Research Area
Product Type
United States ( Change Country )
Abitrexate(Methotrexate) Chemical Structure
Pemetrexed (Alimta)
Pemetrexed (Alimta) is a thymidylate synthase, DHFR and glycinamide ribonucleotide formyltransferase inhibitor with an IC50 of 25, 34, 220 nM.
BSI-201
BSI-201 is a potent PARP1 inhibitor with strong anti-neoplastic effect.
Pemetrexed (Alimta)
Pemetrexed (Alimta) is a thymidylate synthase, DHFR and glycinamide ribonucleotide formyltransferase inhibitor with an IC50 of 25, 34, 220 nM.
Bleomycin sulfate
A glycopeptide antibiotic produced by the bacterium Streptomyces verticillus.
Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
Ifosfamide
Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
Mercaptopurine
Mercaptopurine is an agent used to treat leukemia.
Dacarbazine (DTIC-Dome)
Dacarbazine(DTIC-Dome) is an antineoplastic chemotherapy drug used in the treatment of various cancers.
NSC 131463 (NSC 133723)
NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM.
CX-5461
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM.
Biological Activity
Abitrexate(Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate competitively and irreversibly inhibits dihydrofolate reductase (DHFR), resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. [1,2] In a panel of six pediatric leukemia and lymphoma cell lines, this drug performed growth inhibitory activity with median IC50 78 nM. [3]
Product Information
| Molecular Weight (WM): | 454.44 |
|---|---|
| Formula: | C20H22N8O5 |
| CAS No.: | 59-05-2 |
| Synonyms: |
Methotrexate, Rheumatrex, Trexall
|
| Dissolve in (25°C): | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
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