Veliparib (ABT-888)

Catalog No.S1004 Synonyms: NSC 737664

Veliparib (ABT-888) Chemical Structure

Molecular Weight(MW): 244.29

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

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In DMSO USD 156 In stock
USD 120 In stock
USD 370 In stock
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Cited by 40 Publications

9 Customer Reviews

  • (A) OVCAR-8 cells were exposed to the indicated concentrations of FdUrd along with vehicle, 3 μM ABT-888 or 300 nM AZD2281 for 24 h. Following washing, ABT-888 and AZD2281 were re-added to the plates initially exposed to these agents, and cells were cultured in the continued presence of ABT-888 and AZD2281 for 8 d until colonies formed. (B) OVCAR-8 cells were exposed continuously to the indicated agents for 8 d. (C) OVCAR-8 cells treated as in (A) except that the indicated concentrations of ABT-888 were used.

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.

    OVCAR-8 cells were plated, treated with indicated concentrations of FdUrd and 3 μM ABT-888 using the exposure schemes depicted in (C) and assayed for clonogenicity (D).

    Cancer Research, 2011, 71: 4944-4954. Veliparib (ABT-888) purchased from Selleck.


    Number of foci detected using laser confocal microscopy and fluorescent Fluor 647 anti-H2A.X-phosphorylated (Ser139) antibody. Double-stranded breaks (red) are clearly augmented in cells incubated with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281 compared with PBS and 1% dimethyl sulfoxide controls. Image analysis was performed using ImageJ and the ‘analyze particle’ function.

    Nucl Med Commun 2011 32, 1046-1051. Veliparib (ABT-888) purchased from Selleck.

    Logarithmic growth curves of human Burkitt lymphoma cells over 5 days with 500 nmol/l of ABT-888 and AZD-2281 in combination with 0 Gy (a), 4 Gy (b), 8 Gy (c), and 12 Gy (d) of external beam radiation. The maximal relative reduction was 65.5% of viable cells and occurred with AZD-2281 (500 nmol/l) on day 5. DMSO, dimethyl sulfoxide.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

  • Colorimetric poly(ADP-ribose) polymerase (PARP) activity assay showing the relative activity of the PARP-1 enzyme in Raji lymphocyte tumor cells. Results show a highly significant difference in PARP activity in the controls [PBS and dimethyl sulfoxide (DMSO)] compared with 24 h incubation with 500 nmol/l of ABT-888 and 500 nmol/l of AZD-2281. A significant increase in PARP enzyme activity is shown in DMSO-incubated cells compared with PBS control.* P < 0.05.

    Nucl Med Commun 2011 32(11), 1046-51. Veliparib (ABT-888) purchased from Selleck.

    T47D breast cancer cells were pretreated with indicated concentrations of ABT-888



    Dr.Zhang of Tianjin Medical University. Veliparib (ABT-888) purchased from Selleck.

  • in vivo suppression of PAR formation by the PARP inhibitor ABT-888 upon induction of DNA damage

    Primary human lung fibroblast cells (MRC-5) were pre-treated with the indicated concentration of the PARP inhibitor ABT-888 for two hours. Oxidative DNA damage was induced by 500 µM H2O2 for 10 min and cellular PARP activity was measured by immuno-staining of poly(ADP)-ribose (PAR) (right panels). The in vivo effect of PARP inhibition was compared to cells without DNA damage induction and inhibitor (control) and H2O2-treated cells without inhibitor.
    Average nuclear PAR staining intensities of more than 50 cells were statistically analysed by Kruskal-Wallis and the post-hoc Dunn’s Multiple Comparison tests (left panel). Asterisks indicate highly significant (p<1%) differences to H2O2-treated cells without PARP inhibitor. Thick horizontal bars mark medians and error bars the interquartile range.


    David Schrmann from University of Base. Veliparib (ABT-888) purchased from Selleck.

    Caption:  451 Lu is a melanoma cell line with high PARP expression that is resistant to temozolomide.  Treatment with 25 µM ABT-888 greatly increased sensitivity to temozolomide compared to cells without ABT-888 treatment as measured by MTS assay.



    Dr. Steve Reuland from University of Colorado Denver. Veliparib (ABT-888) purchased from Selleck.

  • Effect of ABT-888 on the viability of endometrial cancer cell line Hec50 and Ishikawa and ovarian cancer cell line SKOV3,Caov3 and PA-1 was detected by WST-1 method after 3 days treatment.



    Dr. Xiangbing Meng of University of Iowa. Veliparib (ABT-888) purchased from Selleck.

Purity & Quality Control

Choose Selective PARP Inhibitors

Biological Activity

Description Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.
Features Increases the efficacy of common cancer therapies such as radiation and alkylating agents.
PARP2 [1]
(Cell-free assay)
PARP1 [1]
(Cell-free assay)
2.9 nM(Ki) 5.2 nM(Ki)
In vitro

ABT-888 is inactive to SIRT2 (>5 μM). [1] ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells. [2] ABT-888 could decrease the PAR levels in both irradiated and nonirradiated H460 cells. ABT-888 also reduces clonogenic survival and inhibits DNA repair by PARP-1 inhibition in H460 cells. ABT-888 increases apoptosis and autophagy in H460 cells when combination with radiation. [3] ABT-888 also inhibits PARP activity in H1299, DU145 and 22RV1 cells and the inhibition is independent of p53 function. ABT-888 (10 μM) suppresses the surviving fraction (SF) by 43% in the clonogenic H1299 cells. ABT-888 shows effective radiosensitivity in oxic H1299 cells. Furthermore, ABT-888 could attenuate the SF of hypoxic-irradiated cells including H1299, DU145 and 22RV1. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
C41 NET1fmxMcW6jc3WgRZN{[Xl? NYe5OoR5OzBibXnu NEXHOotKdmirYnn0bY9vKG:oIGDBVnAyKHerdHigSWM2OCCxZjCwMlAxOiEQvF2= MmfqNVk5QDh5NkC=
Jurkat NECx[mxMcW6jc3WgRZN{[Xl? NYXKR4tmQTZiaB?= M3zEVWROW09? NUPjdVU5UW6qaXLpeIlwdiCxZjDQRXJROSCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4Yh[2WubDD2bYFjcWyrdImge4l1cCCHQ{WwJI9nKDNizszN Mk\INlM5PTBzOUm=
Capan1 NFjOZllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\TO|IhcA>? MWnEUXNQ MnXnRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDCVmNCOiCpZX7lJI12fGG2ZXSgbJVu[W5iQ3HwZY4yKGOnbHzzJJdqfGhiSVO1NEBw\iB|OT63JO69VQ>? NH\RdJkzPDN7OEO4Ny=>
DT40 NVj0cHE2S3m2b4TvfIlkKEG|c3H5 MmjxO|IhcA>? M17HT2ROW09? M3L2fmN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGOqaXPr[Y4hSlKFQUKt[IVncWOrZX70JGRVPDBiY3XscJM> MXiyOFkzOjV6Nx?=
ML-1 NXnKcmtJSXCxcITveIlkKEG|c3H5 NX36WmN[Oi53IN88US=> NV\iRmZSOjRiaB?= NFnKcGVFVVOR NFz4OnJUgW6ncnfpd5Rq[2GubImg[Y5p[W6lZYOgWHJCUUxvaX7keYNm\CCjcH;weI9{cXNiaX6gUWwuOSClZXzsdy=> MmLkNlQ5QTVzM{W=
HCT-116 M4fOZWtqdmG|ZTDBd5NigQ>? MUGwMlUh|ryP MoeyNlQhcA>? MmDaVGFTWCCjY4Tpeol1gSCmZXPy[YF{\XN? M1TQXFI{ODV2MkGz
UM-SCC1 NUHNPWhnS3m2b4TvfIlkKEG|c3H5 M1;RWVExKM7:TR?= M{K4bFI1KGh? MVzS[YR2[2W|IITo[UBk\WyuII\pZYJqdGm2eR?= NEnBT2QzOTlzMk[yNC=>
FaDu NYSwTok2S3m2b4TvfIlkKEG|c3H5 Mn\aNVAh|ryP MlnjNlQhcA>? MnTQVoVlfWOnczD0bIUh[2WubDD2bYFjcWyrdIm= NVvhUGh2OjF7MUK2NlA>
PC-3 M1rCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWWxNEDPxE1? MmTXTY5lfWOnczDhJJNq\26rZnnjZY51KGmwaHnibZRqd25iaX6gZ49td267IH\vdo1ifGmxbtMg NXLkdpo2OjF3N{G5NVI>
EoL-1-cell M12zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHSN5NNUUN3ME2xMlA4QThizszN MkTmV2FPT0WU
NCI-SNU-5 NHuzeHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnsTWM2OD1|LkGyPFQyKM7:TR?= NH7COZJUSU6JRWK=
BV-173 M{GzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjpeHNGUUN3ME21MlQ2PDB7IN88US=> MlXWV2FPT0WU
HCC1806 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rW[2lEPTB;NT63OVE4OyEQvF2= MoT0V2FPT0WU
COLO-680 MnHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37sR2lEPTB;Nj6yNVQxPiEQvF2= MWnTRW5ITVJ?
HCC2218 NF3GO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3roWGlEPTB;Nz63PVcxPCEQvF2= Mkm4V2FPT0WU
SK-MEL-24 MmTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nCNGlEPTB;Nz64NVkzPCEQvF2= MlrnV2FPT0WU
KASUMI-1 M3PUZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjLeWxuUUN3ME24Mlg6OjZ4IN88US=> NUm3XWtTW0GQR1XS
HAL-01 M4r1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPLTWM2OD17Lki4OlIh|ryP M3nLR3NCVkeHUh?=
CAL-33 M3HXW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rnTGlEPTB;MUCuOFM1KM7:TR?= M4LCZnNCVkeHUh?=
SK-MEL-1 M3nBb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fz[GlEPTB;MUKuOFY3OyEQvF2= MkfKV2FPT0WU
Ramos-2G6-4C10 M2DSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHB[pZKSzVyPUGyMlQ4PTJizszN Mnn5V2FPT0WU
KY821 M2fvNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:1TWM2OD1zMj60PFUh|ryP MlPJV2FPT0WU
HEC-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzPPWtKSzVyPUGyMlkyQTZizszN MV7TRW5ITVJ?
SK-NEP-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVi1O3VnUUN3ME2xN{4yPjZizszN NIe3fYlUSU6JRWK=
DU-145 NVnae2huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrwTWM2OD1zMz65NFU{KM7:TR?= MYTTRW5ITVJ?
EW-3 NFfqOYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF2LkW1OlUh|ryP NVWwWppsW0GQR1XS
OS-RC-2 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTF3Lkm1PFkh|ryP NHjt[3FUSU6JRWK=
RPMI-8226 NIjsNZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnZUm9KSzVyPUG2MlIxPDJizszN M1n6UHNCVkeHUh?=
ChaGo-K-1 NFL4V2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluzTWM2OD1zNj61N|I2KM7:TR?= MlzyV2FPT0WU
DEL MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTF4Lk[3NVch|ryP Mn7BV2FPT0WU
GP5d NFz6O21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTF5LkC1N{DPxE1? NYrTR|VoW0GQR1XS
H9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm0TWM2OD1zOD6yPFM{KM7:TR?= MVrTRW5ITVJ?
KYSE-150 M1PRXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j0WWlEPTB;MUiuPVk5PiEQvF2= NFvDOnpUSU6JRWK=
Daoy NELTUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFz1V3lKSzVyPUG5MlU3PDlizszN NF3nVFdUSU6JRWK=
ECC10 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJyLke0OVUh|ryP MXvTRW5ITVJ?
A388 MkLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTJzLkmwPVEh|ryP Mk\pV2FPT0WU
MHH-NB-11 MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn1TWM2OD1{Mz6xN|Y{KM7:TR?= NX3HNpV2W0GQR1XS
HCC1937 NX\4OpF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TyemlEPTB;MkSuO|Q3KM7:TR?= NUH3eoJJW0GQR1XS
TGBC11TKB NFzsdI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnxfVdKSzVyPUK1MlY5PjNizszN M37nbHNCVkeHUh?=
CTV-1 NF3NfYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfITWM2OD1{NT64PVY6KM7:TR?= MWnTRW5ITVJ?
NCI-H2029 NXnqO49FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPudGZ3UUN3ME2yOk41OjN6IN88US=> M3TObHNCVkeHUh?=
HLE MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nid2lEPTB;MkeuNFU1KM7:TR?= MVvTRW5ITVJ?
NCI-H1693 NIe4U4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\VfGlEPTB;MkeuNlg6QCEQvF2= M32xfXNCVkeHUh?=
HCC70 M170Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnvcVBKSzVyPUK3MlczPDZizszN M4ra[nNCVkeHUh?=
BEN NFfDOHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTxTWM2OD1{Nz65OVY3KM7:TR?= M3S1VnNCVkeHUh?=
LB771 NVS1O3VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjCTWM2OD1{OD64N|c{KM7:TR?= NXjjS|cyW0GQR1XS
697 MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWxe25yUUN3ME2yPU4xOjN3IN88US=> NYHyOGQ3W0GQR1XS
EW-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGCzSolKSzVyPUK5MlM5OTRizszN NF7rOIRUSU6JRWK=
MOLT-13 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\IRmlEPTB;MkmuN|gyPCEQvF2= M{XYNXNCVkeHUh?=
L-363 M2rPcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTJ7LkS3PVgh|ryP NHvmcGVUSU6JRWK=
EM-2 MlLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq0Um9KSzVyPUK5MlQ6ODFizszN NVO0XHZtW0GQR1XS
RS4-11 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDITWM2OD1|MD60NlQyKM7:TR?= NIfyVllUSU6JRWK=
A2780 NXfzcmk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PTOGlEPTB;M{CuO|Q2PyEQvF2= M3voT3NCVkeHUh?=
KU812 Mn20S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq4W3JKSzVyPUOyMlM3PDJizszN M1ewOHNCVkeHUh?=
COLO-684 MmmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPOTWM2OD1|Mz6zOVk6KM7:TR?= MlK2V2FPT0WU
MFE-280 NEjHbpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrj[m9KSzVyPUOzMlM5QDlizszN NIHXPHVUSU6JRWK=
KG-1 NFjGSVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTN|Lk[wNFEh|ryP MoPqV2FPT0WU
JVM-3 M2PV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVH5S5BjUUN3ME2zOU42QDZ6IN88US=> MWnTRW5ITVJ?
MV-4-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrGSIVKSzVyPUO1Mlg1QTlizszN M2fXenNCVkeHUh?=
LAMA-84 M1vObmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PafmlEPTB;M{[uO|M1PSEQvF2= M37yXXNCVkeHUh?=
MOLT-16 NInEb3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTN4Lkm1NkDPxE1? MnWzV2FPT0WU
H4 MlfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C4NmlEPTB;M{euOVY4KM7:TR?= NV7vNHlFW0GQR1XS
T47D MlrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nsV2lEPTB;M{euO|AyQCEQvF2= NEDSdG9USU6JRWK=
CAL-54 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTN5Lkm2OkDPxE1? MUTTRW5ITVJ?
SW982 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTN6LkC5PVgh|ryP M1fSb3NCVkeHUh?=
IGROV-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN7LkOzNFQh|ryP M3XnSnNCVkeHUh?=
NB14 MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f2b2lEPTB;NECuO|A{OSEQvF2= M1T3UHNCVkeHUh?=
HCC1187 MoLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDZTWM2OD12MT6yO|cyKM7:TR?= Ml;qV2FPT0WU
SBC-1 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XSdWlEPTB;NEGuN|A3OyEQvF2= M3[zWXNCVkeHUh?=
MOLT-4 NFq5SHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTR{LkK1N|gh|ryP M2TxdHNCVkeHUh?=
JVM-2 M2n3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDiTWM2OD12Mj65NlA4KM7:TR?= MV7TRW5ITVJ?
A4-Fuk MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnoZZNKSzVyPUSzMlU3QTFizszN NGfzUZJUSU6JRWK=
BALL-1 M2jxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTIV2NKSzVyPUSzMlk2OzJizszN NGnNZZVUSU6JRWK=
T98G NHzzcZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MomxTWM2OD12ND64OVE4KM7:TR?= MWXTRW5ITVJ?
Mo-T MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoezTWM2OD12NT62N|g6KM7:TR?= NYOxSIZVW0GQR1XS
ALL-PO M3rTUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDjN5hKSzVyPUS3MlM4QTFizszN MoHhV2FPT0WU
NCI-H510A MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTR5LkmwN|Qh|ryP NFfoO4lUSU6JRWK=
ML-2 M3HiRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf3TWM2OD12OT63PFU3KM7:TR?= MmfDV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo The oral bioavailability of ABT-888 is 56%-92% in mice, Sprague-Dawley rats, beagle dogs, and cynomolgus monkeys after oral administration. [1] ABT-888 (25 mg/kg i.p.) could improve tumor growth delay in a NCI-H460 xenograft model with well tolerated. Combination with radiation, ABT-888 decreases the tumor vessel formation. [3] ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression could be maintained over time. [4]


Animal Research:


+ Expand
  • Animal Models: NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
  • Formulation: Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
  • Dosages: ~25 mg/kg
  • Administration: Orally administered
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 17 mg/mL (69.58 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
0.5% methylcellulose+0.2% Tween 80
For best results, use promptly after mixing.
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 244.29


CAS No. 912444-00-9
Storage powder
Synonyms NSC 737664

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00553189 Completed Solid Tumors|Lymphomas National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) August 9, 2007 Phase 1
NCT03032614 Not yet recruiting Breast Cancer Stage IV|Ovarian Cancer|BRCA1 Mutation|BRCA2 Mutation The University of Texas Health Science Center at San Antonio March 31, 2017 Phase 2
NCT01445522 Completed Neoplasms|Lymphoma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) December 3, 2008 Phase 1
NCT01419548 Withdrawn Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 29, 2011 Phase 1
NCT02723864 Recruiting Neoplasms National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) March 22, 2016 Phase 1
NCT00994071 Completed Medulloblastoma|Pontine Glioma|Ependymoma|Astrocytoma|PNET National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) September 22, 2009 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID