Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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In DMSO USD 190 In stock
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9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell death dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVX6VXoxUUN3ME2wMlAxODB|MUeg{txO NEDJVIdUSU6JRWK=
SK-MEL-30 NHO2WoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMECwN|U2KM7:TR?= NYXocYRsW0GQR1XS
NALM-6 NF\3V2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH2TWM2OD1yLkCwNFM2PiEQvF2= MljhV2FPT0WU
KYSE-450 M1LhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMECwOFY6KM7:TR?= NYPHemJmW0GQR1XS
BHY NHLYRphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHlTlBVUUN3ME2wMlAxODZyMTFOwG0> MWTTRW5ITVJ?
GR-ST MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHaNINKSzVyPUCuNFAxPjR6IN88US=> MY\TRW5ITVJ?
786-0 NGj2NoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMECwO|c3KM7:TR?= MlfaV2FPT0WU
C-33-A MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn6wTWM2OD1yLkCwNFg1QCEQvF2= NXLadW1GW0GQR1XS
BHT-101 MlT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;xRmlKSzVyPUCuNFAyODZizszN MUjTRW5ITVJ?
EB2 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMECxNVgh|ryP NH7O[2hUSU6JRWK=
G-361 MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfJWWFKSzVyPUCuNFAyOjRizszN Mk[yV2FPT0WU
KE-37 NX3NVoRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMECxNlgh|ryP MXfTRW5ITVJ?
MHH-PREB-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;O[pdpUUN3ME2wMlAxOTRizszN MYDTRW5ITVJ?
MCF7 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXRTWM2OD1yLkCwNVU6KM7:TR?= NXTsT4RtW0GQR1XS
LOUCY MmXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrMSol3UUN3ME2wMlAxOTd3IN88US=> MW\TRW5ITVJ?
EW-7 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrlbHZKSzVyPUCuNFAyPzVizszN MUXTRW5ITVJ?
KYSE-510 NUDoXlNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrYTWM2OD1yLkCwNlM{KM7:TR?= NF3tTJBUSU6JRWK=
SK-MEL-3 NF60fIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPKVndUUUN3ME2wMlAxOjZ2IN88US=> MlrIV2FPT0WU
HAL-01 M1u3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjuTWM2OD1yLkCwNlk4KM7:TR?= MmP5V2FPT0WU
HCC2998 NGiwT41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX4VWxKSzVyPUCuNFA{OzVizszN M1e2eHNCVkeHUh?=
A375 M4L1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnCTWM2OD1yLkCwN|Uh|ryP NX24V45jW0GQR1XS
MZ7-mel MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMECzPVkh|ryP MYLTRW5ITVJ?
SH-4 Mk\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnSTWM2OD1yLkCwOFE4KM7:TR?= M2\ydXNCVkeHUh?=
HT-144 NYK3VHN6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfXTWM2OD1yLkCwOFMh|ryP NV7p[pBCW0GQR1XS
KYSE-140 M4rubWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\jNJM2UUN3ME2wMlAxPDN3IN88US=> M4H3ZnNCVkeHUh?=
PSN1 MmjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PxcmlEPTB;MD6wNFQ3PyEQvF2= M2C5bHNCVkeHUh?=
COLO-679 M1z1eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S0emlEPTB;MD6wNFQ6QCEQvF2= NYPVeGV2W0GQR1XS
SW620 NYfITFB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P3cmlEPTB;MD6wNFUyOSEQvF2= MWPTRW5ITVJ?
HGC-27 Ml\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW2cGVKSzVyPUCuNFA2OjRizszN NVvHdZZ1W0GQR1XS
IGROV-1 M2H0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrZb3pKSzVyPUCuNFA3KM7:TR?= NHjFW2NUSU6JRWK=
IGR-1 NYfmfZZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4jvemlEPTB;MD6wNFYxOSEQvF2= NWq5S2RxW0GQR1XS
EW-1 M3L0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnQR2d5UUN3ME2wMlAxPjVzIN88US=> MnfLV2FPT0WU
769-P MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEC2O|gh|ryP NHnKNZpUSU6JRWK=
HN Mni5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G5XWlEPTB;MD6wNFY4QSEQvF2= MmD1V2FPT0WU
SIG-M5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7qZW5KSzVyPUCuNFA4OSEQvF2= NIjUWZBUSU6JRWK=
IST-MEL1 M1jvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMEC4NVgh|ryP M3PJWnNCVkeHUh?=
ST486 M3\PeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4S3VWlEPTB;MD6wNFgzPSEQvF2= MonvV2FPT0WU
ES7 NYSyRoxYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXMTHY3UUN3ME2wMlAxQDR4IN88US=> MVjTRW5ITVJ?
GAK NGHXNpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMEC4OFgh|ryP MoqyV2FPT0WU
BB30-HNC M4j6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXNWIVKSzVyPUCuNFA5PThizszN NETTWFZUSU6JRWK=
IPC-298 NGLubY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfCS4dKSzVyPUCuNFA6OjdizszN NIXZPGNUSU6JRWK=
NKM-1 NIm3b2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fxUmlEPTB;MD6wNFk4OiEQvF2= NYPGS|Q2W0GQR1XS
RKO MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TvRWlEPTB;MD6wNVA1PCEQvF2= MUPTRW5ITVJ?
ACN NX30Olk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwMEGxN|Eh|ryP NIXUSIdUSU6JRWK=
SW1417 NF\0dlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LrcWlEPTB;MD6wNVIzPSEQvF2= MW\TRW5ITVJ?
SR MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;MTWM2OD1yLkCxNlM2KM7:TR?= M1T4N3NCVkeHUh?=
SNG-M M3vo[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXjXW9KSzVyPUCuNFE{OTdizszN NWrqenBMW0GQR1XS
CAL-12T NHLRVI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvRSo95UUN3ME2wMlAyOzR4IN88US=> MlPVV2FPT0WU
HSC-3 M1;mVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLxRo9DUUN3ME2wMlAyOzV3IN88US=> MoPyV2FPT0WU
DOHH-2 M{LVPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf0fIFKSzVyPUCuNFE1OTJizszN NHruVFBUSU6JRWK=
NB69 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7QXolKSzVyPUCuNFE2PjVizszN NV7BbXk1W0GQR1XS
LC-2-ad Ml3RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\nR|NKSzVyPUCuNFE2QDFizszN NXPD[oRZW0GQR1XS
RVH-421 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzQO4NZUUN3ME2wMlAyPjd2IN88US=> M1vFbnNCVkeHUh?=
TGW NVfiTVhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDON2g5UUN3ME2wMlAyPzN7IN88US=> MUTTRW5ITVJ?
HCC1569 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq2TWM2OD1yLkCxO|k4KM7:TR?= M17SXHNCVkeHUh?=
CAL-85-1 NF\oOYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mny4TWM2OD1yLkCxPFMzKM7:TR?= NG\NfnJUSU6JRWK=
RPMI-8402 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH0TJRKSzVyPUCuNFE5PThizszN NV:wNII3W0GQR1XS
THP-1 M4LPVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\EXWRKSzVyPUCuNFE6QThizszN MlvHV2FPT0WU
ONS-76 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDkTWM2OD1yLkCyNFM3KM7:TR?= MkHtV2FPT0WU
A2780 M{\ZWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHVTWM2OD1yLkCyNFc6KM7:TR?= MUTTRW5ITVJ?
RPMI-2650 M{jTRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1z1NGlEPTB;MD6wNlI6PiEQvF2= NY[0TZU2W0GQR1XS
MEL-HO M3HhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmW2TWM2OD1yLkCyN|Q5KM7:TR?= M{G1eXNCVkeHUh?=
MC-CAR NWq0b4VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\u[WlEPTB;MD6wNlM2PiEQvF2= Mor4V2FPT0WU
HSC-2 M4q3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwMEK0OlYh|ryP M3jwXnNCVkeHUh?=
MEL-JUSO MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkiwTWM2OD1yLkCyOFc{KM7:TR?= MlW2V2FPT0WU
CAL-62 NVX4cW9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEK2NFIh|ryP MnntV2FPT0WU
DMS-273 M2LQcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\NUWlEPTB;MD6wNlg1PyEQvF2= NHfyNHdUSU6JRWK=
S-117 NFTPN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVX3[4VkUUN3ME2wMlAzQTB4IN88US=> MoTkV2FPT0WU
SUP-T1 M4TpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES2dlhKSzVyPUCuNFI6PDlizszN MlfDV2FPT0WU
MZ2-MEL NWP5cZJUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP6N|hKSzVyPUCuNFI6PTlizszN M{TpR3NCVkeHUh?=
KYSE-270 M3u2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfBO21PUUN3ME2wMlAzQTd4IN88US=> M2Cxe3NCVkeHUh?=
CMK NWLFUG1tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDiTolqUUN3ME2wMlA{ODJ|IN88US=> M3v1c3NCVkeHUh?=
8505C NXP2TlUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMEOwOEDPxE1? MX7TRW5ITVJ?
NUGC-3 Mm\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DWTWlEPTB;MD6wN|A1QCEQvF2= NILPb4FUSU6JRWK=
A101D Ml[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTITWM2OD1yLkCzNFU2KM7:TR?= MULTRW5ITVJ?
G-401 NIi1WXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\5TWM2OD1yLkCzNFk{KM7:TR?= NUPLZot6W0GQR1XS
OVCAR-8 M{DEUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XJRWlEPTB;MD6wN|ExPyEQvF2= MUHTRW5ITVJ?
IMR-5 NFXhWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S2RWlEPTB;MD6wN|I1PCEQvF2= NYTGclJNW0GQR1XS
DoTc2-4510 M1PjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\HTWlEPTB;MD6wN|M6OyEQvF2= NULPXmlQW0GQR1XS
HOS NH[2R21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMEO0O|Mh|ryP MYLTRW5ITVJ?
HEC-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHrTWpKSzVyPUCuNFM3QCEQvF2= NGX3flZUSU6JRWK=
SW756 M2jZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPMZ4RKSzVyPUCuNFM5OjFizszN NH;weFhUSU6JRWK=
NCI-H64 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rxSmlEPTB;MD6wN|g1OiEQvF2= M4CyXXNCVkeHUh?=
EW-16 NHfYRlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLRTWM2OD1yLkCzPVA6KM7:TR?= Mnn2V2FPT0WU
CAL-51 MljYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV21eGdlUUN3ME2wMlA1ODB3IN88US=> MYnTRW5ITVJ?
KYSE-150 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3npbmlEPTB;MD6wOFAyOSEQvF2= NES1TohUSU6JRWK=
SW1710 NHfJe|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTBwMESwNVgh|ryP MYrTRW5ITVJ?
HuP-T4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\zbGlEPTB;MD6wOFEyQCEQvF2= MUnTRW5ITVJ?
LB373-MEL-D MnvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\xVGlKSzVyPUCuNFQzOzJizszN M3rLOnNCVkeHUh?=
EW-13 NYDS[nRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M363V2lEPTB;MD6wOFQxPiEQvF2= M4n5RnNCVkeHUh?=
HT-29 NH7XVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLqb3hKSzVyPUCuNFQ1QSEQvF2= MXnTRW5ITVJ?
SCC-25 NFzCeZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7h[FhDUUN3ME2wMlA1PDl2IN88US=> NIO2bVFUSU6JRWK=
REH M4jFbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4i2WmlEPTB;MD6wOFY{PSEQvF2= M3zwUnNCVkeHUh?=
L-363 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMES2O|kh|ryP NEjZNmJUSU6JRWK=
NCI-H1770 NGHORYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrMNIZKSzVyPUCuNFQ3QTdizszN Mo\pV2FPT0WU
CHL-1 M2\WbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XybGlEPTB;MD6wOFg2PyEQvF2= NH\kWFBUSU6JRWK=
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RPMI-8866 MnTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjaTWM2OD1yLkGzNlYyKM7:TR?= MVnTRW5ITVJ?
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SW954 NXfMW2l1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnkfZZ1UUN3ME2wMlQxOzN3IN88US=> NEDsW4RUSU6JRWK=
MES-SA NW\CdpEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;XSlhKSzVyPUCuOFA2ODVizszN NH\yR2dUSU6JRWK=
Ca-Ski NFrDdZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDqSnBKSzVyPUCuOFA2OjRizszN MnXBV2FPT0WU
SW13 M2js[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnCTWM2OD1yLkSwOlI3KM7:TR?= M2H6eXNCVkeHUh?=
NCI-H1437 NXHkcYh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3WyeWlEPTB;MD60NFgxPSEQvF2= NEnxUI1USU6JRWK=
U-118-MG NVTPOJlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELI[nVKSzVyPUCuOFA6ODRizszN MV3TRW5ITVJ?
NCI-H1734 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPPSW83UUN3ME2wMlQzODF|IN88US=> NWLnbY1LW0GQR1XS
HDLM-2 Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvxUGxNUUN3ME2wMlQzODN|IN88US=> Mn[zV2FPT0WU
AU565 NHP6fY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkCyTWM2OD1yLkSyOFY5KM7:TR?= MnXDV2FPT0WU
FADU M2HacGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwNEK2OFkh|ryP MVXTRW5ITVJ?
OS-RC-2 MmOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwNEOwPFMh|ryP M1WyXXNCVkeHUh?=
CAMA-1 NF3YblFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwNEO2NlYh|ryP M1vkNXNCVkeHUh?=
MONO-MAC-6 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomyTWM2OD1yLkSzPFQ6KM7:TR?= NEn4NXVUSU6JRWK=
LB831-BLC M4DVW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPYPZFVUUN3ME2wMlQ1OzdzIN88US=> Mn[0V2FPT0WU
SW982 NIHteVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTBwNES1Nlgh|ryP Mn:0V2FPT0WU
SCC-3 NWD0SGY2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwNES1O|kh|ryP NV7vepdOW0GQR1XS
C32 M2\WW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\H[mlEPTB;MD60OVIzQSEQvF2= NH7ZWoZUSU6JRWK=
BFTC-909 NXPSWnpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjPTWM2OD1yLkS1Nlk6KM7:TR?= MWTTRW5ITVJ?
MEG-01 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPUUVJKSzVyPUCuOFU{PzNizszN M{HrSXNCVkeHUh?=
M14 NWXoS5RST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwNEW5O|kh|ryP MVLTRW5ITVJ?
MPP-89 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXvTWM2OD1yLkS2NlU3KM7:TR?= NEWzOGNUSU6JRWK=
HCC1937 NHn1ZZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfYU2xiUUN3ME2wMlQ3Ozh2IN88US=> MorGV2FPT0WU
SW837 M371NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwNE[3NlIh|ryP NXfhdJZ4W0GQR1XS
DU-145 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfOV5l1UUN3ME2wMlQ3PzJ7IN88US=> MXPTRW5ITVJ?
LB996-RCC M3jxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vlNWlEPTB;MD60O|A2PCEQvF2= NVfq[GU4W0GQR1XS
C8166 M1H2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\wVY1CUUN3ME2wMlQ4PCEQvF2= MX\TRW5ITVJ?
MOLT-4 M3jhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwNEe3N|Qh|ryP MX;TRW5ITVJ?
DMS-53 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzTTWM2OD1yLkS3PFA6KM7:TR?= MWrTRW5ITVJ?
TE-5 Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwNEizNFUh|ryP Mk[yV2FPT0WU
KYSE-520 NF20dZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrybXJKSzVyPUCuOFg{PDNizszN NGe3WotUSU6JRWK=
Detroit562 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLNR21KSzVyPUCuOFg5PiEQvF2= M2SxSXNCVkeHUh?=
SIMA NY\HbnV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\mNmlEPTB;MD60PVQyPyEQvF2= NGrEWGtUSU6JRWK=
NCI-H1651 Mln3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mle3TWM2OD1yLkS5Olch|ryP MoXUV2FPT0WU
HCC1599 NXjydlI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPaTWM2OD1yLkS5PVU2KM7:TR?= MlHPV2FPT0WU
ABC-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rXe2lEPTB;MD61NFQ6PiEQvF2= Mlj5V2FPT0WU
CAL-33 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nRU2lEPTB;MD61NFg1PCEQvF2= MXPTRW5ITVJ?
OPM-2 MkXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrlTWM2OD1yLkWwPVM4KM7:TR?= NIO4VWRUSU6JRWK=
RPMI-7951 NF36XFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGL4VpNKSzVyPUCuOVA6PTdizszN M3fSdnNCVkeHUh?=
HT-1080 NH3aUIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPqWJZmUUN3ME2wMlUyOTF7IN88US=> MmPBV2FPT0WU
LC4-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK0S|BoUUN3ME2wMlUyPDB|IN88US=> NEfJemVUSU6JRWK=
OVCAR-3 NEH3VYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\jTWM2OD1yLkWxOVch|ryP NHrxOYdUSU6JRWK=
CAPAN-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrBTWM2OD1yLkWyNlg5KM7:TR?= NYG2VIZlW0GQR1XS
SK-OV-3 NEHjWIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3iTWM2OD1yLkWyOFM1KM7:TR?= M1;mUHNCVkeHUh?=
HuP-T3 NUjuSZBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTSTWM2OD1yLkWyPFI4KM7:TR?= NH[xdVRUSU6JRWK=
NCI-H838 NWnOUoF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwNUK4OFkh|ryP NGHMTHdUSU6JRWK=
K5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPTTWM2OD1yLkWzNlAyKM7:TR?= NWHFVXY4W0GQR1XS
CAL-72 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7ze5BKSzVyPUCuOVM{QDdizszN MYDTRW5ITVJ?
NH-12 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7QTYFnUUN3ME2wMlU{QTV7IN88US=> M125R3NCVkeHUh?=
SNB75 M{jyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j1WmlEPTB;MD61OVc{KM7:TR?= NVH5bJl{W0GQR1XS
BPH-1 M4Xje2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF20fXlKSzVyPUCuOVY{PDRizszN NV[xS3ZPW0GQR1XS
NOMO-1 NWTEfoxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLMXYFKSzVyPUCuOVY{PzJizszN MULTRW5ITVJ?
G-402 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXuTWM2OD1yLkW2OFk6KM7:TR?= NYTPPVNyW0GQR1XS
NCI-H2052 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;3[oRKSzVyPUCuOVY4PDFizszN MVnTRW5ITVJ?
RCM-1 NGnBWWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nPdmlEPTB;MD61O|E3PiEQvF2= NEHZZ4RUSU6JRWK=
COR-L279 NEXxd5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNUexPFUh|ryP MUfTRW5ITVJ?
A253 NIPUc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;HVG5sUUN3ME2wMlU4PTJ3IN88US=> NFi4NVJUSU6JRWK=
SK-MM-2 M4nmUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fMeGlEPTB;MD61O|Y4QSEQvF2= MmSwV2FPT0WU
NCI-H1703 NVHVTlJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDxTWM2OD1yLkW5OFI4KM7:TR?= Mnn3V2FPT0WU
UACC-257 NGfLOXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDJVFJKSzVyPUCuOVk1QDdizszN M13ZcXNCVkeHUh?=
KALS-1 NVjpTmFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrlTWM2OD1yLk[wNFEyKM7:TR?= NVv4cpBYW0GQR1XS
ES5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXuUXFKSzVyPUCuOlA1QCEQvF2= Mn2xV2FPT0WU
MHH-CALL-2 NWrwcnh4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfF[HpsUUN3ME2wMlYxQDh6IN88US=> NHGzT5RUSU6JRWK=
ChaGo-K-1 MkXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwNkGyNlkh|ryP M{W2W3NCVkeHUh?=
TGBC1TKB NUPtXGV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULDeXF[UUN3ME2wMlYyQThizszN NHPNfpBUSU6JRWK=
KU-19-19 Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[zeHRKSzVyPUCuOlQ2QDZizszN NE[ze45USU6JRWK=
COLO-684 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HLSGlEPTB;MD62OVYyOSEQvF2= NGDT[IJUSU6JRWK=
LS-1034 NH:3UVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jxfGlEPTB;MD62OVgyQSEQvF2= NYnv[|M3W0GQR1XS
RT-112 NFf5NZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwNk[1PFch|ryP NYrRN|VIW0GQR1XS
Capan-2 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\Pb|NKSzVyPUCuOlY3OjJizszN M3nOPHNCVkeHUh?=
HSC-4 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrtTWM2OD1yLk[2Olk5KM7:TR?= MXrTRW5ITVJ?
COLO-824 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom0TWM2OD1yLk[3PFI{KM7:TR?= NYXvUXY2W0GQR1XS
NCI-H2170 NH;4OmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLoTWM2OD1yLk[4NlU5KM7:TR?= MWLTRW5ITVJ?
GDM-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rlVGlEPTB;MD62PFQ6PCEQvF2= NF;P[JdUSU6JRWK=
KP-4 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Oc4pKSzVyPUCuOlk2PzNizszN M{\h[XNCVkeHUh?=
VA-ES-BJ NF;Hd4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mme0TWM2OD1yLk[5PVg3KM7:TR?= NXPuN5hiW0GQR1XS
KM-H2 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPGTWM2OD1yLkewNFkyKM7:TR?= M4\HTnNCVkeHUh?=
HH MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XMd2lEPTB;MD63NFY3OiEQvF2= Mmn2V2FPT0WU
DK-MG NIHQeZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm2UGFKSzVyPUCuO|ExOTZizszN NYDoWmdzW0GQR1XS
VM-CUB-1 NFf4ZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITmNYZKSzVyPUCuO|EzPTlizszN MWHTRW5ITVJ?
COLO-829 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PPZWlEPTB;MD63NVk5PSEQvF2= MX\TRW5ITVJ?
OMC-1 NHe5[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwN{KxNFQh|ryP NUHpbVZ6W0GQR1XS
NB12 M{mwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfPfYVKSzVyPUCuO|I2ODRizszN Mof3V2FPT0WU
NCI-H28 M1PtZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTqTWM2OD1yLke0NFg{KM7:TR?= NVzId|BHW0GQR1XS
A673 NIXxVpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjiN2dEUUN3ME2wMlc2OTd5IN88US=> MlSzV2FPT0WU
LB2241-RCC NHXnO5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPxTWM2OD1yLke2NFg4KM7:TR?= MXHTRW5ITVJ?
CCRF-CEM MmnKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwN{ewOVIh|ryP NUXuSVZ3W0GQR1XS
NCI-H510A NFfD[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzIdFZKSzVyPUCuO|cyQDZizszN M3:2TXNCVkeHUh?=
SW48 M1uzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1T3N2lEPTB;MD63O|M{OyEQvF2= NE\abm9USU6JRWK=
NCI-H2081 NUDEOIxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTUOYpVUUN3ME2wMlc5OTR5IN88US=> NXr1[ldGW0GQR1XS
RMG-I MkTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mzemlEPTB;MD63PFIyOiEQvF2= NITSclhUSU6JRWK=
LU-99A M1TlSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rLeGlEPTB;MD63PFQyOyEQvF2= MUTTRW5ITVJ?
KP-N-YS M4j6d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFP4bHBKSzVyPUCuO|g6OjFizszN NXfhSo1zW0GQR1XS
MDA-MB-231 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwOECxN|Eh|ryP M4[2U3NCVkeHUh?=
U031 M3zk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIK3c3lKSzVyPUCuPFE1OjNizszN NX7qTXk2W0GQR1XS
EVSA-T M3z5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\GbWlEPTB;MD64NVY4OiEQvF2= MYnTRW5ITVJ?
MDA-MB-157 NGm4fXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLpc|F7UUN3ME2wMlgzOjdzIN88US=> M2PHW3NCVkeHUh?=
EHEB NVnwUWhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PpV2lEPTB;MD64NlI4PiEQvF2= Mmn1V2FPT0WU
KINGS-1 M4HZcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwOEK1OVUh|ryP MmrkV2FPT0WU
23132-87 NFHPSFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPhTWM2OD1yLkiyPFQ{KM7:TR?= NXHndoRmW0GQR1XS
EFO-21 MkToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrrco9uUUN3ME2wMlg1ODh7IN88US=> NYqxSJMzW0GQR1XS
DOK M{DFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rE[mlEPTB;MD64OFgh|ryP NWDncI0yW0GQR1XS
NCI-H2171 M3mxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWriPFd2UUN3ME2wMlg1QTZizszN MoLaV2FPT0WU
NCI-SNU-5 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwOEW1O{DPxE1? NEfDOXhUSU6JRWK=
SK-N-DZ MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUflbHBYUUN3ME2wMlg2QTR|IN88US=> NY\0WJZXW0GQR1XS
SNU-C2B NInLSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPjPXh6UUN3ME2wMlg3QDBzIN88US=> M3K4ZnNCVkeHUh?=
CP66-MEL NYTzOGNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwOEexNUDPxE1? NV3z[4RZW0GQR1XS
SN12C M1\WTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwOEi2N|ch|ryP NECwRYVUSU6JRWK=
A172 NHex[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDxb|NKSzVyPUCuPFg3QThizszN MYjTRW5ITVJ?
NCI-H2347 NUfz[GJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwOEi3OVMh|ryP NG\SRYtUSU6JRWK=
NCI-H2228 M4[5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX6WnRKSzVyPUCuPFk{OzlizszN NEP4d3dUSU6JRWK=
SNU-387 MoC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G2cGlEPTB;MD65NFI3PCEQvF2= MUXTRW5ITVJ?
SK-MEL-24 NVf0U3ZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETFcFhKSzVyPUCuPVE{PDRizszN MnPBV2FPT0WU
MDA-MB-468 NHf2cJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmwTWM2OD1yLkmxO|Mh|ryP NIDUOVlUSU6JRWK=
NCI-H1694 M1;XVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfLclF1UUN3ME2wMlkyQDd4IN88US=> MUjTRW5ITVJ?
CCF-STTG1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrtO2RxUUN3ME2wMlkzPjN5IN88US=> MmC5V2FPT0WU
K052 M3\V[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrsN3VKSzVyPUCuPVQxPDdizszN MojBV2FPT0WU
NCI-H446 NXrsdpU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwOUWwNUDPxE1? NVWxNmVIW0GQR1XS
MFE-280 Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrEeIJEUUN3ME2wMlk3OjlzIN88US=> NHrSSVhUSU6JRWK=
KU812 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLJTWM2OD1yLkm5N|g6KM7:TR?= M4XjcXNCVkeHUh?=
MDA-MB-361 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3PTWM2OD1yLkm5O|c4KM7:TR?= NVXqbINNW0GQR1XS
Raji MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXYTWM2OD1zLkCyNlY4KM7:TR?= M3vmXXNCVkeHUh?=
TE-6 NW[zNVVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTvTWM2OD1zLkCzOVY3KM7:TR?= MnPFV2FPT0WU
CAL-148 MmHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe0TWM2OD1zLkC0OFQ{KM7:TR?= MUDTRW5ITVJ?
NCI-H1963 NIr5d2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjFPFZKSzVyPUGuNFQ2PTNizszN MnuzV2FPT0WU
SK-N-AS M4\mU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljmTWM2OD1zLkC0Olg2KM7:TR?= M1jZVXNCVkeHUh?=
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Mo-T NHns[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S0UWlEPTB;MT65NFA{QSEQvF2= MYrTRW5ITVJ?
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NCI-H209 NHLS[5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULvNpA4UUN3ME2zMlY4PjV|IN88US=> NUm3Opd3W0GQR1XS
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C-4-II NY[0TJJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPuTWM2OD1|Lke1OlQ{KM7:TR?= MV7TRW5ITVJ?
NCI-H1650 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTNwN{i0OVUh|ryP MorlV2FPT0WU
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NCI-N87 NEL5fGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPFTWM2OD12LkO4PFIyKM7:TR?= M{fSZ3NCVkeHUh?=
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BT-20 NIjYW|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzlTWM2OD12LkS5NFAzKM7:TR?= MWTTRW5ITVJ?
NCI-H1882 NIPGU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nvRmlEPTB;ND61NFU4KM7:TR?= M4j3T3NCVkeHUh?=
WM-115 NGP0WoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr6TWM2OD12LkWwPFgyKM7:TR?= NE\2cZVUSU6JRWK=
SKG-IIIa NEn3Sm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjWN4hKSzVyPUSuOlc4PyEQvF2= MVnTRW5ITVJ?
NCI-H69 M2[3cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH3TWM2OD12LkewNlc2KM7:TR?= MUXTRW5ITVJ?
MSTO-211H NXLMSo5qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHDTWM2OD12LkizOVY2KM7:TR?= NIS0bmpUSU6JRWK=
Mewo MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\neWlEPTB;ND65OlMyOyEQvF2= NHHofHRUSU6JRWK=
GI-ME-N MkPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkOxTWM2OD13LkCwOVA6KM7:TR?= M{DaZ3NCVkeHUh?=
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COLO-800 M4X1U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3GfYZSUUN3ME21MlE6OzR7IN88US=> NH7nOIVUSU6JRWK=
NCI-H1755 NYX2OIlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTVwMkOwNlch|ryP NUP4Wo9qW0GQR1XS
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HCC1954 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PjTGlEPTB;NT64OVk4OSEQvF2= MlXsV2FPT0WU
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LU-165 NXfufmo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzpTWM2OD13Lkm5NFAzKM7:TR?= NH7VNoVUSU6JRWK=
YAPC NXzSfW1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zCXmlEPTB;NT65PVA3QCEQvF2= NIf1NI9USU6JRWK=
LU-139 M2jmWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLhVIZKSzVyPU[uNFg{PjhizszN NXH6dGhNW0GQR1XS
D-502MG MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTGTWM2OD14LkOyNFQ4KM7:TR?= M4KxTHNCVkeHUh?=
IST-SL1 NVHkS5dpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTZwNUO5OFgh|ryP MoTzV2FPT0WU
DG-75 M1fOW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\3TWM2OD14Lki4O|g3KM7:TR?= MVLTRW5ITVJ?
NCI-H1155 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXrO3RsUUN3ME22Mlk2PThzIN88US=> NF;odmxUSU6JRWK=
EFE-184 NXm3NXdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHMdFZ6UUN3ME23MlMyPjl3IN88US=> NF\MbJZUSU6JRWK=
AsPC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\LTnNKSzVyPUeuOFg5ODdizszN NUf5copzW0GQR1XS
SW948 M4TMN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTdwNUizPVUh|ryP MXLTRW5ITVJ?
NCI-H524 NXrLUoI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zHS2lEPTB;OT61PFYzQCEQvF2= NIfNUZBUSU6JRWK=
KOSC-2 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTlwNkK4N|Qh|ryP MoXGV2FPT0WU
T-24 NWjXWlRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfRU3ROUUN3ME25Mlk1PDF3IN88US=> NFLxNpZUSU6JRWK=
NCI-H748 MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK3TWM2OD1zMD62N|k4KM7:TR?= MWLTRW5ITVJ?
NCI-H23 M1TZeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTFyLk[0OFIh|ryP M1OyR3NCVkeHUh?=
UACC-812 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PKWWlEPTB;MUGuO|E4KM7:TR?= M{f0dHNCVkeHUh?=
SCLC-21H MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzPWm5tUUN3ME2xNk4yPTVzIN88US=> NHHobnNUSU6JRWK=
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LB647-SCLC M{LMTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEflToZKSzVyPUG1MlcyQTVizszN NXfMb|hCW0GQR1XS
NCI-H345 NVHnWnc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7Sd|RKSzVyPUG3MlM1OyEQvF2= NUT2TFR3W0GQR1XS
NCI-H1563 MonJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\wfI8yUUN3ME2xPE44PjBzIN88US=> MofZV2FPT0WU
RL NXW3OVc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCwTWM2OD1{MT6yOlU3KM7:TR?= MmPWV2FPT0WU
KY821 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTJ{LkC1OVMh|ryP MkTBV2FPT0WU
JVM-3 NVLz[YY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPITWM2OD1{NT6wOFE{KM7:TR?= NYTUcpJZW0GQR1XS
NCI-H1793 MlO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\tWGlEPTB;MkiuOVQ6QSEQvF2= NYPhfo9XW0GQR1XS
LU-134-A NH60O5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M120TmlEPTB;M{CuNlA{PyEQvF2= M1vnVHNCVkeHUh?=
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P31-FUJ NEGwc|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{naOGlEPTB;M{OuOFg6QSEQvF2= M2LLcXNCVkeHUh?=
LS-513 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETHWnRKSzVyPUO1Mlg5PzlizszN MUjTRW5ITVJ?
SK-MEL-1 MlfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mly1TWM2OD12MD6zOFk6KM7:TR?= NInmSWpUSU6JRWK=
SW684 M17IVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTR|Lkm2OlEh|ryP M2jJR3NCVkeHUh?=
COR-L88 NFrSW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXOXHFKSzVyPUS0MlA3PjVizszN M4HHPHNCVkeHUh?=
NCI-H889 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7BUXhKSzVyPUS1MlAxQDdizszN NGrC[YJUSU6JRWK=
TALL-1 M4HRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknWTWM2OD12Nj6xNVk6KM7:TR?= NGrWVoxUSU6JRWK=
KARPAS-299 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\SXY86UUN3ME20O{4yQTl|IN88US=> NGLSeW9USU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2
NCT00724841 Terminated Metastatic Melanoma Gemin X|Teva Pharmaceutical Industries June 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID