Research Area
Product Type
United States ( Change Country )
Acadesine Chemical Structure
A-769662
A-769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator with an EC50 of 0.8 μM.
BEZ235 (NVP-BEZ235)
BEZ235 (NVP-BEZ235)is a dual ATP-competitive phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM，respectively.
Deforolimus (Ridaforolimus)
Deforolimus (Ridaforolimus) is a small-molecule inhibitor of mTOR.
Perifosine
Perifosine is an Akt inhibitor. the antiproliferative properties of perifosine with an IC50 of 0.6–8.9 µM.
PI-103
PI-103 is a potent, cell-permeable, ATP-competitive PI3K family member inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively.
Rapamycin (Sirolimus)
Rapamycin also known as Sirolimus & Rapamune is an mTOR inhibitor. Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated pathways.
Temsirolimus (Torisel)
Temsirolimus (Torisel) is a mTOR inhibitor.
GDC-0941
Inhibitor of Class I PI3 Kinase,p110a IC50=0.003uM,U87MG IC50=0.95μM.
ZSTK474
ZSTK474 is an inhibitor of PI3K γ(IC50 at 6 nM).
SB 216763
SB 216763 inhibited human GSK-3α with IC50s of 34 nM.
Biological Activity
Acadesine is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. [1]
Product Information
| Molecular Weight (WM): | 258.23 |
|---|---|
| Formula: | C9H14N4O5 |
| CAS No.: | 2627-69-2 |
| Synonyms: |
AICAR, AICA-riboside
|
| Dissolve in (25°C): | DMSO ≥52mg/mL |
| Water ≥52mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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