Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Price Stock Quantity  
USD 190 In stock
USD 170 In stock
USD 320 In stock
USD 870 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Obatoclax Mesylate (GX15-070) Chemical Structure

Obatoclax Mesylate (GX15-070) Chemical Structure
Molecular Weight: 413.49

Validation & Quality Control

9 customer reviews :

Quality Control & MSDS

Related Compound Libraries

Obatoclax Mesylate (GX15-070) is available in the following compound libraries:

Bcl-2 Inhibitors with Unique Features

  • Pan Bcl-2 Inhibitor

    ABT-737 Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.

  • Most Potent Bcl-2 Inhibitor

    ABT-263 (Navitoclax) Bcl-xL, Ki≤ 0.5 nM; Bcl-2, Ki≤ 1 nM; Bcl-w, Ki≤ 1 nM.

  • Newest Bcl-2 Family Activator

    BAM7 Direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.

  • Classic Bcl-2 Inhibitor

    ABT-737 BH3-mimetic inhibitor, Bcl-xL, EC50=78.7 nM; Bcl-2, EC50=30.3 nM; Bcl-w, EC50=197.8 nM.

Product Information

  • Compare Bcl-2 Inhibitors
    Compare Bcl-2 Products
  • Research Area

Product Description

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Targets Bcl-2 [1]
(Cell-free assay)
IC50 0.22 μM(Ki)
In vitro Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]
Cell Data
Cell LinesAssay TypeConcentrationIncubation TimeFormulationActivity DescriptionPMID
KARPAS-45M4L0fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2jwVGlEPTB;MD6wNFAxOzF5IN88US=>MYLTRW5ITVJ?
SK-MEL-30M4DJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHHhTmRKSzVyPUCuNFAxOzV3IN88US=>M2Wz[XNCVkeHUh?=
NALM-6MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NE\5clNKSzVyPUCuNFAxOzV4IN88US=>MoW5V2FPT0WU
KYSE-450M3fqfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUPJR|UxRTBwMECwOFY6KM7:TR?=MkPlV2FPT0WU
BHYMnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHPIeJdKSzVyPUCuNFAxPjBzIN88US=>MmnnV2FPT0WU
GR-STMmDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGLEN3JKSzVyPUCuNFAxPjR6IN88US=>M3zTW3NCVkeHUh?=
786-0MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPnVI91UUN3ME2wMlAxODd5NjFOwG0>NY\3bWV1W0GQR1XS
C-33-AMUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4izWmlEPTB;MD6wNFA5PDhizszNNXLuVFI6W0GQR1XS
BHT-101NXL5S|NkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlvwTWM2OD1yLkCwNVA3KM7:TR?=M1XhR3NCVkeHUh?=
EB2M1zKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3fpXmlEPTB;MD6wNFEyQCEQvF2=M1K5[XNCVkeHUh?=
G-361NHTLd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEfyeWpKSzVyPUCuNFAyOjRizszNMVTTRW5ITVJ?
KE-37MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4\X[mlEPTB;MD6wNFEzQCEQvF2=MY\TRW5ITVJ?
MHH-PREB-1MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYTCTW9uUUN3ME2wMlAxOTRizszNMknKV2FPT0WU
MCF7M2OxSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Ml3jTWM2OD1yLkCwNVU6KM7:TR?=NVPWc|BHW0GQR1XS
LOUCYMmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHjUdHhKSzVyPUCuNFAyPzVizszNNIfOZ3VUSU6JRWK=
EW-7NXvxZnc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NEPw[2dKSzVyPUCuNFAyPzVizszNNELlUYxUSU6JRWK=
KYSE-510MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MV3JR|UxRTBwMECyN|Mh|ryPNFnJWJdUSU6JRWK=
SK-MEL-3M4rhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEjrSnZKSzVyPUCuNFAzPjRizszNNWK2NpluW0GQR1XS
HAL-01M2LUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mn\nTWM2OD1yLkCwNlk4KM7:TR?=M4H6UHNCVkeHUh?=
HCC2998MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUjJR|UxRTBwMECzN|Uh|ryPM17RUHNCVkeHUh?=
A375M{DHOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MU\JR|UxRTBwMECzOUDPxE1?NWfNT5J4W0GQR1XS
MZ7-melNEHqPIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mk\YTWM2OD1yLkCwN|k6KM7:TR?=MYjTRW5ITVJ?
SH-4M1vhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWHBUppLUUN3ME2wMlAxPDF5IN88US=>MmTsV2FPT0WU
HT-144MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVjRNGZ4UUN3ME2wMlAxPDNizszNMUfTRW5ITVJ?
KYSE-140NXPrV|l3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml[wTWM2OD1yLkCwOFM2KM7:TR?=MlS5V2FPT0WU
PSN1NV7CNYFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1G3WGlEPTB;MD6wNFQ3PyEQvF2=NGHyWVBUSU6JRWK=
COLO-679NYPsTm5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4\FVmlEPTB;MD6wNFQ6QCEQvF2=M{fGO3NCVkeHUh?=
SW620NWnK[JFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFXCXJNKSzVyPUCuNFA2OTFizszNMX;TRW5ITVJ?
HGC-27NFS0dIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIizd|hKSzVyPUCuNFA2OjRizszNNFPzcHdUSU6JRWK=
IGROV-1NV\XNG46T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NG\HbGRKSzVyPUCuNFA3KM7:TR?=MnX2V2FPT0WU
IGR-1NHTvZ2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1Hlc2lEPTB;MD6wNFYxOSEQvF2=NWe0V|l{W0GQR1XS
EW-1NGfDNnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUTJR|UxRTBwMEC2OVEh|ryPNV7nTFFIW0GQR1XS
769-PMojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NITHWJJKSzVyPUCuNFA3PzhizszNNUHsb25xW0GQR1XS
HNNWO2UVNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVW3OGpIUUN3ME2wMlAxPjd7IN88US=>MVHTRW5ITVJ?
SIG-M5NU\rNVZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoPiTWM2OD1yLkCwO|Eh|ryPNX3YOZdYW0GQR1XS
IST-MEL1MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVfPWo5oUUN3ME2wMlAxQDF6IN88US=>NULYR5FrW0GQR1XS
ST486MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkTvTWM2OD1yLkCwPFI2KM7:TR?=Mlv1V2FPT0WU
ES7M2nn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXf3TVk{UUN3ME2wMlAxQDR4IN88US=>NWHw[GlIW0GQR1XS
GAKNVrmVYhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M32xTGlEPTB;MD6wNFg1QCEQvF2=M2H5UHNCVkeHUh?=
BB30-HNCMnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnMTWM2OD1yLkCwPFU5KM7:TR?=NILZPWpUSU6JRWK=
IPC-298M{\qd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NITkfFVKSzVyPUCuNFA6OjdizszNNV3EfYFPW0GQR1XS
NKM-1NWjiO2t[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4XXfWlEPTB;MD6wNFk4OiEQvF2=NFLiVZJUSU6JRWK=
RKONHHINZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnLhTWM2OD1yLkCxNFQ1KM7:TR?=MV;TRW5ITVJ?
ACNMojIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M323dmlEPTB;MD6wNVE{OSEQvF2=MmnZV2FPT0WU
SW1417MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4\Qc2lEPTB;MD6wNVIzPSEQvF2=NFzyTXdUSU6JRWK=
SRM1HpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2PZWGlEPTB;MD6wNVI{PSEQvF2=MXfTRW5ITVJ?
SNG-MMYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFHHbXlKSzVyPUCuNFE{OTdizszNMnPHV2FPT0WU
CAL-12TNIW3PVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX7ke4J2UUN3ME2wMlAyOzR4IN88US=>MnK0V2FPT0WU
HSC-3NG\4RXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGrMTYZKSzVyPUCuNFE{PTVizszNNWe3fIhLW0GQR1XS
DOHH-2M4n4PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVP0OGhOUUN3ME2wMlAyPDF{IN88US=>NYLVXlFOW0GQR1XS
NB69NHTZO|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIO3fJhKSzVyPUCuNFE2PjVizszNNX3k[3RZW0GQR1XS
LC-2-adNYSyW4xnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWDJR|UxRTBwMEG1PFEh|ryPMXHTRW5ITVJ?
RVH-421MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUHJR|UxRTBwMEG2O|Qh|ryPMYLTRW5ITVJ?
TGWM{PDWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmLjTWM2OD1yLkCxO|M6KM7:TR?=NWfKeIR1W0GQR1XS
HCC1569M2jOPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{no[2lEPTB;MD6wNVc6PyEQvF2=NFnnNWdUSU6JRWK=
CAL-85-1MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{SwdWlEPTB;MD6wNVg{OiEQvF2=M{DUVXNCVkeHUh?=
RPMI-8402NX7lU|BrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{PsPWlEPTB;MD6wNVg2QCEQvF2=MorsV2FPT0WU
THP-1MknvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2HhT2lEPTB;MD6wNVk6QCEQvF2=NHvaWW1USU6JRWK=
ONS-76NV7nN3Z5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1fN[WlEPTB;MD6wNlA{PiEQvF2=MXjTRW5ITVJ?
A2780NFHteZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml3aTWM2OD1yLkCyNFc6KM7:TR?=NWT2XnU5W0GQR1XS
RPMI-2650MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1LidmlEPTB;MD6wNlI6PiEQvF2=M37oSnNCVkeHUh?=
MEL-HONFnCTJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXXJR|UxRTBwMEKzOFgh|ryPNXHzNXJ5W0GQR1XS
MC-CARMofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{e2TWlEPTB;MD6wNlM2PiEQvF2=MYnTRW5ITVJ?
HSC-2NEn0XJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIXoOo1KSzVyPUCuNFI1PjZizszNMlHWV2FPT0WU
MEL-JUSONEP6NWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NETJSZdKSzVyPUCuNFI1PzNizszNMYXTRW5ITVJ?
CAL-62M1vVeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIfETXRKSzVyPUCuNFI3ODJizszNM4DjcHNCVkeHUh?=
DMS-273NFnDXHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MljXTWM2OD1yLkCyPFQ4KM7:TR?=NYrsS5lVW0GQR1XS
S-117M1vEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGHrU5JKSzVyPUCuNFI6ODZizszNNHLvcG9USU6JRWK=
SUP-T1NHLwUnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3HsVWlEPTB;MD6wNlk1QSEQvF2=NW\5SpJtW0GQR1XS
MZ2-MELNGnjRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3HucWlEPTB;MD6wNlk2QSEQvF2=Mo[3V2FPT0WU
KYSE-270Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NF\v[W9KSzVyPUCuNFI6PzZizszNMonTV2FPT0WU
CMKM{jYO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF\4VXlKSzVyPUCuNFMxOjNizszNNVfQeoxrW0GQR1XS
8505CNWDTe2tvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYjJR|UxRTBwMEOwOEDPxE1?MVjTRW5ITVJ?
NUGC-3M1XxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2XiUGlEPTB;MD6wN|A1QCEQvF2=MmPYV2FPT0WU
A101DMWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYfJR|UxRTBwMEOwOVUh|ryPMXHTRW5ITVJ?
G-401MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH3PeIpKSzVyPUCuNFMxQTNizszNMl\kV2FPT0WU
OVCAR-8NXznZ5VsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWXScHBWUUN3ME2wMlA{OTB5IN88US=>NIDnN4dUSU6JRWK=
IMR-5NEi3V2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M13lRmlEPTB;MD6wN|I1PCEQvF2=NXXy[HRpW0GQR1XS
DoTc2-4510NHSzT4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF;6XINKSzVyPUCuNFM{QTNizszNNGPSe|NUSU6JRWK=
HOSMnzYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoDhTWM2OD1yLkCzOFc{KM7:TR?=Mm\RV2FPT0WU
HEC-1MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHHXWRKSzVyPUCuNFM3QCEQvF2=M1H6UnNCVkeHUh?=
SW756M3fxXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{DRVmlEPTB;MD6wN|gzOSEQvF2=M1TZfXNCVkeHUh?=
NCI-H64NXGxUXh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoHITWM2OD1yLkCzPFQzKM7:TR?=MXrTRW5ITVJ?
EW-16MlLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnvkTWM2OD1yLkCzPVA6KM7:TR?=M4HGR3NCVkeHUh?=
CAL-51NYrVbpFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV3yOFh[UUN3ME2wMlA1ODB3IN88US=>NFTyS3hUSU6JRWK=
KYSE-150NGLOXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYXJR|UxRTBwMESwNVEh|ryPMVXTRW5ITVJ?
SW1710NYq4WJR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGridWVKSzVyPUCuNFQxOThizszNM{f4fXNCVkeHUh?=
HuP-T4M2fX[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFrB[G5KSzVyPUCuNFQyOThizszNMYfTRW5ITVJ?
LB373-MEL-DNXOxTJl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml\sTWM2OD1yLkC0NlMzKM7:TR?=NELXemlUSU6JRWK=
EW-13NUPQUYs1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXTJR|UxRTBwMES0NFYh|ryPNYLobox7W0GQR1XS
HT-29Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoTBTWM2OD1yLkC0OFkh|ryPNWOyZnBGW0GQR1XS
SCC-25MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MW\JR|UxRTBwMES0PVQh|ryPNYPJUWJyW0GQR1XS
REHNGCwOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlzETWM2OD1yLkC0OlM2KM7:TR?=NWXVd2Y3W0GQR1XS
L-363MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY\3eIN1UUN3ME2wMlA1Pjd7IN88US=>M363eXNCVkeHUh?=
NCI-H1770MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnvOTWM2OD1yLkC0Olk4KM7:TR?=MXLTRW5ITVJ?
CHL-1MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXHMcWE3UUN3ME2wMlA1QDV5IN88US=>NGCxZpNUSU6JRWK=
ES1M{OzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFK2bpVKSzVyPUCuNFQ5QDVizszNNIqwXHlUSU6JRWK=
SCC-15NYLNSGJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4fNN2lEPTB;MD6wOFkxOiEQvF2=NVT5OYN2W0GQR1XS
MRK-nu-1NGna[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1H0bGlEPTB;MD6wOFk{PiEQvF2=NIH6eoZUSU6JRWK=
PF-382NH7vdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MWnJR|UxRTBwMES5N|kh|ryPM17aRnNCVkeHUh?=
COLO-680NNEDLSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmnsTWM2OD1yLkC1NFQ4KM7:TR?=MnPKV2FPT0WU
LK-2MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4r5XGlEPTB;MD6wOVA3OyEQvF2=NEXSS4JUSU6JRWK=
NCI-H2342M1jyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmnDTWM2OD1yLkC1NVE4KM7:TR?=Mn7BV2FPT0WU
HMV-IIMYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnrSTWM2OD1yLkC1NlM6KM7:TR?=M{fHeXNCVkeHUh?=
PC-14NYKy[pVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnjOTWM2OD1yLkC1NlUzKM7:TR?=NH;LZ4RUSU6JRWK=
COLO-320-HSRMYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlLhTWM2OD1yLkC1Nlg6KM7:TR?=M3;UWHNCVkeHUh?=
697NVfWTZZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYXJR|UxRTBwMEWzNlMh|ryPM{LkWXNCVkeHUh?=
NEC8MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXXJR|UxRTBwMEW1PUDPxE1?NFP6dIZUSU6JRWK=
LCLC-97TM1Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnPjTWM2OD1yLkC1OVk1KM7:TR?=NEDLV5pUSU6JRWK=
DaoyMmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MY\JR|UxRTBwMEW2NVYh|ryPNU\SfFE{W0GQR1XS
ETK-1MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWXUNVJYUUN3ME2wMlA2Pjd{IN88US=>M1TVTHNCVkeHUh?=
A388M4rhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGKxRVNKSzVyPUCuNFU3QTVizszNNGrrUI1USU6JRWK=
COLO-205M2LE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHrmVGlKSzVyPUCuNFU4OTZizszNM4rpbnNCVkeHUh?=
SK-PN-DWM3PRUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUjDO21RUUN3ME2wMlA2PzJ7IN88US=>MVfTRW5ITVJ?
SF268M2HRSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVPJVFEzUUN3ME2wMlA2PzV4IN88US=>NFrpc5dUSU6JRWK=
OCI-AML2NHzCVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NIfNR5ZKSzVyPUCuNFU4PzdizszNMX3TRW5ITVJ?
GAMGMYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkX0TWM2OD1yLkC1PEDPxE1?MYrTRW5ITVJ?
BCPAPM2ezemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWPpW2wxUUN3ME2wMlA2QDl{IN88US=>NVnjWHpTW0GQR1XS
BC-1NIPQSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVXZcpozUUN3ME2wMlA3ODJ{IN88US=>MYnTRW5ITVJ?
IA-LMMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGjBOlFKSzVyPUCuNFYxPTNizszNMn3vV2FPT0WU
NCI-H1299MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWXJR|UxRTBwME[xN{DPxE1?M4i4[3NCVkeHUh?=
COR-L23MoL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{HuVmlEPTB;MD6wOlE{PCEQvF2=MX7TRW5ITVJ?
KYSE-180NFHNfXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYDS[mR4UUN3ME2wMlA3OTR{IN88US=>MUXTRW5ITVJ?
LOXIMVIM{LWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVLJR|UxRTBwME[xPFgh|ryPMlf5V2FPT0WU
BL-41M2\6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGrOZYFKSzVyPUCuNFYzOTlizszNNGi4e41USU6JRWK=
BL-70MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWjjVIxmUUN3ME2wMlA3OzB{IN88US=>NVHSXJQ5W0GQR1XS
NOS-1NEj4T3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHvtdIxKSzVyPUCuNFY1OTFizszNNEX0U4xUSU6JRWK=
NB13NYnmdpZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWKxOppFUUN3ME2wMlA3PDJzIN88US=>MorxV2FPT0WU
CAL-27MnLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml\0TWM2OD1yLkC2OFY1KM7:TR?=M3TJTHNCVkeHUh?=
CA46MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGniUXpKSzVyPUCuNFY2OzdizszNNHnuWYtUSU6JRWK=
SW962Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTBwME[1Olkh|ryPMkixV2FPT0WU
NCI-H226NIO5SlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2js[WlEPTB;MD6wOlY{OiEQvF2=MV;TRW5ITVJ?
KYSE-70NYPlSGRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXTJR|UxRTBwME[5OFUh|ryPMX3TRW5ITVJ?
DaudiM1zKTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MW\JR|UxRTBwMEewPFEh|ryPM2jiR3NCVkeHUh?=
SW626NEDEZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MonOTWM2OD1yLkC3NlA1KM7:TR?=NWXZdog{W0GQR1XS
ESS-1M4DqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVzrUYZsUUN3ME2wMlA4OjR4IN88US=>MXrTRW5ITVJ?
YTMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlfhTWM2OD1yLkC3N|Q2KM7:TR?=NXzYUWtWW0GQR1XS
P12-ICHIKAWAMW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVHkRlhvUUN3ME2wMlA4OzR7IN88US=>MY\TRW5ITVJ?
BxPC-3NGDodohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX;lXmZlUUN3ME2wMlA4PDV6IN88US=>MoKwV2FPT0WU
CTV-1NFfKO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV\DVIpZUUN3ME2wMlA4PTF5IN88US=>NGPPT3lUSU6JRWK=
MLMANIPEV5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MonPTWM2OD1yLkC3OVM1KM7:TR?=MUnTRW5ITVJ?
WSU-NHLM1W5eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NXfXZ|h{UUN3ME2wMlA4PTV2IN88US=>NUTsN3M4W0GQR1XS
CTB-1M1LpOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYnJR|UxRTBwMEe1PFgh|ryPMYTTRW5ITVJ?
MMAC-SFM2fBcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NILJUVBKSzVyPUCuNFc3PjhizszNNXfxc5R5W0GQR1XS
8-MG-BAMWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFHVTllKSzVyPUCuNFc5ODFizszNNVv6[o9CW0GQR1XS
NCI-H358M3:zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYO5S|N{UUN3ME2wMlA4QDd7IN88US=>NIewR2tUSU6JRWK=
BFTC-905NHzoS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{T2fGlEPTB;MD6wO|kxQSEQvF2=MVvTRW5ITVJ?
NCI-H727NUi4NnBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4rJc2lEPTB;MD6wPFA2OyEQvF2=NVj0[WpLW0GQR1XS
CHP-212NXrORohwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MofyTWM2OD1yLkC4NFk2KM7:TR?=MmT5V2FPT0WU
HOP-62NUfjR4FMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3zzd2lEPTB;MD6wPFI1PSEQvF2=MknaV2FPT0WU
CESSMU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXvnOJpwUUN3ME2wMlA5OjZ7IN88US=>Mny1V2FPT0WU
HuCCT1MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mm\DTWM2OD1yLkC4N|M{KM7:TR?=NXSxT3lxW0GQR1XS
DELM3zESGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVXJR|UxRTBwMEizOFch|ryPM4PLPHNCVkeHUh?=
5637M1PPbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NULZb4FYUUN3ME2wMlA5OzZ5IN88US=>NWWwO3pRW0GQR1XS
RS4-11M2\iN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWPsb3VbUUN3ME2wMlA5PDl5IN88US=>NF\zfVdUSU6JRWK=
KURAMOCHINE\aVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mm\QTWM2OD1yLkC4OVA6KM7:TR?=MXfTRW5ITVJ?
A427NWf2THNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M33KO2lEPTB;MD6wPFUyOiEQvF2=NGi2VI9USU6JRWK=
A3-KAWNYTaOohmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mnf0TWM2OD1yLkC4OVY3KM7:TR?=M3LSdHNCVkeHUh?=
LS-123NUP4cIx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3e3[WlEPTB;MD6wPFcyQSEQvF2=M2\uNHNCVkeHUh?=
LoVoM3jTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{T1TWlEPTB;MD6wPFczKM7:TR?=M1nKTXNCVkeHUh?=
PA-1MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYXJR|UxRTBwMEi3Olkh|ryPMoPkV2FPT0WU
CP50-MEL-BM2TFWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWXZ[JZDUUN3ME2wMlA5Pzl|IN88US=>NYjXVVlnW0GQR1XS
A431MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnnWTWM2OD1yLkC4PFAyKM7:TR?=M1;BPXNCVkeHUh?=
HCT-116MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlroTWM2OD1yLkC4PFAzKM7:TR?=M3HKbnNCVkeHUh?=
A4-FukMYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{LQeGlEPTB;MD6wPFk1PyEQvF2=Ml7JV2FPT0WU
RPMI-6666NWG2W4o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3vvV2lEPTB;MD6wPFk3PyEQvF2=Mn\hV2FPT0WU
Calu-6MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4rMeWlEPTB;MD6wPVAzQSEQvF2=NXTHd4pSW0GQR1XS
KMOE-2M4S3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MkLsTWM2OD1yLkC5NFM6KM7:TR?=M2q3XHNCVkeHUh?=
A704MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTBwMEmxOUDPxE1?NXHwPVNSW0GQR1XS
HO-1-N-1MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUTNd41VUUN3ME2wMlA6OjR7IN88US=>NGHxc3hUSU6JRWK=
NCI-H2122MmqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NELGVopKSzVyPUCuNFk{PzhizszNMnHpV2FPT0WU
U-698-MNXy3T|R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MV3JR|UxRTBwMEm0NFkh|ryPMXnTRW5ITVJ?
IST-SL2NHXZNXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEThSopKSzVyPUCuNFk1PjhizszNMVHTRW5ITVJ?
TE-10M3:3XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MoXVTWM2OD1yLkC5OVg1KM7:TR?=MXfTRW5ITVJ?
PANC-03-27MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnX2TWM2OD1yLkC5OlcyKM7:TR?=MX;TRW5ITVJ?
KYSE-410MmL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2TkVWlEPTB;MD6wPVc6PyEQvF2=NGr1NFJUSU6JRWK=
TE-8MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEfQOYFKSzVyPUCuNFk5QDVizszNNXXLTZhvW0GQR1XS
MN-60M4H3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEnEdFdKSzVyPUCuNFk5QTdizszNMXjTRW5ITVJ?
NCI-H460M3jTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYDEVHFrUUN3ME2wMlExODlizszNM2fROHNCVkeHUh?=
LB771-HNCNV;LPVhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGHKV4xKSzVyPUCuNVAzPTVizszNMoW3V2FPT0WU
ES4MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFXQNINKSzVyPUCuNVAzPjRizszNMVrTRW5ITVJ?
HUTU-80NGDKcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NULYb3JkUUN3ME2wMlExOzZ3IN88US=>NHyy[W9USU6JRWK=
647-VM3PXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{S3OWlEPTB;MD6xNFQxQCEQvF2=M{jnWHNCVkeHUh?=
HTC-C3MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWHJR|UxRTBwMUC0N|Ih|ryPNFXxNFFUSU6JRWK=
NTERA-S-cl-D1MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVjXTYk{UUN3ME2wMlExPDR6IN88US=>NHWzZlJUSU6JRWK=
A2058NFXs[JhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXjJR|UxRTBwMUC2OVUh|ryPM3HMcnNCVkeHUh?=
MZ1-PCNHfGWmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXnJR|UxRTBwMUC4N{DPxE1?M4DPPHNCVkeHUh?=
J82MmjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTBwMUC4PFQh|ryPNUfuNGxTW0GQR1XS
ARH-77MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2nsbmlEPTB;MD6xNUDPxE1?NIfTbpNUSU6JRWK=
Ca9-22NIjKNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkPSTWM2OD1yLkGxNVI5KM7:TR?=MX\TRW5ITVJ?
NCI-H1648NWCwbmR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYLM[nA2UUN3ME2wMlEyOjh4IN88US=>MoXYV2FPT0WU
MC116NHzmbYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXPmSZA1UUN3ME2wMlEyOzN5IN88US=>MkPwV2FPT0WU
EoL-1-cellM4nwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWe4bpQ5UUN3ME2wMlEyPDZ5IN88US=>Mn\GV2FPT0WU
PANC-10-05MorZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NU[w[IZwUUN3ME2wMlEyPDlzIN88US=>NUXSSY5WW0GQR1XS
SF539MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWPHNW8xUUN3ME2wMlEyPjF4IN88US=>NWnvVHkzW0GQR1XS
ES8MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHPTeYNKSzVyPUCuNVE3OzNizszNNF:weGtUSU6JRWK=
NCI-H810M{S2S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mlr2TWM2OD1yLkGxOlY1KM7:TR?=MVLTRW5ITVJ?
J-RT3-T3-5NXPPUopqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXHJR|UxRTBwMUG3OUDPxE1?MY\TRW5ITVJ?
NYMn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoHETWM2OD1yLkGxPFE4KM7:TR?=NHXQNXpUSU6JRWK=
NCI-SNU-1NETOdY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NYW3eG9RUUN3ME2wMlEzOTR6IN88US=>NY\TboZVW0GQR1XS
EFM-19MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGm4T2lKSzVyPUCuNVI{PzRizszNM3HkNXNCVkeHUh?=
HCC1806NEjvWVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MlTWTWM2OD1yLkGyN|g{KM7:TR?=NFPLXJFUSU6JRWK=
HCE-TM1H2OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1LybmlEPTB;MD6xNlU{OSEQvF2=MWrTRW5ITVJ?
HT-1376NGXTSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVHJR|UxRTBwMUK2Olgh|ryPNYPJcFZoW0GQR1XS
BE-13MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MX;JR|UxRTBwMUK4OlYh|ryPMn\LV2FPT0WU
NCI-H520NYDkT3JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlLZTWM2OD1yLkGyPFY4KM7:TR?=M3PLbnNCVkeHUh?=
SK-MES-1NE[0XG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH;WSoRKSzVyPUCuNVI6OTNizszNM{jSZXNCVkeHUh?=
SNU-423MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWrBd3VXUUN3ME2wMlEzQTF2IN88US=>NVXTN|BkW0GQR1XS
Ramos-2G6-4C10MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NY\SWoZ5UUN3ME2wMlEzQTF4IN88US=>NV3pcIMzW0GQR1XS
EW-18NVLiXJh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUfJR|UxRTBwMUOwNlYh|ryPNVfYXG9CW0GQR1XS
NCI-H2087M33Qb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NG\PNodKSzVyPUCuNVMxOjdizszNNGDIXG9USU6JRWK=
COLO-792M1fUPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NGTVRm1KSzVyPUCuNVMyPjVizszNMlvMV2FPT0WU
QIMR-WILMWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEnkNGRKSzVyPUCuNVMzOjNizszNNUDBbHRoW0GQR1XS
ACHNMWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NH\n[|BKSzVyPUCuNVMzPDdizszNNXf2SoF[W0GQR1XS
RPMI-8866M3f5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV7JR|UxRTBwMUOyOlEh|ryPNXL0N2xXW0GQR1XS
SK-LU-1MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGezeI9KSzVyPUCuNVM1PDlizszNMlu5V2FPT0WU
SK-UT-1NYjLZYR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4O1VWlEPTB;MD6xN|YzQCEQvF2=NFqyTXpUSU6JRWK=
MFE-296MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVL1e45mUUN3ME2wMlE{QDZ2IN88US=>MVLTRW5ITVJ?
RDMYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVLJR|UxRTBwMUO5PVch|ryPMny1V2FPT0WU
LS-411NM4rUTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVHJR|UxRTBwMUSyPVUh|ryPMn:4V2FPT0WU
NCI-H747Mn\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTBwMUSzJO69VQ>?NVHwfVh7W0GQR1XS
ES6Mo\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHfadJlKSzVyPUCuNVQ{PiEQvF2=NXXSZ|dEW0GQR1XS
TE-1MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWXJR|UxRTBwMUS0NFch|ryPMmf0V2FPT0WU
SJSA-1NUXibFFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2\SWWlEPTB;MD6xOFcxPyEQvF2=NYH3e294W0GQR1XS
NCI-H1355NX7vR3F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWnJR|UxRTBwMUWyPVMh|ryPMk\5V2FPT0WU
HELMojFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4K3d2lEPTB;MD6xOVQ1PyEQvF2=MXrTRW5ITVJ?
639-VMVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVLJR|UxRTBwMUW1PVYh|ryPM4rKd3NCVkeHUh?=
AN3-CANGjuXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVfJR|UxRTBwMUW2N|kh|ryPNGXjZ2hUSU6JRWK=
SK-MEL-2MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M376PWlEPTB;MD6xOVY3QCEQvF2=MWDTRW5ITVJ?
SW872MmWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXPX[oNGUUN3ME2wMlE3ODR{IN88US=>M{nJdHNCVkeHUh?=
DU-4475M4K2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVPZdFd6UUN3ME2wMlE3OTZ{IN88US=>NWLIeG5mW0GQR1XS
YKG-1NWLJTlcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYDJR|UxRTBwMU[yO|Mh|ryPNHX0VIRUSU6JRWK=
GT3TKBNYXMeGwzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFfCOJNKSzVyPUCuNVYzQDNizszNMXHTRW5ITVJ?
GB-1NI\tXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWDFRpZwUUN3ME2wMlE3PDJ2IN88US=>MnPsV2FPT0WU
KARPAS-422NIfBc3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkTFTWM2OD1yLkG2OVc1KM7:TR?=NUH2UHlKW0GQR1XS
ATN-1NUTnNXdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYTJR|UxRTBwMU[2OVYh|ryPNVnWTIF6W0GQR1XS
HLEM{LFT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnHxTWM2OD1yLkG2PFc4KM7:TR?=M4nDTnNCVkeHUh?=
D-542MGNYnrPGJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1jJNWlEPTB;MD6xOlk5PiEQvF2=M1fxc3NCVkeHUh?=
EB-3MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M2e5Z2lEPTB;MD6xO|MyKM7:TR?=NHnK[GdUSU6JRWK=
HCC1143NWHaclJnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn;vTWM2OD1yLkG3N|k3KM7:TR?=M160RXNCVkeHUh?=
DJM-1NHvEOnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1HjbWlEPTB;MD6xO|Q2OSEQvF2=M1m5O3NCVkeHUh?=
BT-474NGH5WXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MkTuTWM2OD1yLkG3OFg6KM7:TR?=MmL4V2FPT0WU
BB65-RCCM4\HNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUDJR|UxRTBwMUe1OFUh|ryPMn\JV2FPT0WU
NCI-H292NWm0Ump6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYXJR|UxRTBwMUe2NFEh|ryPM1XxbXNCVkeHUh?=
MKN28NX\VSm17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGrEW49KSzVyPUCuNVc3PTNizszNNFjVVlBUSU6JRWK=
TK10MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnXCTWM2OD1yLkG3O|AzKM7:TR?=NXTZZmdbW0GQR1XS
TYK-nuMXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NV3zeVV3UUN3ME2wMlE4QTR7IN88US=>MYrTRW5ITVJ?
8305CM4LTUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWrJR|UxRTBwMUe5O|Eh|ryPNYjidXRIW0GQR1XS
MV-4-11MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn7XTWM2OD1yLkG3PVc4KM7:TR?=MlLCV2FPT0WU
NCI-H522NVjCbYVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHf0[FVKSzVyPUCuNVgxQTRizszNMWnTRW5ITVJ?
Hs-578-TM4rwc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUf4bVdGUUN3ME2wMlE5Ojl{IN88US=>NWjqNnkxW0GQR1XS
LCLC-103HMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIHvWlFKSzVyPUCuNVg2OjdizszNMVrTRW5ITVJ?
MHH-ES-1M3PtU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIXZ[FlKSzVyPUCuNVg3OjlizszNMVvTRW5ITVJ?
NCI-H441MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIHEdHBKSzVyPUCuNVkyPDhizszNMWnTRW5ITVJ?
AM-38NXqySHFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXjJR|UxRTBwMUmyNlUh|ryPMUnTRW5ITVJ?
SW1783NHLIOWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml3FTWM2OD1yLkG5N|A2KM7:TR?=M{jPZnNCVkeHUh?=
SK-HEP-1NGjBZWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17SV2lEPTB;MD6xPVY{PyEQvF2=NV75RYxOW0GQR1XS
OAW-28MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRTBwMkCxO|gh|ryPNIm1WWRUSU6JRWK=
TE-15NEOxR3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXi4VGhbUUN3ME2wMlIxOjV{IN88US=>MnLmV2FPT0WU
HCE-4NF\sOodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4fycmlEPTB;MD6yNFI5PCEQvF2=M3iyTXNCVkeHUh?=
JiyoyeP-2003M1;XRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEXWW2lKSzVyPUCuNlA{OzZizszNNWn1VpZFW0GQR1XS
OVCAR-4Mnu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NW\pcXo6UUN3ME2wMlIxPjJ6IN88US=>MmDSV2FPT0WU
SNU-449M{T0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mnq5TWM2OD1yLkKwO|k4KM7:TR?=MUjTRW5ITVJ?
SBC-5NXfTZlBUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlvZTWM2OD1yLkKxNlE2KM7:TR?=MYnTRW5ITVJ?
T84M4D2W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVLJR|UxRTBwMkGyOFgh|ryPMl;rV2FPT0WU
LP-1NFS3SHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH7tV|FKSzVyPUCuNlE{ODJizszNM3XMUHNCVkeHUh?=
MG-63MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFTwO2NKSzVyPUCuNlE{QDJizszNMoTIV2FPT0WU
OAW-42M3nU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVnJR|UxRTBwMkG0O|gh|ryPM4nPU3NCVkeHUh?=
L-540NXvnOJZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;GTWM2OD1yLkKxOVk5KM7:TR?=NV3oTlBLW0GQR1XS
RH-1NUPyT|N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmXkTWM2OD1yLkKyNlQzKM7:TR?=M4jiOnNCVkeHUh?=
HCT-15NIXq[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGKwe|RKSzVyPUCuNlI1QDRizszNNGW5ZoVUSU6JRWK=
OCUB-MMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnLTTWM2OD1yLkKyOFg5KM7:TR?=NXu0dnp1W0GQR1XS
GP5dM2XnTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVjJR|UxRTBwMkK1Nlgh|ryPMUfTRW5ITVJ?
NCI-H2030NUT3NnJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M4mwe2lEPTB;MD6yNlc{PCEQvF2=NEnZbnVUSU6JRWK=
ML-2NELyXpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYfJR|UxRTBwMkK4PFkh|ryPNIr6OnhUSU6JRWK=
CAL-39NV3ubnpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXLJR|UxRTBwMkK5N|Yh|ryPMYDTRW5ITVJ?
MIA-PaCa-2M{fhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnyyTWM2OD1yLkKzNlg4KM7:TR?=NWjhZWFGW0GQR1XS
TE-9Mo\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkTwTWM2OD1yLkKzN|Ih|ryPNFfjPGlUSU6JRWK=
LB2518-MELMoXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3;XTmlEPTB;MD6yN|M4OiEQvF2=MUXTRW5ITVJ?
DBMl;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MWLJR|UxRTBwMkO0N|gh|ryPMmTKV2FPT0WU
NCI-H596M{Lp[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFmyO25KSzVyPUCuNlM2PzFizszNM1q4OnNCVkeHUh?=
SW1990MnTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWPiOHQ1UUN3ME2wMlI{QTR4IN88US=>MWHTRW5ITVJ?
P30-OHKNH71RVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2TDbmlEPTB;MD6yOFA2KM7:TR?=NIPZeG5USU6JRWK=
ALL-PONXjsdYw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mme3TWM2OD1yLkK0NVY6KM7:TR?=NXrvbYNuW0GQR1XS
Saos-2MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MVfJR|UxRTBwMkS1O|Eh|ryPNXPvNlNIW0GQR1XS
MFH-inoM{WxTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUPzWnM5UUN3ME2wMlI1Pjl{IN88US=>MXPTRW5ITVJ?
OE33NEPITpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHzlZ2xKSzVyPUCuNlUyOSEQvF2=NYjofWxGW0GQR1XS
Calu-3NX3iSZFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXjJR|UxRTBwMkWyPVch|ryPM3\DTnNCVkeHUh?=
HTNVrVUIJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVPqS|E6UUN3ME2wMlI2PjJzIN88US=>MnvXV2FPT0WU
LXF-289M3\nUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVnrdm1bUUN3ME2wMlI2QTh2IN88US=>NHvXXmRUSU6JRWK=
KGNM3TNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MYnJR|UxRTBwMk[wPFkh|ryPNF3wUmZUSU6JRWK=
NCI-H1417MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M33nPGlEPTB;MD6yOlUzPCEQvF2=NVvafYFIW0GQR1XS
SF126NEXVT2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFrhW|dKSzVyPUCuNlc{ODJizszNNIXm[FBUSU6JRWK=
SASNFO3eo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M13x[GlEPTB;MD6yO|MxQCEQvF2=NXzsTJVSW0GQR1XS
22RV1M2XqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWTJR|UxRTBwMkezO|gh|ryPMVTTRW5ITVJ?
GI-1Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NInNfZVKSzVyPUCuNlc1QDdizszNMofkV2FPT0WU
ES3NYTUe2JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mk\JTWM2OD1yLkK3O|Y{KM7:TR?=M1rsN3NCVkeHUh?=
NB1NHvIdHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1PwfGlEPTB;MD6yO|g4PiEQvF2=NVL4OHMxW0GQR1XS
NCI-H650MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnjQTWM2OD1yLkK4N|AzKM7:TR?=NVjaVI5OW0GQR1XS
IST-MES1MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUTZbVhJUUN3ME2wMlI5PTV2IN88US=>NYm3N3Q4W0GQR1XS
UM-UC-3NFzDWG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MV3JR|UxRTBwMkmxOEDPxE1?MU\TRW5ITVJ?
CAL-120NVv3VoRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{XUWWlEPTB;MD6yPVY{OSEQvF2=M2nVb3NCVkeHUh?=
UACC-62MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1j5SmlEPTB;MD6zNFI1OSEQvF2=M3v2[HNCVkeHUh?=
TE-11MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MmO3TWM2OD1yLkOwNlQ6KM7:TR?=NFGxRYNUSU6JRWK=
MKN1MlTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGnJXFZKSzVyPUCuN|A{PiEQvF2=NHftSndUSU6JRWK=
KS-1MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1H1NmlEPTB;MD6zNFUzPiEQvF2=M3\mZXNCVkeHUh?=
GCIYNUezd4pIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3jmNmlEPTB;MD6zNVAxOiEQvF2=M13BfnNCVkeHUh?=
OVCAR-5NHzyd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnLqTWM2OD1yLkOxNVA3KM7:TR?=MVHTRW5ITVJ?
U-266NX73Z2lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3Hu[mlEPTB;MD6zNVE1PyEQvF2=MnzZV2FPT0WU
Calu-1NFK0c29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGO4W|FKSzVyPUCuN|EzQDlizszNM{m1[3NCVkeHUh?=
SK-LMS-1Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmLBTWM2OD1yLkOxOFI6KM7:TR?=M1yzV3NCVkeHUh?=
COLO-741M1PVUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4m2bGlEPTB;MD6zNVYyPCEQvF2=NHv3SWhUSU6JRWK=
RPMI-8226M4DCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXTJR|UxRTBwM{G2OFEh|ryPNX23Xox[W0GQR1XS
KM12NF;yc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NV\0XHlIUUN3ME2wMlMyQDNizszNNYjEcoh4W0GQR1XS
NMC-G1NEnwfG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWnXblU2UUN3ME2wMlMyQDZizszNM2rLZ3NCVkeHUh?=
SJRH30MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3\hcmlEPTB;MD6zNlA2OiEQvF2=NFnCUoNUSU6JRWK=
COR-L105NVfYXYd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmP3TWM2OD1yLkOyNlE5KM7:TR?=MnG3V2FPT0WU
IM-9NE\CWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1jSSmlEPTB;MD6zN|AzOSEQvF2=MV;TRW5ITVJ?
TE-12MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFXKW2dKSzVyPUCuN|M{OTdizszNNH3SfJJUSU6JRWK=
KG-1NYHkRXVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXnpd2JnUUN3ME2wMlM{PDN{IN88US=>M{\0S3NCVkeHUh?=
U251NXHX[5R{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW[xcXpuUUN3ME2wMlM{PDV4IN88US=>MYnTRW5ITVJ?
EFO-27NULne3YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MoXZTWM2OD1yLkOzPVUyKM7:TR?=MYXTRW5ITVJ?
EW-24Ml;mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmHiTWM2OD1yLkOzPVg1KM7:TR?=NFf4T3pUSU6JRWK=
SF295NVHDfZdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYfXXnZwUUN3ME2wMlM{QTl7IN88US=>M3fJNHNCVkeHUh?=
MC-IXCMnvYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MorRTWM2OD1yLkO0OUDPxE1?NHX4O4lUSU6JRWK=
NCI-H2405MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnPzTWM2OD1yLkO0O|MzKM7:TR?=NEj4N5pUSU6JRWK=
NCI-H2009NHvFPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXLNVFRvUUN3ME2wMlM1PzN7IN88US=>M3XGTXNCVkeHUh?=
LB1047-RCCNE\CT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NF\aN2xKSzVyPUCuN|U5OTVizszNNVvGPJh[W0GQR1XS
KNS-81-FDM1q3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mkm1TWM2OD1yLkO2OlY4KM7:TR?=M13MXXNCVkeHUh?=
HOP-92MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVrKZXFlUUN3ME2wMlM3QDNizszNMlTBV2FPT0WU
L-428NIXRbYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXLpdZZwUUN3ME2wMlM4ODF4IN88US=>MnLuV2FPT0WU
C3ANXrVd|BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2HPT2lEPTB;MD6zO|M4QSEQvF2=NInuWHZUSU6JRWK=
NCI-H1792MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlH1TWM2OD1yLkO3OlU2KM7:TR?=MnTUV2FPT0WU
HuH-7NWTXOGFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYTJR|UxRTBwM{e5NUDPxE1?MVPTRW5ITVJ?
AGSNW\sc4M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIHCXG5KSzVyPUCuN|g3OzhizszNNIe4R4VUSU6JRWK=
HT-1197MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEPUUlJKSzVyPUCuN|k1PiEQvF2=MUXTRW5ITVJ?
CGTH-W-1MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFryXGlKSzVyPUCuN|k6OTNizszNNYnJ[lBzW0GQR1XS
KNS-42M{LTOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NYDnOJpJUUN3ME2wMlQxODR3IN88US=>NUjTXW9xW0GQR1XS
HuO-3N1NFLwcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M4rSfGlEPTB;MD60NFA2PSEQvF2=MlrzV2FPT0WU
VMRC-RCZMV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NVPM[oxOUUN3ME2wMlQxOzB|IN88US=>NVrVeGdmW0GQR1XS
SW954MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{HSTmlEPTB;MD60NFM{PSEQvF2=Mn7zV2FPT0WU
MES-SAMl3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYHteoRRUUN3ME2wMlQxPTB3IN88US=>NX6xTIt1W0GQR1XS
Ca-SkiM2HuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3LDXmlEPTB;MD60NFUzPCEQvF2=NY\nfWNwW0GQR1XS
SW13NEm5ZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVTJR|UxRTBwNEC2NlYh|ryPNEHsNG9USU6JRWK=
NCI-H1437M2PqTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NULjenNuUUN3ME2wMlQxQDB3IN88US=>NX7teXBnW0GQR1XS
U-118-MGMYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYPEZ4ZNUUN3ME2wMlQxQTB2IN88US=>MmfxV2FPT0WU
NCI-H1734M2rwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF3CN3FKSzVyPUCuOFIxOTNizszNMl7IV2FPT0WU
HDLM-2NH7mdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NG\jWHJKSzVyPUCuOFIxOzNizszNM1TOZnNCVkeHUh?=
AU565M3\rW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWDJR|UxRTBwNEK0Olgh|ryPMkGyV2FPT0WU
FADUMUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIKy[2xKSzVyPUCuOFI3PDlizszNM{fmU3NCVkeHUh?=
OS-RC-2NGDPWpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGHvemlKSzVyPUCuOFMxQDNizszNMXfTRW5ITVJ?
CAMA-1NVr6elR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn3XTWM2OD1yLkSzOlI3KM7:TR?=M2nPTHNCVkeHUh?=
MONO-MAC-6NUj6TGdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MYHJR|UxRTBwNEO4OFkh|ryPMmriV2FPT0WU
LB831-BLCMlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MnTZTWM2OD1yLkS0N|cyKM7:TR?=NH22eopUSU6JRWK=
SW982M2DCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHi4NoRKSzVyPUCuOFQ2OjhizszNM2r6dnNCVkeHUh?=
SCC-3NYX6ZVRrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVHJR|UxRTBwNES1O|kh|ryPNFvGSpBUSU6JRWK=
C32MnTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVXvUGxKUUN3ME2wMlQ2OjJ7IN88US=>M3nCR3NCVkeHUh?=
BFTC-909MlHWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkfxTWM2OD1yLkS1Nlk6KM7:TR?=MmTYV2FPT0WU
MEG-01MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlnHTWM2OD1yLkS1N|c{KM7:TR?=NVnZZYdiW0GQR1XS
M14NETr[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mn\DTWM2OD1yLkS1PVc6KM7:TR?=NFHOUGxUSU6JRWK=
MPP-89NIDkV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmrPTWM2OD1yLkS2NlU3KM7:TR?=NXK2XnByW0GQR1XS
HCC1937MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYnJR|UxRTBwNE[zPFQh|ryPMYrTRW5ITVJ?
SW837M1TR[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NV:2VpMxUUN3ME2wMlQ3PzJ{IN88US=>NUnuOYR5W0GQR1XS
DU-145NVjLN29VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUjJR|UxRTBwNE[3Nlkh|ryPMn;6V2FPT0WU
LB996-RCCMorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFjXfmlKSzVyPUCuOFcxPTRizszNNVHwXolyW0GQR1XS
C8166Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHfFb|VKSzVyPUCuOFc1KM7:TR?=NInyVYpUSU6JRWK=
MOLT-4M3HPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NVrnNVFTUUN3ME2wMlQ4PzN2IN88US=>NWnKRpVVW0GQR1XS
DMS-53MofMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M13yVmlEPTB;MD60O|gxQSEQvF2=M1\5eHNCVkeHUh?=
TE-5M2qzR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIfpRlFKSzVyPUCuOFg{ODVizszNNIn3eG5USU6JRWK=
KYSE-520M37oZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3[3XmlEPTB;MD60PFM1OyEQvF2=M{XhdXNCVkeHUh?=
Detroit562MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLuVVNKSzVyPUCuOFg5PiEQvF2=MmHaV2FPT0WU
SIMAMoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn32TWM2OD1yLkS5OFE4KM7:TR?=NUfhb5BEW0GQR1XS
NCI-H1651MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWTYU28zUUN3ME2wMlQ6PjdizszNNHPnPWVUSU6JRWK=
HCC1599NYLHOnNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGTlW21KSzVyPUCuOFk6PTVizszNMorMV2FPT0WU
ABC-1NWnpW2tGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkjFTWM2OD1yLkWwOFk3KM7:TR?=Mnn5V2FPT0WU
CAL-33MkTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn34TWM2OD1yLkWwPFQ1KM7:TR?=M2W0VHNCVkeHUh?=
OPM-2Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXfJR|UxRTBwNUC5N|ch|ryPNVjZOJdSW0GQR1XS
RPMI-7951M2X2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MX3JR|UxRTBwNUC5OVch|ryPMV\TRW5ITVJ?
HT-1080MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MljvTWM2OD1yLkWxNVE6KM7:TR?=M1WyOXNCVkeHUh?=
LC4-1NXXuW2dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MW\JR|UxRTBwNUG0NFMh|ryPMYHTRW5ITVJ?
OVCAR-3MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUj4fHE4UUN3ME2wMlUyPTdizszNMkOxV2FPT0WU
CAPAN-1M12yOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4DPNmlEPTB;MD61NlI5QCEQvF2=NWC5c5RkW0GQR1XS
SK-OV-3M{ezbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MljKTWM2OD1yLkWyOFM1KM7:TR?=NH7WSY1USU6JRWK=
HuP-T3MnvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUPFRol4UUN3ME2wMlUzQDJ5IN88US=>MYDTRW5ITVJ?
NCI-H838M1nqfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUfJR|UxRTBwNUK4OFkh|ryPMWHTRW5ITVJ?
K5MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUC1[2FzUUN3ME2wMlU{OjBzIN88US=>Mn7rV2FPT0WU
CAL-72M2HDcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1nuWWlEPTB;MD61N|M5PyEQvF2=NVjlRXNtW0GQR1XS
NH-12M3jhVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWC5doFsUUN3ME2wMlU{QTV7IN88US=>M1\6bnNCVkeHUh?=
SNB75NWT1[IpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHnoPVJKSzVyPUCuOVU4OyEQvF2=M3jROHNCVkeHUh?=
BPH-1MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIfUWohKSzVyPUCuOVY{PDRizszNMnPDV2FPT0WU
NOMO-1NVu1SJl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3Xib2lEPTB;MD61OlM4OiEQvF2=NELC[GlUSU6JRWK=
G-402MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NW\xO4pNUUN3ME2wMlU3PDl7IN88US=>NFrqTmxUSU6JRWK=
NCI-H2052MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NV3NcZdDUUN3ME2wMlU3PzRzIN88US=>M4X2b3NCVkeHUh?=
RCM-1NYrFRVR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIHufFRKSzVyPUCuOVcyPjZizszNNIfQUXdUSU6JRWK=
COR-L279M4[2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUHJR|UxRTBwNUexPFUh|ryPNEO2Z2FUSU6JRWK=
A253NVrpdJlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXzuXJVQUUN3ME2wMlU4PTJ3IN88US=>MknXV2FPT0WU
SK-MM-2NIn5NmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFXI[pFKSzVyPUCuOVc3PzlizszNMWPTRW5ITVJ?
NCI-H1703NIr1[XlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVvJR|UxRTBwNUm0Nlch|ryPMYPTRW5ITVJ?
UACC-257NFfSPVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFG5To1KSzVyPUCuOVk1QDdizszNMXzTRW5ITVJ?
KALS-1NYez[mJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Mn3JTWM2OD1yLk[wNFEyKM7:TR?=M3Pv[3NCVkeHUh?=
ES5MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1LuWWlEPTB;MD62NFQ5KM7:TR?=MWTTRW5ITVJ?
MHH-CALL-2M2fNXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{PXeWlEPTB;MD62NFg5QCEQvF2=MWrTRW5ITVJ?
ChaGo-K-1NEfoWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MULJR|UxRTBwNkGyNlkh|ryPNH7xc5dUSU6JRWK=
TGBC1TKBNVO2VFlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkfBTWM2OD1yLk[xPVgh|ryPMVvTRW5ITVJ?
KU-19-19NF3I[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmiyTWM2OD1yLk[0OVg3KM7:TR?=MYrTRW5ITVJ?
COLO-684MlnQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUTmOldIUUN3ME2wMlY2PjFzIN88US=>M1fLPHNCVkeHUh?=
LS-1034NWHpNVFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\OOHp2UUN3ME2wMlY2QDF7IN88US=>NViyN|NxW0GQR1XS
RT-112M1PvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV;JR|UxRTBwNk[1PFch|ryPMV3TRW5ITVJ?
Capan-2NYTET|dkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NWDJVXBIUUN3ME2wMlY3PjJ{IN88US=>M3TGe3NCVkeHUh?=
HSC-4NInPb2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEPZ[IhKSzVyPUCuOlY3QThizszNM3HtXXNCVkeHUh?=
COLO-824NX[wWHVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmTETWM2OD1yLk[3PFI{KM7:TR?=M3WzTHNCVkeHUh?=
NCI-H2170MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHvLV|JKSzVyPUCuOlgzPThizszNNF;obIZUSU6JRWK=
GDM-1MmD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUXjUmtmUUN3ME2wMlY5PDl2IN88US=>M1jWXXNCVkeHUh?=
KP-4M2rGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4H1SGlEPTB;MD62PVU4OyEQvF2=MVXTRW5ITVJ?
VA-ES-BJNIrRS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnvETWM2OD1yLk[5PVg3KM7:TR?=NI\VfFhUSU6JRWK=
KM-H2M{LyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnXWTWM2OD1yLkewNFkyKM7:TR?=NYHxcHp3W0GQR1XS
HHNIHTXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXuwOYtwUUN3ME2wMlcxPjZ{IN88US=>NGrwcW9USU6JRWK=
DK-MGMnTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MX7JR|UxRTBwN{GwNVYh|ryPM1uyRnNCVkeHUh?=
VM-CUB-1NEDpT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX32XJE2UUN3ME2wMlcyOjV7IN88US=>Ml3OV2FPT0WU
COLO-829M{i2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MmHJTWM2OD1yLkexPVg2KM7:TR?=NWnkUGg6W0GQR1XS
OMC-1NUDpeWJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M{LZfmlEPTB;MD63NlExPCEQvF2=MWHTRW5ITVJ?
NB12M3HPOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MVTJR|UxRTBwN{K1NFQh|ryPMmH3V2FPT0WU
NCI-H28NGnZN|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEnscmlKSzVyPUCuO|QxQDNizszNM{XJSHNCVkeHUh?=
A673M1P5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWTTT|BHUUN3ME2wMlc2OTd5IN88US=>NWG0[FBlW0GQR1XS
LB2241-RCCNW\SemxKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NW\HWlU1UUN3ME2wMlc3ODh5IN88US=>NEnwdIpUSU6JRWK=
CCRF-CEMMmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmHlTWM2OD1yLke3NFUzKM7:TR?=MUDTRW5ITVJ?
NCI-H510AM2LKfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NULGdIxsUUN3ME2wMlc4OTh4IN88US=>MUfTRW5ITVJ?
SW48MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYDObIp[UUN3ME2wMlc4OzN|IN88US=>MXnTRW5ITVJ?
NCI-H2081MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MUPJR|UxRTBwN{ixOFch|ryPNULhW4RDW0GQR1XS
RMG-INVjSfXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M17rOGlEPTB;MD63PFIyOiEQvF2=NH\NUWFUSU6JRWK=
LU-99ANHHrWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYnJR|UxRTBwN{i0NVMh|ryPM{C0bnNCVkeHUh?=
KP-N-YSNIO3NHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NH;PWodKSzVyPUCuO|g6OjFizszNNXqwPFNxW0GQR1XS
MDA-MB-231M{\XZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF71fpVKSzVyPUCuPFAyOzFizszNMlzvV2FPT0WU
U031Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mn:0TWM2OD1yLkixOFI{KM7:TR?=NYf1bGoyW0GQR1XS
EVSA-TM4jjWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NELQV|ZKSzVyPUCuPFE3PzJizszNM2e5NHNCVkeHUh?=
MDA-MB-157MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M2W1XGlEPTB;MD64NlI4OSEQvF2=NE[1VmdUSU6JRWK=
EHEBMWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NWDBPYUzUUN3ME2wMlgzOjd4IN88US=>M3r5N3NCVkeHUh?=
KINGS-1MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXLHPYx2UUN3ME2wMlgzPTV3IN88US=>MXHTRW5ITVJ?
23132-87Ml7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Ml3ITWM2OD1yLkiyPFQ{KM7:TR?=MVTTRW5ITVJ?
EFO-21MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkPrTWM2OD1yLki0NFg6KM7:TR?=MlLZV2FPT0WU
DOKNFPQTlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXPJR|UxRTBwOES4JO69VQ>?MYDTRW5ITVJ?
NCI-H2171MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn;tTWM2OD1yLki0PVYh|ryPMo[wV2FPT0WU
NCI-SNU-5M4fCR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnnZTWM2OD1yLki1OVch|ryPNULTOIZwW0GQR1XS
SK-N-DZMoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlHTTWM2OD1yLki1PVQ{KM7:TR?=NGLp[VdUSU6JRWK=
SNU-C2BMnnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?Mnu3TWM2OD1yLki2PFAyKM7:TR?=MlS1V2FPT0WU
CP66-MELNHvDPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NX7MWWNQUUN3ME2wMlg4OTFizszNNFzBZ3VUSU6JRWK=
SN12CNH;2WXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mlq5TWM2OD1yLki4OlM4KM7:TR?=NF;6dINUSU6JRWK=
A172MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkLMTWM2OD1yLki4Olk5KM7:TR?=NGnsNllUSU6JRWK=
NCI-H2347Ml3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVzJR|UxRTBwOEi3OVMh|ryPNHXYTZJUSU6JRWK=
NCI-H2228MkHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXvJR|UxRTBwOEmzN|kh|ryPNHvyeXZUSU6JRWK=
SNU-387NH7CVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NEHmSIZKSzVyPUCuPVAzPjRizszNNFXGeIRUSU6JRWK=
SK-MEL-24Mn;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MkO1TWM2OD1yLkmxN|Q1KM7:TR?=NYnm[HRQW0GQR1XS
MDA-MB-468MnzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXLJXopHUUN3ME2wMlkyPzNizszNNV\QNZZ6W0GQR1XS
NCI-H1694NFTOWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3jPRWlEPTB;MD65NVg4PiEQvF2=MWLTRW5ITVJ?
CCF-STTG1M4T4d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFOxO|JKSzVyPUCuPVI3OzdizszNNHjtWW1USU6JRWK=
K052MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MYrJR|UxRTBwOUSwOFch|ryPM{D2SXNCVkeHUh?=
NCI-H446MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NEXOdmlKSzVyPUCuPVUxOSEQvF2=NUfH[lVwW0GQR1XS
MFE-280NXO1W5h7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml;1TWM2OD1yLkm2NlkyKM7:TR?=MWrTRW5ITVJ?
KU812MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M3LibmlEPTB;MD65PVM5QSEQvF2=NVzucIRqW0GQR1XS
MDA-MB-361NXjWXGh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MX7JR|UxRTBwOUm3O|ch|ryPNVSz[mZGW0GQR1XS
RajiMmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3fScGlEPTB;MT6wNlI3PyEQvF2=MmTwV2FPT0WU
TE-6MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYPNVG43UUN3ME2xMlA{PTZ4IN88US=>MlfZV2FPT0WU
CAL-148M{j6bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXLJR|UxRTFwMES0OFMh|ryPMnjGV2FPT0WU
NCI-H1963NFzqUFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NHXCb3RKSzVyPUGuNFQ2PTNizszNNITtOohUSU6JRWK=
SK-N-ASNIDmWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmnSTWM2OD1zLkC0Olg2KM7:TR?=MVPTRW5ITVJ?
RERF-LC-MSNWHzWVBYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFWyT4lKSzVyPUGuNFY{PDlizszNNUXjNId7W0GQR1XS
BENMmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{TKUWlEPTB;MT6wO|E{PyEQvF2=MUDTRW5ITVJ?
CAS-1NFXPRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXPJR|UxRTFwMEmxNlMh|ryPMYXTRW5ITVJ?
SW780M4S5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7Mlj1TWM2OD1zLkC5NVgyKM7:TR?=MW\TRW5ITVJ?
LU-65NWfCVHNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NILG[GJKSzVyPUGuNFk1OSEQvF2=NHXJNIRUSU6JRWK=
D-283MEDM3m3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEHJVWJKSzVyPUGuNVIzPzJizszNNYrvTJY4W0GQR1XS
HCC2157NHLUd5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXvJR|UxRTFwMUO2OFIh|ryPNHn6bVFUSU6JRWK=
RCC10RGBNIHWOGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUHvdVQ3UUN3ME2xMlE1ODB4IN88US=>MlnrV2FPT0WU
PLC-PRF-5NYXobWVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NGDr[nJKSzVyPUGuNVUzOjlizszNNITENG1USU6JRWK=
H4M3rsZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUHQT5A4UUN3ME2xMlE2PDN7IN88US=>MXjTRW5ITVJ?
TURMnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M{nlUmlEPTB;MT6xOVc2OiEQvF2=M3TiZnNCVkeHUh?=
NCI-H2141M4DERmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NF7jSY1KSzVyPUGuNVg6PDZizszNNGr3eXlUSU6JRWK=
PFSK-1Ml\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFf6SmpKSzVyPUGuNlA2OzJizszNM1npZXNCVkeHUh?=
SK-MEL-28MnnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHzaW49KSzVyPUGuNlMzOjFizszNNES0WFdUSU6JRWK=
SCC-9NFT6dIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXfCb4lrUUN3ME2xMlI{PjZ3IN88US=>Mlu0V2FPT0WU
T47DNHTZcWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Mnf0TWM2OD1zLkKzOlk3KM7:TR?=NGj5ZlBUSU6JRWK=
TCCSUPMonNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NUf0T4NpUUN3ME2xMlI2ODJ7IN88US=>MULTRW5ITVJ?
SU-DHL-1NUHHV2d5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MlPDTWM2OD1zLkK1NVE5KM7:TR?=NV3rNWpiW0GQR1XS
HL-60NH;5XFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3[xbGlEPTB;MT6yOVU5QCEQvF2=NX;Kfo9DW0GQR1XS
NCI-H1436MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MYDJR|UxRTFwMk[xOFkh|ryPNG\uUndUSU6JRWK=
DMS-114M3TlSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NFH6eHFKSzVyPUGuNlY3OzJizszNMoTBV2FPT0WU
BOKUMoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXjJR|UxRTFwMkiwPVUh|ryPMWDTRW5ITVJ?
MS-1NVPwZ2gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NXLNV49oUUN3ME2xMlI6ODZ7IN88US=>Mn3yV2FPT0WU
NCI-H661M{nKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{jZXWlEPTB;MT6zNFQ4QCEQvF2=MmjUV2FPT0WU
HT-3MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mn\pTWM2OD1zLkOwOVI6KM7:TR?=NWGyOnd2W0GQR1XS
CAL-54NGC5co1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M2DjVWlEPTB;MT6zNFczPSEQvF2=MoP4V2FPT0WU
SW1463NYfrO|JMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWHJR|UxRTFwM{G4O|Ih|ryPNU\pbllyW0GQR1XS
COLO-668NH7rTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWDieWFUUUN3ME2xMlM{ODV4IN88US=>NHf6eVFUSU6JRWK=
PANC-08-13M4LuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnHSTWM2OD1zLkOzPFA{KM7:TR?=M1W2NHNCVkeHUh?=
BB49-HNCMkTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MXzJR|UxRTFwM{SwNUDPxE1?NFXje3ZUSU6JRWK=
M059JMlTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEjycXpKSzVyPUGuN|U5OzJizszNMX\TRW5ITVJ?
NCCITM1jTfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1v5SmlEPTB;MT6zO|k5QCEQvF2=M{PlNHNCVkeHUh?=
LN-405M{P6OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MlPYTWM2OD1zLkO5NlY1KM7:TR?=NHPhZ2NUSU6JRWK=
UMC-11MoDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVvNOZB1UUN3ME2xMlM6QTl4IN88US=>NUK1OXBkW0GQR1XS
NB5M1zae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWi4emMyUUN3ME2xMlQyOjJ5IN88US=>MUnTRW5ITVJ?
TE-441-TMYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIHMSIZKSzVyPUGuOFI5OTdizszNMl[wV2FPT0WU
ME-180M1fzbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWXJR|UxRTFwNESzPVIh|ryPM2HXT3NCVkeHUh?=
HCC70NIT4OI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MX7JR|UxRTFwNE[wPVYh|ryPNYDHRndKW0GQR1XS
no-10M2nle2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MWLJR|UxRTFwNE[xPFEh|ryPM2\L[3NCVkeHUh?=
JEG-3MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4TNN2lEPTB;MT61NFE{OiEQvF2=Ml\qV2FPT0WU
no-11Mof3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MUTJR|UxRTFwNUC4PFIh|ryPMlywV2FPT0WU
CHP-126NGT5PJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnvzTWM2OD1zLkW2OlkyKM7:TR?=NIj0Z4NUSU6JRWK=
EGI-1MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MkjDTWM2OD1zLkW4NFI2KM7:TR?=M1SwN3NCVkeHUh?=
D-392MGMVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXLJR|UxRTFwNUm2N{DPxE1?M2jqR3NCVkeHUh?=
RT4NWfr[IoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NVfqdnB6UUN3ME2xMlU6PjN5IN88US=>MnfVV2FPT0WU
A204MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGCxVW5KSzVyPUGuOVk5ODFizszNNFiwXmlUSU6JRWK=
NCI-H1304NGPJeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFPHSZdKSzVyPUGuOlM2QTFizszNM{LINnNCVkeHUh?=
BeckerNXO2WZc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NIHr[2pKSzVyPUGuOlQzPDFizszNM2PSeHNCVkeHUh?=
OE19M4nodWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M2[0fmlEPTB;MT62OVUyQCEQvF2=MlvvV2FPT0WU
EKVXM1WyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWjvTGxCUUN3ME2xMlY2PjF6IN88US=>M4[zcnNCVkeHUh?=
KLENITBfGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NGn2U3RKSzVyPUGuOlU4OTRizszNNUDMTpQ3W0GQR1XS
K-562NVTwNpAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MWXJR|UxRTFwNkewN|ch|ryPMkjRV2FPT0WU
MDA-MB-175-VIIM4T3NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4D5cGlEPTB;MT62PFk6PyEQvF2=M2LCc3NCVkeHUh?=
NCI-H716NXe1S41iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MXXJR|UxRTFwNkmzNFQh|ryPNEjaSJZUSU6JRWK=
Caov-3MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEC5d4ZKSzVyPUGuOlk1OTNizszNNH\IZphUSU6JRWK=
HCC1187NUXwWGhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFzvTlZKSzVyPUGuO|A2PDVizszNMkPXV2FPT0WU
CAKI-1M3j4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIXvVnBKSzVyPUGuO|IzQTJizszNMo\vV2FPT0WU
MOLT-16MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?Mmf3TWM2OD1zLkezN|A4KM7:TR?=M{DReHNCVkeHUh?=
PC-3Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MlfnTWM2OD1zLke1NFgh|ryPMmr4V2FPT0WU
DV-90NFj1[IZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFy4dopKSzVyPUGuO|U2QDVizszNM4[wOHNCVkeHUh?=
RXF393M2LUNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIL1cWhKSzVyPUGuO|czQTRizszNMlvaV2FPT0WU
SK-NEP-1NVXXfYh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MVzJR|UxRTFwOEKzN|kh|ryPM3TBNXNCVkeHUh?=
HCC1419MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NFnLcJlKSzVyPUGuPFI3QTJizszNMXzTRW5ITVJ?
BV-173NFTFUFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NI\IboJKSzVyPUGuPFI6QTVizszNM2rERnNCVkeHUh?=
MKN7M4j1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M4j6c2lEPTB;MT64PVIzKM7:TR?=M{jQOXNCVkeHUh?=
LAN-6NFrKdYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NWrjOVVDUUN3ME2xMlg6PTV|IN88US=>NHLFfWFUSU6JRWK=
Mo-TMYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHHHNG1KSzVyPUGuPVAxOzlizszNMnnIV2FPT0WU
HCC1395MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NYP0WohlUUN3ME2xMlkzQDZ|IN88US=>NY[zeoZQW0GQR1XS
HC-1MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3XoV2lEPTB;MT65N|Q4KM7:TR?=MmHoV2FPT0WU
HPAF-IINFHXcVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NE[wVo9KSzVyPUGuPVQ1OThizszNNXXmVIFKW0GQR1XS
CPC-NNFqw[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoDMTWM2OD1zLkm4NFAzKM7:TR?=NEjWepdUSU6JRWK=
MKN45M2HWXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NU\Kd|BwUUN3ME2xMlk6OTF7IN88US=>NH;ZbWlUSU6JRWK=
NCI-H1693Mn7SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGewUWxKSzVyPUKuNFA1OzNizszNNHLJToFUSU6JRWK=
SHP-77M1r0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHvQdFFKSzVyPUKuNFA2OzNizszNMVPTRW5ITVJ?
NCI-H1522M{Ty[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTJwMEG3NlQh|ryPMlXIV2FPT0WU
SW1573NEfjbpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=Ml[0TWM2OD1{LkCyNkDPxE1?MXXTRW5ITVJ?
DBTRG-05MGMWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{e3XmlEPTB;Mj6wOlA5PyEQvF2=M1rHPXNCVkeHUh?=
SCC-4NYfMclRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MorhTWM2OD1{LkG0N|Eh|ryPNV\qN5ZKW0GQR1XS
DMS-153NGfrOm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnyxTWM2OD1{LkG2OlY5KM7:TR?=NV7mZ|NxW0GQR1XS
MDA-MB-415MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M1u0NGlEPTB;Mj6xO|UzKM7:TR?=NEj2TWpUSU6JRWK=
NCI-H2126MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEL4bmdKSzVyPUKuNlI5QDhizszNNWj3em1HW0GQR1XS
MDA-MB-453NEDsb2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MoLZTWM2OD1{LkKzN|Ih|ryPM2fMUXNCVkeHUh?=
U-87-MGM1nJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NWXzcoJCUUN3ME2yMlI5PTl{IN88US=>M3;oc3NCVkeHUh?=
LNCaP-Clone-FGCNXrvbJZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MnXoTWM2OD1{LkOwNVAzKM7:TR?=MWXTRW5ITVJ?
NCI-H1581NXTF[Zp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3LNb2lEPTB;Mj6zNlExPSEQvF2=NEf4[WpUSU6JRWK=
BC-3NVHxeIppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2jheGlEPTB;Mj6zOlUxQSEQvF2=NEHJfY1USU6JRWK=
HCC38NFHhSIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MnrlTWM2OD1{LkO4OFQ4KM7:TR?=NXrS[JcyW0GQR1XS
HCC2218MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFLMPYFKSzVyPUKuOFA5ODlizszNMWXTRW5ITVJ?
RO82-W-1MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MXPJR|UxRTJwNEGyOUDPxE1?NIDhcmhUSU6JRWK=
C2BBe1NGH1cmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M17zU2lEPTB;Mj60NVU4QCEQvF2=NHH5bWNUSU6JRWK=
LAMA-84MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoH1TWM2OD1{LkW3N|Y5KM7:TR?=NVPBc2dbW0GQR1XS
GMS-10NEXWeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M1Hy[WlEPTB;Mj61O|YyOSEQvF2=NWXQWZBlW0GQR1XS
GCTM2LTW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7NEGyUlhKSzVyPUKuOVg3QTRizszNM3vTVnNCVkeHUh?=
SK-CO-1MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MnTHTWM2OD1{Lk[xOlYh|ryPNGPV[VhUSU6JRWK=
NCI-H526NGPJeZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUHJR|UxRTJwNkO0OUDPxE1?Mn7XV2FPT0WU
SW1088M3n6PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NX;COYhwUUN3ME2yMlc4QDN7IN88US=>MlLqV2FPT0WU
HT55MkfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1XmdmlEPTB;Mj63PFY6PSEQvF2=M13WbnNCVkeHUh?=
NB10MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYTVUlFKUUN3ME2yMlgyPzR6IN88US=>MX7TRW5ITVJ?
UACC-893MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NHnrfItKSzVyPUKuPFU4PDlizszNM3jlXXNCVkeHUh?=
NCI-H1618NFnpSJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MVjJR|UxRTJwOEixOVMh|ryPM3r3SnNCVkeHUh?=
NCI-H1092NH;3ZndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MUDJR|UxRTNwMEe4NVIh|ryPM1nDZXNCVkeHUh?=
SBC-1M1HvU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MorJTWM2OD1|LkC4OVU{KM7:TR?=M2q4SHNCVkeHUh?=
NCI-H1623Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MmGxTWM2OD1|LkC5N|Qh|ryPMkXVV2FPT0WU
SiHaMX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4DsVGlEPTB;Mz6xNVk4PyEQvF2=MYrTRW5ITVJ?
D-263MGMYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4DCVGlEPTB;Mz6xOFc5QCEQvF2=MVnTRW5ITVJ?
NCI-H1573NYW5fYVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NF\ObGhKSzVyPUOuNVk3PDFizszNM3XuS3NCVkeHUh?=
NCI-H82MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{TjZ2lEPTB;Mz6zOFQ{QSEQvF2=MnvsV2FPT0WU
NCI-H2196NGPP[W1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M3\xfmlEPTB;Mz6zOVAxQCEQvF2=MWjTRW5ITVJ?
MFM-223NI\DfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFPte3pKSzVyPUOuN|c{PTFizszNMoXEV2FPT0WU
COLO-678MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlrOTWM2OD1|LkO4NVg3KM7:TR?=NUPPbYhWW0GQR1XS
EW-3NWKxZmhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M2fGdWlEPTB;Mz60NFk2KM7:TR?=M1vjNHNCVkeHUh?=
MHH-NB-11NXv5[pJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MUHJR|UxRTNwNESwOlkh|ryPMW\TRW5ITVJ?
EM-2MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXn2ZoNLUUN3ME2zMlY{QThizszNNW\xPXVLW0GQR1XS
FTC-133MoH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MV3JR|UxRTNwNkW0OVgh|ryPNInyfIZUSU6JRWK=
NCI-H209NWTySZMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV;sN4xoUUN3ME2zMlY4PjV|IN88US=>Mn76V2FPT0WU
TGBC24TKBMl3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NH\oXVRKSzVyPUOuOlg{PTVizszNNIr0cHpUSU6JRWK=
LC-1FMn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NWLMTG1MUUN3ME2zMlcyPzZ2IN88US=>MWTTRW5ITVJ?
C-4-IINYDRXVhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M13WNmlEPTB;Mz63OVY1OyEQvF2=MoDMV2FPT0WU
NCI-H1650M3f1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NIX5elZKSzVyPUOuO|g1PTVizszNMoX2V2FPT0WU
JVM-2M4LrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NUHJR5hiUUN3ME2zMlk{PjN7IN88US=>M{LrRnNCVkeHUh?=
CaR-1M3HY[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHW4enpKSzVyPUOuPVc3OTdizszNNIGweGxUSU6JRWK=
MDA-MB-134-VIMmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NEPzSJZKSzVyPUSuNFI6PTJizszNMULTRW5ITVJ?
NCI-H719NVjlRVkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NFXBem1KSzVyPUSuNVU{QDhizszNMX3TRW5ITVJ?
GOTOMly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NYruSlgzUUN3ME20MlI6PzB3IN88US=>MkHUV2FPT0WU
NCI-N87NFX1V4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NVXtUnM3UUN3ME20MlM5QDJzIN88US=>NWri[2NSW0GQR1XS
NB6NVPCfWY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MkX2TWM2OD12LkSyOVA6KM7:TR?=NVHFZmx[W0GQR1XS
DSH1Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M1LpZ2lEPTB;ND60O|EyPiEQvF2=NHmzdmJUSU6JRWK=
BT-20MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NGG3dYxKSzVyPUSuOFkxODJizszNNF;2SIxUSU6JRWK=
NCI-H1882NYLSRpBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3rGNWlEPTB;ND61NFU4KM7:TR?=M4nwfHNCVkeHUh?=
WM-115MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NGDpfnRKSzVyPUSuOVA5QDFizszNMUjTRW5ITVJ?
SKG-IIIaMXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXPobIt2UUN3ME20MlY4PzdizszNNYnCbYV{W0GQR1XS
NCI-H69MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NX3ZeXJuUUN3ME20MlcxOjd3IN88US=>M4DjNXNCVkeHUh?=
MSTO-211HNI\6SFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NXHBfHl{UUN3ME20Mlg{PTZ3IN88US=>MYHTRW5ITVJ?
MewoMX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NUH5T4JMUUN3ME20Mlk3OzF|IN88US=>NIXhZ5dUSU6JRWK=
GI-ME-NNX;BZpRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NHnub4tKSzVyPUWuNFA2ODlizszNMXXTRW5ITVJ?
T98GMXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NF;SN5pKSzVyPUWuNFY2ODhizszNMV7TRW5ITVJ?
ECC4MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4H5UWlEPTB;NT6wPVM4OiEQvF2=MYrTRW5ITVJ?
EW-11M3KwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7NHfDcZdKSzVyPUWuNVgxQTlizszNMUPTRW5ITVJ?
COLO-800NWTYc5o5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M1HSTmlEPTB;NT6xPVM1QSEQvF2=NIPsTmJUSU6JRWK=
NCI-H1755NGXwfZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=M{\GUmlEPTB;NT6yN|AzPyEQvF2=M4j6SnNCVkeHUh?=
KMS-12-PEMnqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NXH1NpVwUUN3ME21MlM2ODh3IN88US=>NEf1e|JUSU6JRWK=
HCC1954M3XnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXvJR|UxRTVwOEW5O|Eh|ryPM3;nOnNCVkeHUh?=
NCI-H187MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M4nHPWlEPTB;NT65Nlk5QSEQvF2=NVjVTY5RW0GQR1XS
LU-165M{f4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTVwOUmwNFIh|ryPNVzvRpVXW0GQR1XS
YAPCMWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NIrjc4xKSzVyPUWuPVkxPjhizszNMnzCV2FPT0WU
LU-139MoDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MoX2TWM2OD14LkC4N|Y5KM7:TR?=MYnTRW5ITVJ?
D-502MGM3;5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3jvSGlEPTB;Nj6zNlA1PyEQvF2=MYjTRW5ITVJ?
IST-SL1MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MWjJR|UxRTZwNUO5OFgh|ryPMYrTRW5ITVJ?
DG-75MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NXf5T2NmUUN3ME22Mlg5Pzh4IN88US=>MWTTRW5ITVJ?
NCI-H1155M1X2PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MojKTWM2OD14Lkm1OVgyKM7:TR?=M3zQbHNCVkeHUh?=
EFE-184NHXkXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MmTETWM2OD15LkOxOlk2KM7:TR?=Ml3WV2FPT0WU
AsPC-1M4LqNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M{HhRWlEPTB;Nz60PFgxPyEQvF2=MUTTRW5ITVJ?
SW948M2npSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MUXJR|UxRTdwNUizPVUh|ryPM1m3V3NCVkeHUh?=
NCI-H524MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?M{C4eGlEPTB;OT61PFYzQCEQvF2=NEfyRnRUSU6JRWK=
KOSC-2MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M3XYVmlEPTB;OT62Nlg{PCEQvF2=MlTGV2FPT0WU
T-24NX7ZUGd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=M3i5U2lEPTB;OT65OFQyPSEQvF2=NFXoNWhUSU6JRWK=
NCI-H748M37BNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1fUO2lEPTB;MUCuOlM6PyEQvF2=NFfmTW9USU6JRWK=
NCI-H23MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFjLbHFKSzVyPUGwMlY1PDJizszNMkHTV2FPT0WU
UACC-812Mm\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NVPZ[4t{UUN3ME2xNU44OTdizszNNUDV[IdjW0GQR1XS
SCLC-21HNH\XWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NILIcoRKSzVyPUGyMlE2PTFizszNMnPYV2FPT0WU
NCI-SNU-16M3X5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MXfJR|UxRTF|LkGyOVgh|ryPM2q0ZXNCVkeHUh?=
HD-MY-ZMoP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?M4TXdWlEPTB;MUSuOlM3OyEQvF2=NU\sdo1SW0GQR1XS
SK-N-FING\JRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MULJR|UxRTF2Lki5NVIh|ryPNUTtN5BrW0GQR1XS
LB647-SCLCM{jscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M1W1N2lEPTB;MUWuO|E6PSEQvF2=M4Ow[3NCVkeHUh?=
NCI-H345NXfxZ3FzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=MmHyTWM2OD1zNz6zOFMh|ryPMXvTRW5ITVJ?
NCI-H1563M4TWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MV\JR|UxRTF6Lke2NFEh|ryPNF;QbZhUSU6JRWK=
RLNEHRU3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NG\EcYNKSzVyPUKxMlI3PTZizszNNYnEWXZuW0GQR1XS
KY821NXPrWWNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NV[1SlhLUUN3ME2yNk4xPTV|IN88US=>MV3TRW5ITVJ?
JVM-3M4fYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7MnPmTWM2OD1{NT6wOFE{KM7:TR?=NEe0fZJUSU6JRWK=
NCI-H1793NXnGelBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=Ml\XTWM2OD1{OD61OFk6KM7:TR?=NUH4O4ZVW0GQR1XS
LU-134-ANIHnSZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NFe2VXJKSzVyPUOwMlIxOzdizszNMmT3V2FPT0WU
NCI-H1395NXrRXFZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm=NYDlO3JMUUN3ME2zNk4zPDNzIN88US=>MVnTRW5ITVJ?
NCI-H1993MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?MlnsTWM2OD1|Mj64NlE5KM7:TR?=MmruV2FPT0WU
P31-FUJNIDWcmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MW\JR|UxRTN|LkS4PVkh|ryPNWm5N4UzW0GQR1XS
LS-513NHL1c41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MYTJR|UxRTN3Lki4O|kh|ryPMn:5V2FPT0WU
SK-MEL-1M13kZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7M3u1cmlEPTB;NECuN|Q6QSEQvF2=NWG4OWk4W0GQR1XS
SW684MnTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?MVfJR|UxRTR|Lkm2OlEh|ryPM3ezOXNCVkeHUh?=
COR-L88NGrxZ5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=NUjEN|Q6UUN3ME20OE4xPjZ3IN88US=>MnLLV2FPT0WU
NCI-H889MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?NHvZVm5KSzVyPUS1MlAxQDdizszNNGfLO3RUSU6JRWK=
TALL-1NFXsWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=MXjJR|UxRTR4LkGxPVkh|ryPM{fxfHNCVkeHUh?=
KARPAS-299MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?NFXhXFFKSzVyPUS3MlE6QTNizszNNV;QeYtIW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.

Protocol(Only for Reference)

Kinase Assay: [1]

Bcl-2 Binding affinity calculation A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.

Cell Assay: [2]

Cell lines Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
Concentrations ~10 μM
Incubation Time 48-72 hours
Method Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.

Animal Study: [1]

Animal Models Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
Formulation Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
Dosages 0.0313, 0.25, 0.5 and 2 mg/kg
Administration Administered intravenously (tail vein) once a day

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Nguyen M, et al. Proc Natl Acad Sci, 2007, 104(49), 19512-191517.

[2] Trudel S, et al. Blood, 2009, 113(2), 299-305.

view more

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-30)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymp  ...more Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|  ...more Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2

view more

Chemical Information

Download Obatoclax Mesylate (GX15-070) SDF
Molecular Weight (MW) 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 83 mg/mL (200.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name (Z)-2-(5-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-4-methoxy-5H-pyrrol-2-yl)-1H-indole mesylate

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related Bcl-2 Products

  • A-1210477

    A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members.

  • MI-773 (SAR405838)

    MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.

  • ABT-263 (Navitoclax)

    ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

  • Venetoclax (ABT-199, GDC-0199)

    Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of <0.01 nM in cell-free assays, >4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3.

    Features:Re-engineered version of ABT-263 (Navitoclax).

  • ABT-737

    ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM in cell-free assays, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.

  • UMI-77

    UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.

  • TW-37

    TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.

  • Sabutoclax

    Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.

  • AT101

    AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. Phase 2.

Recently Viewed Items

Tags: buy Obatoclax Mesylate (GX15-070) | Obatoclax Mesylate (GX15-070) supplier | purchase Obatoclax Mesylate (GX15-070) | Obatoclax Mesylate (GX15-070) cost | Obatoclax Mesylate (GX15-070) manufacturer | order Obatoclax Mesylate (GX15-070) | Obatoclax Mesylate (GX15-070) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Contact Us