Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

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In DMSO USD 156 In stock
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USD 370 In stock
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Cited by 40 Publications

9 Customer Reviews

  • (A) OVCAR-8 cells were exposed to the indicated concentrations of FdUrd along with vehicle, 3 μM ABT-888 or 300 nM AZD2281 for 24 h. Following washing, ABT-888 and AZD2281 were re-added to the plates initially exposed to these agents, and cells were cultured in the continued presence of ABT-888 and AZD2281 for 8 d until colonies formed. (B) OVCAR-8 cells were exposed continuously to the indicated agents for 8 d. (C) OVCAR-8 cells treated as in (A) except that the indicated concentrations of ABT-888 were used.

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

    OVCAR-8 cells were plated, treated with indicated concentrations of FdUrd and 3 μM ABT-888 using the exposure schemes depicted in (C) and assayed for clonogenicity (D).

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

  •  

    Number of foci detected using laser confocal microscopy and fluorescent Fluor 647 anti-H2A.X-phosphorylated (Ser139) antibody. Double-stranded breaks (red) are clearly augmented in cells incubated with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281 compared with PBS and 1% dimethyl sulfoxide controls. Image analysis was performed using ImageJ and the ‘analyze particle’ function.

    Nucl Med Commun 2011 32, 1046-1051. Veliparib (ABT-888) purchased from Selleck.

    Logarithmic growth curves of human Burkitt lymphoma cells over 5 days with 500 nmol/l of ABT-888 and AZD-2281 in combination with 0 Gy (a), 4 Gy (b), 8 Gy (c), and 12 Gy (d) of external beam radiation. The maximal relative reduction was 65.5% of viable cells and occurred with AZD-2281 (500 nmol/l) on day 5. DMSO, dimethyl sulfoxide.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

  • Colorimetric poly(ADP-ribose) polymerase (PARP) activity assay showing the relative activity of the PARP-1 enzyme in Raji lymphocyte tumor cells. Results show a highly significant difference in PARP activity in the controls [PBS and dimethyl sulfoxide (DMSO)] compared with 24 h incubation with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281. A significant increase in PARP enzyme activity is shown in DMSO-incubated cells compared with PBS control.* P < 0.05.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

    T47D breast cancer cells were pretreated with indicated concentrations of ABT-888

     

     

    Dr.Zhang of Tianjin Medical University. Veliparib (ABT-888) purchased from Selleck.

  • in vivo suppression of PAR formation by the PARP inhibitor ABT-888 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor ABT-888 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.
     
     

     

    David Schrmann from University of Base. Veliparib (ABT-888) purchased from Selleck.

    Caption:  451 Lu is a melanoma cell line with high PARP expression that is resistant to temozolomide.  Treatment with 25 µM ABT-888 greatly increased sensitivity to temozolomide compared to cells without ABT-888 treatment as measured by MTS assay.

     

     

    Dr. Steve Reuland from University of Colorado Denver. Veliparib (ABT-888) purchased from Selleck.

  • Effect of ABT-888 on the viability of endometrial cancer cell line Hec50 and Ishikawa and ovarian cancer cell line SKOV3,Caov3 and PA-1 was detected by WST-1 method after 3 days treatment.

     
     

     

    Dr. Xiangbing Meng of University of Iowa. Veliparib (ABT-888) purchased from Selleck.

Purity & Quality Control

Choose Selective PARP Inhibitors

Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
Targets
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
C41 Moj2T4lv[XOnIFHzd4F6 M1vpelMxKG2rbh?= NH3GUGhKdmirYnn0bY9vKG:oIGDBVnAyKHerdHigSWM2OCCxZjCwMlAxOiEQvF2= M{DGU|E6QDh6N{[w
Jurkat M1\DV2tqdmG|ZTDBd5NigQ>? NH7wVI46PiCq M1GzSWROW09? NFz3RVVKdmirYnn0bY9vKG:oIGDBVnAyKGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDv[kBk\WyuII\pZYJqdGm2eTD3bZRpKEWFNUCgc4YhOyEQvF2= MluyNlM5PTBzOUm=
Capan1 M2LHW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rlfFczKGh? MmjaSG1UVw>? MXnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IFLSR2EzKGenbnWgcZV1[XSnZDDoeY1idiCFYYDhclEh[2WubIOge4l1cCCLQ{WwJI9nKDN7Lkeg{txO MnjHNlQ{QTh|OEO=
DT40 MmTiR5l1d3SxeHnjJGF{e2G7 MYS3NkBp NUjBUFdTTE2VTx?= MoS1R5l1d3SxeHnjbZR6KGGpYXnud5Qh[2irY3vlckBDWkODMj3k[YZq[2mnboSgSHQ1OCClZXzsdy=> NW\BW4w4OjR7MkK1PFc>
ML-1 NIjONZVCeG:ydH;0bYMhSXO|YYm= NWSwO3l6Oi53IN88US=> M3HKUFI1KGh? NVvuRog1TE2VTx?= NV36NlhyW3mwZYLnbZN1cWOjbHz5JIVvcGGwY3XzJHRTSUmOLXnu[JVk\WRiYYDvdJRwe2m|IHnuJG1NNTFiY3XscJM> MnnDNlQ5QTVzM{W=
HCT-116 MVjLbY5ie2ViQYPzZZk> MWKwMlUh|ryP MXqyOEBp NGXQfJpRSVKSIHHjeIl3cXS7IHTlZ5Jm[XOncx?= NXXHbII3OjNyNUSyNVM>
UM-SCC1 NIjDcJdEgXSxdH;4bYMhSXO|YYm= NYfkWmV[OTBizszN MnHTNlQhcA>? MWfS[YR2[2W|IITo[UBk\WyuII\pZYJqdGm2eR?= NGfrPG8zOTlzMk[yNC=>
FaDu NWX6NZhDS3m2b4TvfIlkKEG|c3H5 MYWxNEDPxE1? NEHpcYEzPCCq MUDS[YR2[2W|IITo[UBk\WyuII\pZYJqdGm2eR?= NXPrcYZEOjF7MUK2NlA>
PC-3 NFzp[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\VUlExKM7:TR?= NUO1cJF3UW6mdXPld{BiKHOrZ37p[olk[W62IHnubIljcXSrb36gbY4h[2:ub375JIZwem2jdHnvcuKh MljYNlE2PzF7MUK=
EoL-1-cell MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTFwMEe5PEDPxE1? MlSwV2FPT0WU
NCI-SNU-5 NWL2TFBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNwMUK4OFEh|ryP NW\OfVRKW0GQR1XS
BV-173 M3W1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonmTWM2OD13LkS1OFA6KM7:TR?= M2WwT3NCVkeHUh?=
HCC1806 NVz2SFU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTLZoFCUUN3ME21Mlc2OTd|IN88US=> NYH0coVMW0GQR1XS
COLO-680 NWDLZY9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;ibmpKSzVyPU[uNlE1ODZizszN Ml32V2FPT0WU
HCC2218 MkLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTdwN{m3NFQh|ryP NWrqcnNJW0GQR1XS
SK-MEL-24 NH\RU4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvITWM2OD15LkixPVI1KM7:TR?= NIrKZlJUSU6JRWK=
NCI-H720 M4PaZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnESItKSzVyPUiuOFM3ODNizszN NEXJNY1USU6JRWK=
KASUMI-1 M3HoSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXKTWM2OD16Lki5NlY3KM7:TR?= M3XkdnNCVkeHUh?=
HAL-01 M3;QWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37uSmlEPTB;OT64PFYzKM7:TR?= NF[zb4RUSU6JRWK=
CAL-33 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFyLkSzOEDPxE1? NYfyVIh5W0GQR1XS
SK-MEL-1 NUHvb21ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF{LkS2OlMh|ryP NFniTHJUSU6JRWK=
Ramos-2G6-4C10 Ml;hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrQTWM2OD1zMj60O|UzKM7:TR?= NVvpfpc4W0GQR1XS
KY821 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkGyTWM2OD1zMj60PFUh|ryP MoWwV2FPT0WU
HEC-1 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDublJHUUN3ME2xNk46OTl4IN88US=> MnuyV2FPT0WU
SK-NEP-1 M4Hme2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTF|LkG2OkDPxE1? NGrobWVUSU6JRWK=
MN-60 NEPVOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGm0bHhKSzVyPUGzMlU{QDlizszN MlnkV2FPT0WU
DU-145 M1HjS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DKdmlEPTB;MUOuPVA2OyEQvF2= NXS2dYlRW0GQR1XS
EW-3 NVrVU4hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvxVXVrUUN3ME2xOE42PTZ3IN88US=> NHTsZZZUSU6JRWK=
OS-RC-2 NH;s[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PXTGlEPTB;MUWuPVU5QSEQvF2= NEe1UG1USU6JRWK=
RPMI-8226 MnvqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHGySGtKSzVyPUG2MlIxPDJizszN NYrvXXR4W0GQR1XS
ChaGo-K-1 NVzDbno6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfpUWhKSzVyPUG2MlU{OjVizszN NXH6eXRYW0GQR1XS
DEL NGPFZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXD[Y1HUUN3ME2xOk43PzF5IN88US=> MXTTRW5ITVJ?
GP5d MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTF5LkC1N{DPxE1? NGjlVGRUSU6JRWK=
COLO-668 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml24TWM2OD1zNz62Nlk1KM7:TR?= NFjvZnFUSU6JRWK=
H9 NGnJTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTF6LkK4N|Mh|ryP M{nFbnNCVkeHUh?=
NKM-1 NVTmXZhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrQTWM2OD1zOD61NVE6KM7:TR?= MmPsV2FPT0WU
KYSE-150 NFf0ZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3wempKSzVyPUG4Mlk6QDZizszN M3\N[HNCVkeHUh?=
Daoy NYjkN4NTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvC[FR4UUN3ME2xPU42PjR7IN88US=> NFrGdYVUSU6JRWK=
ECC10 NEnsPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vPfGlEPTB;MkCuO|Q2PSEQvF2= MV7TRW5ITVJ?
A388 MnLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\TTWM2OD1{MT65NFkyKM7:TR?= MWXTRW5ITVJ?
MHH-NB-11 NIPsfZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[2OmlEPTB;MkOuNVM3OyEQvF2= Ml;SV2FPT0WU
HCC1937 NYHGOIc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf3T5NxUUN3ME2yOE44PDZizszN MW\TRW5ITVJ?
TGBC11TKB MlPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3o[nhKSzVyPUK1MlY5PjNizszN M2LGNHNCVkeHUh?=
CTV-1 M1;SVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfCSHNKSzVyPUK1Mlg6PjlizszN Ml36V2FPT0WU
NCI-H2029 MkW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqxTWM2OD1{Nj60NlM5KM7:TR?= NX;DSo9lW0GQR1XS
HLE NVjIWG5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnSTYFPUUN3ME2yO{4xPTRizszN NHzoSVJUSU6JRWK=
NCI-H1693 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJ5LkK4PVgh|ryP NYixcWZsW0GQR1XS
HCC70 NIX1RXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSyTWM2OD1{Nz63NlQ3KM7:TR?= NXHQcYJZW0GQR1XS
BEN NEDYS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHxeYVGUUN3ME2yO{46PTZ4IN88US=> M1HVOHNCVkeHUh?=
LB771 M3\GVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGftb29KSzVyPUK4Mlg{PzNizszN MnPuV2FPT0WU
697 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHnTWM2OD1{OT6wNlM2KM7:TR?= MYfTRW5ITVJ?
LU-139 MnO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP5cZRbUUN3ME2yPU4{PzR6IN88US=> NW\zb5QxW0GQR1XS
EW-13 M1LKR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ7LkO4NVQh|ryP MXnTRW5ITVJ?
MOLT-13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrPVnRXUUN3ME2yPU4{QDF2IN88US=> M{DlNnNCVkeHUh?=
L-363 NF3rfoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj2ZZl[UUN3ME2yPU41Pzl6IN88US=> MWTTRW5ITVJ?
EM-2 MkXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnsTWM2OD1{OT60PVAyKM7:TR?= NFnyRlFUSU6JRWK=
RS4-11 Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDSbm9KSzVyPUOwMlQzPDFizszN MYPTRW5ITVJ?
A2780 NVPQR2I1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LiVWlEPTB;M{CuO|Q2PyEQvF2= MofLV2FPT0WU
KU812 M1\Tcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XjOmlEPTB;M{KuN|Y1OiEQvF2= MVzTRW5ITVJ?
COLO-684 M2rFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnoNWFKSzVyPUOzMlM2QTlizszN NGDhcZVUSU6JRWK=
MFE-280 M1P6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnVNYlKSzVyPUOzMlM5QDlizszN MkLKV2FPT0WU
KG-1 NH7OUVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS5PYtWUUN3ME2zN{43ODBzIN88US=> NUm2OlhEW0GQR1XS
JVM-3 M3fLR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojqTWM2OD1|NT61PFY5KM7:TR?= NW\YZ444W0GQR1XS
MV-4-11 NX;T[XUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlraTWM2OD1|NT64OFk6KM7:TR?= M2\2T3NCVkeHUh?=
LAMA-84 M2TnfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW1fXZSUUN3ME2zOk44OzR3IN88US=> MkX1V2FPT0WU
MOLT-16 NGDYUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTN4Lkm1NkDPxE1? NWPXcFZ6W0GQR1XS
H4 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLFSHBKSzVyPUO3MlU3PyEQvF2= NV\QU5BoW0GQR1XS
T47D MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7JTGJKSzVyPUO3MlcxOThizszN MXPTRW5ITVJ?
CAL-54 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jETGlEPTB;M{euPVY3KM7:TR?= M3XXdnNCVkeHUh?=
SW982 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojPTWM2OD1|OD6wPVk5KM7:TR?= NXXTV4JOW0GQR1XS
IGROV-1 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH4W2gzUUN3ME2zPU4{OzB2IN88US=> NVLMTXJUW0GQR1XS
NB14 NIfld3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRyLkewN|Eh|ryP MnvXV2FPT0WU
HCC1187 NHGyeGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j5b2lEPTB;NEGuNlc4OSEQvF2= MYfTRW5ITVJ?
SBC-1 NFf4O4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3VbHREUUN3ME20NU4{ODZ|IN88US=> MYrTRW5ITVJ?
KARPAS-45 NGK5R49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXac49KSzVyPUSxMlQ5OThizszN Mlu4V2FPT0WU
MOLT-4 MlLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonTTWM2OD12Mj6yOVM5KM7:TR?= NEniZohUSU6JRWK=
JVM-2 NFTYU4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPrTWM2OD12Mj65NlA4KM7:TR?= M2jaOHNCVkeHUh?=
A4-Fuk NV\PV4g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPrVnlKSzVyPUSzMlU3QTFizszN MoPXV2FPT0WU
MDA-MB-361 NGTPSZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnhTWM2OD12Mz64OFE1KM7:TR?= Mn\oV2FPT0WU
BALL-1 MkTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPKTWM2OD12Mz65OVMzKM7:TR?= NGTTfItUSU6JRWK=
T98G M3vve2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HaSmlEPTB;NESuPFUyPyEQvF2= NETCPHFUSU6JRWK=
Mo-T MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{SxTGlEPTB;NEWuOlM5QSEQvF2= NGHGUFRUSU6JRWK=
MHH-PREB-1 M2fLeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHP5PFJKSzVyPUS1Mlc2QDVizszN NHfydZNUSU6JRWK=
ALL-PO NULTZYdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfvTWM2OD12Nz6zO|kyKM7:TR?= NIXJZmRUSU6JRWK=
NCI-H510A MkHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfPNoFKSzVyPUS3MlkxOzRizszN NHLkb2pUSU6JRWK=
ML-2 NUHibHgzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jaUGlEPTB;NEmuO|g2PiEQvF2= NX;wbXEzW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
0.5% methylcellulose+0.2% Tween 80
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29
Formula

C13H16N4O

CAS No. 912444-00-9
Storage powder
Synonyms NSC 737664

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Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00553189 Completed Solid Tumors|Lymphomas National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9, 2007 Phase 1
NCT03032614 Not yet recruiting Breast Cancer Stage IV|Ovarian Cancer|BRCA1 Mutation|BRCA2 Mutation The University of Texas Health Science Center at San Antonio March 31, 2017 Phase 2
NCT01445522 Completed Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) December 3, 2008 Phase 1
NCT01419548 Withdrawn Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 29, 2011 Phase 1
NCT02723864 Recruiting Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 22, 2016 Phase 1
NCT00994071 Completed Medulloblastoma|Pontine Glioma|Ependymoma|Astrocytoma|PNET National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 22, 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID