendazole in olive oil causes a statistically significant increase in embryolethality at doses of 7.83 mg/kg per day and higher, with complete resorption in all dams at 31.33 mg/kg per day in rats. [5] Flubendazole treatment causes a slight increase of metyrapone and daunorubicin activities in hepatic as well as intestinal cytosol in birds. Flubendazole treatment leads to statistically significant inhibition of intestinal GST activity. Flubendazole treatment leads to slight but significant inhibition (decrease to 69%) of 7-ethoxyresorufin activity in hepatic microsomes. [6]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)
Body Surface Area (m2)0.0070.0250.
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)


[1] Elissondo M, et al. Parasitol Res,?006, 98(4), 317-323.

[2] Moreno L, et al. J Vet Pharmacol Ther,?004, 27(5), 299-308.

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Chemical Information

Download Flubendazole SDF
Molecular Weight (MW) 313.28


CAS No. 31430-15-6
Storage 3 years -20℃powder
2 years -80℃in solvent
Synonyms Flumoxanal, NSC 313680
Solubility (25°C) * In vitro DMSO 3 mg/mL warming (9.57 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name N-​[6-​(4-​fluorobenzoyl)​-​1H-​benzimidazol-​2-​yl]​-carbamic acid methyl ester

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