Research Area
Product Type
United States ( Change Country )
STF-62247 Chemical Structure
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Biological Activity
Mutations and/or inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene occur in the majority of Renal Cell Carcinoma (RCC) of the clear cell phenotype. [1]
STF-62247 selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. [1,2,3] STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM). [3]
References on STF-62247
- [1] Nat Med 1995;1:822–826
- [3] Autophagy 2008;944-946
Chemical Information
| Molecular Weight (WM): | 267.35 |
|---|---|
| Formula: | C15H13N3S |
| CAS No.: | 315702-99-9 |
| Synonyms: |
STF62247
|
| Dissolve in (25°C): | DMSO ≥53mg/mL |
| Water <1mg/mL | |
| Ethanol ≥3mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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