|
S1001
|
ABT-263 (Navitoclax) |
ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively. |
|
|
|
S1002
|
ABT-737 |
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. |
|
|
|
S1057
|
Obatoclax mesylate (GX15-070) |
Obatoclax (GX15-070) is an inhibitor of Bcl-2 with Ki of 0.22 μM. |
|
|
|
S1121
|
TW-37 |
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM, respectively. |
|
|
|
S2812
|
AT101 |
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members. |
|
|
|
S8061
|
Sabutoclax |
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively. |
|
|
|
S8048
|
ABT-199 (GDC-0199 ) |
ABT-199 is a Bcl-2-selective inhibitor with Ki < 0.010 nM. |
|
|
|
S7034
|
BM-1074 |
BM-1074 is a potent and efficacious Bcl-2/Bcl-xL inhibitor with Ki of <1 nM. |
|
|
|
S1071
|
HA14-1 |
HA14-1 is a nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of~9 μM. |
|
|
