Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

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In DMSO USD 156 In stock
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Cited by 40 Publications

9 Customer Reviews

  • (A) OVCAR-8 cells were exposed to the indicated concentrations of FdUrd along with vehicle, 3 μM ABT-888 or 300 nM AZD2281 for 24 h. Following washing, ABT-888 and AZD2281 were re-added to the plates initially exposed to these agents, and cells were cultured in the continued presence of ABT-888 and AZD2281 for 8 d until colonies formed. (B) OVCAR-8 cells were exposed continuously to the indicated agents for 8 d. (C) OVCAR-8 cells treated as in (A) except that the indicated concentrations of ABT-888 were used.

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

    OVCAR-8 cells were plated, treated with indicated concentrations of FdUrd and 3 μM ABT-888 using the exposure schemes depicted in (C) and assayed for clonogenicity (D).

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

  •  

    Number of foci detected using laser confocal microscopy and fluorescent Fluor 647 anti-H2A.X-phosphorylated (Ser139) antibody. Double-stranded breaks (red) are clearly augmented in cells incubated with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281 compared with PBS and 1% dimethyl sulfoxide controls. Image analysis was performed using ImageJ and the ‘analyze particle’ function.

    Nucl Med Commun 2011 32, 1046-1051. Veliparib (ABT-888) purchased from Selleck.

    Logarithmic growth curves of human Burkitt lymphoma cells over 5 days with 500 nmol/l of ABT-888 and AZD-2281 in combination with 0 Gy (a), 4 Gy (b), 8 Gy (c), and 12 Gy (d) of external beam radiation. The maximal relative reduction was 65.5% of viable cells and occurred with AZD-2281 (500 nmol/l) on day 5. DMSO, dimethyl sulfoxide.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

  • Colorimetric poly(ADP-ribose) polymerase (PARP) activity assay showing the relative activity of the PARP-1 enzyme in Raji lymphocyte tumor cells. Results show a highly significant difference in PARP activity in the controls [PBS and dimethyl sulfoxide (DMSO)] compared with 24 h incubation with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281. A significant increase in PARP enzyme activity is shown in DMSO-incubated cells compared with PBS control.* P < 0.05.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

    T47D breast cancer cells were pretreated with indicated concentrations of ABT-888

     

     

    Dr.Zhang of Tianjin Medical University. Veliparib (ABT-888) purchased from Selleck.

  • in vivo suppression of PAR formation by the PARP inhibitor ABT-888 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor ABT-888 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.
     
     

     

    David Schrmann from University of Base. Veliparib (ABT-888) purchased from Selleck.

    Caption:  451 Lu is a melanoma cell line with high PARP expression that is resistant to temozolomide.  Treatment with 25 µM ABT-888 greatly increased sensitivity to temozolomide compared to cells without ABT-888 treatment as measured by MTS assay.

     

     

    Dr. Steve Reuland from University of Colorado Denver. Veliparib (ABT-888) purchased from Selleck.

  • Effect of ABT-888 on the viability of endometrial cancer cell line Hec50 and Ishikawa and ovarian cancer cell line SKOV3,Caov3 and PA-1 was detected by WST-1 method after 3 days treatment.

     
     

     

    Dr. Xiangbing Meng of University of Iowa. Veliparib (ABT-888) purchased from Selleck.

Purity & Quality Control

Choose Selective PARP Inhibitors

Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
Targets
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
C41 M{jROWtqdmG|ZTDBd5NigQ>? M1e0S|MxKG2rbh?= MnHLTY5pcWKrdHnvckBw\iCSQWLQNUB4cXSqIFXDOVAhd2ZiMD6wNFIh|ryP NH33fpcyQTh6OEe2NC=>
Jurkat MkKzT4lv[XOnIFHzd4F6 NWPv[5JQQTZiaB?= NHv1XXJFVVOR NYP0enI4UW6qaXLpeIlwdiCxZjDQRXJROSCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[2WubDD2bYFjcWyrdImge4l1cCCHQ{WwJI9nKDNizszN MmfQNlM5PTBzOUm=
Capan1 NUP3W49PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLUO|IhcA>? NWjEZYhjTE2VTx?= Mk\CRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDCVmNCOiCpZX7lJI12fGG2ZXSgbJVu[W5iQ3HwZY4yKGOnbHzzJJdqfGhiSVO1NEBw\iB|OT63JO69VQ>? Mn20NlQ{QTh|OEO=
DT40 M4PmbGN6fG:2b4jpZ{BCe3OjeR?= NH[0UIY4OiCq NILL[ItFVVOR MXHDfZRwfG:6aXPpeJkh[WejaX7zeEBkcGmla3XuJGJTS0F{LXTl[olkcWWwdDDEWFQxKGOnbHzz NXzydW1uOjR7MkK1PFc>
ML-1 NFv2WllCeG:ydH;0bYMhSXO|YYm= NID4OoYzNjVizszN M{PQO|I1KGh? NGLENJhFVVOR MWfTfY5memerc4TpZ4FtdHliZX7oZY5k\XNiVGLBTWwucW6mdXPl[EBieG:ydH;zbZMhcW5iTVytNUBk\Wyucx?= M4nmRlI1QDl3MUO1
HCT-116 MkLOT4lv[XOnIFHzd4F6 NI\kW4MxNjVizszN NH;hSIkzPCCq NFm5UJJRSVKSIHHjeIl3cXS7IHTlZ5Jm[XOncx?= M3PGNVI{ODV2MkGz
UM-SCC1 NH;2dWZEgXSxdH;4bYMhSXO|YYm= NVjUVnlbOTBizszN MVKyOEBp NFWx[ZZT\WS3Y3XzJJRp\SClZXzsJJZq[WKrbHn0fS=> MmCxNlE6OTJ4MkC=
FaDu M2f3b2N6fG:2b4jpZ{BCe3OjeR?= M{LPTFExKM7:TR?= NGfNdmEzPCCq MmnWVoVlfWOnczD0bIUh[2WubDD2bYFjcWyrdIm= NGfrdnUzOTlzMk[yNC=>
PC-3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYKxNEDPxE1? NYLERY82UW6mdXPld{BiKHOrZ37p[olk[W62IHnubIljcXSrb36gbY4h[2:ub375JIZwem2jdHnvcuKh NW\YcIJZOjF3N{G5NVI>
EoL-1-cell MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwMEe5PEDPxE1? M3TXN3NCVkeHUh?=
NCI-SNU-5 NEHkcIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPYTWM2OD1|LkGyPFQyKM7:TR?= NHq3RoVUSU6JRWK=
BV-173 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[1SFdqUUN3ME21MlQ2PDB7IN88US=> NEHYc49USU6JRWK=
HCC1806 NGLySldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLx[GRtUUN3ME21Mlc2OTd|IN88US=> NHXRWlRUSU6JRWK=
COLO-680 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3zOI9KSzVyPU[uNlE1ODZizszN M4TMbXNCVkeHUh?=
HCC2218 NHzx[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LlPWlEPTB;Nz63PVcxPCEQvF2= NVH1eZBwW0GQR1XS
SK-MEL-24 M3G4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HPcWlEPTB;Nz64NVkzPCEQvF2= NEPHOYlUSU6JRWK=
NCI-H720 NUHFcoRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnmVXcyUUN3ME24MlQ{PjB|IN88US=> M1vxfHNCVkeHUh?=
KASUMI-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnQNG1RUUN3ME24Mlg6OjZ4IN88US=> MUfTRW5ITVJ?
HAL-01 M{XE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nVWGlEPTB;OT64PFYzKM7:TR?= NF7VRnpUSU6JRWK=
CAL-33 M3P3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf5SpVKSzVyPUGwMlQ{PCEQvF2= NYLmNHVQW0GQR1XS
SK-MEL-1 M4XPb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfjNGpKSzVyPUGyMlQ3PjNizszN NXTofFR7W0GQR1XS
Ramos-2G6-4C10 NXTDN45kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHXNYhMUUN3ME2xNk41PzV{IN88US=> M{LjRnNCVkeHUh?=
KY821 M3HyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKzTWM2OD1zMj60PFUh|ryP MVfTRW5ITVJ?
HEC-1 M3zKbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrUSFJKUUN3ME2xNk46OTl4IN88US=> NEnIU5hUSU6JRWK=
SK-NEP-1 NV\jco1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvIT2xIUUN3ME2xN{4yPjZizszN M4HxcXNCVkeHUh?=
MN-60 MmTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXCcmVKSzVyPUGzMlU{QDlizszN MlK4V2FPT0WU
DU-145 M2Pm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEj4b5BKSzVyPUGzMlkxPTNizszN NVzJcXpSW0GQR1XS
EW-3 NEfjeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXq[2VKSzVyPUG0MlU2PjVizszN NGXDfIJUSU6JRWK=
OS-RC-2 NUDWeWx{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjVT5FXUUN3ME2xOU46PTh7IN88US=> NUG0Rpl5W0GQR1XS
RPMI-8226 MoTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPoTWM2OD1zNj6yNFQzKM7:TR?= M3vjSXNCVkeHUh?=
ChaGo-K-1 MnH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkSGlEPTB;MU[uOVMzPSEQvF2= NEDT[mdUSU6JRWK=
DEL NGLDfHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF4Lk[3NVch|ryP M1HlbnNCVkeHUh?=
GP5d M3Pacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHe3SJdKSzVyPUG3MlA2OyEQvF2= MlfsV2FPT0WU
COLO-668 NYTjbHliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O3dWlEPTB;MUeuOlI6PCEQvF2= NE\STWpUSU6JRWK=
H9 NIrtNm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYiyfZZVUUN3ME2xPE4zQDN|IN88US=> M1X5[nNCVkeHUh?=
NKM-1 M3nI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTF6LkWxNVkh|ryP MULTRW5ITVJ?
KYSE-150 MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NES5dlRKSzVyPUG4Mlk6QDZizszN M{PsdHNCVkeHUh?=
Daoy NYTCVGZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP6enJKSzVyPUG5MlU3PDlizszN M3\kdHNCVkeHUh?=
ECC10 NEXBXVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJyLke0OVUh|ryP MnXBV2FPT0WU
A388 NWXHVWdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\wTWM2OD1{MT65NFkyKM7:TR?= MXrTRW5ITVJ?
MHH-NB-11 MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ|LkGzOlMh|ryP NHX1SpFUSU6JRWK=
HCC1937 NYnZNYl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2Lke0OkDPxE1? MVvTRW5ITVJ?
TGBC11TKB NF;oT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJ3Lk[4OlMh|ryP NEjpNpBUSU6JRWK=
CTV-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDR[pdKSzVyPUK1Mlg6PjlizszN NVHSR3E3W0GQR1XS
NCI-H2029 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HpXGlEPTB;Mk[uOFI{QCEQvF2= MmPYV2FPT0WU
HLE MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XW[2lEPTB;MkeuNFU1KM7:TR?= NUPXVIxrW0GQR1XS
NCI-H1693 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJ5LkK4PVgh|ryP NUfZ[FJOW0GQR1XS
HCC70 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUj5VIxqUUN3ME2yO{44OjR4IN88US=> MoL6V2FPT0WU
BEN M2L1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJ5Lkm1OlYh|ryP NV:x[4hLW0GQR1XS
LB771 NVjZRVBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C0OGlEPTB;MkiuPFM4OyEQvF2= MmLlV2FPT0WU
697 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJ7LkCyN|Uh|ryP MWPTRW5ITVJ?
LU-139 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnWdlZSUUN3ME2yPU4{PzR6IN88US=> MXLTRW5ITVJ?
EW-13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJ7LkO4NVQh|ryP NF7TTVdUSU6JRWK=
MOLT-13 M13SRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ7LkO4NVQh|ryP M{jGfnNCVkeHUh?=
L-363 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ7LkS3PVgh|ryP NYLBc3l6W0GQR1XS
EM-2 MmPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHpTWM2OD1{OT60PVAyKM7:TR?= M{\vXHNCVkeHUh?=
RS4-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;KNGlEPTB;M{CuOFI1OSEQvF2= NWi0N5BEW0GQR1XS
A2780 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2SzTWlEPTB;M{CuO|Q2PyEQvF2= NHTBeIxUSU6JRWK=
KU812 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7TTHlKSzVyPUOyMlM3PDJizszN Mo\zV2FPT0WU
COLO-684 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XhNmlEPTB;M{OuN|U6QSEQvF2= NHLwXmNUSU6JRWK=
MFE-280 NFTJPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjZTWM2OD1|Mz6zPFg6KM7:TR?= MUHTRW5ITVJ?
KG-1 NIXIU|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTN|Lk[wNFEh|ryP NHrMW5BUSU6JRWK=
JVM-3 NXy4SJFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTN3LkW4Olgh|ryP NWTETWRjW0GQR1XS
MV-4-11 Mne1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTN3Lki0PVkh|ryP MY\TRW5ITVJ?
LAMA-84 Mn74S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNNnpKSzVyPUO2Mlc{PDVizszN MnrzV2FPT0WU
MOLT-16 M3\sVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILzWVdKSzVyPUO2Mlk2OiEQvF2= NWXSUJRrW0GQR1XS
H4 NYfYVJJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn6TWM2OD1|Nz61Olch|ryP M{fZXHNCVkeHUh?=
T47D MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN5LkewNVgh|ryP NVexXJlSW0GQR1XS
CAL-54 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\XbnZKSzVyPUO3Mlk3PiEQvF2= M4Xpd3NCVkeHUh?=
SW982 M1n0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\q[ZpYUUN3ME2zPE4xQTl6IN88US=> NF3qO4lUSU6JRWK=
IGROV-1 MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnoVVh1UUN3ME2zPU4{OzB2IN88US=> NEjIT5BUSU6JRWK=
NB14 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3xcWhuUUN3ME20NE44ODNzIN88US=> MlmwV2FPT0WU
HCC1187 M2fJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XyPGlEPTB;NEGuNlc4OSEQvF2= NFi3eG1USU6JRWK=
SBC-1 M1G2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTOVmNNUUN3ME20NU4{ODZ|IN88US=> MofTV2FPT0WU
KARPAS-45 Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXIOpZKUUN3ME20NU41QDF6IN88US=> MljqV2FPT0WU
MOLT-4 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\OcmlEPTB;NEKuNlU{QCEQvF2= MXTTRW5ITVJ?
JVM-2 MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjvb|B5UUN3ME20Nk46OjB5IN88US=> MXLTRW5ITVJ?
A4-Fuk M4rMR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ieVZwUUN3ME20N{42PjlzIN88US=> MUTTRW5ITVJ?
MDA-MB-361 NW\JVHp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\KW2lEPTB;NEOuPFQyPCEQvF2= MkfOV2FPT0WU
BALL-1 M37iS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTR|Lkm1N|Ih|ryP MUTTRW5ITVJ?
T98G NGHDOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TQOmlEPTB;NESuPFUyPyEQvF2= NYfMfFF1W0GQR1XS
Mo-T NH\TZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTR3Lk[zPFkh|ryP NWHsUWhSW0GQR1XS
MHH-PREB-1 NVvaOWxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSwTWM2OD12NT63OVg2KM7:TR?= NXzvWml1W0GQR1XS
ALL-PO Mk\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR5LkO3PVEh|ryP MnH0V2FPT0WU
NCI-H510A MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHsTXhKSzVyPUS3MlkxOzRizszN M3m4OXNCVkeHUh?=
ML-2 NHTCRVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4D6bWlEPTB;NEmuO|g2PiEQvF2= MYLTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
0.5% methylcellulose+0.2% Tween 80
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29
Formula

C13H16N4O

CAS No. 912444-00-9
Storage powder
in solvent
Synonyms NSC 737664

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00553189 Completed Solid Tumors|Lymphomas National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9, 2007 Phase 1
NCT03032614 Not yet recruiting Breast Cancer Stage IV|Ovarian Cancer|BRCA1 Mutation|BRCA2 Mutation The University of Texas Health Science Center at San Antonio March 31, 2017 Phase 2
NCT01445522 Completed Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) December 3, 2008 Phase 1
NCT01419548 Withdrawn Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 29, 2011 Phase 1
NCT02723864 Recruiting Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 22, 2016 Phase 1
NCT00994071 Completed Medulloblastoma|Pontine Glioma|Ependymoma|Astrocytoma|PNET National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 22, 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID