Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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In DMSO USD 190 In stock
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9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell death dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMECwNFMyPyEQvF2= NHn5WFFUSU6JRWK=
SK-MEL-30 NWm3[o5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPDOG1{UUN3ME2wMlAxODN3NTFOwG0> M33KbHNCVkeHUh?=
NALM-6 M1HiVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rLZmlEPTB;MD6wNFA{PTZizszN M{D4OXNCVkeHUh?=
KYSE-450 NH;rcFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMECwOFY6KM7:TR?= MkX6V2FPT0WU
BHY M3HIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfnZWpKSzVyPUCuNFAxPjBzIN88US=> NUnldVl7W0GQR1XS
GR-ST MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfGeWlKSzVyPUCuNFAxPjR6IN88US=> M2rTZnNCVkeHUh?=
786-0 NXzHbos1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\ufWlEPTB;MD6wNFA4PzZizszN NHPCNIpUSU6JRWK=
C-33-A MnruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4juNWlEPTB;MD6wNFA5PDhizszN MUPTRW5ITVJ?
BHT-101 MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TscmlEPTB;MD6wNFExPiEQvF2= Mk\0V2FPT0WU
EB2 M3XuXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUi4b5hyUUN3ME2wMlAxOTF6IN88US=> MkjPV2FPT0WU
G-361 NHTJ[YhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMECxNlQh|ryP M1\JeHNCVkeHUh?=
KE-37 MnS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPnc2RKSzVyPUCuNFAyOjhizszN Mme2V2FPT0WU
MHH-PREB-1 NVfI[3AxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMECxOEDPxE1? MmrOV2FPT0WU
MCF7 M{X4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHUZpN6UUN3ME2wMlAxOTV7IN88US=> M32yXHNCVkeHUh?=
LOUCY NVjScoF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfpPY96UUN3ME2wMlAxOTd3IN88US=> Mn24V2FPT0WU
EW-7 M1HLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rpSWlEPTB;MD6wNFE4PSEQvF2= M2jxNXNCVkeHUh?=
KYSE-510 MlKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:1TG5XUUN3ME2wMlAxOjN|IN88US=> MlTXV2FPT0WU
SK-MEL-3 NHTsWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:1TWM2OD1yLkCwNlY1KM7:TR?= M1jSXXNCVkeHUh?=
HAL-01 MlHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwMECyPVch|ryP MYrTRW5ITVJ?
HCC2998 M371fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMECzN|Uh|ryP NXXzVYJUW0GQR1XS
A375 MlTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMECzOUDPxE1? NWrjZ5pQW0GQR1XS
MZ7-mel MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDYNnVyUUN3ME2wMlAxOzl7IN88US=> NYr6bodHW0GQR1XS
SH-4 M1nJTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFq0OJJKSzVyPUCuNFA1OTdizszN MkXDV2FPT0WU
HT-144 M1fKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmGwTWM2OD1yLkCwOFMh|ryP M{fO[HNCVkeHUh?=
KYSE-140 NFW4SVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoizTWM2OD1yLkCwOFM2KM7:TR?= NH7Wc|ZUSU6JRWK=
PSN1 NHPUS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHFUJhKSzVyPUCuNFA1PjdizszN MoHVV2FPT0WU
COLO-679 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvXR|dKSzVyPUCuNFA1QThizszN Mn;qV2FPT0WU
SW620 NV\5V|l7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIX0OZBKSzVyPUCuNFA2OTFizszN NIjWfJBUSU6JRWK=
HGC-27 NUficVd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwMEC1NlQh|ryP NIjsd3JUSU6JRWK=
IGROV-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7UNFB5UUN3ME2wMlAxPiEQvF2= NITMdXpUSU6JRWK=
IGR-1 M4X3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\pTWM2OD1yLkCwOlAyKM7:TR?= NUfmOXdGW0GQR1XS
EW-1 NVHxfXlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwMEC2OVEh|ryP MVjTRW5ITVJ?
769-P M2[zdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjDXIpkUUN3ME2wMlAxPjd6IN88US=> NXzheYlQW0GQR1XS
HN MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nWOGlEPTB;MD6wNFY4QSEQvF2= M1nhOnNCVkeHUh?=
SIG-M5 NFeySFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwMEC3NUDPxE1? NXjIbHlKW0GQR1XS
IST-MEL1 NHnvWIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEC4NVgh|ryP NHqw[|VUSU6JRWK=
ST486 NFzEcJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrJVWZKSzVyPUCuNFA5OjVizszN NFPENZNUSU6JRWK=
ES7 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHtdZhKSzVyPUCuNFA5PDZizszN NEfjPVZUSU6JRWK=
GAK MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojnTWM2OD1yLkCwPFQ5KM7:TR?= MnTGV2FPT0WU
BB30-HNC MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml[2TWM2OD1yLkCwPFU5KM7:TR?= MUHTRW5ITVJ?
IPC-298 NX3Re2dST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\mTWM2OD1yLkCwPVI4KM7:TR?= NIXYbIJUSU6JRWK=
NKM-1 NETMNlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnQd5VKSzVyPUCuNFA6PzJizszN M3ez[HNCVkeHUh?=
RKO M1rTT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nO[WlEPTB;MD6wNVA1PCEQvF2= M1Pt[XNCVkeHUh?=
ACN NHfOem9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMEGxN|Eh|ryP MkW3V2FPT0WU
SW1417 NHzse2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXyPGtKSzVyPUCuNFEzOjVizszN NX7XNFl[W0GQR1XS
SR M37EeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXqfJRKSzVyPUCuNFEzOzVizszN M4OzTXNCVkeHUh?=
SNG-M MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:2TWM2OD1yLkCxN|E4KM7:TR?= NGqxdmlUSU6JRWK=
CAL-12T NEDJVYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHGSHRyUUN3ME2wMlAyOzR4IN88US=> NUnyS|B1W0GQR1XS
HSC-3 NFT2flJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMEGzOVUh|ryP MnnaV2FPT0WU
DOHH-2 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D3R2lEPTB;MD6wNVQyOiEQvF2= MkTuV2FPT0WU
NB69 NGe5TFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\6VnpQUUN3ME2wMlAyPTZ3IN88US=> NHPzVWVUSU6JRWK=
LC-2-ad MlL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXybJhKSzVyPUCuNFE2QDFizszN NX\KNIVkW0GQR1XS
RVH-421 NYHONmpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfjb5hSUUN3ME2wMlAyPjd2IN88US=> M1v0U3NCVkeHUh?=
TGW M4TZWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLKTWM2OD1yLkCxO|M6KM7:TR?= MYnTRW5ITVJ?
HCC1569 M2LEXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDSbnIzUUN3ME2wMlAyPzl5IN88US=> NXHPZolTW0GQR1XS
CAL-85-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLIW4tLUUN3ME2wMlAyQDN{IN88US=> MnO0V2FPT0WU
RPMI-8402 NIPWTYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEG4OVgh|ryP MXPTRW5ITVJ?
THP-1 M2jZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEG5PVgh|ryP NHHJNY1USU6JRWK=
ONS-76 Ml7FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\hT2lEPTB;MD6wNlA{PiEQvF2= NWDZT5FtW0GQR1XS
A2780 NYDPVmRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEKwO|kh|ryP MnT2V2FPT0WU
RPMI-2650 M4rJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEKyPVYh|ryP MW\TRW5ITVJ?
MEL-HO MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPhTWM2OD1yLkCyN|Q5KM7:TR?= M4nneHNCVkeHUh?=
MC-CAR Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDDPVVDUUN3ME2wMlAzOzV4IN88US=> M13mZ3NCVkeHUh?=
HSC-2 M2fHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HtN2lEPTB;MD6wNlQ3PiEQvF2= Mn;YV2FPT0WU
MEL-JUSO NEKwRlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnnTWM2OD1yLkCyOFc{KM7:TR?= MUXTRW5ITVJ?
CAL-62 NIr0NZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHPTWM2OD1yLkCyOlAzKM7:TR?= MkDvV2FPT0WU
DMS-273 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjFWZRKSzVyPUCuNFI5PDdizszN M3jJR3NCVkeHUh?=
S-117 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMEK5NFYh|ryP Mk\0V2FPT0WU
SUP-T1 NHXUS3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj4TWM2OD1yLkCyPVQ6KM7:TR?= MofRV2FPT0WU
MZ2-MEL M{W0OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\aOWlEPTB;MD6wNlk2QSEQvF2= MXLTRW5ITVJ?
KYSE-270 NU\5VYlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fONWlEPTB;MD6wNlk4PiEQvF2= MofNV2FPT0WU
CMK M2HyW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvKTWM2OD1yLkCzNFI{KM7:TR?= MWTTRW5ITVJ?
8505C MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrqcldUUUN3ME2wMlA{ODRizszN NGjsRVNUSU6JRWK=
NUGC-3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILYeGZKSzVyPUCuNFMxPDhizszN MUfTRW5ITVJ?
A101D MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTkTWM2OD1yLkCzNFU2KM7:TR?= MlTzV2FPT0WU
G-401 NETVSZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HUbGlEPTB;MD6wN|A6OyEQvF2= MkT4V2FPT0WU
OVCAR-8 NV22TG9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMEOxNFch|ryP NHTsfmlUSU6JRWK=
IMR-5 M3Hx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP6eVRUUUN3ME2wMlA{OjR2IN88US=> NVv2Rm8{W0GQR1XS
DoTc2-4510 NF3C[29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\3PG9iUUN3ME2wMlA{Ozl|IN88US=> MYfTRW5ITVJ?
HOS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEO0O|Mh|ryP NX[yflM1W0GQR1XS
HEC-1 MlP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;2e5hKSzVyPUCuNFM3QCEQvF2= MWHTRW5ITVJ?
SW756 M1LETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEO4NlEh|ryP Mk[3V2FPT0WU
NCI-H64 NGTUOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NImxNYpKSzVyPUCuNFM5PDJizszN NYrzSItKW0GQR1XS
EW-16 NV;EWmszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\0TWM2OD1yLkCzPVA6KM7:TR?= MUHTRW5ITVJ?
CAL-51 MoLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMESwNFUh|ryP NITtcHpUSU6JRWK=
KYSE-150 M4Dw[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;pTWM2OD1yLkC0NFEyKM7:TR?= MUHTRW5ITVJ?
SW1710 Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrFVYZKSzVyPUCuNFQxOThizszN NEXUcXpUSU6JRWK=
HuP-T4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTXTWM2OD1yLkC0NVE5KM7:TR?= M2LDN3NCVkeHUh?=
LB373-MEL-D MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LBeWlEPTB;MD6wOFI{OiEQvF2= M{ToSHNCVkeHUh?=
EW-13 NU\4fngyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rjbmlEPTB;MD6wOFQxPiEQvF2= M2m5U3NCVkeHUh?=
HT-29 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwMES0PUDPxE1? M1vMVnNCVkeHUh?=
SCC-25 NFLBZ2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTqN4dKSzVyPUCuNFQ1QTRizszN MnnuV2FPT0WU
REH NV\JU2RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fqc2lEPTB;MD6wOFY{PSEQvF2= Mk\mV2FPT0WU
L-363 NE[5Sm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTBwMES2O|kh|ryP MXPTRW5ITVJ?
NCI-H1770 MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnOd|U4UUN3ME2wMlA1Pjl5IN88US=> NHroXoZUSU6JRWK=
CHL-1 NH:2WZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMES4OVch|ryP M1XVdXNCVkeHUh?=
ES1 MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe0RndKSzVyPUCuNFQ5QDVizszN MXnTRW5ITVJ?
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NCI-H747 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LQNGlEPTB;MD6xOFMh|ryP NEfCUlFUSU6JRWK=
ES6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXjbJhTUUN3ME2wMlE1OzZizszN NIfMNlRUSU6JRWK=
TE-1 MoXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7pdIFMUUN3ME2wMlE1PDB5IN88US=> NX7hPFNXW0GQR1XS
SJSA-1 NVLh[3NlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPpdGhKSzVyPUCuNVQ4ODdizszN NFi1ZZdUSU6JRWK=
NCI-H1355 M3zGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr4TWM2OD1yLkG1Nlk{KM7:TR?= MnPvV2FPT0WU
HEL NU\OSVBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rSZWlEPTB;MD6xOVQ1PyEQvF2= M1rQWHNCVkeHUh?=
639-V NH\2eHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzYWXFKSzVyPUCuNVU2QTZizszN NVu1WJBCW0GQR1XS
AN3-CA NWnBOGp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGGzVYRKSzVyPUCuNVU3OzlizszN M{DKbnNCVkeHUh?=
SK-MEL-2 Mnf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm2W|FKSzVyPUCuNVU3PjhizszN NEntb4FUSU6JRWK=
SW872 NYjmcoFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXzUHQ5UUN3ME2wMlE3ODR{IN88US=> MnTsV2FPT0WU
DU-4475 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWCwepV5UUN3ME2wMlE3OTZ{IN88US=> MXXTRW5ITVJ?
YKG-1 NFXWTVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWD2eI43UUN3ME2wMlE3Ojd|IN88US=> MW\TRW5ITVJ?
GT3TKB NFPkXZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEG4XnFKSzVyPUCuNVYzQDNizszN NHfCfHlUSU6JRWK=
GB-1 NH;ocGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTBwMU[0NlQh|ryP M3;BZ3NCVkeHUh?=
KARPAS-422 NWX3epVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HQWWlEPTB;MD6xOlU4PCEQvF2= MkjMV2FPT0WU
ATN-1 MojhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMU[2OVYh|ryP Mon6V2FPT0WU
HLE M1zGfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXSUVJKSzVyPUCuNVY5PzdizszN NVTteYlXW0GQR1XS
D-542MG MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jUfGlEPTB;MD6xOlk5PiEQvF2= NF3UeWlUSU6JRWK=
EB-3 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMUezNUDPxE1? NUfDVZdUW0GQR1XS
HCC1143 M{jwSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMUezPVYh|ryP MlXTV2FPT0WU
DJM-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXMTWM2OD1yLkG3OFUyKM7:TR?= NXPVU|l3W0GQR1XS
BT-474 NUi3[WpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\VN5FCUUN3ME2wMlE4PDh7IN88US=> Mln5V2FPT0WU
BB65-RCC Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\zW45KSzVyPUCuNVc2PDVizszN MVfTRW5ITVJ?
NCI-H292 MkO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPBPIpKSzVyPUCuNVc3ODFizszN Mnz2V2FPT0WU
MKN28 NUe4VphsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDiXmlRUUN3ME2wMlE4PjV|IN88US=> MXPTRW5ITVJ?
TK10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fkSGlEPTB;MD6xO|cxOiEQvF2= NHPTWVdUSU6JRWK=
TYK-nu NIPR[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfGe|VKSzVyPUCuNVc6PDlizszN MmW3V2FPT0WU
8305C MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XqVGlEPTB;MD6xO|k4OSEQvF2= M3fFbHNCVkeHUh?=
MV-4-11 NFL5PJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zjXmlEPTB;MD6xO|k4PyEQvF2= NEXBR|NUSU6JRWK=
NCI-H522 NXXVSlAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT5TWM2OD1yLkG4NFk1KM7:TR?= NYfwfWFvW0GQR1XS
Hs-578-T M3LGbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMUiyPVIh|ryP NILaSYdUSU6JRWK=
LCLC-103H M2TWN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LGbmlEPTB;MD6xPFUzPyEQvF2= NIjGdpZUSU6JRWK=
MHH-ES-1 M{K3bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojDTWM2OD1yLkG4OlI6KM7:TR?= MnLSV2FPT0WU
NCI-H441 M3vIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TremlEPTB;MD6xPVE1QCEQvF2= NGrUXWFUSU6JRWK=
AM-38 M3\ud2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrIdnVKSzVyPUCuNVkzOjVizszN MXfTRW5ITVJ?
SW1783 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jBOWlEPTB;MD6xPVMxPSEQvF2= M1Pld3NCVkeHUh?=
SK-HEP-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nse2lEPTB;MD6xPVY{PyEQvF2= MoTEV2FPT0WU
OAW-28 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H6dWlEPTB;MD6yNFE4QCEQvF2= NFTUVINUSU6JRWK=
TE-15 MoDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\NfmlEPTB;MD6yNFI2OiEQvF2= MonpV2FPT0WU
HCE-4 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG3TWM2OD1yLkKwNlg1KM7:TR?= NIG5c2JUSU6JRWK=
JiyoyeP-2003 MnPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMkCzN|Yh|ryP NGryZVhUSU6JRWK=
OVCAR-4 M{jFRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK3TXpKSzVyPUCuNlA3OjhizszN NX3hVldSW0GQR1XS
SNU-449 MmK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPmUVJKSzVyPUCuNlA4QTdizszN NF3we3hUSU6JRWK=
SBC-5 NVj4doxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMkGyNVUh|ryP MoC3V2FPT0WU
T84 NVLmd3h5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Xr[mlEPTB;MD6yNVI1QCEQvF2= NXXxb5JXW0GQR1XS
LP-1 NWXYcZo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fTbmlEPTB;MD6yNVMxOiEQvF2= NGrWXGJUSU6JRWK=
MG-63 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PjcmlEPTB;MD6yNVM5OiEQvF2= NVq4TJdzW0GQR1XS
OAW-42 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr4SJhtUUN3ME2wMlIyPDd6IN88US=> MlfiV2FPT0WU
L-540 MkLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLtcIJRUUN3ME2wMlIyPTl6IN88US=> NX72SphnW0GQR1XS
RH-1 M2Pn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP4TWM2OD1yLkKyNlQzKM7:TR?= M17MUnNCVkeHUh?=
HCT-15 MofTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMkK0PFQh|ryP MmLTV2FPT0WU
OCUB-M MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMkK0PFgh|ryP MVTTRW5ITVJ?
GP5d NFnpb4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DJTGlEPTB;MD6yNlUzQCEQvF2= MUTTRW5ITVJ?
NCI-H2030 M1TNfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfJW5l4UUN3ME2wMlIzPzN2IN88US=> NX:2flhZW0GQR1XS
ML-2 NET4XGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfXTWM2OD1yLkKyPFg6KM7:TR?= M3L2ZnNCVkeHUh?=
CAL-39 MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DBcmlEPTB;MD6yNlk{PiEQvF2= M4fTXXNCVkeHUh?=
MIA-PaCa-2 NFTTXlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3GzTmlEPTB;MD6yN|I5PyEQvF2= NXu1TVZzW0GQR1XS
TE-9 MoPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[5TWM2OD1yLkKzN|Ih|ryP MXzTRW5ITVJ?
LB2518-MEL NYfZSHpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HYNWlEPTB;MD6yN|M4OiEQvF2= NVrjUm17W0GQR1XS
DB NEiwWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[1V|dKSzVyPUCuNlM1OzhizszN M2jxbnNCVkeHUh?=
NCI-H596 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwMkO1O|Eh|ryP NUHYd|hjW0GQR1XS
SW1990 NFztfY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn0TWM2OD1yLkKzPVQ3KM7:TR?= MXLTRW5ITVJ?
P30-OHK NIexZVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHFTWM2OD1yLkK0NFUh|ryP NFTOOVdUSU6JRWK=
ALL-PO Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XCRmlEPTB;MD6yOFE3QSEQvF2= NI[4eI5USU6JRWK=
Saos-2 M37hUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XlcGlEPTB;MD6yOFU4OSEQvF2= Mnm0V2FPT0WU
MFH-ino NVToPXl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGO3[FNKSzVyPUCuNlQ3QTJizszN MoL0V2FPT0WU
OE33 NVSxb|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HZ[GlEPTB;MD6yOVEyKM7:TR?= NX7YWW5GW0GQR1XS
Calu-3 NHy0UWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInWNZRKSzVyPUCuNlUzQTdizszN NE[0b5JUSU6JRWK=
HT NGDyZlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPpTWM2OD1yLkK1OlIyKM7:TR?= M{H0WHNCVkeHUh?=
LXF-289 M1PMc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jn[GlEPTB;MD6yOVk5PCEQvF2= MkPLV2FPT0WU
KGN NGjKOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMk[wPFkh|ryP MUfTRW5ITVJ?
NCI-H1417 NVfQSYtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnI[HpKSzVyPUCuNlY2OjRizszN M{KwNHNCVkeHUh?=
SF126 NFuzOGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\BfpFKSzVyPUCuNlc{ODJizszN NYXwT3BMW0GQR1XS
SAS NYH2fnY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\F[pZHUUN3ME2wMlI4OzB6IN88US=> MWTTRW5ITVJ?
22RV1 NWLCVGxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH1dllTUUN3ME2wMlI4Ozd6IN88US=> NIjDdHZUSU6JRWK=
GI-1 M3;6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV20Z|VVUUN3ME2wMlI4PDh5IN88US=> MY\TRW5ITVJ?
ES3 NEXHUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorTTWM2OD1yLkK3O|Y{KM7:TR?= M1Hsd3NCVkeHUh?=
NB1 NEn6bZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK2dlJKSzVyPUCuNlc5PzZizszN MXTTRW5ITVJ?
NCI-H650 M4\aS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnKdZhpUUN3ME2wMlI5OzB{IN88US=> MX7TRW5ITVJ?
IST-MES1 M4HRb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\1O2lEPTB;MD6yPFU2PCEQvF2= NXnPOGFNW0GQR1XS
UM-UC-3 NYDSdopMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q5OWlEPTB;MD6yPVE1KM7:TR?= M2HBenNCVkeHUh?=
CAL-120 Mo[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnhRoJ2UUN3ME2wMlI6PjNzIN88US=> NXX5RoF{W0GQR1XS
UACC-62 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml71TWM2OD1yLkOwNlQyKM7:TR?= NX;pVXV5W0GQR1XS
TE-11 M3nWO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXoTWM2OD1yLkOwNlQ6KM7:TR?= NHLoT3lUSU6JRWK=
MKN1 MmizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnu4TWM2OD1yLkOwN|Yh|ryP MX7TRW5ITVJ?
KS-1 Ml[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TmV2lEPTB;MD6zNFUzPiEQvF2= NFXpOoJUSU6JRWK=
GCIY MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTmbYNnUUN3ME2wMlMyODB{IN88US=> Mlu3V2FPT0WU
OVCAR-5 NUP4TIoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT1[Xd6UUN3ME2wMlMyOTB4IN88US=> M3\oXXNCVkeHUh?=
U-266 NXfP[4x5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwM{GxOFch|ryP MmrvV2FPT0WU
Calu-1 M4j6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PkW2lEPTB;MD6zNVI5QSEQvF2= MlToV2FPT0WU
SK-LMS-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwM{G0Nlkh|ryP MoT0V2FPT0WU
COLO-741 NG\VTmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwM{G2NVQh|ryP NIrJN2VUSU6JRWK=
RPMI-8226 M1rIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HndWlEPTB;MD6zNVY1OSEQvF2= MkDiV2FPT0WU
KM12 NWnGcGlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLWdWRKSzVyPUCuN|E5OyEQvF2= MX\TRW5ITVJ?
NMC-G1 M1vjSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjme3BKSzVyPUCuN|E5PiEQvF2= M3LyUHNCVkeHUh?=
SJRH30 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTPTWM2OD1yLkOyNFUzKM7:TR?= MWfTRW5ITVJ?
COR-L105 M1jKc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvrbot6UUN3ME2wMlMzOjF6IN88US=> NEXiTnZUSU6JRWK=
IM-9 NHnLXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLabYNRUUN3ME2wMlM{ODJzIN88US=> MVjTRW5ITVJ?
TE-12 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr6NGFKSzVyPUCuN|M{OTdizszN M3nDZnNCVkeHUh?=
KG-1 NWHyeZNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInrfXlKSzVyPUCuN|M1OzJizszN M33HW3NCVkeHUh?=
U251 MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorvTWM2OD1yLkOzOFU3KM7:TR?= Mn74V2FPT0WU
EFO-27 NEHib2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXwWJhKSzVyPUCuN|M6PTFizszN NVXJRYN5W0GQR1XS
EW-24 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HYbmlEPTB;MD6zN|k5PCEQvF2= NXXFTnI5W0GQR1XS
SF295 MoO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvvUnFKSzVyPUCuN|M6QTlizszN MVfTRW5ITVJ?
MC-IXC MojrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H6NWlEPTB;MD6zOFUh|ryP M{HCWXNCVkeHUh?=
NCI-H2405 M4jYeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwM{S3N|Ih|ryP MkflV2FPT0WU
NCI-H2009 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW2bGhKSzVyPUCuN|Q4OzlizszN M37vdXNCVkeHUh?=
LB1047-RCC Mli0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7VXZBKSzVyPUCuN|U5OTVizszN NIHoNZNUSU6JRWK=
KNS-81-FD MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln2TWM2OD1yLkO2OlY4KM7:TR?= NYHsfVZPW0GQR1XS
HOP-92 NF;qd45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[y[WlEPTB;MD6zOlg{KM7:TR?= M1zTUXNCVkeHUh?=
L-428 NFL5TohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfUPXhKSzVyPUCuN|cxOTZizszN MmDhV2FPT0WU
C3A NFS4dW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPYbJB1UUN3ME2wMlM4Ozd7IN88US=> NWPJPJg4W0GQR1XS
NCI-H1792 M2HPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTBwM{e2OVUh|ryP MlftV2FPT0WU
HuH-7 NEjVNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfKWHNKSzVyPUCuN|c6OSEQvF2= NH7kXldUSU6JRWK=
AGS MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX35V2FyUUN3ME2wMlM5PjN6IN88US=> MWXTRW5ITVJ?
HT-1197 M3TPV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVq5foxZUUN3ME2wMlM6PDZizszN Mn7pV2FPT0WU
CGTH-W-1 M3;3cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwM{m5NVMh|ryP NHfsV5ZUSU6JRWK=
KNS-42 NG\pcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwNECwOFUh|ryP M2HMS3NCVkeHUh?=
HuO-3N1 NH7RdGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPUNFJKSzVyPUCuOFAxPTVizszN NG\mTJRUSU6JRWK=
VMRC-RCZ Mo[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwNECzNFMh|ryP NYqwbWl3W0GQR1XS
SW954 NF3hUHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHCWWpKSzVyPUCuOFA{OzVizszN Mlz1V2FPT0WU
MES-SA NHzHWmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe2W3Q4UUN3ME2wMlQxPTB3IN88US=> NEWyUWFUSU6JRWK=
Ca-Ski MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwNEC1NlQh|ryP M4n3dHNCVkeHUh?=
SW13 NGLEeVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzneFlKSzVyPUCuOFA3OjZizszN MVfTRW5ITVJ?
NCI-H1437 MkDCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwNEC4NFUh|ryP M{LXcnNCVkeHUh?=
U-118-MG Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7RTWM2OD1yLkSwPVA1KM7:TR?= M4\rZnNCVkeHUh?=
NCI-H1734 NETXTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS0RVhNUUN3ME2wMlQzODF|IN88US=> MnvCV2FPT0WU
HDLM-2 MlXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3sNW1YUUN3ME2wMlQzODN|IN88US=> NXPnWIt4W0GQR1XS
AU565 NVXae5VpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHS2XGlKSzVyPUCuOFI1PjhizszN MkDFV2FPT0WU
FADU NXPke3pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HPNGlEPTB;MD60NlY1QSEQvF2= NUm0PHFmW0GQR1XS
OS-RC-2 NHHHW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rWUWlEPTB;MD60N|A5OyEQvF2= M4r4bXNCVkeHUh?=
CAMA-1 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\yTWM2OD1yLkSzOlI3KM7:TR?= MmHmV2FPT0WU
MONO-MAC-6 M1XxZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml21TWM2OD1yLkSzPFQ6KM7:TR?= M{m3eHNCVkeHUh?=
LB831-BLC Mm\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fXS2lEPTB;MD60OFM4OSEQvF2= MXXTRW5ITVJ?
SW982 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HMZWlEPTB;MD60OFUzQCEQvF2= NUTRR2ZpW0GQR1XS
SCC-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL0TWM2OD1yLkS0OVc6KM7:TR?= NWTleXk6W0GQR1XS
C32 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzse3BKSzVyPUCuOFUzOjlizszN NVnhNoxVW0GQR1XS
BFTC-909 NYPUPWF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TlUGlEPTB;MD60OVI6QSEQvF2= M12ySXNCVkeHUh?=
MEG-01 M1\1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC1RYZKSzVyPUCuOFU{PzNizszN MnTJV2FPT0WU
M14 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwNEW5O|kh|ryP MmDiV2FPT0WU
MPP-89 MnjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\tO2lnUUN3ME2wMlQ3OjV4IN88US=> NUDuXYdJW0GQR1XS
HCC1937 M2TWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\YdWlEPTB;MD60OlM5PCEQvF2= MlTOV2FPT0WU
SW837 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYX6bVd7UUN3ME2wMlQ3PzJ{IN88US=> MYjTRW5ITVJ?
DU-145 NXLYdGRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwNE[3Nlkh|ryP M{DK[HNCVkeHUh?=
LB996-RCC Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DGUmlEPTB;MD60O|A2PCEQvF2= M1joV3NCVkeHUh?=
C8166 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\hbGxqUUN3ME2wMlQ4PCEQvF2= MXHTRW5ITVJ?
MOLT-4 NYPhbmVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwNEe3N|Qh|ryP MYPTRW5ITVJ?
DMS-53 NFnqSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zhWGlEPTB;MD60O|gxQSEQvF2= NHrqS4ZUSU6JRWK=
TE-5 NHnQVmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXofJhtUUN3ME2wMlQ5OzB3IN88US=> M3j0XnNCVkeHUh?=
KYSE-520 NYm2XIFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ThRmlEPTB;MD60PFM1OyEQvF2= NEG0cnpUSU6JRWK=
Detroit562 NGLJO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwNEi4OkDPxE1? MlOxV2FPT0WU
SIMA M4L5OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwNEm0NVch|ryP MmWwV2FPT0WU
NCI-H1651 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwNEm2O{DPxE1? Ml7wV2FPT0WU
HCC1599 Ml;NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXuUlExUUN3ME2wMlQ6QTV3IN88US=> MYXTRW5ITVJ?
ABC-1 M3K3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTIU485UUN3ME2wMlUxPDl4IN88US=> MX\TRW5ITVJ?
CAL-33 MnrXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNUC4OFQh|ryP NXXOUGgzW0GQR1XS
OPM-2 NF3DWHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nzXWlEPTB;MD61NFk{PyEQvF2= NXHBbIFEW0GQR1XS
RPMI-7951 NGGxc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTiZ5JKSzVyPUCuOVA6PTdizszN M2jMeHNCVkeHUh?=
HT-1080 M{LxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTWTWM2OD1yLkWxNVE6KM7:TR?= NYTQb2o{W0GQR1XS
LC4-1 NXTlcoh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwNUG0NFMh|ryP NVLuPIplW0GQR1XS
OVCAR-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNUG1O{DPxE1? MnrxV2FPT0WU
CAPAN-1 M173SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWwe45iUUN3ME2wMlUzOjh6IN88US=> MmrMV2FPT0WU
SK-OV-3 M1PseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrXSFNoUUN3ME2wMlUzPDN2IN88US=> M{L5NHNCVkeHUh?=
HuP-T3 NX7XVoxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPMN3FKSzVyPUCuOVI5OjdizszN M4DVe3NCVkeHUh?=
NCI-H838 NH3Qc3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDCVoVKSzVyPUCuOVI5PDlizszN NYfMVVZEW0GQR1XS
K5 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwNUOyNFEh|ryP NEHjcIpUSU6JRWK=
CAL-72 NFvNc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXHfZVKSzVyPUCuOVM{QDdizszN NWrKfm9MW0GQR1XS
NH-12 NYHX[GxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwNUO5OVkh|ryP NHzzeXVUSU6JRWK=
SNB75 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXO4[4doUUN3ME2wMlU2PzNizszN MmLDV2FPT0WU
BPH-1 NWTadVBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vxU2lEPTB;MD61OlM1PCEQvF2= M2S1enNCVkeHUh?=
NOMO-1 NHjVdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXjUnBKSzVyPUCuOVY{PzJizszN NEnqTnVUSU6JRWK=
G-402 NFy3TIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof6TWM2OD1yLkW2OFk6KM7:TR?= NX;1OVNxW0GQR1XS
NCI-H2052 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[4b2lEPTB;MD61Olc1OSEQvF2= NGftZ2VUSU6JRWK=
RCM-1 M2PiVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXUSIhCUUN3ME2wMlU4OTZ4IN88US=> MkDJV2FPT0WU
COR-L279 M{\w[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULxfplJUUN3ME2wMlU4OTh3IN88US=> MV;TRW5ITVJ?
A253 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrGd2toUUN3ME2wMlU4PTJ3IN88US=> NYG4SVlFW0GQR1XS
SK-MM-2 M1O5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHxTWM2OD1yLkW3Olc6KM7:TR?= NIfR[JZUSU6JRWK=
NCI-H1703 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTKN2hKSzVyPUCuOVk1OjdizszN NXXNOI5XW0GQR1XS
UACC-257 NVrHVolVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwNUm0PFch|ryP Mmn3V2FPT0WU
KALS-1 NX2wOVJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fLV2lEPTB;MD62NFAyOSEQvF2= MoPoV2FPT0WU
ES5 Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVziTWV1UUN3ME2wMlYxPDhizszN M{LN[HNCVkeHUh?=
MHH-CALL-2 NYn5UYZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHId4NyUUN3ME2wMlYxQDh6IN88US=> MnHuV2FPT0WU
ChaGo-K-1 M1jMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuzTWM2OD1yLk[xNlI6KM7:TR?= NUfDdXZ7W0GQR1XS
TGBC1TKB MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwNkG5PEDPxE1? MVvTRW5ITVJ?
KU-19-19 MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwNkS1PFYh|ryP MofaV2FPT0WU
COLO-684 M4SwXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmwdldsUUN3ME2wMlY2PjFzIN88US=> MkPPV2FPT0WU
LS-1034 NX71VVI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWH5UFlWUUN3ME2wMlY2QDF7IN88US=> MlzLV2FPT0WU
RT-112 Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwNk[1PFch|ryP NYrzSI91W0GQR1XS
Capan-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwNk[2NlIh|ryP NV\jeVJlW0GQR1XS
HSC-4 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL6TWM2OD1yLk[2Olk5KM7:TR?= NX[yc21RW0GQR1XS
COLO-824 NEOy[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4G1fmlEPTB;MD62O|gzOyEQvF2= NHHZdXlUSU6JRWK=
NCI-H2170 NWq0N2FbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\uO3RTUUN3ME2wMlY5OjV6IN88US=> M3HwcHNCVkeHUh?=
GDM-1 NGDUSppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XTeGlEPTB;MD62PFQ6PCEQvF2= M2jmZ3NCVkeHUh?=
KP-4 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HTfmlEPTB;MD62PVU4OyEQvF2= MmrJV2FPT0WU
VA-ES-BJ NGfKWpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTBwNkm5PFYh|ryP M4n3TnNCVkeHUh?=
KM-H2 NHTpbWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHBNoJKSzVyPUCuO|AxQTFizszN NV;1c|EyW0GQR1XS
HH NGrCOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDsXW9PUUN3ME2wMlcxPjZ{IN88US=> MkXjV2FPT0WU
DK-MG M{WwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwN{GwNVYh|ryP NV3UbZp6W0GQR1XS
VM-CUB-1 NHr6e3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwN{GyOVkh|ryP MYHTRW5ITVJ?
COLO-829 Ml62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWH3dWFFUUN3ME2wMlcyQTh3IN88US=> M3fyVXNCVkeHUh?=
OMC-1 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;Cd5RuUUN3ME2wMlczOTB2IN88US=> M1zNUHNCVkeHUh?=
NB12 NWC1Z5F7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwN{K1NFQh|ryP M1:zbnNCVkeHUh?=
NCI-H28 M1XPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LMVWlEPTB;MD63OFA5OyEQvF2= Mnv4V2FPT0WU
A673 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\F[ndKSzVyPUCuO|UyPzdizszN NYCzOZZoW0GQR1XS
LB2241-RCC NFn6XHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwN{[wPFch|ryP MmeyV2FPT0WU
CCRF-CEM NWLlTFFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjRRY9LUUN3ME2wMlc4ODV{IN88US=> MW\TRW5ITVJ?
NCI-H510A NX6yN4w6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\jTWM2OD1yLke3NVg3KM7:TR?= NEXPcmZUSU6JRWK=
SW48 MlP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljmTWM2OD1yLke3N|M{KM7:TR?= NFfBV4dUSU6JRWK=
NCI-H2081 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy2fW5KSzVyPUCuO|gyPDdizszN MYLTRW5ITVJ?
RMG-I MmD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwN{iyNVIh|ryP NITS[|VUSU6JRWK=
LU-99A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjWNGg4UUN3ME2wMlc5PDF|IN88US=> NVvwTJlTW0GQR1XS
KP-N-YS NYG3PXliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXf6XIV1UUN3ME2wMlc5QTJzIN88US=> MXPTRW5ITVJ?
MDA-MB-231 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHJbIZKSzVyPUCuPFAyOzFizszN M4jM[nNCVkeHUh?=
U031 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XtV2lEPTB;MD64NVQzOyEQvF2= M2T1O3NCVkeHUh?=
EVSA-T MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv1eFZqUUN3ME2wMlgyPjd{IN88US=> NWLxe5ZDW0GQR1XS
MDA-MB-157 MoPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHntc2NKSzVyPUCuPFIzPzFizszN MV\TRW5ITVJ?
EHEB NH3zSFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVz3VJdOUUN3ME2wMlgzOjd4IN88US=> MmX5V2FPT0WU
KINGS-1 NWfFZ2NST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPGWnFTUUN3ME2wMlgzPTV3IN88US=> Mnn4V2FPT0WU
23132-87 MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwOEK4OFMh|ryP NWH6SGtQW0GQR1XS
EFO-21 M{[wUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDLTWM2OD1yLki0NFg6KM7:TR?= M3fEfHNCVkeHUh?=
DOK M2W5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwOES4JO69VQ>? MXTTRW5ITVJ?
NCI-H2171 MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3z2SGlEPTB;MD64OFk3KM7:TR?= M2f3XXNCVkeHUh?=
NCI-SNU-5 M1vERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwOEW1O{DPxE1? MWfTRW5ITVJ?
SK-N-DZ NXXuXo9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPiTWM2OD1yLki1PVQ{KM7:TR?= NVLPO5pUW0GQR1XS
SNU-C2B NUnxfpJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorYTWM2OD1yLki2PFAyKM7:TR?= M4TUSXNCVkeHUh?=
CP66-MEL M1HKWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\L[pdtUUN3ME2wMlg4OTFizszN M4DXdHNCVkeHUh?=
SN12C M3PRRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwOEi2N|ch|ryP NF\CNYlUSU6JRWK=
A172 MnfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HxPWlEPTB;MD64PFY6QCEQvF2= MX\TRW5ITVJ?
NCI-H2347 NVf4[WJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDrUGRZUUN3ME2wMlg5PzV|IN88US=> NHK4d4FUSU6JRWK=
NCI-H2228 M2nRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvPUHJ5UUN3ME2wMlg6OzN7IN88US=> NWjMbVVTW0GQR1XS
SNU-387 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrFTWM2OD1yLkmwNlY1KM7:TR?= MYTTRW5ITVJ?
SK-MEL-24 M1noc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULzdVJTUUN3ME2wMlkyOzR2IN88US=> MkKxV2FPT0WU
MDA-MB-468 MoPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwOUG3N{DPxE1? NXjJTYdtW0GQR1XS
NCI-H1694 NILUXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwOUG4O|Yh|ryP NFzwd3dUSU6JRWK=
CCF-STTG1 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH5PYZKSzVyPUCuPVI3OzdizszN NFTDUlRUSU6JRWK=
K052 NH3lNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC4PZZKSzVyPUCuPVQxPDdizszN MXzTRW5ITVJ?
NCI-H446 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzvR|lKSzVyPUCuPVUxOSEQvF2= NHv2NW9USU6JRWK=
MFE-280 NInjPVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jzeWlEPTB;MD65OlI6OSEQvF2= NEjrWZhUSU6JRWK=
KU812 NYnUOJFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoSxTWM2OD1yLkm5N|g6KM7:TR?= MWPTRW5ITVJ?
MDA-MB-361 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHv3S|hKSzVyPUCuPVk4PzdizszN Mny1V2FPT0WU
Raji M1nJSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jPe2lEPTB;MT6wNlI3PyEQvF2= MorGV2FPT0WU
TE-6 MlnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlr4TWM2OD1zLkCzOVY3KM7:TR?= NFrqUVNUSU6JRWK=
CAL-148 NWj6UJJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TaTWlEPTB;MT6wOFQ1OyEQvF2= M3HwWnNCVkeHUh?=
NCI-H1963 NVLW[WhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXkTWM2OD1zLkC0OVU{KM7:TR?= M2jnRnNCVkeHUh?=
SK-N-AS MoPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3niZ2lEPTB;MT6wOFY5PSEQvF2= MULTRW5ITVJ?
RERF-LC-MS MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLzTWM2OD1zLkC2N|Q6KM7:TR?= M2nUUnNCVkeHUh?=
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NCI-N87 NIHyXFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7WRnpKUUN3ME20MlM5QDJzIN88US=> M4\scXNCVkeHUh?=
NB6 NUOxNJJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2L0[2lEPTB;ND60NlUxQSEQvF2= Ml[2V2FPT0WU
DSH1 NEjySYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITMSlVKSzVyPUSuOFcyOTZizszN Mk\SV2FPT0WU
BT-20 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzOVpFEUUN3ME20MlQ6ODB{IN88US=> NWLKOJN6W0GQR1XS
NCI-H1882 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\lSmlEPTB;ND61NFU4KM7:TR?= NUL1Vnc2W0GQR1XS
WM-115 NYXaZlY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NViwcmtTUUN3ME20MlUxQDhzIN88US=> MnK2V2FPT0WU
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NCI-H69 NF;ZdolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTRwN{CyO|Uh|ryP NXy4Xm9pW0GQR1XS
MSTO-211H M330VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDuSXIxUUN3ME20Mlg{PTZ3IN88US=> NWHzXmhGW0GQR1XS
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COLO-800 NYfyOJZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPCVIx6UUN3ME21MlE6OzR7IN88US=> MYjTRW5ITVJ?
NCI-H1755 NFjnXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECxToNKSzVyPUWuNlMxOjdizszN NF;4emZUSU6JRWK=
KMS-12-PE M{ftW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTVwM{WwPFUh|ryP NVnKWFhsW0GQR1XS
HCC1954 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTVwOEW5O|Eh|ryP NX7NSFVCW0GQR1XS
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D-502MG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTZwM{KwOFch|ryP M1LPc3NCVkeHUh?=
IST-SL1 Mn75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTZwNUO5OFgh|ryP NXjRNW54W0GQR1XS
DG-75 MnXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvKR|lKSzVyPU[uPFg4QDZizszN MX7TRW5ITVJ?
NCI-H1155 NYXybW5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUOwTItkUUN3ME22Mlk2PThzIN88US=> MY\TRW5ITVJ?
EFE-184 NFnoNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTdwM{G2PVUh|ryP NULuU4ZNW0GQR1XS
AsPC-1 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXy1cGxUUUN3ME23MlQ5QDB5IN88US=> MlXYV2FPT0WU
SW948 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HZPGlEPTB;Nz61PFM6PSEQvF2= MWXTRW5ITVJ?
NCI-H524 M3PIfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzCeGxKSzVyPUmuOVg3OjhizszN M4HvV3NCVkeHUh?=
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T-24 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHrTWM2OD17Lkm0OFE2KM7:TR?= NUfTRldHW0GQR1XS
NCI-H748 NFLjOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K1b2lEPTB;MUCuOlM6PyEQvF2= MWrTRW5ITVJ?
NCI-H23 NW\HNVhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnPRXd4UUN3ME2xNE43PDR{IN88US=> M323SnNCVkeHUh?=
UACC-812 MkHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIm0OY9KSzVyPUGxMlcyPyEQvF2= MXvTRW5ITVJ?
SCLC-21H M3rDc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXOW4ZKSzVyPUGyMlE2PTFizszN M4GxTHNCVkeHUh?=
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SK-N-FI M1jEbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvsTWM2OD1zND64PVEzKM7:TR?= NIr4VXFUSU6JRWK=
LB647-SCLC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTQWYY6UUN3ME2xOU44OTl3IN88US=> MXPTRW5ITVJ?
NCI-H345 M1PyXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1GwUmlEPTB;MUeuN|Q{KM7:TR?= MnXpV2FPT0WU
NCI-H1563 Mon0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnMTWM2OD1zOD63OlAyKM7:TR?= MoHYV2FPT0WU
RL NUTEcZozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVy1b2ZvUUN3ME2yNU4zPjV4IN88US=> MXvTRW5ITVJ?
KY821 MkPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJ{LkC1OVMh|ryP NVHGeldIW0GQR1XS
JVM-3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFH3[HpKSzVyPUK1MlA1OTNizszN MV7TRW5ITVJ?
NCI-H1793 MljXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfBTWM2OD1{OD61OFk6KM7:TR?= MlHsV2FPT0WU
LU-134-A NFvNfYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD4RnYxUUN3ME2zNE4zODN5IN88US=> MoTxV2FPT0WU
NCI-H1395 NH3RNpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HlfmlEPTB;M{KuNlQ{OSEQvF2= MX7TRW5ITVJ?
NCI-H1993 NHfGVGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HlNGlEPTB;M{KuPFIyQCEQvF2= Mn[0V2FPT0WU
P31-FUJ M4HnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\kTWM2OD1|Mz60PFk6KM7:TR?= NHnHVIVUSU6JRWK=
LS-513 M2jxXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDVNldKSzVyPUO1Mlg5PzlizszN M{X2bHNCVkeHUh?=
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COR-L88 NYD2SJh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWToWW1TUUN3ME20OE4xPjZ3IN88US=> NH7xN4lUSU6JRWK=
NCI-H889 NUHlVGVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXNTWM2OD12NT6wNFg4KM7:TR?= MkXaV2FPT0WU
TALL-1 Mn\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK0ZlVKSzVyPUS2MlEyQTlizszN M37nRnNCVkeHUh?=
KARPAS-299 NFPJcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYOyT2Y4UUN3ME20O{4yQTl|IN88US=> NIX6SWFUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2
NCT00724841 Terminated Metastatic Melanoma Gemin X|Teva Pharmaceutical Industries June 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID