Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

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In DMSO USD 156 In stock
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Cited by 40 Publications

9 Customer Reviews

  • (A) OVCAR-8 cells were exposed to the indicated concentrations of FdUrd along with vehicle, 3 μM ABT-888 or 300 nM AZD2281 for 24 h. Following washing, ABT-888 and AZD2281 were re-added to the plates initially exposed to these agents, and cells were cultured in the continued presence of ABT-888 and AZD2281 for 8 d until colonies formed. (B) OVCAR-8 cells were exposed continuously to the indicated agents for 8 d. (C) OVCAR-8 cells treated as in (A) except that the indicated concentrations of ABT-888 were used.

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

    OVCAR-8 cells were plated, treated with indicated concentrations of FdUrd and 3 μM ABT-888 using the exposure schemes depicted in (C) and assayed for clonogenicity (D).

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.


    Number of foci detected using laser confocal microscopy and fluorescent Fluor 647 anti-H2A.X-phosphorylated (Ser139) antibody. Double-stranded breaks (red) are clearly augmented in cells incubated with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281 compared with PBS and 1% dimethyl sulfoxide controls. Image analysis was performed using ImageJ and the ‘analyze particle’ function.

    Nucl Med Commun 2011 32, 1046-1051. Veliparib (ABT-888) purchased from Selleck.

    Logarithmic growth curves of human Burkitt lymphoma cells over 5 days with 500 nmol/l of ABT-888 and AZD-2281 in combination with 0 Gy (a), 4 Gy (b), 8 Gy (c), and 12 Gy (d) of external beam radiation. The maximal relative reduction was 65.5% of viable cells and occurred with AZD-2281 (500 nmol/l) on day 5. DMSO, dimethyl sulfoxide.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

  • Colorimetric poly(ADP-ribose) polymerase (PARP) activity assay showing the relative activity of the PARP-1 enzyme in Raji lymphocyte tumor cells. Results show a highly significant difference in PARP activity in the controls [PBS and dimethyl sulfoxide (DMSO)] compared with 24 h incubation with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281. A significant increase in PARP enzyme activity is shown in DMSO-incubated cells compared with PBS control.* P < 0.05.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

    T47D breast cancer cells were pretreated with indicated concentrations of ABT-888



    Dr.Zhang of Tianjin Medical University. Veliparib (ABT-888) purchased from Selleck.

  • in vivo suppression of PAR formation by the PARP inhibitor ABT-888 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor ABT-888 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.


    David Schrmann from University of Base. Veliparib (ABT-888) purchased from Selleck.

    Caption:  451 Lu is a melanoma cell line with high PARP expression that is resistant to temozolomide.  Treatment with 25 µM ABT-888 greatly increased sensitivity to temozolomide compared to cells without ABT-888 treatment as measured by MTS assay.



    Dr. Steve Reuland from University of Colorado Denver. Veliparib (ABT-888) purchased from Selleck.

  • Effect of ABT-888 on the viability of endometrial cancer cell line Hec50 and Ishikawa and ovarian cancer cell line SKOV3,Caov3 and PA-1 was detected by WST-1 method after 3 days treatment.



    Dr. Xiangbing Meng of University of Iowa. Veliparib (ABT-888) purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Jurkat M4fDU2tqdmG|ZTDBd5NigQ>? MXS5OkBp MULEUXNQ NUDzeGhXUW6qaXLpeIlwdiCxZjDQRXJROSCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[2WubDD2bYFjcWyrdImge4l1cCCHQ{WwJI9nKDNizszN M4fxRlI{QDVyMUm5
Capan1 NInjb3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHzWWQ4OiCq MoLSSG1UVw>? NGD4[FZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JGJTS0F{IHflcoUhdXW2YYTl[EBpfW2jbjDDZZBidjFiY3XscJMhf2m2aDDJR|UxKG:oIEO5Mlch|ryP MXeyOFM6QDN6Mx?=
DT40 NIPCV3hEgXSxdH;4bYMhSXO|YYm= NICxbnI4OiCq NV3NWGZDTE2VTx?= NGiwXolEgXSxdH;4bYNqfHliYXfhbY5{fCClaHnjb4VvKEKUQ1GyMYRm\mmlaXXueEBFXDRyIHPlcIx{ Ml34NlQ6OjJ3OEe=
HCT-116 MX7LbY5ie2ViQYPzZZk> MnzJNE42KM7:TR?= M1f6N|I1KGh? NGCye2pRSVKSIHHjeIl3cXS7IHTlZ5Jm[XOncx?= NH;F[5UzOzB3NEKxNy=>
UM-SCC1 M2S4XWN6fG:2b4jpZ{BCe3OjeR?= NETTdWkyOCEQvF2= MlPzNlQhcA>? NVLuc5FxWmWmdXPld{B1cGViY3XscEB3cWGkaXzpeJk> MnXaNlE6OTJ4MkC=
FaDu M{fnXmN6fG:2b4jpZ{BCe3OjeR?= M3\sV|ExKM7:TR?= M3P6elI1KGh? MV7S[YR2[2W|IITo[UBk\WyuII\pZYJqdGm2eR?= NEHjb2ozOTlzMk[yNC=>
PC-3 MmXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCxNEDPxE1? MWDJcoR2[2W|IHGgd4lodmmoaXPhcpQhcW6qaXLpeIlwdiCrbjDjc4xwdnliZn;ycYF1cW:wwrC= M1rPTlIyPTdzOUGy
EoL-1-cell NV\HOWZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvDTWM2OD1zLkC3PVgh|ryP MVrTRW5ITVJ?
NCI-SNU-5 NFq2UFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonDTWM2OD1|LkGyPFQyKM7:TR?= M2fFeXNCVkeHUh?=
BV-173 M4DyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDvVpdKSzVyPUWuOFU1ODlizszN M2nndnNCVkeHUh?=
HCC1806 NInKNYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\RSXlyUUN3ME21Mlc2OTd|IN88US=> NF\V[HBUSU6JRWK=
COLO-680 NFXJSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTZwMkG0NFYh|ryP M{HuUnNCVkeHUh?=
HCC2218 NF\3flRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTdwN{m3NFQh|ryP NFW5bIRUSU6JRWK=
NCI-H720 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;uO5VjUUN3ME24MlQ{PjB|IN88US=> NUewZZZnW0GQR1XS
KASUMI-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRThwOEmyOlYh|ryP NUjQO441W0GQR1XS
HAL-01 NELmZoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4SxfWlEPTB;OT64PFYzKM7:TR?= MkPsV2FPT0WU
CAL-33 M1SxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzSRotFUUN3ME2xNE41OzRizszN MVvTRW5ITVJ?
SK-MEL-1 NETXblRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnBTWM2OD1zMj60OlY{KM7:TR?= Ml3lV2FPT0WU
Ramos-2G6-4C10 NXnsNZJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTF{LkS3OVIh|ryP NF24RXNUSU6JRWK=
HEC-1 NEPIbI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;tRZhKSzVyPUGyMlkyQTZizszN MojGV2FPT0WU
SK-NEP-1 MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK1TWM2OD1zMz6xOlYh|ryP NYTvUHVVW0GQR1XS
MN-60 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom4TWM2OD1zMz61N|g6KM7:TR?= NEn5NItUSU6JRWK=
DU-145 NGXaRWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e4SWlEPTB;MUOuPVA2OyEQvF2= MmXqV2FPT0WU
EW-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\JUndMUUN3ME2xOE42PTZ3IN88US=> MnPUV2FPT0WU
OS-RC-2 M3:zNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnFW|ROUUN3ME2xOU46PTh7IN88US=> M1HvbnNCVkeHUh?=
RPMI-8226 NHHycpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXq5Uo9FUUN3ME2xOk4zODR{IN88US=> NWTXW5JoW0GQR1XS
ChaGo-K-1 M2\JfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF4LkWzNlUh|ryP NETVUJVUSU6JRWK=
GP5d NED3WY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3pN4tKSzVyPUG3MlA2OyEQvF2= MVPTRW5ITVJ?
COLO-668 NYfodGJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjmTWM2OD1zNz62Nlk1KM7:TR?= NYjBO5JZW0GQR1XS
H9 NEnHSIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzyTWM2OD1zOD6yPFM{KM7:TR?= NYfxe4ZlW0GQR1XS
KYSE-150 M2Gxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TycmlEPTB;MUiuPVk5PiEQvF2= NWrj[5lxW0GQR1XS
Daoy M1r0SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{GwUWlEPTB;MUmuOVY1QSEQvF2= Ml3hV2FPT0WU
A388 M1\xS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fUTmlEPTB;MkGuPVA6OSEQvF2= M1LZTnNCVkeHUh?=
MHH-NB-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17oS2lEPTB;MkOuNVM3OyEQvF2= MlXPV2FPT0WU
HCC1937 MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLxW2t[UUN3ME2yOE44PDZizszN NYjuUVlNW0GQR1XS
TGBC11TKB MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[2NpZKSzVyPUK1MlY5PjNizszN NXn5[pI1W0GQR1XS
NCI-H2029 NFS3eZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJ4LkSyN|gh|ryP NXu2OHV[W0GQR1XS
HCC70 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzIcolKSzVyPUK3MlczPDZizszN MYXTRW5ITVJ?
BEN NETodZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTJ5Lkm1OlYh|ryP NYeyO3R[W0GQR1XS
LB771 NELzUVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfqT5dKSzVyPUK4Mlg{PzNizszN MYfTRW5ITVJ?
697 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV64[lM1UUN3ME2yPU4xOjN3IN88US=> NWHSeoY1W0GQR1XS
LU-139 NUnNO2x3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjk[YhKSzVyPUK5MlM4PDhizszN MV\TRW5ITVJ?
EW-13 M2\iOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\ITWM2OD1{OT6zPFE1KM7:TR?= MY\TRW5ITVJ?
MOLT-13 NFjKfmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIezVZhKSzVyPUK5MlM5OTRizszN NVjkN48xW0GQR1XS
L-363 NUXLb25qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;p[XRlUUN3ME2yPU41Pzl6IN88US=> MnmzV2FPT0WU
RS4-11 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLuWIQ5UUN3ME2zNE41OjRzIN88US=> NWq4eVZDW0GQR1XS
A2780 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnr5TWM2OD1|MD63OFU4KM7:TR?= Ml76V2FPT0WU
KU812 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTN{LkO2OFIh|ryP MlfXV2FPT0WU
KG-1 MnrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH1Nm9pUUN3ME2zN{43ODBzIN88US=> NVj6[4JXW0GQR1XS
JVM-3 NWq0R45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHlTWM2OD1|NT61PFY5KM7:TR?= M3W4PXNCVkeHUh?=
LAMA-84 MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmyTWM2OD1|Nj63N|Q2KM7:TR?= NHHLVG1USU6JRWK=
MOLT-16 M1zwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN4Lkm1NkDPxE1? Mlq5V2FPT0WU
H4 NIfTTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHhTWM2OD1|Nz61Olch|ryP MWTTRW5ITVJ?
T47D NGXL[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX6zeWlqUUN3ME2zO{44ODF6IN88US=> NUHlPI94W0GQR1XS
CAL-54 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn3TWM2OD1|Nz65OlYh|ryP M3S1N3NCVkeHUh?=
NB14 Mo\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2juN2lEPTB;NECuO|A{OSEQvF2= NYXVT4xrW0GQR1XS
HCC1187 NHS3d5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTRzLkK3O|Eh|ryP M1;OOHNCVkeHUh?=
KARPAS-45 M3TBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTRzLkS4NVgh|ryP MUDTRW5ITVJ?
MOLT-4 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjtbllKSzVyPUSyMlI2OzhizszN NUnadpJHW0GQR1XS
JVM-2 MlqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfJTWM2OD12Mj65NlA4KM7:TR?= NYjBfGNbW0GQR1XS
A4-Fuk NXezVFNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TmeWlEPTB;NEOuOVY6OSEQvF2= M3The3NCVkeHUh?=
BALL-1 MonzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XNfmlEPTB;NEOuPVU{OiEQvF2= M{TjV3NCVkeHUh?=
T98G MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\FdG5KSzVyPUS0Mlg2OTdizszN NYPzfYx3W0GQR1XS
Mo-T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1viVGlEPTB;NEWuOlM5QSEQvF2= M3fJU3NCVkeHUh?=
MHH-PREB-1 MnL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\wTWM2OD12NT63OVg2KM7:TR?= M{jBOHNCVkeHUh?=
NCI-H510A M4Pwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17HbGlEPTB;NEeuPVA{PCEQvF2= NYG2dG1UW0GQR1XS
ML-2 NELpOJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[2cJpKSzVyPUS5Mlc5PTZizszN NHXS[2pUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]


Animal Research:


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  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 0.5% methylcellulose+0.2% Tween 80 5 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29


CAS No. 912444-00-9
Storage powder
in solvent
Synonyms NSC 737664

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00553189 Completed Solid Tumors|Lymphomas National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9, 2007 Phase 1
NCT03032614 Not yet recruiting Breast Cancer Stage IV|Ovarian Cancer|BRCA1 Mutation|BRCA2 Mutation The University of Texas Health Science Center at San Antonio March 31, 2017 Phase 2
NCT01445522 Completed Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) December 3, 2008 Phase 1
NCT01419548 Withdrawn Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 29, 2011 Phase 1
NCT02723864 Recruiting Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 22, 2016 Phase 1
NCT00994071 Completed Medulloblastoma|Pontine Glioma|Ependymoma|Astrocytoma|PNET National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 22, 2009 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID