Cidofovir

Catalog No.S1516 Batch:S151609

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Technical Data

Formula

C8H14N3O6P

Molecular Weight 279.19 CAS No. 113852-37-2
Solubility (25°C)* In vitro Water 5 mg/mL (17.9 mM)
DMSO Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Cidofovir suppresses virus replication by selective inhibition of viral DNA synthesis.
In vitro

Cidofovir inhibits human cytomegalovirus (HCMV) infection in cultured cells. Cidofovir is inhibitory to CMV plaque formation even when added to the cells at 48 hr post infection with IC50 of 0.9 μg/mL for Davis and 1.6 μg/mL for AD-169 strains,respectively. [1] Cidofovir also inhibits herpes simplex virus infection. In addition, Cidofovir blocks cell fusion induced by HSV-1 in monkey kidney cells and blocks the expression of HSV-l-specific proteins and the synthesis of viral DNA. [3]

In vivo

Cidofovir (5 mg/kg/day) subcutaneously for 5 days significantly reduces average virus infectivity titer in blood, spleen, lung and salivary gland in infected guinea pigs. Cidofovir significantly reduces lymphocytosis and average tissue indexe of spleen in infected animals. [2]. Cidofovir suppresses all manifestations (skin lesions, paralysis of the hind legs, and mortality) of hairless mice infected intracutaneously with HSV-1 or HSV-2. The most remarkable feature of Cidofovir is that a single administration of the compound, even as late as 4 days after infection, conferees significant protection against HSV-1 or HSV-2 infection. [4] Cidofovir inhibits growth of the highly aggressive melanoma tumor arising from mouse melanoma B16 cells grafted subcutaneously in C57B16/J mice. [5]

Protocol (from reference)

Customer Product Validation

, , Viruses 2015, 7, 2268-2287.

Data from [Data independently produced by , , Int J Oncol, 2016, 48(4):1519-30. ]

Selleck's Cidofovir has been cited by 8 publications

Triptolide inhibits human telomerase reverse transcriptase by downregulating translation factors SP1 and c-Myc in Epstein-Barr virus-positive B lymphocytes [ Oncol Lett, 2021, 21(4):280] PubMed: 33732356
Tubuloids derived from human adult kidney and urine for personalized disease modeling. [ Nat Biotechnol, 2019, 37(3):303-313] PubMed: 30833775
Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor. [ Antiviral Res, 2019, 162:178-185] PubMed: 30578797
A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice [ J Virol, 2019, 93(4)] PubMed: 30463976
Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. [ Virology, 2019, 536:16-19] PubMed: 31394407
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. [ Neuron, 2017, 96(6):1290-1302] PubMed: 29268096
Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi's sarcoma-associated and herpesvirus-related primary effusion lymphoma cells [Long C, et al. Int J Oncol, 2016, 48(4):1519-30] PubMed: 26821279
Celecoxib Inhibits the Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK. [Chen J, et al. Viruses, 2015, 7(5):2268-87] PubMed: 25951487

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.