Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

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In DMSO USD 156 In stock
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Cited by 40 Publications

9 Customer Reviews

  • (A) OVCAR-8 cells were exposed to the indicated concentrations of FdUrd along with vehicle, 3 μM ABT-888 or 300 nM AZD2281 for 24 h. Following washing, ABT-888 and AZD2281 were re-added to the plates initially exposed to these agents, and cells were cultured in the continued presence of ABT-888 and AZD2281 for 8 d until colonies formed. (B) OVCAR-8 cells were exposed continuously to the indicated agents for 8 d. (C) OVCAR-8 cells treated as in (A) except that the indicated concentrations of ABT-888 were used.

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

    OVCAR-8 cells were plated, treated with indicated concentrations of FdUrd and 3 μM ABT-888 using the exposure schemes depicted in (C) and assayed for clonogenicity (D).

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.


    Number of foci detected using laser confocal microscopy and fluorescent Fluor 647 anti-H2A.X-phosphorylated (Ser139) antibody. Double-stranded breaks (red) are clearly augmented in cells incubated with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281 compared with PBS and 1% dimethyl sulfoxide controls. Image analysis was performed using ImageJ and the ‘analyze particle’ function.

    Nucl Med Commun 2011 32, 1046-1051. Veliparib (ABT-888) purchased from Selleck.

    Logarithmic growth curves of human Burkitt lymphoma cells over 5 days with 500 nmol/l of ABT-888 and AZD-2281 in combination with 0 Gy (a), 4 Gy (b), 8 Gy (c), and 12 Gy (d) of external beam radiation. The maximal relative reduction was 65.5% of viable cells and occurred with AZD-2281 (500 nmol/l) on day 5. DMSO, dimethyl sulfoxide.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

  • Colorimetric poly(ADP-ribose) polymerase (PARP) activity assay showing the relative activity of the PARP-1 enzyme in Raji lymphocyte tumor cells. Results show a highly significant difference in PARP activity in the controls [PBS and dimethyl sulfoxide (DMSO)] compared with 24 h incubation with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281. A significant increase in PARP enzyme activity is shown in DMSO-incubated cells compared with PBS control.* P < 0.05.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

    T47D breast cancer cells were pretreated with indicated concentrations of ABT-888



    Dr.Zhang of Tianjin Medical University. Veliparib (ABT-888) purchased from Selleck.

  • in vivo suppression of PAR formation by the PARP inhibitor ABT-888 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor ABT-888 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.


    David Schrmann from University of Base. Veliparib (ABT-888) purchased from Selleck.

    Caption:  451 Lu is a melanoma cell line with high PARP expression that is resistant to temozolomide.  Treatment with 25 µM ABT-888 greatly increased sensitivity to temozolomide compared to cells without ABT-888 treatment as measured by MTS assay.



    Dr. Steve Reuland from University of Colorado Denver. Veliparib (ABT-888) purchased from Selleck.

  • Effect of ABT-888 on the viability of endometrial cancer cell line Hec50 and Ishikawa and ovarian cancer cell line SKOV3,Caov3 and PA-1 was detected by WST-1 method after 3 days treatment.



    Dr. Xiangbing Meng of University of Iowa. Veliparib (ABT-888) purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
C41 M{jROWtqdmG|ZTDBd5NigQ>? M1e0S|MxKG2rbh?= MnHLTY5pcWKrdHnvckBw\iCSQWLQNUB4cXSqIFXDOVAhd2ZiMD6wNFIh|ryP NH33fpcyQTh6OEe2NC=>
Jurkat MkKzT4lv[XOnIFHzd4F6 NWPv[5JQQTZiaB?= NHv1XXJFVVOR NYP0enI4UW6qaXLpeIlwdiCxZjDQRXJROSCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[2WubDD2bYFjcWyrdImge4l1cCCHQ{WwJI9nKDNizszN MmfQNlM5PTBzOUm=
Capan1 NUP3W49PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLUO|IhcA>? NWjEZYhjTE2VTx?= Mk\CRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDCVmNCOiCpZX7lJI12fGG2ZXSgbJVu[W5iQ3HwZY4yKGOnbHzzJJdqfGhiSVO1NEBw\iB|OT63JO69VQ>? Mn20NlQ{QTh|OEO=
DT40 M4PmbGN6fG:2b4jpZ{BCe3OjeR?= NH[0UIY4OiCq NILL[ItFVVOR MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBkcGmla3XuJGJTS0F{LXTl[olkcWWwdDDEWFQxKGOnbHzz NXzydW1uOjR7MkK1PFc>
ML-1 NFv2WllCeG:ydH;0bYMhSXO|YYm= NID4OoYzNjVizszN M{PQO|I1KGh? NGLENJhFVVOR MWfTfY5memerc4TpZ4FtdHliZX7oZY5k\XNiVGLBTWwucW6mdXPl[EBieG:ydH;zbZMhcW5iTVytNUBk\Wyucx?= M4nmRlI1QDl3MUO1
FaDu M2f3b2N6fG:2b4jpZ{BCe3OjeR?= M{LPTFExKM7:TR?= NGfNdmEzPCCq MmnWVoVlfWOnczD0bIUh[2WubDD2bYFjcWyrdIm= NGfrdnUzOTlzMk[yNC=>
PC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYKxNEDPxE1? NYLERY82UW6mdXPld{BiKHOrZ37p[olk[W62IHnubIljcXSrb36gbY4h[2:ub375JIZwem2jdHnvcuKh NW\YcIJZOjF3N{G5NVI>
EoL-1-cell MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwMEe5PEDPxE1? M3TXN3NCVkeHUh?=
BV-173 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[1SFdqUUN3ME21MlQ2PDB7IN88US=> NEHYc49USU6JRWK=
HCC1806 NGLySldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLx[GRtUUN3ME21Mlc2OTd|IN88US=> NHXRWlRUSU6JRWK=
COLO-680 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3zOI9KSzVyPU[uNlE1ODZizszN M4TMbXNCVkeHUh?=
HCC2218 NHzx[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LlPWlEPTB;Nz63PVcxPCEQvF2= NVH1eZBwW0GQR1XS
SK-MEL-24 M3G4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HPcWlEPTB;Nz64NVkzPCEQvF2= NEPHOYlUSU6JRWK=
NCI-H720 NUHFcoRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnmVXcyUUN3ME24MlQ{PjB|IN88US=> M1vxfHNCVkeHUh?=
HAL-01 M{XE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nVWGlEPTB;OT64PFYzKM7:TR?= NF7VRnpUSU6JRWK=
CAL-33 M3P3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf5SpVKSzVyPUGwMlQ{PCEQvF2= NYLmNHVQW0GQR1XS
SK-MEL-1 M4XPb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfjNGpKSzVyPUGyMlQ3PjNizszN NXTofFR7W0GQR1XS
Ramos-2G6-4C10 NXTDN45kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHXNYhMUUN3ME2xNk41PzV{IN88US=> M{LjRnNCVkeHUh?=
KY821 M3HyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKzTWM2OD1zMj60PFUh|ryP MVfTRW5ITVJ?
HEC-1 M3zKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrUSFJKUUN3ME2xNk46OTl4IN88US=> NEnIU5hUSU6JRWK=
SK-NEP-1 NV\jco1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvIT2xIUUN3ME2xN{4yPjZizszN M4HxcXNCVkeHUh?=
MN-60 MmTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXCcmVKSzVyPUGzMlU{QDlizszN MlK4V2FPT0WU
DU-145 M2Pm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj4b5BKSzVyPUGzMlkxPTNizszN NVzJcXpSW0GQR1XS
EW-3 NEfjeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXq[2VKSzVyPUG0MlU2PjVizszN NGXDfIJUSU6JRWK=
RPMI-8226 MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPoTWM2OD1zNj6yNFQzKM7:TR?= M3vjSXNCVkeHUh?=
ChaGo-K-1 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkSGlEPTB;MU[uOVMzPSEQvF2= NEDT[mdUSU6JRWK=
DEL NGLDfHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF4Lk[3NVch|ryP M1HlbnNCVkeHUh?=
GP5d M3Pacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe3SJdKSzVyPUG3MlA2OyEQvF2= MlfsV2FPT0WU
H9 NIrtNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYiyfZZVUUN3ME2xPE4zQDN|IN88US=> M1X5[nNCVkeHUh?=
NKM-1 M3nI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF6LkWxNVkh|ryP MULTRW5ITVJ?
KYSE-150 MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES5dlRKSzVyPUG4Mlk6QDZizszN M{PsdHNCVkeHUh?=
Daoy NYTCVGZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP6enJKSzVyPUG5MlU3PDlizszN M3\kdHNCVkeHUh?=
MHH-NB-11 MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ|LkGzOlMh|ryP NHX1SpFUSU6JRWK=
HCC1937 NYnZNYl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2Lke0OkDPxE1? MVvTRW5ITVJ?
TGBC11TKB NF;oT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ3Lk[4OlMh|ryP NEjpNpBUSU6JRWK=
CTV-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDR[pdKSzVyPUK1Mlg6PjlizszN NVHSR3E3W0GQR1XS
NCI-H2029 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HpXGlEPTB;Mk[uOFI{QCEQvF2= MmPYV2FPT0WU
HLE MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XW[2lEPTB;MkeuNFU1KM7:TR?= NUPXVIxrW0GQR1XS
NCI-H1693 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ5LkK4PVgh|ryP NUfZ[FJOW0GQR1XS
HCC70 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj5VIxqUUN3ME2yO{44OjR4IN88US=> MoL6V2FPT0WU
BEN M2L1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ5Lkm1OlYh|ryP NV:x[4hLW0GQR1XS
697 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJ7LkCyN|Uh|ryP MWPTRW5ITVJ?
LU-139 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnWdlZSUUN3ME2yPU4{PzR6IN88US=> MXLTRW5ITVJ?
MOLT-13 M13SRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ7LkO4NVQh|ryP M{jGfnNCVkeHUh?=
L-363 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ7LkS3PVgh|ryP NYLBc3l6W0GQR1XS
EM-2 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHpTWM2OD1{OT60PVAyKM7:TR?= M{\vXHNCVkeHUh?=
A2780 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SzTWlEPTB;M{CuO|Q2PyEQvF2= NHTBeIxUSU6JRWK=
KU812 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7TTHlKSzVyPUOyMlM3PDJizszN Mo\zV2FPT0WU
COLO-684 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XhNmlEPTB;M{OuN|U6QSEQvF2= NHLwXmNUSU6JRWK=
MFE-280 NFTJPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjZTWM2OD1|Mz6zPFg6KM7:TR?= MUHTRW5ITVJ?
MV-4-11 Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTN3Lki0PVkh|ryP MY\TRW5ITVJ?
LAMA-84 Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNNnpKSzVyPUO2Mlc{PDVizszN MnrzV2FPT0WU
MOLT-16 M3\sVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILzWVdKSzVyPUO2Mlk2OiEQvF2= NWXSUJRrW0GQR1XS
H4 NYfYVJJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn6TWM2OD1|Nz61Olch|ryP M{fZXHNCVkeHUh?=
T47D MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN5LkewNVgh|ryP NVexXJlSW0GQR1XS
CAL-54 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\XbnZKSzVyPUO3Mlk3PiEQvF2= M4Xpd3NCVkeHUh?=
SW982 M1n0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\q[ZpYUUN3ME2zPE4xQTl6IN88US=> NF3qO4lUSU6JRWK=
NB14 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3xcWhuUUN3ME20NE44ODNzIN88US=> MlmwV2FPT0WU
HCC1187 M2fJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XyPGlEPTB;NEGuNlc4OSEQvF2= NFi3eG1USU6JRWK=
SBC-1 M1G2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTOVmNNUUN3ME20NU4{ODZ|IN88US=> MofTV2FPT0WU
JVM-2 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjvb|B5UUN3ME20Nk46OjB5IN88US=> MXLTRW5ITVJ?
A4-Fuk M4rMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ieVZwUUN3ME20N{42PjlzIN88US=> MUTTRW5ITVJ?
BALL-1 M37iS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTR|Lkm1N|Ih|ryP MUTTRW5ITVJ?
Mo-T NH\TZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTR3Lk[zPFkh|ryP NWHsUWhSW0GQR1XS
ALL-PO Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR5LkO3PVEh|ryP MnH0V2FPT0WU
NCI-H510A MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHsTXhKSzVyPUS3MlkxOzRizszN M3m4OXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]


Animal Research:


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  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
0.5% methylcellulose+0.2% Tween 80
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29


CAS No. 912444-00-9
Storage powder
in solvent
Synonyms NSC 737664

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00553189 Completed Solid Tumors|Lymphomas National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9, 2007 Phase 1
NCT03032614 Not yet recruiting Breast Cancer Stage IV|Ovarian Cancer|BRCA1 Mutation|BRCA2 Mutation The University of Texas Health Science Center at San Antonio March 31, 2017 Phase 2
NCT01445522 Completed Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) December 3, 2008 Phase 1
NCT01419548 Withdrawn Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 29, 2011 Phase 1
NCT02723864 Recruiting Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 22, 2016 Phase 1
NCT00994071 Completed Medulloblastoma|Pontine Glioma|Ependymoma|Astrocytoma|PNET National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 22, 2009 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID