Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

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In DMSO USD 190 In stock
USD 170 In stock
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9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell death dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 NWPkN|B1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nKeWlEPTB;MD6wNFAxOzF5IN88US=> NHfxVVJUSU6JRWK=
SK-MEL-30 M{HTUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXyTWM2OD1yLkCwNFM2PSEQvF2= NYHUUnhwW0GQR1XS
NALM-6 NX7YU2NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjudZJWUUN3ME2wMlAxODN3NjFOwG0> NUjaZW9IW0GQR1XS
KYSE-450 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwMECwOFY6KM7:TR?= MkHjV2FPT0WU
BHY NHm2PZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY[1NW9QUUN3ME2wMlAxODZyMTFOwG0> M3jrc3NCVkeHUh?=
GR-ST NWDUdldQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Re5VKSzVyPUCuNFAxPjR6IN88US=> M4D0UnNCVkeHUh?=
786-0 NXTQVWxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMECwO|c3KM7:TR?= M{LrcXNCVkeHUh?=
C-33-A M3LObWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjxOmcyUUN3ME2wMlAxODh2ODFOwG0> NUXGPIQzW0GQR1XS
BHT-101 M4fjeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH6PZpKSzVyPUCuNFAyODZizszN M3njZ3NCVkeHUh?=
EB2 NWHVflRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLyTWM2OD1yLkCwNVE5KM7:TR?= MXzTRW5ITVJ?
G-361 NX\Kd3NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMECxNlQh|ryP M13ZfHNCVkeHUh?=
KE-37 NIDEXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXWUFcxUUN3ME2wMlAxOTJ6IN88US=> NUi1d5FnW0GQR1XS
MHH-PREB-1 M33ofWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPQTWM2OD1yLkCwNVQh|ryP NXHOT4VoW0GQR1XS
MCF7 NV20bXpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi2WGZKSzVyPUCuNFAyPTlizszN MVfTRW5ITVJ?
LOUCY MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET6bYxKSzVyPUCuNFAyPzVizszN MlzKV2FPT0WU
EW-7 NYruSmpIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LoVWlEPTB;MD6wNFE4PSEQvF2= M33zUnNCVkeHUh?=
KYSE-510 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojJTWM2OD1yLkCwNlM{KM7:TR?= MkDkV2FPT0WU
SK-MEL-3 MlT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDHfm9KSzVyPUCuNFAzPjRizszN MnzvV2FPT0WU
HAL-01 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXNNGQyUUN3ME2wMlAxOjl5IN88US=> NEP1PJNUSU6JRWK=
HCC2998 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIj4eGFKSzVyPUCuNFA{OzVizszN NFvJ[HJUSU6JRWK=
A375 NUL3TXhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMECzOUDPxE1? NIH6eJVUSU6JRWK=
MZ7-mel Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXXem5KSzVyPUCuNFA{QTlizszN NWi2THZjW0GQR1XS
SH-4 Mnf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvmepRkUUN3ME2wMlAxPDF5IN88US=> MnTuV2FPT0WU
HT-144 NWrk[XZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHqbotYUUN3ME2wMlAxPDNizszN NXvsWZNOW0GQR1XS
KYSE-140 NXTMdYJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEC0N|Uh|ryP M2fEdXNCVkeHUh?=
PSN1 M3Htemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwMEC0Olch|ryP NVS2[VhxW0GQR1XS
COLO-679 M1nxT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMEC0PVgh|ryP MWDTRW5ITVJ?
SW620 NIH4WXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zKbmlEPTB;MD6wNFUyOSEQvF2= NGX6TWVUSU6JRWK=
HGC-27 M13ZSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TsXGlEPTB;MD6wNFUzPCEQvF2= MlfJV2FPT0WU
IGROV-1 MmTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVroSnZVUUN3ME2wMlAxPiEQvF2= M{HhfHNCVkeHUh?=
IGR-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzYfm9KUUN3ME2wMlAxPjBzIN88US=> MoG3V2FPT0WU
EW-1 NHXTNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jlPGlEPTB;MD6wNFY2OSEQvF2= MnnEV2FPT0WU
769-P M17jTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLtTWM2OD1yLkCwOlc5KM7:TR?= MmT2V2FPT0WU
HN NWDDfmt5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVX5UGFRUUN3ME2wMlAxPjd7IN88US=> MYfTRW5ITVJ?
SIG-M5 M1HGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEC3NUDPxE1? NHfrXZFUSU6JRWK=
IST-MEL1 M{fvU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLKSnZKSzVyPUCuNFA5OThizszN NUDUNXBSW0GQR1XS
ST486 NVfrfYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDvTWM2OD1yLkCwPFI2KM7:TR?= MYjTRW5ITVJ?
ES7 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jxfmlEPTB;MD6wNFg1PiEQvF2= MYnTRW5ITVJ?
GAK NFTmTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEC4OFgh|ryP MlPUV2FPT0WU
BB30-HNC MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnac3NKSzVyPUCuNFA5PThizszN MnrEV2FPT0WU
IPC-298 NHS4cJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEC5Nlch|ryP MnnyV2FPT0WU
NKM-1 MkLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LWWGlEPTB;MD6wNFk4OiEQvF2= NHPoU2VUSU6JRWK=
RKO NH7mfoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTUSYxKSzVyPUCuNFExPDRizszN M1G5VHNCVkeHUh?=
ACN NH22d2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nSdGlEPTB;MD6wNVE{OSEQvF2= MVLTRW5ITVJ?
SW1417 M4f3Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzVUmdKSzVyPUCuNFEzOjVizszN NX3ucpA{W0GQR1XS
SR NH;LNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHkemxKSzVyPUCuNFEzOzVizszN MV7TRW5ITVJ?
SNG-M NHe0WG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q4RWlEPTB;MD6wNVMyPyEQvF2= MXLTRW5ITVJ?
CAL-12T MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPyTWM2OD1yLkCxN|Q3KM7:TR?= NH32S3VUSU6JRWK=
HSC-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Lsb2lEPTB;MD6wNVM2PSEQvF2= M3rlR3NCVkeHUh?=
DOHH-2 NWPSUJF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTuOYFsUUN3ME2wMlAyPDF{IN88US=> Ml7wV2FPT0WU
NB69 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\4TI1KSzVyPUCuNFE2PjVizszN Mn\RV2FPT0WU
LC-2-ad NVz6cGtlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nXOWlEPTB;MD6wNVU5OSEQvF2= NHr4V2NUSU6JRWK=
RVH-421 NIm3cVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfDTWM2OD1yLkCxOlc1KM7:TR?= NHXMSGtUSU6JRWK=
TGW MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm2TWM2OD1yLkCxO|M6KM7:TR?= NHvYUmpUSU6JRWK=
HCC1569 NHK2[FlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7BZlZLUUN3ME2wMlAyPzl5IN88US=> MVfTRW5ITVJ?
CAL-85-1 MlHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfHTWM2OD1yLkCxPFMzKM7:TR?= NWLidXlLW0GQR1XS
RPMI-8402 M1e1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX5TWM2OD1yLkCxPFU5KM7:TR?= MlnJV2FPT0WU
THP-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLETWM2OD1yLkCxPVk5KM7:TR?= MULTRW5ITVJ?
ONS-76 NHHRdmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mki2TWM2OD1yLkCyNFM3KM7:TR?= MkiyV2FPT0WU
A2780 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfob2ZKSzVyPUCuNFIxPzlizszN Mmm3V2FPT0WU
RPMI-2650 NF;p[JNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PjXWlEPTB;MD6wNlI6PiEQvF2= M4TjXnNCVkeHUh?=
MEL-HO NXGxXGZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\kd5pUUUN3ME2wMlAzOzR6IN88US=> NXLaRWdrW0GQR1XS
MC-CAR NIDvcGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDXdZVjUUN3ME2wMlAzOzV4IN88US=> MlPOV2FPT0WU
HSC-2 MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PUemlEPTB;MD6wNlQ3PiEQvF2= M1H4NHNCVkeHUh?=
MEL-JUSO NF7DeYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy4PYRKSzVyPUCuNFI1PzNizszN NGTGRYZUSU6JRWK=
CAL-62 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXWTWM2OD1yLkCyOlAzKM7:TR?= NFnDdY5USU6JRWK=
DMS-273 MlizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTBwMEK4OFch|ryP NXnHV5NGW0GQR1XS
S-117 MlPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMEK5NFYh|ryP NHPYT2lUSU6JRWK=
SUP-T1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nke2lEPTB;MD6wNlk1QSEQvF2= MkfFV2FPT0WU
MZ2-MEL NV:4OXFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEK5OVkh|ryP NH7aNmNUSU6JRWK=
KYSE-270 MnPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMEK5O|Yh|ryP MWLTRW5ITVJ?
CMK NEjLZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37MPGlEPTB;MD6wN|AzOyEQvF2= M2L4dXNCVkeHUh?=
8505C NI[4dXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7BTWM2OD1yLkCzNFQh|ryP M2L5OnNCVkeHUh?=
NUGC-3 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEOwOFgh|ryP NXHh[2RmW0GQR1XS
A101D NXzkdZdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFT3W2ZKSzVyPUCuNFMxPTVizszN NYXNbooyW0GQR1XS
G-401 MoT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX4TWM2OD1yLkCzNFk{KM7:TR?= MYXTRW5ITVJ?
OVCAR-8 NUSwZWU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTBwMEOxNFch|ryP Ml;6V2FPT0WU
IMR-5 M2jM[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLYTYhKSzVyPUCuNFMzPDRizszN MmK0V2FPT0WU
DoTc2-4510 NYG1ZVVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLmeo1{UUN3ME2wMlA{Ozl|IN88US=> M175OHNCVkeHUh?=
HOS NX;tdYpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHCVZhKSzVyPUCuNFM1PzNizszN NUPYbYhOW0GQR1XS
HEC-1 NUP1TJNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUj2N4VoUUN3ME2wMlA{PjhizszN MmTSV2FPT0WU
SW756 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX70VGdRUUN3ME2wMlA{QDJzIN88US=> NFPVSotUSU6JRWK=
NCI-H64 NIK0OGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;4S4lQUUN3ME2wMlA{QDR{IN88US=> MojrV2FPT0WU
EW-16 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEO5NFkh|ryP NVSwdnVqW0GQR1XS
CAL-51 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwMESwNFUh|ryP NG\GeYVUSU6JRWK=
KYSE-150 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XTb2lEPTB;MD6wOFAyOSEQvF2= MX;TRW5ITVJ?
SW1710 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrnWYJKSzVyPUCuNFQxOThizszN MXjTRW5ITVJ?
HuP-T4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PEW2lEPTB;MD6wOFEyQCEQvF2= MoTQV2FPT0WU
LB373-MEL-D MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMESyN|Ih|ryP M2nJ[3NCVkeHUh?=
EW-13 M3:2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Tt[mlEPTB;MD6wOFQxPiEQvF2= MnS0V2FPT0WU
HT-29 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fDc2lEPTB;MD6wOFQ6KM7:TR?= MmPzV2FPT0WU
SCC-25 NHzxW2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKzc5hKSzVyPUCuNFQ1QTRizszN M3zUNnNCVkeHUh?=
REH Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3ThNGlEPTB;MD6wOFY{PSEQvF2= Mm\VV2FPT0WU
L-363 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMES2O|kh|ryP NEDyUlZUSU6JRWK=
NCI-H1770 NYnl[G9jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HUTmlEPTB;MD6wOFY6PyEQvF2= M{nCPXNCVkeHUh?=
CHL-1 NF\2ZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMES4OVch|ryP MojjV2FPT0WU
ES1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4L6UGlEPTB;MD6wOFg5PSEQvF2= NXLWXopnW0GQR1XS
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LS-411N NWLy[GxFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMUSyPVUh|ryP NVrDeHhbW0GQR1XS
NCI-H747 NF:2TYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMUSzJO69VQ>? NWrDTmc5W0GQR1XS
ES6 M{nj[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2f2dGlEPTB;MD6xOFM3KM7:TR?= NFTsU21USU6JRWK=
TE-1 MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zlcmlEPTB;MD6xOFQxPyEQvF2= NXPMOXpTW0GQR1XS
SJSA-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:2R2lEPTB;MD6xOFcxPyEQvF2= NIDZPFZUSU6JRWK=
NCI-H1355 NYjnPY94T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\pSoRsUUN3ME2wMlE2Ojl|IN88US=> M1rSOHNCVkeHUh?=
HEL M2X0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofrTWM2OD1yLkG1OFQ4KM7:TR?= MmPHV2FPT0WU
639-V NX;lVIJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDNWnUzUUN3ME2wMlE2PTl4IN88US=> NY\nNHdxW0GQR1XS
AN3-CA NIHl[oNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT6TWM2OD1yLkG1OlM6KM7:TR?= MlruV2FPT0WU
SK-MEL-2 NXPZRnR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PYPGlEPTB;MD6xOVY3QCEQvF2= NFHY[mFUSU6JRWK=
SW872 M1;IWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlKwTWM2OD1yLkG2NFQzKM7:TR?= MXXTRW5ITVJ?
DU-4475 NGHhZ4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\pd2lEPTB;MD6xOlE3OiEQvF2= Mlr5V2FPT0WU
YKG-1 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMU[yO|Mh|ryP NETNWlVUSU6JRWK=
GT3TKB MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrYc4VqUUN3ME2wMlE3Ojh|IN88US=> NF7mVI5USU6JRWK=
GB-1 M2nNXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LCcGlEPTB;MD6xOlQzPCEQvF2= Mn;PV2FPT0WU
KARPAS-422 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTBwMU[1O|Qh|ryP MWXTRW5ITVJ?
ATN-1 M4\QWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi3V4xKSzVyPUCuNVY3PTZizszN M3;vNHNCVkeHUh?=
HLE MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvXTWM2OD1yLkG2PFc4KM7:TR?= NX7le3hXW0GQR1XS
D-542MG MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\ldldKSzVyPUCuNVY6QDZizszN M13OeHNCVkeHUh?=
EB-3 M4OwOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fqemlEPTB;MD6xO|MyKM7:TR?= M1ywPXNCVkeHUh?=
HCC1143 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnVTWM2OD1yLkG3N|k3KM7:TR?= NFq1UXdUSU6JRWK=
DJM-1 NUjxO5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf1XoJMUUN3ME2wMlE4PDVzIN88US=> NUSxUXlIW0GQR1XS
BT-474 M3;y[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXTTWM2OD1yLkG3OFg6KM7:TR?= MXrTRW5ITVJ?
BB65-RCC NF2ycnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHi4NnRKSzVyPUCuNVc2PDVizszN MX;TRW5ITVJ?
NCI-H292 NEi1U5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfJTWM2OD1yLkG3OlAyKM7:TR?= MV3TRW5ITVJ?
MKN28 M13YfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMUe2OVMh|ryP MX3TRW5ITVJ?
TK10 M3nOeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3iOHY4UUN3ME2wMlE4PzB{IN88US=> M4TROHNCVkeHUh?=
TYK-nu NUK3e5NRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfUTWM2OD1yLkG3PVQ6KM7:TR?= NGK3NnhUSU6JRWK=
8305C MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXUZXJKSzVyPUCuNVc6PzFizszN NEOwbnZUSU6JRWK=
MV-4-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMUe5O|ch|ryP MUTTRW5ITVJ?
NCI-H522 NE\mXVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KxPGlEPTB;MD6xPFA6PCEQvF2= NFTub4VUSU6JRWK=
Hs-578-T NUfic|gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPmd2p6UUN3ME2wMlE5Ojl{IN88US=> NVr2[WRXW0GQR1XS
LCLC-103H NWjzb5Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvKTWM2OD1yLkG4OVI4KM7:TR?= MUPTRW5ITVJ?
MHH-ES-1 M1zFdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfVPJBKSzVyPUCuNVg3OjlizszN M4L5SXNCVkeHUh?=
NCI-H441 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT2UlgxUUN3ME2wMlE6OTR6IN88US=> M4rEOHNCVkeHUh?=
AM-38 M2TpcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMUmyNlUh|ryP MkPsV2FPT0WU
SW1783 NWHQO5NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\RTWM2OD1yLkG5N|A2KM7:TR?= MXfTRW5ITVJ?
SK-HEP-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTRTWM2OD1yLkG5OlM4KM7:TR?= MWPTRW5ITVJ?
OAW-28 MnnpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETvbpVKSzVyPUCuNlAyPzhizszN MWjTRW5ITVJ?
TE-15 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMkCyOVIh|ryP MlfJV2FPT0WU
HCE-4 M{TCTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPnNXdKSzVyPUCuNlAzQDRizszN MnX3V2FPT0WU
JiyoyeP-2003 NIL5cm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1T2NmlEPTB;MD6yNFM{PiEQvF2= MlTkV2FPT0WU
OVCAR-4 NYTjb3FTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwMkC2Nlgh|ryP NIPTS5VUSU6JRWK=
SNU-449 MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMkC3PVch|ryP MoHiV2FPT0WU
SBC-5 NUTiSpRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzrTWM2OD1yLkKxNlE2KM7:TR?= NF22PI9USU6JRWK=
T84 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjqU3hiUUN3ME2wMlIyOjR6IN88US=> MkDJV2FPT0WU
LP-1 Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;ZbGlEPTB;MD6yNVMxOiEQvF2= NUHa[VBZW0GQR1XS
MG-63 NYniWZlET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\KcGNlUUN3ME2wMlIyOzh{IN88US=> Ml\GV2FPT0WU
OAW-42 M2LwOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLhTWM2OD1yLkKxOFc5KM7:TR?= M{H1fXNCVkeHUh?=
L-540 MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMkG1PVgh|ryP NELsZY5USU6JRWK=
RH-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTGTWM2OD1yLkKyNlQzKM7:TR?= MXTTRW5ITVJ?
HCT-15 NY\WVoVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfjeoVxUUN3ME2wMlIzPDh2IN88US=> NYXnVpFVW0GQR1XS
OCUB-M M376Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXS[mdwUUN3ME2wMlIzPDh6IN88US=> M2W3S3NCVkeHUh?=
GP5d NWTX[I5uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO4WIZKSzVyPUCuNlI2OjhizszN M4q0SnNCVkeHUh?=
NCI-H2030 NEPnVIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;tfGlEPTB;MD6yNlc{PCEQvF2= NIPvWWxUSU6JRWK=
ML-2 NV7LNWV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorJTWM2OD1yLkKyPFg6KM7:TR?= MUnTRW5ITVJ?
CAL-39 NE\2OohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\zTWM2OD1yLkKyPVM3KM7:TR?= NFrweFdUSU6JRWK=
MIA-PaCa-2 NIrGNHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMkOyPFch|ryP MXfTRW5ITVJ?
TE-9 NGnUOIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzje|FKSzVyPUCuNlM{OiEQvF2= NH3yO|hUSU6JRWK=
LB2518-MEL MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuy[IhKSzVyPUCuNlM{PzJizszN M1S0SHNCVkeHUh?=
DB MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDMcpZNUUN3ME2wMlI{PDN6IN88US=> MV3TRW5ITVJ?
NCI-H596 NFHWUoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n5bmlEPTB;MD6yN|U4OSEQvF2= MoPJV2FPT0WU
SW1990 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LSWGlEPTB;MD6yN|k1PiEQvF2= M2OzO3NCVkeHUh?=
P30-OHK M2j1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT3[odKSzVyPUCuNlQxPSEQvF2= MX3TRW5ITVJ?
ALL-PO MnPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwMkSxOlkh|ryP NVKySm1tW0GQR1XS
Saos-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXwTWM2OD1yLkK0OVcyKM7:TR?= MoD0V2FPT0WU
MFH-ino NHfsOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SwbGlEPTB;MD6yOFY6OiEQvF2= NVfBPJdFW0GQR1XS
OE33 NUeyPIZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2m4SGlEPTB;MD6yOVEyKM7:TR?= NILQU4RUSU6JRWK=
Calu-3 NFL4[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7rTWM2OD1yLkK1Nlk4KM7:TR?= M3r6OXNCVkeHUh?=
HT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2WweGlEPTB;MD6yOVYzOSEQvF2= MVvTRW5ITVJ?
LXF-289 NIPiOXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LM[GlEPTB;MD6yOVk5PCEQvF2= MWPTRW5ITVJ?
KGN NVO1eZUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMk[wPFkh|ryP MUHTRW5ITVJ?
NCI-H1417 M{fwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnkeIdyUUN3ME2wMlI3PTJ2IN88US=> NUDtRZJIW0GQR1XS
SF126 NVzSWnJPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfTfodKSzVyPUCuNlc{ODJizszN NEHDRlJUSU6JRWK=
SAS M{[0NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rkXmlEPTB;MD6yO|MxQCEQvF2= M4D1W3NCVkeHUh?=
22RV1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;HUJBjUUN3ME2wMlI4Ozd6IN88US=> MW\TRW5ITVJ?
GI-1 NH\kRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofUTWM2OD1yLkK3OFg4KM7:TR?= NW\2R5o2W0GQR1XS
ES3 NEXYN4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTrZXVbUUN3ME2wMlI4PzZ|IN88US=> M3rRbXNCVkeHUh?=
NB1 MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwMke4O|Yh|ryP NYnBXXZ1W0GQR1XS
NCI-H650 NWXqVVRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPtS|U2UUN3ME2wMlI5OzB{IN88US=> NVPpdZBQW0GQR1XS
IST-MES1 M{GyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\QTHJKSzVyPUCuNlg2PTRizszN NXzu[WNpW0GQR1XS
UM-UC-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HhdGlEPTB;MD6yPVE1KM7:TR?= MYPTRW5ITVJ?
CAL-120 NH;LZ|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Xkb2lEPTB;MD6yPVY{OSEQvF2= MXrTRW5ITVJ?
UACC-62 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK4NW1KSzVyPUCuN|AzPDFizszN NGLCbJRUSU6JRWK=
TE-11 NETKb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mom0TWM2OD1yLkOwNlQ6KM7:TR?= NWq4bIN6W0GQR1XS
MKN1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvIT2RyUUN3ME2wMlMxOzZizszN NFPjXo5USU6JRWK=
KS-1 NV7yepZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWe0W5Z[UUN3ME2wMlMxPTJ4IN88US=> M1fZXnNCVkeHUh?=
GCIY MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;sZVhRUUN3ME2wMlMyODB{IN88US=> M3i1WHNCVkeHUh?=
OVCAR-5 NIfYboNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDicXJ6UUN3ME2wMlMyOTB4IN88US=> NHLNOWJUSU6JRWK=
U-266 NVXadnZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nHOWlEPTB;MD6zNVE1PyEQvF2= MVvTRW5ITVJ?
Calu-1 MlXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTBwM{GyPFkh|ryP MWDTRW5ITVJ?
SK-LMS-1 M4jKcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHixR2VKSzVyPUCuN|E1OjlizszN NEL2XldUSU6JRWK=
COLO-741 NXPxO2wyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LX[WlEPTB;MD6zNVYyPCEQvF2= MmLUV2FPT0WU
RPMI-8226 NIHocopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXF[IV5UUN3ME2wMlMyPjRzIN88US=> NF;lSmhUSU6JRWK=
KM12 MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PE[GlEPTB;MD6zNVg{KM7:TR?= NFnZOohUSU6JRWK=
NMC-G1 NIi2[WFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HZN2lEPTB;MD6zNVg3KM7:TR?= NFXZSGNUSU6JRWK=
SJRH30 NV7kVnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfKOms5UUN3ME2wMlMzODV{IN88US=> MmLIV2FPT0WU
COR-L105 M3LkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;sT3FxUUN3ME2wMlMzOjF6IN88US=> M3rYbHNCVkeHUh?=
IM-9 NYSyVWNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwM{OwNlEh|ryP NHy2RmpUSU6JRWK=
TE-12 NH\l[5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[2bWlEPTB;MD6zN|MyPyEQvF2= NXzYc5MxW0GQR1XS
KG-1 Mon3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjFTWM2OD1yLkOzOFMzKM7:TR?= M2TvfHNCVkeHUh?=
U251 MoTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ZTWM2OD1yLkOzOFU3KM7:TR?= NWn4Z2ZMW0GQR1XS
EFO-27 NF7jNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrESVl5UUN3ME2wMlM{QTVzIN88US=> M2PVcXNCVkeHUh?=
EW-24 NUfaRYxXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXQTWM2OD1yLkOzPVg1KM7:TR?= M3HhdHNCVkeHUh?=
SF295 NHHuRoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVOwNmM1UUN3ME2wMlM{QTl7IN88US=> MlG4V2FPT0WU
MC-IXC NWTpSIQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwM{S1JO69VQ>? MVTTRW5ITVJ?
NCI-H2405 MnH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLQTWM2OD1yLkO0O|MzKM7:TR?= M3jqb3NCVkeHUh?=
NCI-H2009 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnnTWM2OD1yLkO0O|M6KM7:TR?= NIrDdlJUSU6JRWK=
LB1047-RCC MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUexNVJGUUN3ME2wMlM2QDF3IN88US=> M{DnOXNCVkeHUh?=
KNS-81-FD NYHEbHJoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwM{[2Olch|ryP M1jVcXNCVkeHUh?=
HOP-92 MkPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHOwSpFKSzVyPUCuN|Y5OyEQvF2= NVzzd3lDW0GQR1XS
L-428 NEXOU4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPj[2xKSzVyPUCuN|cxOTZizszN MWLTRW5ITVJ?
C3A MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;JTWM2OD1yLkO3N|c6KM7:TR?= M1HtO3NCVkeHUh?=
NCI-H1792 NV;rUIdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mly4TWM2OD1yLkO3OlU2KM7:TR?= Mm\vV2FPT0WU
HuH-7 NILnVZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPlcFFKSzVyPUCuN|c6OSEQvF2= M1LITXNCVkeHUh?=
AGS NX3JRWZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XLVWlEPTB;MD6zPFY{QCEQvF2= M4fqcHNCVkeHUh?=
HT-1197 NGO1fGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO5WGRKUUN3ME2wMlM6PDZizszN NGX6VVVUSU6JRWK=
CGTH-W-1 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2npbWlEPTB;MD6zPVkyOyEQvF2= MYPTRW5ITVJ?
KNS-42 NVfzfYszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHFTWM2OD1yLkSwNFQ2KM7:TR?= MmO5V2FPT0WU
HuO-3N1 NXrTXGZ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M325V2lEPTB;MD60NFA2PSEQvF2= MUPTRW5ITVJ?
VMRC-RCZ MlXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXmSFhUUUN3ME2wMlQxOzB|IN88US=> M{TocnNCVkeHUh?=
SW954 Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzB[YJ2UUN3ME2wMlQxOzN3IN88US=> NVvEXmV1W0GQR1XS
MES-SA NIDo[mFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwNEC1NFUh|ryP MX3TRW5ITVJ?
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SW13 NInZbJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwNEC2NlYh|ryP NXe2UGYyW0GQR1XS
NCI-H1437 NUPGdoh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD4b2FtUUN3ME2wMlQxQDB3IN88US=> MluwV2FPT0WU
U-118-MG M{X6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULobolOUUN3ME2wMlQxQTB2IN88US=> NHTJb|hUSU6JRWK=
NCI-H1734 M4HydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLMPWJKSzVyPUCuOFIxOTNizszN MmDQV2FPT0WU
HDLM-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17SfGlEPTB;MD60NlA{OyEQvF2= MX3TRW5ITVJ?
AU565 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDpW29xUUN3ME2wMlQzPDZ6IN88US=> MYPTRW5ITVJ?
FADU NYXLXoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrXSFdKSzVyPUCuOFI3PDlizszN NV\VNGl5W0GQR1XS
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CAMA-1 NFfRXmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO1S4FUUUN3ME2wMlQ{PjJ4IN88US=> NHv2cI5USU6JRWK=
MONO-MAC-6 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvScndKSzVyPUCuOFM5PDlizszN MljQV2FPT0WU
LB831-BLC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Dw[2lEPTB;MD60OFM4OSEQvF2= NIXuS2VUSU6JRWK=
SW982 NIrpSZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwNES1Nlgh|ryP MXLTRW5ITVJ?
SCC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;3PWlEPTB;MD60OFU4QSEQvF2= NYfoV|M2W0GQR1XS
C32 NHz2UoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{K0S2lEPTB;MD60OVIzQSEQvF2= MmD2V2FPT0WU
BFTC-909 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrPTWM2OD1yLkS1Nlk6KM7:TR?= MkT5V2FPT0WU
MEG-01 M3;5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4SyOWlEPTB;MD60OVM4OyEQvF2= M2TBTXNCVkeHUh?=
M14 NI\wPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWW0SIZvUUN3ME2wMlQ2QTd7IN88US=> Mo\VV2FPT0WU
MPP-89 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvoTWM2OD1yLkS2NlU3KM7:TR?= MnKwV2FPT0WU
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SW837 M2n6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjhc3lKSzVyPUCuOFY4OjJizszN MnrpV2FPT0WU
DU-145 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwNE[3Nlkh|ryP M{\1OnNCVkeHUh?=
LB996-RCC M{e2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS4ZWVKSzVyPUCuOFcxPTRizszN NEjNWnRUSU6JRWK=
C8166 MoG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwNEe0JO69VQ>? NX\IS|RZW0GQR1XS
MOLT-4 M4XKRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorPTWM2OD1yLkS3O|M1KM7:TR?= Ml\mV2FPT0WU
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TE-5 NV74Wot5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwNEizNFUh|ryP NF3jeo9USU6JRWK=
KYSE-520 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrRSWJKSzVyPUCuOFg{PDNizszN MV\TRW5ITVJ?
Detroit562 M{XV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfxTndKSzVyPUCuOFg5PiEQvF2= MYTTRW5ITVJ?
SIMA MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzNNG9KSzVyPUCuOFk1OTdizszN NV7FTHZxW0GQR1XS
NCI-H1651 NEntbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwNEm2O{DPxE1? NV7FeW9YW0GQR1XS
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ABC-1 NGLxcFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDrZnFKSzVyPUCuOVA1QTZizszN M2rtfnNCVkeHUh?=
CAL-33 MojzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\KcooxUUN3ME2wMlUxQDR2IN88US=> MmD3V2FPT0WU
OPM-2 Mn70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXuT3lxUUN3ME2wMlUxQTN5IN88US=> M{\OWHNCVkeHUh?=
RPMI-7951 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fwW2lEPTB;MD61NFk2PyEQvF2= MkLVV2FPT0WU
HT-1080 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHiUHZrUUN3ME2wMlUyOTF7IN88US=> MVfTRW5ITVJ?
LC4-1 M{DYdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\ZbWlEPTB;MD61NVQxOyEQvF2= MXLTRW5ITVJ?
OVCAR-3 NILvbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrUTWM2OD1yLkWxOVch|ryP NHTWSIZUSU6JRWK=
CAPAN-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwNUKyPFgh|ryP MlPPV2FPT0WU
SK-OV-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rmd2lEPTB;MD61NlQ{PCEQvF2= NXP4fZB4W0GQR1XS
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NCI-H838 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO1TWM2OD1yLkWyPFQ6KM7:TR?= NHK0W3RUSU6JRWK=
K5 NH;IZ2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC0TWM2OD1yLkWzNlAyKM7:TR?= MVzTRW5ITVJ?
CAL-72 MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mzcmlEPTB;MD61N|M5PyEQvF2= NILJfGpUSU6JRWK=
NH-12 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrZTWM2OD1yLkWzPVU6KM7:TR?= MkXBV2FPT0WU
SNB75 MmfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;repJKSzVyPUCuOVU4OyEQvF2= NIH4[pdUSU6JRWK=
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NOMO-1 NV;QToRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXG3SGhuUUN3ME2wMlU3Ozd{IN88US=> NYX6bXZWW0GQR1XS
G-402 NEPNOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTSUZJ7UUN3ME2wMlU3PDl7IN88US=> NFP1UXJUSU6JRWK=
NCI-H2052 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;j[lhpUUN3ME2wMlU3PzRzIN88US=> NXrQPYJ4W0GQR1XS
RCM-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTrWGFSUUN3ME2wMlU4OTZ4IN88US=> NIj4XXFUSU6JRWK=
COR-L279 NWm5WZQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwNUexPFUh|ryP M{nidnNCVkeHUh?=
A253 NEH6PYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwNUe1NlUh|ryP Mo\uV2FPT0WU
SK-MM-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XZWGlEPTB;MD61O|Y4QSEQvF2= NIqwRlZUSU6JRWK=
NCI-H1703 M3zVVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwNUm0Nlch|ryP MYLTRW5ITVJ?
UACC-257 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{O0c2lEPTB;MD61PVQ5PyEQvF2= Ml3aV2FPT0WU
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MHH-CALL-2 NF\IZnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TOfWlEPTB;MD62NFg5QCEQvF2= MV7TRW5ITVJ?
ChaGo-K-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e1S2lEPTB;MD62NVIzQSEQvF2= M1\3[nNCVkeHUh?=
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COLO-684 M4e4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j4PGlEPTB;MD62OVYyOSEQvF2= NEnYOFdUSU6JRWK=
LS-1034 NGDjN|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNkW4NVkh|ryP M{nQe3NCVkeHUh?=
RT-112 MnnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHuWIpjUUN3ME2wMlY3PTh5IN88US=> MWPTRW5ITVJ?
Capan-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH[3cpNKSzVyPUCuOlY3OjJizszN NF20VVVUSU6JRWK=
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COLO-824 MmrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK2WItKSzVyPUCuOlc5OjNizszN Ml[3V2FPT0WU
NCI-H2170 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vWZ2lEPTB;MD62PFI2QCEQvF2= MlfoV2FPT0WU
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KP-4 MkDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qwU2lEPTB;MD62PVU4OyEQvF2= NFvoO4RUSU6JRWK=
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KM-H2 NXfBXXZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLqXVVXUUN3ME2wMlcxODlzIN88US=> NVTsWFJwW0GQR1XS
HH MlPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnsdpRYUUN3ME2wMlcxPjZ{IN88US=> M4DoPHNCVkeHUh?=
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COLO-829 MofhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHLTWM2OD1yLkexPVg2KM7:TR?= MYHTRW5ITVJ?
OMC-1 NFHlRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XsSWlEPTB;MD63NlExPCEQvF2= MVzTRW5ITVJ?
NB12 NX\3NXd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfsNIw2UUN3ME2wMlczPTB2IN88US=> NFXuNotUSU6JRWK=
NCI-H28 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PJOWlEPTB;MD63OFA5OyEQvF2= NWfqUYpbW0GQR1XS
A673 MnryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfobJYyUUN3ME2wMlc2OTd5IN88US=> NF3XeYpUSU6JRWK=
LB2241-RCC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofiTWM2OD1yLke2NFg4KM7:TR?= NFXObFlUSU6JRWK=
CCRF-CEM NFLPfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIro[|ZKSzVyPUCuO|cxPTJizszN M3LmfHNCVkeHUh?=
NCI-H510A NIfTNIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnUVppHUUN3ME2wMlc4OTh4IN88US=> MULTRW5ITVJ?
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NCI-H2081 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPxVXBxUUN3ME2wMlc5OTR5IN88US=> NHLsO4RUSU6JRWK=
RMG-I MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTnN4V4UUN3ME2wMlc5OjF{IN88US=> MYXTRW5ITVJ?
LU-99A M4L3OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mwVGlEPTB;MD63PFQyOyEQvF2= NEn0PFFUSU6JRWK=
KP-N-YS Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P4dGlEPTB;MD63PFkzOSEQvF2= MX\TRW5ITVJ?
MDA-MB-231 M2TW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwOECxN|Eh|ryP NGm0RVJUSU6JRWK=
U031 NVfLSIFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rR[WlEPTB;MD64NVQzOyEQvF2= NGK2TmFUSU6JRWK=
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MDA-MB-157 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{n4bWlEPTB;MD64NlI4OSEQvF2= M1;FW3NCVkeHUh?=
EHEB NXfrPYlKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PMeGlEPTB;MD64NlI4PiEQvF2= MmPYV2FPT0WU
KINGS-1 M3vW[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLSTWM2OD1yLkiyOVU2KM7:TR?= MVLTRW5ITVJ?
23132-87 NGrndGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwOEK4OFMh|ryP NGjFV|lUSU6JRWK=
EFO-21 NX7pc2NJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkD1TWM2OD1yLki0NFg6KM7:TR?= MWPTRW5ITVJ?
DOK M{XhRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvsTWM2OD1yLki0PEDPxE1? NH;ueWdUSU6JRWK=
NCI-H2171 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLxfXBKSzVyPUCuPFQ6PiEQvF2= M1fFVHNCVkeHUh?=
NCI-SNU-5 M2nCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jNZWlEPTB;MD64OVU4KM7:TR?= Mlm4V2FPT0WU
SK-N-DZ MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXFZWY5UUN3ME2wMlg2QTR|IN88US=> MoC0V2FPT0WU
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SN12C NX;aVoxqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[1b4RPUUN3ME2wMlg5PjN5IN88US=> NWe5N2w3W0GQR1XS
A172 NGP5UllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfkc|ZKSzVyPUCuPFg3QThizszN NIH3NoVUSU6JRWK=
NCI-H2347 NYf4XJE2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\mTWM2OD1yLki4O|U{KM7:TR?= MmLGV2FPT0WU
NCI-H2228 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLwTWM2OD1yLki5N|M6KM7:TR?= NGrUPHVUSU6JRWK=
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MDA-MB-468 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXFNnBKSzVyPUCuPVE4OyEQvF2= M1O2eHNCVkeHUh?=
NCI-H1694 NFHIV3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKTGlKSzVyPUCuPVE5PzZizszN MWDTRW5ITVJ?
CCF-STTG1 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK2NW9KSzVyPUCuPVI3OzdizszN MnzOV2FPT0WU
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MFE-280 MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwOU[yPVEh|ryP NXLDTYhIW0GQR1XS
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MDA-MB-361 NYrCWo5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPaTppNUUN3ME2wMlk6Pzd5IN88US=> M{HTeXNCVkeHUh?=
Raji MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3YbWpKSzVyPUGuNFIzPjdizszN MY\TRW5ITVJ?
TE-6 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrKTVdKSzVyPUGuNFM2PjZizszN NIrVW4xUSU6JRWK=
CAL-148 NYXWNXM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvWOVlKSzVyPUGuNFQ1PDNizszN MlXaV2FPT0WU
NCI-H1963 MoD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHj4UGlKSzVyPUGuNFQ2PTNizszN NX;E[GJbW0GQR1XS
SK-N-AS NHe0cWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjkT41KSzVyPUGuNFQ3QDVizszN NXrkN|BLW0GQR1XS
RERF-LC-MS NI\kemRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTFwME[zOFkh|ryP NXjQd4NPW0GQR1XS
BEN NHTjOlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jrV2lEPTB;MT6wO|E{PyEQvF2= MUnTRW5ITVJ?
CAS-1 M1zp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fndGlEPTB;MT6wPVEzOyEQvF2= NFfX[lRUSU6JRWK=
SW780 NFSwblNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFwMEmxPFEh|ryP NXezR|h{W0GQR1XS
LU-65 M{Wyb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fBSWlEPTB;MT6wPVQyKM7:TR?= MXjTRW5ITVJ?
D-283MED MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rJWGlEPTB;MT6xNlI4OiEQvF2= MoPMV2FPT0WU
HCC2157 NFy0c2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPtdJhTUUN3ME2xMlE{PjR{IN88US=> MVHTRW5ITVJ?
RCC10RGB MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DjdGlEPTB;MT6xOFAxPiEQvF2= Mor1V2FPT0WU
PLC-PRF-5 NEPmR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi1fYZHUUN3ME2xMlE2OjJ7IN88US=> M1Tod3NCVkeHUh?=
H4 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH6NZJKSzVyPUGuNVU1OzlizszN MniyV2FPT0WU
TUR Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrGNGlKSzVyPUGuNVU4PTJizszN NVXW[GduW0GQR1XS
NCI-H2141 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnrNXdKSzVyPUGuNVg6PDZizszN MVTTRW5ITVJ?
PFSK-1 MlfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Moe0TWM2OD1zLkKwOVMzKM7:TR?= NUOyW3J2W0GQR1XS
SK-MEL-28 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrFTWM2OD1zLkKzNlIyKM7:TR?= NF3vXI9USU6JRWK=
SCC-9 M1\PcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ruWWlEPTB;MT6yN|Y3PSEQvF2= MWHTRW5ITVJ?
T47D MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Szd2lEPTB;MT6yN|Y6PiEQvF2= MVvTRW5ITVJ?
TCCSUP M3;GWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGTnUFVKSzVyPUGuNlUxOjlizszN M2\JTHNCVkeHUh?=
SU-DHL-1 NFm1TJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Xz[GlEPTB;MT6yOVEyQCEQvF2= NX;2emY{W0GQR1XS
HL-60 M3fsTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFwMkW1PFgh|ryP NH\kemJUSU6JRWK=
NCI-H1436 NHWxVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\NW|VKSzVyPUGuNlYyPDlizszN M4XoNnNCVkeHUh?=
DMS-114 Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDvdnVKSzVyPUGuNlY3OzJizszN M4PBT3NCVkeHUh?=
BOKU NFvhN25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTFwMkiwPVUh|ryP NUXCdIhrW0GQR1XS
MS-1 NVLTbVBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjDPWZKSzVyPUGuNlkxPjlizszN MYLTRW5ITVJ?
NCI-H661 NXvzXYg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHRTWM2OD1zLkOwOFc5KM7:TR?= NXrzcHlmW0GQR1XS
HT-3 NGTRRppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\vW4VKSzVyPUGuN|A2OjlizszN NWjlWnBHW0GQR1XS
CAL-54 M4rmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTFwM{C3NlUh|ryP M37PTHNCVkeHUh?=
SW1463 NEW2[FNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7hOGpKSzVyPUGuN|E5PzJizszN MnLIV2FPT0WU
COLO-668 M4fLRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfWc|ljUUN3ME2xMlM{ODV4IN88US=> NXHRb2t{W0GQR1XS
PANC-08-13 M4DmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HWN2lEPTB;MT6zN|gxOyEQvF2= M3\MSnNCVkeHUh?=
BB49-HNC MlvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fUWWlEPTB;MT6zOFAyKM7:TR?= NX\rc2pCW0GQR1XS
M059J M3HpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwM{W4N|Ih|ryP NX3qZpdPW0GQR1XS
NCCIT NWTYUFNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPnTWM2OD1zLkO3PVg5KM7:TR?= NHPZdJRUSU6JRWK=
LN-405 NUTrXpJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwM{myOlQh|ryP NXrZ[WVJW0GQR1XS
UMC-11 NWHqWFM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP1TWM2OD1zLkO5PVk3KM7:TR?= NUC1bHBTW0GQR1XS
NB5 NWjMeVRzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrDT2xJUUN3ME2xMlQyOjJ5IN88US=> NVX4VHA6W0GQR1XS
TE-441-T NEfaSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fPVWlEPTB;MT60NlgyPyEQvF2= M4DKOHNCVkeHUh?=
ME-180 M3;4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITSNmNKSzVyPUGuOFQ{QTJizszN NG\UeXZUSU6JRWK=
HCC70 M3[2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorlTWM2OD1zLkS2NFk3KM7:TR?= NEPBbVJUSU6JRWK=
no-10 NV[zUYdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3nTWM2OD1zLkS2NVgyKM7:TR?= NV7WWnJLW0GQR1XS
JEG-3 NXLqS4pPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITlUlVKSzVyPUGuOVAyOzJizszN Mor0V2FPT0WU
no-11 NW[yWGVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkOxTWM2OD1zLkWwPFgzKM7:TR?= MXzTRW5ITVJ?
CHP-126 M2ewUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUf3cJhGUUN3ME2xMlU3PjlzIN88US=> NXXTc2hOW0GQR1XS
EGI-1 MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe1VVRKSzVyPUGuOVgxOjVizszN M3jaRnNCVkeHUh?=
D-392MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwNUm2N{DPxE1? M1nIXHNCVkeHUh?=
RT4 NVu2O5dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTvdHpCUUN3ME2xMlU6PjN5IN88US=> MkTmV2FPT0WU
A204 NUXNZWNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXL1VIpCUUN3ME2xMlU6QDBzIN88US=> MlzuV2FPT0WU
NCI-H1304 M2PlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfFTWM2OD1zLk[zOVkyKM7:TR?= M1PKWXNCVkeHUh?=
Becker NW[3T3NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwNkSyOFEh|ryP MkTEV2FPT0WU
OE19 MkXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX2bYtjUUN3ME2xMlY2PTF6IN88US=> MWTTRW5ITVJ?
EKVX MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O3c2lEPTB;MT62OVYyQCEQvF2= NUPQS5hrW0GQR1XS
KLE NFTncZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTHdlNkUUN3ME2xMlY2PzF2IN88US=> MWfTRW5ITVJ?
K-562 NV3xcJpKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYiw[2VlUUN3ME2xMlY4ODN5IN88US=> MmTKV2FPT0WU
MDA-MB-175-VII NX;RdZVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzTTWM2OD1zLk[4PVk4KM7:TR?= MVzTRW5ITVJ?
NCI-H716 M3mw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTFwNkmzNFQh|ryP NV3QTndoW0GQR1XS
Caov-3 NVvx[HRPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHQb3hKSzVyPUGuOlk1OTNizszN NF7IOnBUSU6JRWK=
HCC1187 NYrMbpRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVj5TGhuUUN3ME2xMlcxPTR3IN88US=> MUjTRW5ITVJ?
CAKI-1 NXPLd3hST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17FVGlEPTB;MT63NlI6OiEQvF2= NIfOUpJUSU6JRWK=
MOLT-16 M{DhWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFwN{OzNFch|ryP NVHZNlh[W0GQR1XS
PC-3 NGjDNXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrud4s5UUN3ME2xMlc2ODhizszN MWDTRW5ITVJ?
DV-90 M2LWd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjkd2xoUUN3ME2xMlc2PTh3IN88US=> NFnOU5dUSU6JRWK=
RXF393 MmjES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFwN{eyPVQh|ryP NVn1U2ZyW0GQR1XS
SK-NEP-1 Mmj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fCfmlEPTB;MT64NlM{QSEQvF2= NYXPVJVQW0GQR1XS
HCC1419 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXMTFlKSzVyPUGuPFI3QTJizszN MWPTRW5ITVJ?
BV-173 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7FTWM2OD1zLkiyPVk2KM7:TR?= NUTSTnBVW0GQR1XS
MKN7 NYjXOYNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX5V5N2UUN3ME2xMlg6OjJizszN MY\TRW5ITVJ?
LAN-6 NIr3N45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33pVWlEPTB;MT64PVU2OyEQvF2= NHr6bG1USU6JRWK=
Mo-T M2fzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XIUWlEPTB;MT65NFA{QSEQvF2= NIK0OFhUSU6JRWK=
HCC1395 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPmTWM2OD1zLkmyPFY{KM7:TR?= NWHnT3VmW0GQR1XS
HC-1 NFvjeINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjpTG1KSzVyPUGuPVM1PyEQvF2= NYiwWW5CW0GQR1XS
HPAF-II MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW5W3lKSzVyPUGuPVQ1OThizszN MoTXV2FPT0WU
CPC-N Ml;nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojxTWM2OD1zLkm4NFAzKM7:TR?= NWT1NWM{W0GQR1XS
MKN45 MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DvR2lEPTB;MT65PVEyQSEQvF2= MkXPV2FPT0WU
NCI-H1693 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLHb2dRUUN3ME2yMlAxPDN|IN88US=> MWXTRW5ITVJ?
SHP-77 NIHQO4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwMEC1N|Mh|ryP MWnTRW5ITVJ?
NCI-H1522 NGXzTXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\1[WlEPTB;Mj6wNVczPCEQvF2= M{LveHNCVkeHUh?=
SW1573 M3jXWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFz5VVBKSzVyPUKuNFIzKM7:TR?= NFL4THBUSU6JRWK=
DBTRG-05MG MoLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm0W4tKSzVyPUKuNFYxQDdizszN M4D4dXNCVkeHUh?=
SCC-4 M2\aSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XLRWlEPTB;Mj6xOFMyKM7:TR?= MULTRW5ITVJ?
DMS-153 M3\V[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHtd2ExUUN3ME2yMlE3PjZ6IN88US=> NWfNWJJPW0GQR1XS
MDA-MB-415 NIXvZXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnXSnRKSzVyPUKuNVc2OiEQvF2= MlTYV2FPT0WU
NCI-H2126 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwMkK4PFgh|ryP NIDwSWlUSU6JRWK=
MDA-MB-453 MkH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPpe2xTUUN3ME2yMlI{OzJizszN NH;yS|hUSU6JRWK=
U-87-MG NGHmTWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Luc2lEPTB;Mj6yPFU6OiEQvF2= MlXxV2FPT0WU
LNCaP-Clone-FGC NGrPb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTJwM{CxNFIh|ryP NVjQ[FU1W0GQR1XS
NCI-H1581 M1vaWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfMWmlKSzVyPUKuN|IyODVizszN NHL3VFBUSU6JRWK=
BC-3 M3X6WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[zSWtKSzVyPUKuN|Y2ODlizszN MknOV2FPT0WU
HCC38 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJwM{i0OFch|ryP MVHTRW5ITVJ?
HCC2218 NULQc3dGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTJwNEC4NFkh|ryP NXTtWGVEW0GQR1XS
RO82-W-1 NYf3TY03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\S[WlEPTB;Mj60NVI2KM7:TR?= NFS0S2hUSU6JRWK=
C2BBe1 M4LNemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwNEG1O|gh|ryP MoS0V2FPT0WU
LAMA-84 NWe2c24zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3:2NWlEPTB;Mj61O|M3QCEQvF2= NIjFbGpUSU6JRWK=
GMS-10 NGX6[W9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTnbZB2UUN3ME2yMlU4PjFzIN88US=> M1exUHNCVkeHUh?=
GCT NFLkZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fnXGlEPTB;Mj61PFY6PCEQvF2= MULTRW5ITVJ?
SK-CO-1 M2TOO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:5epJPUUN3ME2yMlYyPjZizszN MV;TRW5ITVJ?
NCI-H526 NX[2PY4zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;OOYxYUUN3ME2yMlY{PDVizszN MmS5V2FPT0WU
SW1088 M1TCNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJwN{e4N|kh|ryP NWDhVIo{W0GQR1XS
HT55 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HVV2lEPTB;Mj63PFY6PSEQvF2= M3nh[HNCVkeHUh?=
NB10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jx[GlEPTB;Mj64NVc1QCEQvF2= Mn7kV2FPT0WU
UACC-893 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTnTWM2OD1{Lki1O|Q6KM7:TR?= M1rVWHNCVkeHUh?=
NCI-H1618 NGTX[ZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO4N5BKSzVyPUKuPFgyPTNizszN NVTENpQ{W0GQR1XS
NCI-H1092 M1\Qc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPJVZhKSzVyPUOuNFc5OTJizszN M4\WbHNCVkeHUh?=
SBC-1 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfoXoZIUUN3ME2zMlA5PTV|IN88US=> MkDiV2FPT0WU
NCI-H1623 NVzCT2NHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTNwMEmzOEDPxE1? NHnNSlRUSU6JRWK=
SiHa NILOfWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LhSmlEPTB;Mz6xNVk4PyEQvF2= NUf3XI9KW0GQR1XS
D-263MG NIradVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNwMUS3PFgh|ryP NIjMSm9USU6JRWK=
NCI-H1573 M3HtRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTxTWM2OD1|LkG5OlQyKM7:TR?= NVXiV|dHW0GQR1XS
NCI-H82 M3uxRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK5fJhpUUN3ME2zMlM1PDN7IN88US=> M{TuTXNCVkeHUh?=
NCI-H2196 NHTyemVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4eySGlEPTB;Mz6zOVAxQCEQvF2= NU\ob2lDW0GQR1XS
MFM-223 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoO2TWM2OD1|LkO3N|UyKM7:TR?= NI\D[mpUSU6JRWK=
COLO-678 NETvfVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDtdGwyUUN3ME2zMlM5OTh4IN88US=> M1;zXHNCVkeHUh?=
EW-3 M3nkfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[2[2RkUUN3ME2zMlQxQTVizszN NFPBO2JUSU6JRWK=
MHH-NB-11 NHXOS5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\IPGlEPTB;Mz60OFA3QSEQvF2= NUHuR29LW0GQR1XS
EM-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfT[HpKSzVyPUOuOlM6QCEQvF2= MVHTRW5ITVJ?
FTC-133 NWm0UoRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\CTWM2OD1|Lk[1OFU5KM7:TR?= MkPNV2FPT0WU
NCI-H209 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;FSo1KSzVyPUOuOlc3PTNizszN M1;u[HNCVkeHUh?=
TGBC24TKB MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LMU2lEPTB;Mz62PFM2PSEQvF2= M{TYRXNCVkeHUh?=
LC-1F M2fOWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\LTWM2OD1|LkexO|Y1KM7:TR?= M2PQc3NCVkeHUh?=
C-4-II NGmzOJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq1SYVqUUN3ME2zMlc2PjR|IN88US=> NUnr[ZZQW0GQR1XS
NCI-H1650 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnMO41vUUN3ME2zMlc5PDV3IN88US=> NIDSOnJUSU6JRWK=
JVM-2 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTNwOUO2N|kh|ryP NUXTRmduW0GQR1XS
CaR-1 MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTNwOUe2NVch|ryP MkLkV2FPT0WU
MDA-MB-134-VI MlLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT3TWM2OD12LkCyPVUzKM7:TR?= M3ryTnNCVkeHUh?=
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BT-20 NYjlVnRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq2elV3UUN3ME20MlQ6ODB{IN88US=> NILlNWpUSU6JRWK=
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WM-115 NEDmSJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\iTWM2OD12LkWwPFgyKM7:TR?= M4L1OXNCVkeHUh?=
SKG-IIIa MmTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXKO45KSzVyPUSuOlc4PyEQvF2= MVzTRW5ITVJ?
NCI-H69 M2PCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LjXGlEPTB;ND63NFI4PSEQvF2= NXzROpp7W0GQR1XS
MSTO-211H M2\FTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7COYNrUUN3ME20Mlg{PTZ3IN88US=> NVn6SHZ{W0GQR1XS
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COLO-800 NX65[WtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTaUVNKSzVyPUWuNVk{PDlizszN M3HzR3NCVkeHUh?=
NCI-H1755 NGTCdYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon4TWM2OD13LkKzNFI4KM7:TR?= M3X1cnNCVkeHUh?=
KMS-12-PE NWPoTG9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjGZZk6UUN3ME21MlM2ODh3IN88US=> NWP6Xo5LW0GQR1XS
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D-502MG MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUO5dIhVUUN3ME22MlMzODR5IN88US=> NYPic45xW0GQR1XS
IST-SL1 M{TmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfMTWM2OD14LkWzPVQ5KM7:TR?= M4\jcnNCVkeHUh?=
DG-75 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\uO5ZXUUN3ME22Mlg5Pzh4IN88US=> NUPrVFVYW0GQR1XS
NCI-H1155 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTZwOUW1PFEh|ryP MUDTRW5ITVJ?
EFE-184 MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nvT2lEPTB;Nz6zNVY6PSEQvF2= MWXTRW5ITVJ?
AsPC-1 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTJTJNQUUN3ME23MlQ5QDB5IN88US=> NWf3[GNkW0GQR1XS
SW948 NUPNTHllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfnfZJTUUN3ME23MlU5Ozl3IN88US=> NH;NdYtUSU6JRWK=
NCI-H524 NYHSV|lFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HZT2lEPTB;OT61PFYzQCEQvF2= Mme0V2FPT0WU
KOSC-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P3SWlEPTB;OT62Nlg{PCEQvF2= M4jxPHNCVkeHUh?=
T-24 M4L4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfqZm5KSzVyPUmuPVQ1OTVizszN M{HVdHNCVkeHUh?=
NCI-H748 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELuSpVKSzVyPUGwMlY{QTdizszN NEL5cllUSU6JRWK=
NCI-H23 M{DUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DzemlEPTB;MUCuOlQ1OiEQvF2= M4r6dnNCVkeHUh?=
UACC-812 NHTw[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjr[Ws3UUN3ME2xNU44OTdizszN NX\Me3QzW0GQR1XS
SCLC-21H NGfsdXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LOZWlEPTB;MUKuNVU2OSEQvF2= NIf4OmJUSU6JRWK=
NCI-SNU-16 NFnN[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GyNWlEPTB;MUOuNVI2QCEQvF2= MmjJV2FPT0WU
HD-MY-Z M4jDOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe3fmJrUUN3ME2xOE43OzZ|IN88US=> NETTOGdUSU6JRWK=
SK-N-FI NILTfnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK1TWM2OD1zND64PVEzKM7:TR?= NXfQTpJNW0GQR1XS
LB647-SCLC MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\EdlNKSzVyPUG1MlcyQTVizszN M3ezPXNCVkeHUh?=
NCI-H345 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjFdpUzUUN3ME2xO{4{PDNizszN Ml;EV2FPT0WU
NCI-H1563 MluyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHjTWM2OD1zOD63OlAyKM7:TR?= NXLoTpE4W0GQR1XS
RL NEDPSWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOxWJVKSzVyPUKxMlI3PTZizszN M1nVfHNCVkeHUh?=
KY821 NGHzTXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LGWmlEPTB;MkKuNFU2OyEQvF2= MmLJV2FPT0WU
JVM-3 MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJ3LkC0NVMh|ryP NY\rWHNSW0GQR1XS
NCI-H1793 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTUTWM2OD1{OD61OFk6KM7:TR?= NHXLb5dUSU6JRWK=
LU-134-A M3TLTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojGTWM2OD1|MD6yNFM4KM7:TR?= NFKxWIRUSU6JRWK=
NCI-H1395 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTDTWM2OD1|Mj6yOFMyKM7:TR?= M3juSHNCVkeHUh?=
NCI-H1993 NEjSV5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL0[FE2UUN3ME2zNk45OjF6IN88US=> MXLTRW5ITVJ?
P31-FUJ M2SzPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrqXHNKSzVyPUOzMlQ5QTlizszN MW\TRW5ITVJ?
LS-513 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTN3Lki4O|kh|ryP NF;2SmFUSU6JRWK=
SK-MEL-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTRyLkO0PVkh|ryP MV;TRW5ITVJ?
SW684 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf0UWVGUUN3ME20N{46PjZzIN88US=> MWrTRW5ITVJ?
COR-L88 NFLqVXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\WTWM2OD12ND6wOlY2KM7:TR?= NF\ZT|BUSU6JRWK=
NCI-H889 M1:xdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTsc4lGUUN3ME20OU4xODh5IN88US=> NUHtbZkzW0GQR1XS
TALL-1 MlfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTR4LkGxPVkh|ryP M3e0WHNCVkeHUh?=
KARPAS-299 MoTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPMfVJ{UUN3ME20O{4yQTl|IN88US=> NWfz[5c{W0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay:[1]
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research:[2]
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2
NCT00724841 Terminated Metastatic Melanoma Gemin X|Teva Pharmaceutical Industries June 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID