Benzamide

Catalog No.S4715

Benzamide Chemical Structure

Molecular Weight(MW): 121.14

Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.

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Biological Activity

Description Benzamide, an inhibitor of poly(ADP-ribose) polymerase, is a derivative of benzoic acid.
Targets
PARP [4]
(Cell-free assay)
3.3 μM
In vitro

Benzamide, an inhibitor of PARP is protective against excitatory amino acid-induced cell death in primary cultures of neurons derived from neonatal rat brain. In addition, benzamide has more recently been shown to partially prevent the loss of dopaminergic cells and the increase in reactive gliosis caused by METH in vitro in fetal rat mesencephalic cells in culture[1]. Benzamide prevents transformation in a cell cycle-specific manner, maximal prevention coinciding with early S phase, also characteristic of maximal susceptibility to transformation[2].

In vivo PARP inhibitor benzamide is neuroprotective in C57Bl/6N mice against different types of neurotoxicities and without affecting body temperature[2]. Benzamide treatment significantly decreases the iNOS expression and number of apoptotic neurons and thereby improves the neuronal survival and memory during GCI. Benzamide administration (160 mg/kg i.p.) does not induce hypothermia and reaches the CNS in 30 min in the concentration range of 0.09-0.64 mM, at which, it shows neuroprotection[3].

Protocol

Cell Research:

[2]

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  • Cell lines: Primary human fibroblasts
  • Concentrations: 1 mM
  • Incubation Time: 10 hr
  • Method:

    Exposure to carcinogens and benzamide is done 10 hr after the release of the metabolically induced G1/S block and exposure lasts 10 hr, followed by three washings and refeeding with fresh media.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 24 mg/mL (198.11 mM)
Ethanol 24 mg/mL (198.11 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 121.14
Formula

C7H7NO

CAS No. 55-21-0
Storage powder
Synonyms

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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PARP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID