Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Size Price Stock Quantity  
In DMSO USD 190 In stock
USD 170 In stock
USD 320 In stock
USD 870 In stock

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9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell death dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm0eHhKSzVyPUCuNFAxODNzNzFOwG0> NVXj[4N4W0GQR1XS
SK-MEL-30 NFHVOJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn70TWM2OD1yLkCwNFM2PSEQvF2= NYq1VFNzW0GQR1XS
NALM-6 NVfFcYxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMECwN|U3KM7:TR?= NXvySHB4W0GQR1XS
KYSE-450 M3\ZXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmO1TWM2OD1yLkCwNFQ3QSEQvF2= NVrJdFJ4W0GQR1XS
BHY NE\aRYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3VfWdKSzVyPUCuNFAxPjBzIN88US=> NIDMZ|VUSU6JRWK=
GR-ST MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL3TWM2OD1yLkCwNFY1QCEQvF2= NHLEZYFUSU6JRWK=
786-0 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFe4NXFKSzVyPUCuNFAxPzd4IN88US=> NWG3b|lIW0GQR1XS
C-33-A MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DaVmlEPTB;MD6wNFA5PDhizszN M1TVfHNCVkeHUh?=
BHT-101 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTVTWM2OD1yLkCwNVA3KM7:TR?= MnrrV2FPT0WU
EB2 Moj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXPTWM2OD1yLkCwNVE5KM7:TR?= MXvTRW5ITVJ?
G-361 NV;mRZlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrTOlVKSzVyPUCuNFAyOjRizszN NGW1VHVUSU6JRWK=
KE-37 NYWyRXZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVraflRUUUN3ME2wMlAxOTJ6IN88US=> NFzhcHNUSU6JRWK=
MHH-PREB-1 Mkf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTBwMECxOEDPxE1? MVXTRW5ITVJ?
MCF7 MlTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMECxOVkh|ryP NUH3bVhwW0GQR1XS
LOUCY MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;OTWM2OD1yLkCwNVc2KM7:TR?= M13vbnNCVkeHUh?=
EW-7 MlzCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTnTWM2OD1yLkCwNVc2KM7:TR?= MUPTRW5ITVJ?
KYSE-510 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnf5TWM2OD1yLkCwNlM{KM7:TR?= MXTTRW5ITVJ?
SK-MEL-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMECyOlQh|ryP M1rwfXNCVkeHUh?=
HAL-01 M2nFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LVOGlEPTB;MD6wNFI6PyEQvF2= NID6S3pUSU6JRWK=
HCC2998 NEXCOGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzOTWM2OD1yLkCwN|M2KM7:TR?= NXjsZ4VGW0GQR1XS
A375 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Wy[WlEPTB;MD6wNFM2KM7:TR?= M1\SVHNCVkeHUh?=
MZ7-mel M1jufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33XUmlEPTB;MD6wNFM6QSEQvF2= NVfDWI5wW0GQR1XS
SH-4 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInOTHFKSzVyPUCuNFA1OTdizszN M3W2enNCVkeHUh?=
HT-144 NV;l[lJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEC0N{DPxE1? MUXTRW5ITVJ?
KYSE-140 NHfPUXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTsTWM2OD1yLkCwOFM2KM7:TR?= M3;0O3NCVkeHUh?=
PSN1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLjTWM2OD1yLkCwOFY4KM7:TR?= Ml32V2FPT0WU
COLO-679 M4DScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfKWGtKSzVyPUCuNFA1QThizszN NIjicJhUSU6JRWK=
SW620 MlX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMEC1NVEh|ryP M{\WW3NCVkeHUh?=
HGC-27 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\aW5RKSzVyPUCuNFA2OjRizszN NEfRbWNUSU6JRWK=
IGROV-1 M{foRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moq3TWM2OD1yLkCwOkDPxE1? NYf1UY1HW0GQR1XS
IGR-1 NVnK[o9LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofrTWM2OD1yLkCwOlAyKM7:TR?= Mln5V2FPT0WU
EW-1 NHvJVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e5SWlEPTB;MD6wNFY2OSEQvF2= M4rBOXNCVkeHUh?=
769-P NV20S5JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnpTWlrUUN3ME2wMlAxPjd6IN88US=> MkT4V2FPT0WU
HN MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jKW2lEPTB;MD6wNFY4QSEQvF2= NF7DOotUSU6JRWK=
SIG-M5 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEC3NUDPxE1? NXG3XHNjW0GQR1XS
IST-MEL1 MnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LhVmlEPTB;MD6wNFgyQCEQvF2= NIPQblBUSU6JRWK=
ST486 NFvXTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGX5S4tKSzVyPUCuNFA5OjVizszN NU\KO25QW0GQR1XS
ES7 MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwMEC4OFYh|ryP NX7SUYN7W0GQR1XS
GAK NGLn[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMEC4OFgh|ryP M1TLb3NCVkeHUh?=
BB30-HNC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHpTWM2OD1yLkCwPFU5KM7:TR?= MlvhV2FPT0WU
IPC-298 MkjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEC5Nlch|ryP NU\1To5iW0GQR1XS
NKM-1 NFvoXpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfUUJRtUUN3ME2wMlAxQTd{IN88US=> NEPHXnZUSU6JRWK=
RKO MoKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULhPFVsUUN3ME2wMlAyODR2IN88US=> NELP[oFUSU6JRWK=
ACN MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTBwMEGxN|Eh|ryP NUfxe4wzW0GQR1XS
SW1417 MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jpemlEPTB;MD6wNVIzPSEQvF2= MWTTRW5ITVJ?
SR MmDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFL2bFZKSzVyPUCuNFEzOzVizszN M4DOTnNCVkeHUh?=
SNG-M MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[3TWM2OD1yLkCxN|E4KM7:TR?= Mn;iV2FPT0WU
CAL-12T NFHmO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHmdId[UUN3ME2wMlAyOzR4IN88US=> MlPvV2FPT0WU
HSC-3 NUfLTXE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fwZWlEPTB;MD6wNVM2PSEQvF2= MV;TRW5ITVJ?
DOHH-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvr[XRUUUN3ME2wMlAyPDF{IN88US=> MkDjV2FPT0WU
NB69 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXnTWM2OD1yLkCxOVY2KM7:TR?= NXHGRolqW0GQR1XS
LC-2-ad NHfHRpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXqTpZKSzVyPUCuNFE2QDFizszN M3rqfXNCVkeHUh?=
RVH-421 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHZNFJKSzVyPUCuNFE3PzRizszN M3fiTXNCVkeHUh?=
TGW Mn;OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELTUJZKSzVyPUCuNFE4OzlizszN M161XXNCVkeHUh?=
HCC1569 M{jpR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TXcmlEPTB;MD6wNVc6PyEQvF2= NVzGR|JNW0GQR1XS
CAL-85-1 NYXuemJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEG4N|Ih|ryP NWLEOGVrW0GQR1XS
RPMI-8402 NEjRfFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEG4OVgh|ryP MkH2V2FPT0WU
THP-1 NH3yb3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fmVGlEPTB;MD6wNVk6QCEQvF2= NV7lcnhmW0GQR1XS
ONS-76 M3\JfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMEKwN|Yh|ryP M3vKe3NCVkeHUh?=
A2780 NGjLXplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P1NGlEPTB;MD6wNlA4QSEQvF2= MXvTRW5ITVJ?
RPMI-2650 NXvqTYtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHixeo5KSzVyPUCuNFIzQTZizszN MWPTRW5ITVJ?
MEL-HO NYHEeGV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEKzOFgh|ryP Ml;OV2FPT0WU
MC-CAR MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qyUWlEPTB;MD6wNlM2PiEQvF2= M37EdHNCVkeHUh?=
HSC-2 NEPt[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Xn[GlEPTB;MD6wNlQ3PiEQvF2= M17SN3NCVkeHUh?=
MEL-JUSO M4jVdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7TTWM2OD1yLkCyOFc{KM7:TR?= NYHNNI5vW0GQR1XS
CAL-62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfmNYRIUUN3ME2wMlAzPjB{IN88US=> MXjTRW5ITVJ?
DMS-273 NVzEWGYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fB[GlEPTB;MD6wNlg1PyEQvF2= NYThZZppW0GQR1XS
S-117 NFfEbYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmGzTWM2OD1yLkCyPVA3KM7:TR?= MVrTRW5ITVJ?
SUP-T1 MnvhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMEK5OFkh|ryP M4LFTXNCVkeHUh?=
MZ2-MEL MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrPWYNKSzVyPUCuNFI6PTlizszN M3zhb3NCVkeHUh?=
KYSE-270 NXn1RpU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjPdWJ2UUN3ME2wMlAzQTd4IN88US=> M4TmWXNCVkeHUh?=
CMK NWr6SGZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHUOGtKSzVyPUCuNFMxOjNizszN NG[1VGtUSU6JRWK=
8505C NVTWZ4NwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP5[pJKSzVyPUCuNFMxPCEQvF2= MYTTRW5ITVJ?
NUGC-3 NH7sepRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzwTWM2OD1yLkCzNFQ5KM7:TR?= MlnRV2FPT0WU
A101D NIDSVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fLO2lEPTB;MD6wN|A2PSEQvF2= M{LT[HNCVkeHUh?=
G-401 NWXabYcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW4[ZhJUUN3ME2wMlA{ODl|IN88US=> NUX6XZJPW0GQR1XS
OVCAR-8 Ml;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPkTWM2OD1yLkCzNVA4KM7:TR?= M2raTXNCVkeHUh?=
IMR-5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXN[4hKSzVyPUCuNFMzPDRizszN NF\lcIhUSU6JRWK=
DoTc2-4510 NWnpe3M{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfvTWM2OD1yLkCzN|k{KM7:TR?= MnLDV2FPT0WU
HOS NWr3Z|dlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rrcWlEPTB;MD6wN|Q4OyEQvF2= MXHTRW5ITVJ?
HEC-1 NXm0fmZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[4TWM2OD1yLkCzOlgh|ryP NG\ifWNUSU6JRWK=
SW756 M{TWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvxTGZKSzVyPUCuNFM5OjFizszN NXTKNFVVW0GQR1XS
NCI-H64 M2\LSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG2SoV1UUN3ME2wMlA{QDR{IN88US=> M3LxTnNCVkeHUh?=
EW-16 M1TSUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTVS4dJUUN3ME2wMlA{QTB7IN88US=> M33OW3NCVkeHUh?=
CAL-51 Mmm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMESwNFUh|ryP M4D1NHNCVkeHUh?=
KYSE-150 NX;2bnlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMESwNVEh|ryP NUPmS483W0GQR1XS
SW1710 M13kXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMESwNVgh|ryP MkTKV2FPT0WU
HuP-T4 NVzGZZh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMESxNVgh|ryP NWDzT5BxW0GQR1XS
LB373-MEL-D MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDPTGZKSzVyPUCuNFQzOzJizszN M3LtR3NCVkeHUh?=
EW-13 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTDeYd6UUN3ME2wMlA1PDB4IN88US=> M{LCbXNCVkeHUh?=
HT-29 M3fzRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMES0PUDPxE1? MULTRW5ITVJ?
SCC-25 NVrBRZlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMES0PVQh|ryP MYXTRW5ITVJ?
REH MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PDdGlEPTB;MD6wOFY{PSEQvF2= M3zOUnNCVkeHUh?=
L-363 M{iyS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Kx[GlEPTB;MD6wOFY4QSEQvF2= NGDMdHBUSU6JRWK=
NCI-H1770 NUCzUGlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHvW3ZKSzVyPUCuNFQ3QTdizszN MV3TRW5ITVJ?
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RD NIOzRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jmOmlEPTB;MD6xN|k6PyEQvF2= MVzTRW5ITVJ?
LS-411N M2Dpc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMUSyPVUh|ryP MlzTV2FPT0WU
NCI-H747 NVvGUFl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGf4VYFKSzVyPUCuNVQ{KM7:TR?= NXTCO5c5W0GQR1XS
ES6 NF;ieVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjqTWM2OD1yLkG0N|Yh|ryP MVzTRW5ITVJ?
TE-1 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Hn[2lEPTB;MD6xOFQxPyEQvF2= NXvXSWZNW0GQR1XS
SJSA-1 NVLmcY5sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF32TnFKSzVyPUCuNVQ4ODdizszN NHrjOm9USU6JRWK=
NCI-H1355 NWLZZnFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXaTWM2OD1yLkG1Nlk{KM7:TR?= MVHTRW5ITVJ?
HEL M1XwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7YZ28xUUN3ME2wMlE2PDR5IN88US=> NWmyWWlHW0GQR1XS
639-V NHftenJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLNHdKSzVyPUCuNVU2QTZizszN M2TwdnNCVkeHUh?=
AN3-CA MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DlTWlEPTB;MD6xOVY{QSEQvF2= MmC0V2FPT0WU
SK-MEL-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXq1UG4zUUN3ME2wMlE2PjZ6IN88US=> MUDTRW5ITVJ?
SW872 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;kVGlEPTB;MD6xOlA1OiEQvF2= MUTTRW5ITVJ?
DU-4475 NULE[oFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX23coR3UUN3ME2wMlE3OTZ{IN88US=> Mlz4V2FPT0WU
YKG-1 M{PLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYmydHd1UUN3ME2wMlE3Ojd|IN88US=> M1jDVHNCVkeHUh?=
GT3TKB NFfjXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMU[yPFMh|ryP MV7TRW5ITVJ?
GB-1 M{HzN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvETWM2OD1yLkG2OFI1KM7:TR?= MojRV2FPT0WU
KARPAS-422 NGnW[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPlR2ZQUUN3ME2wMlE3PTd2IN88US=> NIDxdpVUSU6JRWK=
ATN-1 NFzYZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrQNo1KSzVyPUCuNVY3PTZizszN MX\TRW5ITVJ?
HLE MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXCTWM2OD1yLkG2PFc4KM7:TR?= MXXTRW5ITVJ?
D-542MG NGDFOW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vnSmlEPTB;MD6xOlk5PiEQvF2= MlO5V2FPT0WU
EB-3 M331Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMUezNUDPxE1? MVLTRW5ITVJ?
HCC1143 MnjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzxTWM2OD1yLkG3N|k3KM7:TR?= MV;TRW5ITVJ?
DJM-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\kfmlEPTB;MD6xO|Q2OSEQvF2= MoL4V2FPT0WU
BT-474 M1;2Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3lXnJtUUN3ME2wMlE4PDh7IN88US=> Mn7KV2FPT0WU
BB65-RCC M3jiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvEWmNPUUN3ME2wMlE4PTR3IN88US=> NYHldXRGW0GQR1XS
NCI-H292 M{\YOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHqeJNKSzVyPUCuNVc3ODFizszN NF:0WoZUSU6JRWK=
MKN28 M1vsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILrU4ZKSzVyPUCuNVc3PTNizszN NFHlS4tUSU6JRWK=
TK10 MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwMUe3NFIh|ryP MX\TRW5ITVJ?
TYK-nu NV:4fphCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMUe5OFkh|ryP MmDwV2FPT0WU
8305C NUnoSFd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPVTWM2OD1yLkG3PVcyKM7:TR?= MnHwV2FPT0WU
MV-4-11 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfjNJpKSzVyPUCuNVc6PzdizszN MnPBV2FPT0WU
NCI-H522 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLRcFFOUUN3ME2wMlE5ODl2IN88US=> M3nzXXNCVkeHUh?=
Hs-578-T MoPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnmxTWM2OD1yLkG4NlkzKM7:TR?= M4LEV3NCVkeHUh?=
LCLC-103H MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXqTFBKSzVyPUCuNVg2OjdizszN NUDqUYtFW0GQR1XS
MHH-ES-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMUi2Nlkh|ryP MkTYV2FPT0WU
NCI-H441 NVfTdlR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlWzTWM2OD1yLkG5NVQ5KM7:TR?= NWrKd4JyW0GQR1XS
AM-38 Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjLRpNIUUN3ME2wMlE6OjJ3IN88US=> MUjTRW5ITVJ?
SW1783 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTHU21CUUN3ME2wMlE6OzB3IN88US=> NETjPVhUSU6JRWK=
SK-HEP-1 NWnmOlg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;xbnZWUUN3ME2wMlE6PjN5IN88US=> NUG1dYZOW0GQR1XS
OAW-28 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMkCxO|gh|ryP NVOxTWMzW0GQR1XS
TE-15 NIfNcY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEKz[3BKSzVyPUCuNlAzPTJizszN MWHTRW5ITVJ?
HCE-4 NFTNZlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMkCyPFQh|ryP MV3TRW5ITVJ?
JiyoyeP-2003 NHXKZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1y0TGlEPTB;MD6yNFM{PiEQvF2= M4TMOHNCVkeHUh?=
OVCAR-4 M1vGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTDc255UUN3ME2wMlIxPjJ6IN88US=> MlrsV2FPT0WU
SNU-449 Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfRTWM2OD1yLkKwO|k4KM7:TR?= NUDBd4I4W0GQR1XS
SBC-5 MkHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCzXXJKSzVyPUCuNlEzOTVizszN NYPUXFViW0GQR1XS
T84 NYq5ZWlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMkGyOFgh|ryP MXzTRW5ITVJ?
LP-1 NH3GS|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF61WpZKSzVyPUCuNlE{ODJizszN MY\TRW5ITVJ?
MG-63 Mn3JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfPTWM2OD1yLkKxN|gzKM7:TR?= M2DDcXNCVkeHUh?=
OAW-42 MlyxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zYRWlEPTB;MD6yNVQ4QCEQvF2= NYiwb24zW0GQR1XS
L-540 NHz6UIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjke4pKSzVyPUCuNlE2QThizszN NFz2VJBUSU6JRWK=
RH-1 NXfJPGlGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXHWHJKSzVyPUCuNlIzPDJizszN M4e5SnNCVkeHUh?=
HCT-15 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMkK0PFQh|ryP MWHTRW5ITVJ?
OCUB-M MnHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHFTWM2OD1yLkKyOFg5KM7:TR?= MWPTRW5ITVJ?
GP5d NF\iZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwMkK1Nlgh|ryP NEH2VYhUSU6JRWK=
NCI-H2030 Mn3ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NECzRYJKSzVyPUCuNlI4OzRizszN MkTRV2FPT0WU
ML-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\QTIpKSzVyPUCuNlI5QDlizszN NEizS3hUSU6JRWK=
CAL-39 NXP4VG0yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;mbWpKSzVyPUCuNlI6OzZizszN M3;yWHNCVkeHUh?=
MIA-PaCa-2 MlX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVSzfYV{UUN3ME2wMlI{Ojh5IN88US=> MnLlV2FPT0WU
TE-9 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnWT49KSzVyPUCuNlM{OiEQvF2= NWLZNWFCW0GQR1XS
LB2518-MEL NYG2NWJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPGO3hKSzVyPUCuNlM{PzJizszN M2PRS3NCVkeHUh?=
DB Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMkO0N|gh|ryP NVHveXNEW0GQR1XS
NCI-H596 M{\sTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDoTWM2OD1yLkKzOVcyKM7:TR?= M4jOVnNCVkeHUh?=
SW1990 M4P5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;BTZNFUUN3ME2wMlI{QTR4IN88US=> MV;TRW5ITVJ?
P30-OHK NWPtOmtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jl[mlEPTB;MD6yOFA2KM7:TR?= M3TiVXNCVkeHUh?=
ALL-PO MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwMkSxOlkh|ryP MmTDV2FPT0WU
Saos-2 M2WzNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrz[m8zUUN3ME2wMlI1PTdzIN88US=> NULoRY9sW0GQR1XS
MFH-ino M2nRdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMkS2PVIh|ryP MUfTRW5ITVJ?
OE33 NYLBeJlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zsVWlEPTB;MD6yOVEyKM7:TR?= MljSV2FPT0WU
Calu-3 MoTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMkWyPVch|ryP MoTPV2FPT0WU
HT NXPKNI9wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwMkW2NlEh|ryP M{TL[XNCVkeHUh?=
LXF-289 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfzcJBKSzVyPUCuNlU6QDRizszN M4PiNXNCVkeHUh?=
KGN NYnPXWZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTBwMk[wPFkh|ryP M{T3dnNCVkeHUh?=
NCI-H1417 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3ZPId3UUN3ME2wMlI3PTJ2IN88US=> MXnTRW5ITVJ?
SF126 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\XXGlEPTB;MD6yO|MxOiEQvF2= Mni0V2FPT0WU
SAS NXXIdolET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DWdmlEPTB;MD6yO|MxQCEQvF2= NUnO[4luW0GQR1XS
22RV1 NEfBZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPJTWM2OD1yLkK3N|c5KM7:TR?= NILmeYdUSU6JRWK=
GI-1 MoXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrLWG5KSzVyPUCuNlc1QDdizszN MlrjV2FPT0WU
ES3 NHjLXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvJTWM2OD1yLkK3O|Y{KM7:TR?= NE\xNm5USU6JRWK=
NB1 M4r6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\GR2lEPTB;MD6yO|g4PiEQvF2= M4jHT3NCVkeHUh?=
NCI-H650 NH3VenZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMkizNFIh|ryP M{TCWnNCVkeHUh?=
IST-MES1 NUDBW5pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvlSmg1UUN3ME2wMlI5PTV2IN88US=> MYLTRW5ITVJ?
UM-UC-3 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMkmxOEDPxE1? MXjTRW5ITVJ?
CAL-120 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\aeWlEPTB;MD6yPVY{OSEQvF2= NYr6VHJ3W0GQR1XS
UACC-62 NHTzV4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DSPGlEPTB;MD6zNFI1OSEQvF2= NUnPVVhEW0GQR1XS
TE-11 M1;CUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK4TWM2OD1yLkOwNlQ6KM7:TR?= M1zkOnNCVkeHUh?=
MKN1 NVj2cpVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTBwM{CzOkDPxE1? NWjUO5JUW0GQR1XS
KS-1 NV\PZmpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHn4cYdKSzVyPUCuN|A2OjZizszN MVnTRW5ITVJ?
GCIY M160SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorETWM2OD1yLkOxNFAzKM7:TR?= MlTkV2FPT0WU
OVCAR-5 NETrOXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwM{GxNFYh|ryP MoDqV2FPT0WU
U-266 NGryU|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\yfY9DUUN3ME2wMlMyOTR5IN88US=> NITnVW1USU6JRWK=
Calu-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjKT5hKSzVyPUCuN|EzQDlizszN NFvOfXVUSU6JRWK=
SK-LMS-1 NGDado1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy4XJZEUUN3ME2wMlMyPDJ7IN88US=> NHjid4VUSU6JRWK=
COLO-741 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfaTWM2OD1yLkOxOlE1KM7:TR?= MYDTRW5ITVJ?
RPMI-8226 MmnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnJXlI6UUN3ME2wMlMyPjRzIN88US=> MmXUV2FPT0WU
KM12 M{TWR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwM{G4N{DPxE1? M3HrUnNCVkeHUh?=
NMC-G1 Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXToZng2UUN3ME2wMlMyQDZizszN MWTTRW5ITVJ?
SJRH30 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnewTWM2OD1yLkOyNFUzKM7:TR?= NUTybppxW0GQR1XS
COR-L105 MmToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3sTlExUUN3ME2wMlMzOjF6IN88US=> M3vXPXNCVkeHUh?=
IM-9 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3DR4FKSzVyPUCuN|MxOjFizszN NUjxc3YxW0GQR1XS
TE-12 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPodIE4UUN3ME2wMlM{OzF5IN88US=> Ml7tV2FPT0WU
KG-1 M4L5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjIOodwUUN3ME2wMlM{PDN{IN88US=> NFLGOnRUSU6JRWK=
U251 M1;Zfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPVZZhKSzVyPUCuN|M1PTZizszN NGT2[3JUSU6JRWK=
EFO-27 M2PDTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwM{O5OVEh|ryP Moe0V2FPT0WU
EW-24 NVzOeFVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnleHhKSzVyPUCuN|M6QDRizszN MnTYV2FPT0WU
SF295 M1vM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwM{O5PVkh|ryP MnLUV2FPT0WU
MC-IXC MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDpOFFqUUN3ME2wMlM1PSEQvF2= NGrHRYZUSU6JRWK=
NCI-H2405 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvyc4FNUUN3ME2wMlM1PzN{IN88US=> NX70UVJwW0GQR1XS
NCI-H2009 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTaTWM2OD1yLkO0O|M6KM7:TR?= NUCxU3RNW0GQR1XS
LB1047-RCC MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVmzPHNHUUN3ME2wMlM2QDF3IN88US=> MmfqV2FPT0WU
KNS-81-FD M{XBNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1O1bGlEPTB;MD6zOlY3PyEQvF2= NH6zNWVUSU6JRWK=
HOP-92 NGX5Z49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jVeWlEPTB;MD6zOlg{KM7:TR?= MUPTRW5ITVJ?
L-428 NXzVTpVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\YXWlEPTB;MD6zO|AyPiEQvF2= MljNV2FPT0WU
C3A NYPjXWtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D1dmlEPTB;MD6zO|M4QSEQvF2= MlzVV2FPT0WU
NCI-H1792 NHjlPIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwM{e2OVUh|ryP NITofpJUSU6JRWK=
HuH-7 NFn4S|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEiy[2lKSzVyPUCuN|c6OSEQvF2= NULoc|ZTW0GQR1XS
AGS MoLOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[yd4pYUUN3ME2wMlM5PjN6IN88US=> NUX2Sm5bW0GQR1XS
HT-1197 NYXLZlZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHRSZNKSzVyPUCuN|k1PiEQvF2= NGK0OoxUSU6JRWK=
CGTH-W-1 NFnybnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TVZ2lEPTB;MD6zPVkyOyEQvF2= NHjje3hUSU6JRWK=
KNS-42 MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LVe2lEPTB;MD60NFA1PSEQvF2= M2nGUHNCVkeHUh?=
HuO-3N1 NE\SXY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LhU2lEPTB;MD60NFA2PSEQvF2= NYTsWG1jW0GQR1XS
VMRC-RCZ NXXVdGo1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwNECzNFMh|ryP Mn2wV2FPT0WU
SW954 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorhTWM2OD1yLkSwN|M2KM7:TR?= M1fUO3NCVkeHUh?=
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Ca-Ski MnjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwNEC1NlQh|ryP NUnyUI5EW0GQR1XS
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NCI-H1437 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUD3Z5JwUUN3ME2wMlQxQDB3IN88US=> MX3TRW5ITVJ?
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AU565 M3jUZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzsenhQUUN3ME2wMlQzPDZ6IN88US=> MorPV2FPT0WU
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CAMA-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7KTWM2OD1yLkSzOlI3KM7:TR?= M1T1[3NCVkeHUh?=
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LB831-BLC MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfMVpVIUUN3ME2wMlQ1OzdzIN88US=> MUfTRW5ITVJ?
SW982 M3XiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPkW2p{UUN3ME2wMlQ1PTJ6IN88US=> M1LCZ3NCVkeHUh?=
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C32 MoHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHWTWM2OD1yLkS1NlI6KM7:TR?= M320XHNCVkeHUh?=
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MEG-01 NIjvTYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HUfWlEPTB;MD60OVM4OyEQvF2= NED1PZVUSU6JRWK=
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MPP-89 M1O1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3y1XmlEPTB;MD60OlI2PiEQvF2= MnSzV2FPT0WU
HCC1937 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLVU|NNUUN3ME2wMlQ3Ozh2IN88US=> NVrpOIxGW0GQR1XS
SW837 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzVTWM2OD1yLkS2O|IzKM7:TR?= MXHTRW5ITVJ?
DU-145 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwNE[3Nlkh|ryP MX;TRW5ITVJ?
LB996-RCC MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwNEewOVQh|ryP MVfTRW5ITVJ?
C8166 MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXtO|AyUUN3ME2wMlQ4PCEQvF2= MYHTRW5ITVJ?
MOLT-4 NF\2NI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy2S4tiUUN3ME2wMlQ4PzN2IN88US=> MmLPV2FPT0WU
DMS-53 NITmd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV74V5EyUUN3ME2wMlQ4QDB7IN88US=> M3XDNXNCVkeHUh?=
TE-5 NHK1dINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\XTWM2OD1yLkS4N|A2KM7:TR?= Mo\zV2FPT0WU
KYSE-520 NInYfWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXwUIJKSzVyPUCuOFg{PDNizszN NIfjTZRUSU6JRWK=
Detroit562 NELHelBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3viTWlEPTB;MD60PFg3KM7:TR?= NGnQd4RUSU6JRWK=
SIMA Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzHTWM2OD1yLkS5OFE4KM7:TR?= NXjmTId1W0GQR1XS
NCI-H1651 NHvTNXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHzbZpKSzVyPUCuOFk3PyEQvF2= M3;XS3NCVkeHUh?=
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ABC-1 NVW0VZZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:zTWM2OD1yLkWwOFk3KM7:TR?= NEG3bmdUSU6JRWK=
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OPM-2 M1i0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M322TWlEPTB;MD61NFk{PyEQvF2= MVjTRW5ITVJ?
RPMI-7951 MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\iOoFKSzVyPUCuOVA6PTdizszN NHHCXXRUSU6JRWK=
HT-1080 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPaXppKSzVyPUCuOVEyOTlizszN Mn[1V2FPT0WU
LC4-1 NXrEWop[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnv3TWM2OD1yLkWxOFA{KM7:TR?= NW\ENHNvW0GQR1XS
OVCAR-3 M{TTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUiwfnQ6UUN3ME2wMlUyPTdizszN NIf6WFFUSU6JRWK=
CAPAN-1 NI\HTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzPd3JKSzVyPUCuOVIzQDhizszN NWTBfmNLW0GQR1XS
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HuP-T3 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwNUK4Nlch|ryP NI[2c|BUSU6JRWK=
NCI-H838 MmXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjuflNKSzVyPUCuOVI5PDlizszN NXPmZWtFW0GQR1XS
K5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLUTWM2OD1yLkWzNlAyKM7:TR?= NHzGZ3NUSU6JRWK=
CAL-72 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DFVmlEPTB;MD61N|M5PyEQvF2= M4fTd3NCVkeHUh?=
NH-12 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPPNHJKSzVyPUCuOVM6PTlizszN MU\TRW5ITVJ?
SNB75 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX4RopoUUN3ME2wMlU2PzNizszN NXPzfYJiW0GQR1XS
BPH-1 MnHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEmyRYNKSzVyPUCuOVY{PDRizszN NXLUZmNqW0GQR1XS
NOMO-1 M4ToVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;YR4w3UUN3ME2wMlU3Ozd{IN88US=> NXHINoUxW0GQR1XS
G-402 MnixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTjd4toUUN3ME2wMlU3PDl7IN88US=> NY\UdIdlW0GQR1XS
NCI-H2052 M4DL[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PsVGlEPTB;MD61Olc1OSEQvF2= NIjKeHBUSU6JRWK=
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COR-L279 M3mwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPxRoxKSzVyPUCuOVcyQDVizszN Ml7RV2FPT0WU
A253 M2C0U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PuVGlEPTB;MD61O|UzPSEQvF2= NGLyS|RUSU6JRWK=
SK-MM-2 M1TJXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13UTWlEPTB;MD61O|Y4QSEQvF2= MkL0V2FPT0WU
NCI-H1703 NGi0OI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH1W2NZUUN3ME2wMlU6PDJ5IN88US=> MYDTRW5ITVJ?
UACC-257 M{\MWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNUm0PFch|ryP NYnXZ4t5W0GQR1XS
KALS-1 M{HTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;RXGlEPTB;MD62NFAyOSEQvF2= MU\TRW5ITVJ?
ES5 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwNkC0PEDPxE1? MnvmV2FPT0WU
MHH-CALL-2 NGPXSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfTTWM2OD1yLk[wPFg5KM7:TR?= MX\TRW5ITVJ?
ChaGo-K-1 NWjJW2xuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwNkGyNlkh|ryP Mnz3V2FPT0WU
TGBC1TKB NEXX[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3XPFI3UUN3ME2wMlYyQThizszN NX3hWWw2W0GQR1XS
KU-19-19 M{DsWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfZTWM2OD1yLk[0OVg3KM7:TR?= MonRV2FPT0WU
COLO-684 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfTeHBKSzVyPUCuOlU3OTFizszN MlG4V2FPT0WU
LS-1034 NUHiOYlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnJZmxCUUN3ME2wMlY2QDF7IN88US=> NIHBUnFUSU6JRWK=
RT-112 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHLTWM2OD1yLk[2OVg4KM7:TR?= M{DN[HNCVkeHUh?=
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HSC-4 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq1TWdEUUN3ME2wMlY3Pjl6IN88US=> MkHXV2FPT0WU
COLO-824 NVjUcYJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDCOFRDUUN3ME2wMlY4QDJ|IN88US=> NIK5eGFUSU6JRWK=
NCI-H2170 NFnkSXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoT3TWM2OD1yLk[4NlU5KM7:TR?= NXfvepltW0GQR1XS
GDM-1 NVHhe|VtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;FZWlEPTB;MD62PFQ6PCEQvF2= Mo\EV2FPT0WU
KP-4 NH\L[3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\UW5VKSzVyPUCuOlk2PzNizszN MX3TRW5ITVJ?
VA-ES-BJ MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;3OmlEPTB;MD62PVk5PiEQvF2= NGjz[VFUSU6JRWK=
KM-H2 NGmzTYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH5TWM2OD1yLkewNFkyKM7:TR?= MXHTRW5ITVJ?
HH NXGzOnpET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwN{C2OlIh|ryP NH75bGlUSU6JRWK=
DK-MG M3H0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFGwZopKSzVyPUCuO|ExOTZizszN NViy[GpWW0GQR1XS
VM-CUB-1 M1nJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3iyS2lEPTB;MD63NVI2QSEQvF2= M2DHT3NCVkeHUh?=
COLO-829 M2fvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUW3ZYRoUUN3ME2wMlcyQTh3IN88US=> NF\oXmlUSU6JRWK=
OMC-1 NFL0S4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTFN|hmUUN3ME2wMlczOTB2IN88US=> MnfmV2FPT0WU
NB12 NYjwR2hWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvJTWM2OD1yLkeyOVA1KM7:TR?= MkDuV2FPT0WU
NCI-H28 M3jxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLqTWM2OD1yLke0NFg{KM7:TR?= NEXCVINUSU6JRWK=
A673 MmPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nURmlEPTB;MD63OVE4PyEQvF2= MoSwV2FPT0WU
LB2241-RCC NHK4R3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrJXVJKSzVyPUCuO|YxQDdizszN MoXQV2FPT0WU
CCRF-CEM NHnHfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwN{ewOVIh|ryP MmLEV2FPT0WU
NCI-H510A MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwN{exPFYh|ryP M17DN3NCVkeHUh?=
SW48 NYrNdIZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nzc2lEPTB;MD63O|M{OyEQvF2= MkXKV2FPT0WU
NCI-H2081 NX;CclFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwN{ixOFch|ryP MWfTRW5ITVJ?
RMG-I NUjWeZZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLFU2VKSzVyPUCuO|gzOTJizszN MVnTRW5ITVJ?
LU-99A MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwN{i0NVMh|ryP MmWwV2FPT0WU
KP-N-YS M1Xobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwN{i5NlEh|ryP MXfTRW5ITVJ?
MDA-MB-231 NYDBOGlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwOECxN|Eh|ryP MVrTRW5ITVJ?
U031 M{TIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32wWGlEPTB;MD64NVQzOyEQvF2= MmrZV2FPT0WU
EVSA-T MoHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TkOWlEPTB;MD64NVY4OiEQvF2= NIHsSZpUSU6JRWK=
MDA-MB-157 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnmTWM2OD1yLkiyNlcyKM7:TR?= NVvpPHhuW0GQR1XS
EHEB NGLUZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWG3XGtzUUN3ME2wMlgzOjd4IN88US=> M{TCe3NCVkeHUh?=
KINGS-1 M4rOOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fNbWlEPTB;MD64NlU2PSEQvF2= MXLTRW5ITVJ?
23132-87 Mn\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwOEK4OFMh|ryP NU[0XJR4W0GQR1XS
EFO-21 NYnZXXliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTTR3NKSzVyPUCuPFQxQDlizszN NYLt[otwW0GQR1XS
DOK MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzCb|JOUUN3ME2wMlg1QCEQvF2= NHLjWphUSU6JRWK=
NCI-H2171 Ml30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofaTWM2OD1yLki0PVYh|ryP M4jqVXNCVkeHUh?=
NCI-SNU-5 NFn1WoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTRR4ExUUN3ME2wMlg2PTdizszN M3\PZnNCVkeHUh?=
SK-N-DZ NXfOU4x[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTBwOEW5OFMh|ryP M{nSZnNCVkeHUh?=
SNU-C2B MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPvOIRKSzVyPUCuPFY5ODFizszN MUTTRW5ITVJ?
CP66-MEL MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPzOJBtUUN3ME2wMlg4OTFizszN NHy4eJBUSU6JRWK=
SN12C NW\BZ2V6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjqd29KSzVyPUCuPFg3OzdizszN NI[wXY1USU6JRWK=
A172 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVG3NXVHUUN3ME2wMlg5Pjl6IN88US=> NH7PfHVUSU6JRWK=
NCI-H2347 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn2eXJKSzVyPUCuPFg4PTNizszN NV31SopTW0GQR1XS
NCI-H2228 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETOcGlKSzVyPUCuPFk{OzlizszN NILodJRUSU6JRWK=
SNU-387 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTsUG9KSzVyPUCuPVAzPjRizszN NUjSSlNbW0GQR1XS
SK-MEL-24 MmX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTtTWM2OD1yLkmxN|Q1KM7:TR?= MYLTRW5ITVJ?
MDA-MB-468 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33tXWlEPTB;MD65NVc{KM7:TR?= Mo\sV2FPT0WU
NCI-H1694 NV;iT45wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrJbJJKSzVyPUCuPVE5PzZizszN MX7TRW5ITVJ?
CCF-STTG1 M{fCemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LXXmlEPTB;MD65NlY{PyEQvF2= NVP5XpBpW0GQR1XS
K052 MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwOUSwOFch|ryP M1fxTHNCVkeHUh?=
NCI-H446 NWLSTVJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTp[VZJUUN3ME2wMlk2ODFizszN M{\SUXNCVkeHUh?=
MFE-280 NV\zNYRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PWTmlEPTB;MD65OlI6OSEQvF2= NY\XZo5YW0GQR1XS
KU812 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HGSmlEPTB;MD65PVM5QSEQvF2= NWXCOpZsW0GQR1XS
MDA-MB-361 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXQTWM2OD1yLkm5O|c4KM7:TR?= NISz[JlUSU6JRWK=
Raji NF7mV2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3HeVVYUUN3ME2xMlAzOjZ5IN88US=> Moj1V2FPT0WU
TE-6 M4TwZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTFwMEO1OlYh|ryP MknkV2FPT0WU
CAL-148 M4GybWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXPW3o{UUN3ME2xMlA1PDR|IN88US=> MmPhV2FPT0WU
NCI-H1963 NHHFO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\CTWM2OD1zLkC0OVU{KM7:TR?= MkPXV2FPT0WU
SK-N-AS NF\DUVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFwMES2PFUh|ryP NGDtVmlUSU6JRWK=
RERF-LC-MS M1WyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HkOmlEPTB;MT6wOlM1QSEQvF2= NYjDRXE3W0GQR1XS
BEN MknFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrKU3JKSzVyPUGuNFcyOzdizszN MkXkV2FPT0WU
CAS-1 NEXJe2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILPW2JKSzVyPUGuNFkyOjNizszN M{\HcnNCVkeHUh?=
SW780 M{nOV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPUO482UUN3ME2xMlA6OThzIN88US=> Mk[0V2FPT0WU
LU-65 NIXnZXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV22NI0zUUN3ME2xMlA6PDFizszN MknXV2FPT0WU
D-283MED NFPkPIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrRTWM2OD1zLkGyNlczKM7:TR?= NVLPPZBxW0GQR1XS
HCC2157 MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;yXY1UUUN3ME2xMlE{PjR{IN88US=> NEnwVo1USU6JRWK=
RCC10RGB M{PsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXRTWM2OD1zLkG0NFA3KM7:TR?= Mn34V2FPT0WU
PLC-PRF-5 NViwUYtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\VSlBKSzVyPUGuNVUzOjlizszN NIrWUoNUSU6JRWK=
H4 M1LVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTFwMUW0N|kh|ryP NFq0SWZUSU6JRWK=
TUR NYjIN2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTFwMUW3OVIh|ryP NHPidXpUSU6JRWK=
NCI-H2141 MojDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn2TWM2OD1zLkG4PVQ3KM7:TR?= NYfhdXdmW0GQR1XS
PFSK-1 Moe0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjSS4E5UUN3ME2xMlIxPTN{IN88US=> NFXvSGFUSU6JRWK=
SK-MEL-28 M{XvSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPTR2xpUUN3ME2xMlI{OjJzIN88US=> MlLQV2FPT0WU
SCC-9 NHrRd|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[0O4hoUUN3ME2xMlI{PjZ3IN88US=> M3zJbnNCVkeHUh?=
T47D MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwMkO2PVYh|ryP M4rPU3NCVkeHUh?=
TCCSUP NEjjOFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37TUmlEPTB;MT6yOVAzQSEQvF2= M4nNenNCVkeHUh?=
SU-DHL-1 M1;WOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwMkWxNVgh|ryP MWnTRW5ITVJ?
HL-60 M3mzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTFwMkW1PFgh|ryP MojjV2FPT0WU
NCI-H1436 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfCOnZKSzVyPUGuNlYyPDlizszN MUPTRW5ITVJ?
DMS-114 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTFwMk[2N|Ih|ryP NUL4fZFMW0GQR1XS
BOKU Mo[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDVXllKSzVyPUGuNlgxQTVizszN M{TLO3NCVkeHUh?=
MS-1 Mnz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTVTWM2OD1zLkK5NFY6KM7:TR?= M4n5SHNCVkeHUh?=
NCI-H661 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\HTWVKSzVyPUGuN|A1PzhizszN M4i0ZXNCVkeHUh?=
HT-3 NVLvO|RGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojCTWM2OD1zLkOwOVI6KM7:TR?= MYTTRW5ITVJ?
CAL-54 Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnhTWM2OD1zLkOwO|I2KM7:TR?= NHzTN|JUSU6JRWK=
SW1463 MoTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDaVFlKSzVyPUGuN|E5PzJizszN NVTQ[m4zW0GQR1XS
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ME-180 NIDLcItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrv[VZzUUN3ME2xMlQ1Ozl{IN88US=> Ml\GV2FPT0WU
HCC70 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\lZ|lRUUN3ME2xMlQ3ODl4IN88US=> MmPLV2FPT0WU
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JEG-3 NVXwclBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfEUIs4UUN3ME2xMlUxOTN{IN88US=> MWXTRW5ITVJ?
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EGI-1 NWDCVHdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwNUiwNlUh|ryP MV3TRW5ITVJ?
D-392MG M3OwTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLsTWM2OD1zLkW5OlMh|ryP M2noZnNCVkeHUh?=
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Becker NFnxTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3e5SGlEPTB;MT62OFI1OSEQvF2= NUXWS41VW0GQR1XS
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K-562 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjYTWM2OD1zLk[3NFM4KM7:TR?= MXzTRW5ITVJ?
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NCI-H716 M2Xq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnVTWM2OD1zLk[5N|A1KM7:TR?= NE\WVHRUSU6JRWK=
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HCC1395 NFXhNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PRdWlEPTB;MT65Nlg3OyEQvF2= NV3XPHBUW0GQR1XS
HC-1 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moq1TWM2OD1zLkmzOFch|ryP M2P5d3NCVkeHUh?=
HPAF-II NGi1UlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIH1OXZKSzVyPUGuPVQ1OThizszN NEn2fHNUSU6JRWK=
CPC-N MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjWb2FKSzVyPUGuPVgxODJizszN MkThV2FPT0WU
MKN45 NV;RT4FUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfncll5UUN3ME2xMlk6OTF7IN88US=> M3PKeHNCVkeHUh?=
NCI-H1693 M1XtN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3IbFBSUUN3ME2yMlAxPDN|IN88US=> M1i2fnNCVkeHUh?=
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NCI-H1522 NXq3fXdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTJwMEG3NlQh|ryP M3uz[HNCVkeHUh?=
SW1573 M4TvPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnW0TWM2OD1{LkCyNkDPxE1? MonCV2FPT0WU
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SCC-4 NWr2e|B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwMUSzNUDPxE1? NXHWcXRIW0GQR1XS
DMS-153 NIHHOWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;SRZlKSzVyPUKuNVY3PjhizszN M{L0VHNCVkeHUh?=
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MDA-MB-453 M{C2U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17DPGlEPTB;Mj6yN|MzKM7:TR?= M{PNXHNCVkeHUh?=
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LNCaP-Clone-FGC M1zxOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2W5fWlEPTB;Mj6zNFExOiEQvF2= MlLaV2FPT0WU
NCI-H1581 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1OxZmlEPTB;Mj6zNlExPSEQvF2= M1rK[3NCVkeHUh?=
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LAMA-84 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJwNUezOlgh|ryP MmHOV2FPT0WU
GMS-10 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XCSGlEPTB;Mj61O|YyOSEQvF2= M1q3XXNCVkeHUh?=
GCT MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDOVZJKSzVyPUKuOVg3QTRizszN NHPDV|NUSU6JRWK=
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NCI-H526 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH2V25KSzVyPUKuOlM1PSEQvF2= MkjSV2FPT0WU
SW1088 MkTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\6VoZKUUN3ME2yMlc4QDN7IN88US=> MYHTRW5ITVJ?
HT55 M2DzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PNT2lEPTB;Mj63PFY6PSEQvF2= M17lPXNCVkeHUh?=
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D-263MG NV\aZ3hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3mTWM2OD1|LkG0O|g5KM7:TR?= NXLkR2FJW0GQR1XS
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NCI-H82 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXRPGxpUUN3ME2zMlM1PDN7IN88US=> M{\EZXNCVkeHUh?=
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MHH-NB-11 MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHmzNHNKSzVyPUOuOFQxPjlizszN MmTKV2FPT0WU
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FTC-133 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTSN|BQUUN3ME2zMlY2PDV6IN88US=> NH;ZNG5USU6JRWK=
NCI-H209 NXPZSHBCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;sTWM2OD1|Lk[3OlU{KM7:TR?= NYfZb4VkW0GQR1XS
TGBC24TKB MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGC1bHRKSzVyPUOuOlg{PTVizszN Mn;LV2FPT0WU
LC-1F NEnLNplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTNwN{G3OlQh|ryP M2j4UHNCVkeHUh?=
C-4-II M{PqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrPTWM2OD1|Lke1OlQ{KM7:TR?= MYfTRW5ITVJ?
NCI-H1650 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrUTWM2OD1|Lke4OFU2KM7:TR?= NYiybZc4W0GQR1XS
JVM-2 MmnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;aTWM2OD1|LkmzOlM6KM7:TR?= MVHTRW5ITVJ?
CaR-1 Ml;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGO0SXFKSzVyPUOuPVc3OTdizszN MVfTRW5ITVJ?
MDA-MB-134-VI NHThTYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTRwMEK5OVIh|ryP M2Ll[XNCVkeHUh?=
NCI-H719 M1i4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGi4O3pKSzVyPUSuNVU{QDhizszN MVPTRW5ITVJ?
GOTO MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq5fFNvUUN3ME20MlI6PzB3IN88US=> MVjTRW5ITVJ?
NCI-N87 NFPXVoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLyTWM2OD12LkO4PFIyKM7:TR?= MnSyV2FPT0WU
NB6 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrpTWM2OD12LkSyOVA6KM7:TR?= MVHTRW5ITVJ?
DSH1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7VOpd1UUN3ME20MlQ4OTF4IN88US=> MXTTRW5ITVJ?
BT-20 MkPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjSRmlFUUN3ME20MlQ6ODB{IN88US=> NF;sS|BUSU6JRWK=
NCI-H1882 MkHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHCVIFmUUN3ME20MlUxPTdizszN MmjhV2FPT0WU
WM-115 M162TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTRwNUC4PFEh|ryP NXLndnJ{W0GQR1XS
SKG-IIIa MkGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\MSYcyUUN3ME20MlY4PzdizszN M3TheXNCVkeHUh?=
NCI-H69 M2fVOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XI[WlEPTB;ND63NFI4PSEQvF2= Ml\yV2FPT0WU
MSTO-211H MmrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[1TWM2OD12LkizOVY2KM7:TR?= MVrTRW5ITVJ?
Mewo NFjCV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\pRW9bUUN3ME20Mlk3OzF|IN88US=> M{j2NnNCVkeHUh?=
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COLO-800 NUTJNmh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTVwMUmzOFkh|ryP NHTLcYFUSU6JRWK=
NCI-H1755 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP0fXJKSzVyPUWuNlMxOjdizszN MX;TRW5ITVJ?
KMS-12-PE NHLw[2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHu4WIdKSzVyPUWuN|UxQDVizszN Mm[1V2FPT0WU
HCC1954 M33zPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTDTVlKSzVyPUWuPFU6PzFizszN NWSwcFB[W0GQR1XS
NCI-H187 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTuTWM2OD13LkmyPVg6KM7:TR?= M4jWV3NCVkeHUh?=
LU-165 MnP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTVwOUmwNFIh|ryP M4[zN3NCVkeHUh?=
YAPC NILvd3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnezTWM2OD13Lkm5NFY5KM7:TR?= NWP1SHhpW0GQR1XS
LU-139 MkPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLnN4xKSzVyPU[uNFg{PjhizszN MonVV2FPT0WU
D-502MG M{TFSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLtTWM2OD14LkOyNFQ4KM7:TR?= NVzyfo5oW0GQR1XS
IST-SL1 M4fqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTZwNUO5OFgh|ryP MUnTRW5ITVJ?
DG-75 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X2OGlEPTB;Nj64PFc5PiEQvF2= M{PZOXNCVkeHUh?=
NCI-H1155 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTZwOUW1PFEh|ryP Mln6V2FPT0WU
EFE-184 M{TpUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTQTWM2OD15LkOxOlk2KM7:TR?= M2L4dXNCVkeHUh?=
AsPC-1 NYHlWFQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;HPZZKSzVyPUeuOFg5ODdizszN NYXWdoF[W0GQR1XS
SW948 NVO2O2drT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTdwNUizPVUh|ryP MVTTRW5ITVJ?
NCI-H524 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TXd2lEPTB;OT61PFYzQCEQvF2= NHPsWoZUSU6JRWK=
KOSC-2 NXPmZW55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi5UWt6UUN3ME25MlYzQDN2IN88US=> MlfqV2FPT0WU
T-24 MnW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHQTWM2OD17Lkm0OFE2KM7:TR?= M4TSUHNCVkeHUh?=
NCI-H748 M2fFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP6OphKSzVyPUGwMlY{QTdizszN NYLj[nlTW0GQR1XS
NCI-H23 MnzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTFyLk[0OFIh|ryP NYX4dJRIW0GQR1XS
UACC-812 M4D6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX2PHRKSzVyPUGxMlcyPyEQvF2= NWf6SGtEW0GQR1XS
SCLC-21H NXrHVXM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;YTWM2OD1zMj6xOVUyKM7:TR?= M{nyVXNCVkeHUh?=
NCI-SNU-16 NFr5TFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTXTWM2OD1zMz6xNlU5KM7:TR?= M4n5NnNCVkeHUh?=
HD-MY-Z MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT1TWM2OD1zND62N|Y{KM7:TR?= M4DV[XNCVkeHUh?=
SK-N-FI NGjxU3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTFNFlKSzVyPUG0Mlg6OTJizszN Ml;WV2FPT0WU
LB647-SCLC NXzLbG83T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUGyTItIUUN3ME2xOU44OTl3IN88US=> NHLwUHlUSU6JRWK=
NCI-H345 NGXreGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofTTWM2OD1zNz6zOFMh|ryP M1vsenNCVkeHUh?=
NCI-H1563 NWTueXpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TqWGlEPTB;MUiuO|YxOSEQvF2= MkXIV2FPT0WU
RL MkfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\BSGlEPTB;MkGuNlY2PiEQvF2= NHzhNFNUSU6JRWK=
KY821 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XPemlEPTB;MkKuNFU2OyEQvF2= NVXWcWtkW0GQR1XS
JVM-3 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjtOVAxUUN3ME2yOU4xPDF|IN88US=> MYjTRW5ITVJ?
NCI-H1793 Mn\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{C3bGlEPTB;MkiuOVQ6QSEQvF2= MY\TRW5ITVJ?
LU-134-A Mnn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXsTWM2OD1|MD6yNFM4KM7:TR?= NV7K[ZFZW0GQR1XS
NCI-H1395 MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PmR2lEPTB;M{KuNlQ{OSEQvF2= MXHTRW5ITVJ?
NCI-H1993 MlTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3zTWM2OD1|Mj64NlE5KM7:TR?= MlnNV2FPT0WU
P31-FUJ NWj2NHZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN|LkS4PVkh|ryP MWfTRW5ITVJ?
LS-513 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\lR2JDUUN3ME2zOU45QDd7IN88US=> Ml;qV2FPT0WU
SK-MEL-1 Ml;wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TJWWlEPTB;NECuN|Q6QSEQvF2= NFy5SXhUSU6JRWK=
SW684 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTR|Lkm2OlEh|ryP NVPQdG5CW0GQR1XS
COR-L88 Mn\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnwNVRSUUN3ME20OE4xPjZ3IN88US=> M3T0bnNCVkeHUh?=
NCI-H889 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnUTWM2OD12NT6wNFg4KM7:TR?= M3rMcXNCVkeHUh?=
TALL-1 M3;OO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jKTWlEPTB;NE[uNVE6QSEQvF2= MmfKV2FPT0WU
KARPAS-299 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO4U4tEUUN3ME20O{4yQTl|IN88US=> M3zL[3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2
NCT00724841 Terminated Metastatic Melanoma Gemin X|Teva Pharmaceutical Industries June 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID