Obatoclax Mesylate (GX15-070)

Catalog No.S1057

Obatoclax Mesylate (GX15-070) Chemical Structure

Molecular Weight(MW): 413.49

Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.

Size Price Stock Quantity  
In DMSO USD 190 In stock
USD 170 In stock
USD 320 In stock
USD 870 In stock

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9 Customer Reviews

  • In vivo antitumor efficacies of AZD2281 and GX15-070 alone or in combination in a BxPC-3 xenograft model. Tumor specimens were fixed in 10% formalin, embedded in paraffin, and cut into 4 lm-thick slides for H&E, PCNA, and CD34 staining.

    Cancer Lett 2014 348, 20-8. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Gx15-070 induces autophagy and necroptosis in TET cells. Time-course electron microscopic morphology of T1682 cells treated with Gx15-070 at the indicated concentrations. After 1-h treatment, lamellar bodies (yellow arrow) consistent with early signs of autophagy and mitochondrial structural changes with loss of cristae (orange arrow) were evident. After 6-h treatment, early signs of necroptosis with intact nuclear envelope (top panel), and mitochondrial swelling with loss of mitochondrial matrix and cytoplasm vacuolization were observed (bottom panel). After 48-h treatment, late stages of necroptotic cell death (yellow arrow) and advanced stages of autophagy (orange arrow) were evident. The bottom panel depicts advanced stage of autophagic cell death with cytoplasmic vacuolization and lamellar bound structures consistent with autophagosomes.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • ffect of Gx15-070 of mTOR pathway and on AMPKα. Effect of 6h Gx15-070 treatment on T1682 cells compared with untreated cells and cells starved for 6 h. The treatment induced a progressive reduction of p-AKT (Ser473 and Thr308) and p-RPS6 with the exception of 500 nM concentration. Progressive increase of LC3B-II and AMPKα phosphorylation was observed in Gx15-070 concentration-dependent manner.

    Cell Death Dis 2012 19, 3:e351. Obatoclax Mesylate (GX15-070) purchased from Selleck.

     

    Upregulation of A1 is crucial for resistance to ABT-737. The role of different anti-apoptotic Bcl-2 factors in determining resistance to ABT-737 was investigated, comparing the pro-apoptotic effect of ABT-737, antimycin A and obatoclax on activated (filled circles) and non-activated (open circles) BM3.3 CD8 T cells. T-cell activation induced resistance to ABT-737 and to antimycin A, but not to obatoclax, demonstrating a crucial role of A1 in this phenomenon. Percentage of cells treated with DMSO-containing vehicle is given. Half maximal inhibitory concentration (IC50) and 95% confidence interval (95% CI) are reported in the table.

    Cell death dis 2012 3, e299. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • HUH6 cells (C-H) were incubated with and without 10 ng/ml TNF-α and obatoclax at 0.1, 0.3 uM. Fewer mitochondria with an intact membrane potential were observed in JC-1 staining when obatoclax and TNF-α were added to the culture. Reddish points indicate the aggregation of JC-1 in intact mitochondria, and missing of reddish points indicate the start of apoptosis.

    Exp Cell Res 2014 322, 217-25. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    Cell proliferation assays were carried out in SET-2 cells treated with increasing concentrations of NVP-BSK805 (empty triangles/solid line), obatoclax (filled squares/dotted line) or NVP-BSK805 in combination with a fixed obatoclax concentration of 700 nM (filled triangles/stippled line) for 72 hours.

     

     

    BMC Cancer 2011 11, 24. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • MEF cells were treated for  24 hours with the Bcl-2 antagonists  Obatoclax Mesylate at the indicated doses.Acute survival was monitored by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).

     

     

    Dr. Christine Hawkins of La Trobe University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

    MDB-MA-231 cells were exposed to 30 μM cisplatin in the absence or in thepresence of 1 μM Obatoclax Mesylate .The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

     

     

    Dr. Zhang of Tianjin Medical University. Obatoclax Mesylate (GX15-070) purchased from Selleck.

  • Obataclax triggers cell death similarly in parental and ABT-737-resistant cells. Parental and ABT-R cells were treated with obataclax (Nalm-6 and Nalm-6 ABT-R: 10 uM; Reh and Reh ABT-R: 5 uM) for 18 h. (A) Cell viability was determined by trypan blue exclusion assay. (B) Mcl-1, NOXA, Bim, and b-actin as a loading control were analyzed by immunoblot. 

    Obatoclax Mesylate (GX15-070) purchased from Selleck.

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Obatoclax Mesylate (GX15-070) is an antagonist of Bcl-2 with Ki of 0.22 μM in a cell-free assay, can assist in overcoming MCL-1 mediated resistance to apoptosis. Phase 3.
Features Potential 1st-in-class small molecule antagonist of Bcl-2 designed to inhibit all relevant Bcl-2 family members, including Mcl-1.
Targets
Bcl-2 [1]
(Cell-free assay)
0.22 μM(Ki)
In vitro

Obatoclax completely inhibits Bak recovery of Mcl-1 at 5 μM in SK-Mel5 cells and overcomes resistance to ABT-373-induced apoptosis conferred by Mcl-1 in KB/Bcl-2 cells. [1] Obatoclax is a BH3 mimetic which binds to a broad spectrum of Bcl-2 family members, including Bcl-2, Bcl-xL, and Mcl-1. Obatoclax uniquely displaces BH3 domains by activation of the pocket of Mcl-1 followed by a triggering of apoptosis mediated by oligomerization of Bak and release of cytochrome c. Obatoclax is sensitive to Bcl-xL in cell lines lacking it or showing low expression. It shows low cytotoxicity to Mcl-1, Bcl-2, and Bcl-xL in all the strongly-expressed cell lines. Obatoclax inhibits multiple myeloma (MM) cell lines (KMS12PE, KMS18, MY5, etc.) with IC50 values ranging from 52 to 1100 nM and the inhibition is umimpaired even in the presence of IL-6 or IGF-1, which are resistance to cytotoxic agents, at a concentration of 150 nM. Obatoclax enhances the antimyeloma activity induced by melphalan, dexamethasone, or bortezomib. [2] Obatoclax potentiates TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-mediated apoptosis by unsequestering Bak and Bim from Bcl-2/Bcl-xL or Mcl-1 proteins in PANC-1 and BxPC-3 cells. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KARPAS-45 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP0UVFrUUN3ME2wMlAxODB|MUeg{txO MkP6V2FPT0WU
SK-MEL-30 NV2wT25OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwMECwN|U2KM7:TR?= MnPnV2FPT0WU
NALM-6 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7BfJo4UUN3ME2wMlAxODN3NjFOwG0> M3vKeHNCVkeHUh?=
KYSE-450 NYXJ[Wl5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37LbWlEPTB;MD6wNFA1PjlizszN MkW3V2FPT0WU
BHY M1nWPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMECwOlAyKM7:TR?= MnrtV2FPT0WU
GR-ST NFvKdVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMECwOlQ5KM7:TR?= NX\KR2hOW0GQR1XS
786-0 NIfG[JdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jsOmlEPTB;MD6wNFA4PzZizszN MVTTRW5ITVJ?
C-33-A M{X2Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFKyNYpKSzVyPUCuNFAxQDR6IN88US=> NWDRXG5TW0GQR1XS
BHT-101 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrVdINKSzVyPUCuNFAyODZizszN M4PTcnNCVkeHUh?=
EB2 NXLUN5hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMECxNVgh|ryP MWLTRW5ITVJ?
G-361 NIPmXopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjxTWM2OD1yLkCwNVI1KM7:TR?= MmTjV2FPT0WU
KE-37 NVq3O3Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\HbZJrUUN3ME2wMlAxOTJ6IN88US=> M3PXU3NCVkeHUh?=
MHH-PREB-1 NVnmOFJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMECxOEDPxE1? MYrTRW5ITVJ?
MCF7 M2j0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXxUWxKSzVyPUCuNFAyPTlizszN MVHTRW5ITVJ?
LOUCY NEDSZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rOPGlEPTB;MD6wNFE4PSEQvF2= NITN[nlUSU6JRWK=
EW-7 NHLB[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICwdm5KSzVyPUCuNFAyPzVizszN NFzOcFZUSU6JRWK=
KYSE-510 M3Lwbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\aTWM2OD1yLkCwNlM{KM7:TR?= NXXYfHhoW0GQR1XS
SK-MEL-3 NV\3OIxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorvTWM2OD1yLkCwNlY1KM7:TR?= NIHqW5lUSU6JRWK=
HAL-01 NHzlZldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDVbXJKSzVyPUCuNFAzQTdizszN M4X6d3NCVkeHUh?=
HCC2998 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPmTWM2OD1yLkCwN|M2KM7:TR?= NWrFSWZLW0GQR1XS
A375 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMECzOUDPxE1? MVrTRW5ITVJ?
MZ7-mel NYP5bmpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\BZ2tKSzVyPUCuNFA{QTlizszN M4LubHNCVkeHUh?=
SH-4 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjCfnNKSzVyPUCuNFA1OTdizszN MmfLV2FPT0WU
HT-144 MnLPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMEC0N{DPxE1? MmTNV2FPT0WU
KYSE-140 M4\ISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWf3OnY{UUN3ME2wMlAxPDN3IN88US=> M2XHUHNCVkeHUh?=
PSN1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;yTWM2OD1yLkCwOFY4KM7:TR?= NEjlPVNUSU6JRWK=
COLO-679 NWPT[GVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXBb2M1UUN3ME2wMlAxPDl6IN88US=> MVvTRW5ITVJ?
SW620 NEnuVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7T[JhwUUN3ME2wMlAxPTFzIN88US=> MYPTRW5ITVJ?
HGC-27 NYXtNWJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4np[2lEPTB;MD6wNFUzPCEQvF2= MXTTRW5ITVJ?
IGROV-1 NILGWpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[yU2lEPTB;MD6wNFYh|ryP MkLBV2FPT0WU
IGR-1 NYizWXpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\6eFZiUUN3ME2wMlAxPjBzIN88US=> NEDB[W1USU6JRWK=
EW-1 NVixboFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPVTWM2OD1yLkCwOlUyKM7:TR?= NUDrZnBCW0GQR1XS
769-P NE\3RW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPFfmNKSzVyPUCuNFA3PzhizszN NEfXW3pUSU6JRWK=
HN NX\Rd2M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7BTWM2OD1yLkCwOlc6KM7:TR?= MlPjV2FPT0WU
SIG-M5 NX7QZmdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:zTmlEPTB;MD6wNFcyKM7:TR?= MmTiV2FPT0WU
IST-MEL1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwMEC4NVgh|ryP NX\1SmtHW0GQR1XS
ST486 MmnaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P6VmlEPTB;MD6wNFgzPSEQvF2= NVPoUI02W0GQR1XS
ES7 NHSxOnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33PbGlEPTB;MD6wNFg1PiEQvF2= M1vJcnNCVkeHUh?=
GAK NELRS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonXTWM2OD1yLkCwPFQ5KM7:TR?= NID5S5FUSU6JRWK=
BB30-HNC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7hTWM2OD1yLkCwPFU5KM7:TR?= NGHoZWtUSU6JRWK=
IPC-298 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv0boFiUUN3ME2wMlAxQTJ5IN88US=> M{PJOHNCVkeHUh?=
NKM-1 NHr4WmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGWxZnJKSzVyPUCuNFA6PzJizszN NXX5THh[W0GQR1XS
RKO NHLhVXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEGwOFQh|ryP MXnTRW5ITVJ?
ACN NFKwbG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjqSGp5UUN3ME2wMlAyOTNzIN88US=> MVHTRW5ITVJ?
SW1417 NYX3TldvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\vdXpKSzVyPUCuNFEzOjVizszN NYPW[mhPW0GQR1XS
SR NX;TN|I1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEGyN|Uh|ryP MX7TRW5ITVJ?
SNG-M NXfk[XpuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEGzNVch|ryP MkPFV2FPT0WU
CAL-12T NVjsZZdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P0e2lEPTB;MD6wNVM1PiEQvF2= NFnYPIVUSU6JRWK=
HSC-3 M3XtSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHwUlVxUUN3ME2wMlAyOzV3IN88US=> M3XqdXNCVkeHUh?=
DOHH-2 NULZeFJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrLTWM2OD1yLkCxOFEzKM7:TR?= MorYV2FPT0WU
NB69 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMEG1OlUh|ryP M1;rc3NCVkeHUh?=
LC-2-ad NX;HeIlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfvVIs2UUN3ME2wMlAyPThzIN88US=> Mn;0V2FPT0WU
RVH-421 NWr4c|F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\DTWM2OD1yLkCxOlc1KM7:TR?= NFTp[IpUSU6JRWK=
TGW NHTiTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXHTWM2OD1yLkCxO|M6KM7:TR?= MUHTRW5ITVJ?
HCC1569 MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMEG3PVch|ryP MXPTRW5ITVJ?
CAL-85-1 M32xV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X4RWlEPTB;MD6wNVg{OiEQvF2= M1\scXNCVkeHUh?=
RPMI-8402 NV\kXWt1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMEG4OVgh|ryP MoKwV2FPT0WU
THP-1 NXG4[2ZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDGfJg6UUN3ME2wMlAyQTl6IN88US=> MX;TRW5ITVJ?
ONS-76 NEfaWWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrK[4NKSzVyPUCuNFIxOzZizszN MlLxV2FPT0WU
A2780 NFPCPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEKwO|kh|ryP Mo[zV2FPT0WU
RPMI-2650 NUS0O|ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX0TpBDUUN3ME2wMlAzOjl4IN88US=> M2P2bnNCVkeHUh?=
MEL-HO MnHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPuTWM2OD1yLkCyN|Q5KM7:TR?= MULTRW5ITVJ?
MC-CAR MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEKzOVYh|ryP NEezS4VUSU6JRWK=
HSC-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWeySoI5UUN3ME2wMlAzPDZ4IN88US=> M{HTV3NCVkeHUh?=
MEL-JUSO NGq1RlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj1VlZKSzVyPUCuNFI1PzNizszN NXLrVoJtW0GQR1XS
CAL-62 MoT4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHznZ21KSzVyPUCuNFI3ODJizszN MVzTRW5ITVJ?
DMS-273 MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPXRXZwUUN3ME2wMlAzQDR5IN88US=> NXLxOm5zW0GQR1XS
S-117 Ml7lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXyV2xDUUN3ME2wMlAzQTB4IN88US=> NVnNfIZ7W0GQR1XS
SUP-T1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILKV2NKSzVyPUCuNFI6PDlizszN MWHTRW5ITVJ?
MZ2-MEL M1vmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT3b2Y3UUN3ME2wMlAzQTV7IN88US=> M3vtfHNCVkeHUh?=
KYSE-270 M4TqSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEK5O|Yh|ryP NV;aPJZ2W0GQR1XS
CMK M2fLemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\4eXNKSzVyPUCuNFMxOjNizszN M2LJfXNCVkeHUh?=
8505C NE\XeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf1bmhzUUN3ME2wMlA{ODRizszN M{nGZnNCVkeHUh?=
NUGC-3 NEjocYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzie3lKSzVyPUCuNFMxPDhizszN NUS5XoxvW0GQR1XS
A101D NGn6e5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTkcHhjUUN3ME2wMlA{ODV3IN88US=> NYPmOIJJW0GQR1XS
G-401 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTBwMEOwPVMh|ryP M2nzN3NCVkeHUh?=
OVCAR-8 M{K5T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMEOxNFch|ryP NYT3bpJ[W0GQR1XS
IMR-5 MlPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrOS29KSzVyPUCuNFMzPDRizszN MVvTRW5ITVJ?
DoTc2-4510 MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMEOzPVMh|ryP NIPJSnpUSU6JRWK=
HOS NEPUO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLsO3VKSzVyPUCuNFM1PzNizszN MVPTRW5ITVJ?
HEC-1 M1jZcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMEO2PEDPxE1? MnnUV2FPT0WU
SW756 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMEO4NlEh|ryP NF;tb4RUSU6JRWK=
NCI-H64 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrHWm1KSzVyPUCuNFM5PDJizszN MlqzV2FPT0WU
EW-16 M3T3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;aXG1KSzVyPUCuNFM6ODlizszN NWL6V4R3W0GQR1XS
CAL-51 NX71doFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\HOGFLUUN3ME2wMlA1ODB3IN88US=> NIXKV2JUSU6JRWK=
KYSE-150 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT4O4JOUUN3ME2wMlA1ODFzIN88US=> MorzV2FPT0WU
SW1710 NHPVXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELkb|VKSzVyPUCuNFQxOThizszN MUTTRW5ITVJ?
HuP-T4 NYfVOYlTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUD4dHFbUUN3ME2wMlA1OTF6IN88US=> M4LJR3NCVkeHUh?=
LB373-MEL-D MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHKfJlKSzVyPUCuNFQzOzJizszN M2T0VHNCVkeHUh?=
EW-13 NUnEZmV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMES0NFYh|ryP M4TFZnNCVkeHUh?=
HT-29 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfRTWM2OD1yLkC0OFkh|ryP MmjEV2FPT0WU
SCC-25 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMES0PVQh|ryP NEi3WYRUSU6JRWK=
REH NGr4VmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPsTWM2OD1yLkC0OlM2KM7:TR?= MXjTRW5ITVJ?
L-363 M{XRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPnSWh7UUN3ME2wMlA1Pjd7IN88US=> M4\1fXNCVkeHUh?=
NCI-H1770 M2ixcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXqwfppoUUN3ME2wMlA1Pjl5IN88US=> MofNV2FPT0WU
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LS-411N NETXR5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPKTWM2OD1yLkG0Nlk2KM7:TR?= MmDLV2FPT0WU
NCI-H747 M1Ttdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLyTWM2OD1yLkG0N{DPxE1? M2nHNHNCVkeHUh?=
ES6 NWn0bY12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrVTWM2OD1yLkG0N|Yh|ryP MV3TRW5ITVJ?
TE-1 NEKxOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPXTWM2OD1yLkG0OFA4KM7:TR?= NEX6RnhUSU6JRWK=
SJSA-1 NIewfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfvZnhnUUN3ME2wMlE1PzB5IN88US=> NFLkTVBUSU6JRWK=
NCI-H1355 NWfQSYFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TFS2lEPTB;MD6xOVI6OyEQvF2= MmfsV2FPT0WU
HEL NH;lSFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXJZ4ZKSzVyPUCuNVU1PDdizszN MkL4V2FPT0WU
639-V MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjTTWM2OD1yLkG1OVk3KM7:TR?= MV\TRW5ITVJ?
AN3-CA MnzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmK2TWM2OD1yLkG1OlM6KM7:TR?= NV7SW5dbW0GQR1XS
SK-MEL-2 MorQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PJRWlEPTB;MD6xOVY3QCEQvF2= M4\RfXNCVkeHUh?=
SW872 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTsTWM2OD1yLkG2NFQzKM7:TR?= MmrTV2FPT0WU
DU-4475 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTmTWM2OD1yLkG2NVYzKM7:TR?= NFLuZ3RUSU6JRWK=
YKG-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMU[yO|Mh|ryP MkPTV2FPT0WU
GT3TKB NUL5WXJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTBwMU[yPFMh|ryP MVfTRW5ITVJ?
GB-1 M{LB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTBwMU[0NlQh|ryP MV;TRW5ITVJ?
KARPAS-422 NXu5O3c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2roTmlEPTB;MD6xOlU4PCEQvF2= MYXTRW5ITVJ?
ATN-1 NIm5XoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDRTldiUUN3ME2wMlE3PjV4IN88US=> MlrRV2FPT0WU
HLE NHrTWpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMU[4O|ch|ryP MVvTRW5ITVJ?
D-542MG MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;1bmtKSzVyPUCuNVY6QDZizszN M1rjNHNCVkeHUh?=
EB-3 NV3JR|l4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC1WXlSUUN3ME2wMlE4OzFizszN M4H2c3NCVkeHUh?=
HCC1143 NVm0fmdXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2KxbWlEPTB;MD6xO|M6PiEQvF2= MkPqV2FPT0WU
DJM-1 M2GyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTBwMUe0OVEh|ryP MV;TRW5ITVJ?
BT-474 NHm1ZW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HyO2lEPTB;MD6xO|Q5QSEQvF2= NFLEZ4NUSU6JRWK=
BB65-RCC MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Pa[GlEPTB;MD6xO|U1PSEQvF2= M1rPb3NCVkeHUh?=
NCI-H292 NVPpclVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWra[21rUUN3ME2wMlE4PjBzIN88US=> NULWTYRkW0GQR1XS
MKN28 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37ITmlEPTB;MD6xO|Y2OyEQvF2= Mki3V2FPT0WU
TK10 M2nqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfETWM2OD1yLkG3O|AzKM7:TR?= NInRWZZUSU6JRWK=
TYK-nu NIjN[oFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnP6TWM2OD1yLkG3PVQ6KM7:TR?= MWPTRW5ITVJ?
8305C NUHSUIFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mme0TWM2OD1yLkG3PVcyKM7:TR?= NYexbZlMW0GQR1XS
MV-4-11 NGflRZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMUe5O|ch|ryP Mk\1V2FPT0WU
NCI-H522 NWKy[FkzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrk[|RKSzVyPUCuNVgxQTRizszN MXHTRW5ITVJ?
Hs-578-T MnrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\vOFRKSzVyPUCuNVgzQTJizszN MYHTRW5ITVJ?
LCLC-103H MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfw[IpKSzVyPUCuNVg2OjdizszN MmnBV2FPT0WU
MHH-ES-1 M{HVNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMUi2Nlkh|ryP M33SfXNCVkeHUh?=
NCI-H441 M3jLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;2NmlEPTB;MD6xPVE1QCEQvF2= NH\melRUSU6JRWK=
AM-38 MlOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTBwMUmyNlUh|ryP Ml7WV2FPT0WU
SW1783 MkTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ztNGlEPTB;MD6xPVMxPSEQvF2= NGrhc2dUSU6JRWK=
SK-HEP-1 NV\GZ|JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP2TWM2OD1yLkG5OlM4KM7:TR?= NXjMTIFNW0GQR1XS
OAW-28 NY\rR4M2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTTOFJJUUN3ME2wMlIxOTd6IN88US=> MYnTRW5ITVJ?
TE-15 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DNcWlEPTB;MD6yNFI2OiEQvF2= NXzLTVd7W0GQR1XS
HCE-4 NFHheJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDOUGpPUUN3ME2wMlIxOjh2IN88US=> MmPNV2FPT0WU
JiyoyeP-2003 M1fIV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT0SJpDUUN3ME2wMlIxOzN4IN88US=> Mm\lV2FPT0WU
OVCAR-4 NYX6ZY14T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMkC2Nlgh|ryP Mmf3V2FPT0WU
SNU-449 NFm0eXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMkC3PVch|ryP M{TtVHNCVkeHUh?=
SBC-5 NE\Zdm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV36c2g1UUN3ME2wMlIyOjF3IN88US=> MoqzV2FPT0WU
T84 NEnpS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\mPJU5UUN3ME2wMlIyOjR6IN88US=> M1zpVnNCVkeHUh?=
LP-1 M37BXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnRTWM2OD1yLkKxN|AzKM7:TR?= NWfTS3BQW0GQR1XS
MG-63 M2fLbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL3TWM2OD1yLkKxN|gzKM7:TR?= NXPFNI93W0GQR1XS
OAW-42 M{jTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17N[WlEPTB;MD6yNVQ4QCEQvF2= NFyzd3BUSU6JRWK=
L-540 NFHZVWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[wNWlEPTB;MD6yNVU6QCEQvF2= NXLoXllbW0GQR1XS
RH-1 NH3TS4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\GTWM2OD1yLkKyNlQzKM7:TR?= NHHx[phUSU6JRWK=
HCT-15 NIrCbI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMkK0PFQh|ryP NFHLT49USU6JRWK=
OCUB-M NEGyd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMkK0PFgh|ryP MV7TRW5ITVJ?
GP5d NFjaT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYmwN|dbUUN3ME2wMlIzPTJ6IN88US=> MYTTRW5ITVJ?
NCI-H2030 NYD5dZpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zDd2lEPTB;MD6yNlc{PCEQvF2= M{HwOHNCVkeHUh?=
ML-2 NWXlXXQ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml32TWM2OD1yLkKyPFg6KM7:TR?= MVzTRW5ITVJ?
CAL-39 NF\zTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\LTWM2OD1yLkKyPVM3KM7:TR?= M{\i[HNCVkeHUh?=
MIA-PaCa-2 NHO3XodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnyzTWM2OD1yLkKzNlg4KM7:TR?= NVPsbmR5W0GQR1XS
TE-9 NXXFS|BJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMkOzNkDPxE1? M3rnRXNCVkeHUh?=
LB2518-MEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwMkOzO|Ih|ryP NIPrd5BUSU6JRWK=
DB M1SzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr1SGlKSzVyPUCuNlM1OzhizszN MUPTRW5ITVJ?
NCI-H596 NFnwdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwMkO1O|Eh|ryP MWrTRW5ITVJ?
SW1990 M4HqT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPCb2xKSzVyPUCuNlM6PDZizszN NHraeGdUSU6JRWK=
P30-OHK MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWruNXB4UUN3ME2wMlI1ODVizszN MVrTRW5ITVJ?
ALL-PO MkGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfQVnRKSzVyPUCuNlQyPjlizszN NFjsNJVUSU6JRWK=
Saos-2 NGPWeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMkS1O|Eh|ryP MV\TRW5ITVJ?
MFH-ino MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3kOpNKSzVyPUCuNlQ3QTJizszN MmPXV2FPT0WU
OE33 MljOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLpbZBCUUN3ME2wMlI2OTFizszN NGO5XYJUSU6JRWK=
Calu-3 NVm2b4tDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDCTWM2OD1yLkK1Nlk4KM7:TR?= NXXhWW9MW0GQR1XS
HT MnHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonITWM2OD1yLkK1OlIyKM7:TR?= NF\3WGJUSU6JRWK=
LXF-289 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfiV2VVUUN3ME2wMlI2QTh2IN88US=> MV3TRW5ITVJ?
KGN M1fncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nBc2lEPTB;MD6yOlA5QSEQvF2= NIXoV|JUSU6JRWK=
NCI-H1417 MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHkTWM2OD1yLkK2OVI1KM7:TR?= MnzUV2FPT0WU
SF126 M4rISmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi5[GZKSzVyPUCuNlc{ODJizszN MWjTRW5ITVJ?
SAS M37p[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vROmlEPTB;MD6yO|MxQCEQvF2= NEfNWpNUSU6JRWK=
22RV1 NUPwSVczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjFXo9KSzVyPUCuNlc{PzhizszN NIHtXWZUSU6JRWK=
GI-1 NXH3UmtyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe3XFBKUUN3ME2wMlI4PDh5IN88US=> MX7TRW5ITVJ?
ES3 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMke3OlMh|ryP NH7LcmRUSU6JRWK=
NB1 M{TUOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwMke4O|Yh|ryP Mn[2V2FPT0WU
NCI-H650 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorYTWM2OD1yLkK4N|AzKM7:TR?= MXnTRW5ITVJ?
IST-MES1 MnLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMki1OVQh|ryP NGjGd5FUSU6JRWK=
UM-UC-3 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W2cGlEPTB;MD6yPVE1KM7:TR?= M3XlVHNCVkeHUh?=
CAL-120 M3flU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fBTGlEPTB;MD6yPVY{OSEQvF2= M17GdnNCVkeHUh?=
UACC-62 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i3SmlEPTB;MD6zNFI1OSEQvF2= NWi2XINDW0GQR1XS
TE-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonuTWM2OD1yLkOwNlQ6KM7:TR?= NGPT[ZFUSU6JRWK=
MKN1 MnXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu2TWM2OD1yLkOwN|Yh|ryP MnriV2FPT0WU
KS-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwM{C1NlYh|ryP M4HoSHNCVkeHUh?=
GCIY NXvDfXNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXZbGdNUUN3ME2wMlMyODB{IN88US=> MVfTRW5ITVJ?
OVCAR-5 M3P1Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3QdY93UUN3ME2wMlMyOTB4IN88US=> MYLTRW5ITVJ?
U-266 M1HocWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrudWRzUUN3ME2wMlMyOTR5IN88US=> MWTTRW5ITVJ?
Calu-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTBwM{GyPFkh|ryP M1XLRXNCVkeHUh?=
SK-LMS-1 NVjzV2lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXBTWM2OD1yLkOxOFI6KM7:TR?= M2L6RnNCVkeHUh?=
COLO-741 NYHCSXM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DNe2lEPTB;MD6zNVYyPCEQvF2= NFLhR3lUSU6JRWK=
RPMI-8226 NWnoeI5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwM{G2OFEh|ryP M330THNCVkeHUh?=
KM12 NFHWZ|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwM{G4N{DPxE1? M4rqXnNCVkeHUh?=
NMC-G1 M4rScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwM{G4OkDPxE1? MXTTRW5ITVJ?
SJRH30 NUTFSJpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7EeHpsUUN3ME2wMlMzODV{IN88US=> M1fiTXNCVkeHUh?=
COR-L105 Mn30S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq4TWM2OD1yLkOyNlE5KM7:TR?= Mlv0V2FPT0WU
IM-9 NHq4UWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC2R2pwUUN3ME2wMlM{ODJzIN88US=> MX7TRW5ITVJ?
TE-12 NF7JSJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LBPGlEPTB;MD6zN|MyPyEQvF2= MVnTRW5ITVJ?
KG-1 NI\Bbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwM{O0N|Ih|ryP NXj1SZZoW0GQR1XS
U251 NH6ydZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rQS2lEPTB;MD6zN|Q2PiEQvF2= MmP4V2FPT0WU
EFO-27 M4PROGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWwcoZKSzVyPUCuN|M6PTFizszN NU\VbJhWW0GQR1XS
EW-24 NVu1eWt{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwM{O5PFQh|ryP MmriV2FPT0WU
SF295 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf5PXpSUUN3ME2wMlM{QTl7IN88US=> NEDNT2lUSU6JRWK=
MC-IXC Mon5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz6d5gxUUN3ME2wMlM1PSEQvF2= NWnyW|ZVW0GQR1XS
NCI-H2405 Mnf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zJbmlEPTB;MD6zOFc{OiEQvF2= M1zKXnNCVkeHUh?=
NCI-H2009 NXjyOlBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzBc2k3UUN3ME2wMlM1PzN7IN88US=> NUDzbHJnW0GQR1XS
LB1047-RCC NXXrcJRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{W4NVUh|ryP MmjUV2FPT0WU
KNS-81-FD M33wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13GW2lEPTB;MD6zOlY3PyEQvF2= NEHZU|lUSU6JRWK=
HOP-92 NHTqc4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwM{[4N{DPxE1? NVPWVHlGW0GQR1XS
L-428 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;IWmpKSzVyPUCuN|cxOTZizszN NF;DUJdUSU6JRWK=
C3A MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrUUZFKSzVyPUCuN|c{PzlizszN Ml;iV2FPT0WU
NCI-H1792 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmK5TWM2OD1yLkO3OlU2KM7:TR?= Mlz3V2FPT0WU
HuH-7 NHjwXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;oNGdzUUN3ME2wMlM4QTFizszN M{DBTnNCVkeHUh?=
AGS MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwM{i2N|gh|ryP NEG4NJJUSU6JRWK=
HT-1197 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX[zZlk5UUN3ME2wMlM6PDZizszN Mn20V2FPT0WU
CGTH-W-1 NGXyXItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwM{m5NVMh|ryP MX;TRW5ITVJ?
KNS-42 M332[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jpRWlEPTB;MD60NFA1PSEQvF2= Mn3rV2FPT0WU
HuO-3N1 MlTVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrkfHVKSzVyPUCuOFAxPTVizszN M2DWfnNCVkeHUh?=
VMRC-RCZ NEj0e2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwNECzNFMh|ryP NHTEdnZUSU6JRWK=
SW954 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnz1TWM2OD1yLkSwN|M2KM7:TR?= MlLNV2FPT0WU
MES-SA Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwNEC1NFUh|ryP NGr5XlBUSU6JRWK=
Ca-Ski NVnW[nRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[zTWM2OD1yLkSwOVI1KM7:TR?= Mkm1V2FPT0WU
SW13 M1PyV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LTTGlEPTB;MD60NFYzPiEQvF2= Mn3KV2FPT0WU
NCI-H1437 M2i0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwNEC4NFUh|ryP NYK5V2luW0GQR1XS
U-118-MG NXe5VllKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwNEC5NFQh|ryP NGjtSoVUSU6JRWK=
NCI-H1734 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzLTWM2OD1yLkSyNFE{KM7:TR?= M2PPTHNCVkeHUh?=
HDLM-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3zTWM2OD1yLkSyNFM{KM7:TR?= M2L5VnNCVkeHUh?=
AU565 M4Lt[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r5WmlEPTB;MD60NlQ3QCEQvF2= NX7HS5Y5W0GQR1XS
FADU NGnBd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPX[IpKSzVyPUCuOFI3PDlizszN Mn7YV2FPT0WU
OS-RC-2 M2D4Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHIR2hKSzVyPUCuOFMxQDNizszN NXjVWoo1W0GQR1XS
CAMA-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwNEO2NlYh|ryP MXTTRW5ITVJ?
MONO-MAC-6 NX6wW|BNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[yTWM2OD1yLkSzPFQ6KM7:TR?= M1LjVHNCVkeHUh?=
LB831-BLC NHHNfllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jSfGlEPTB;MD60OFM4OSEQvF2= MYLTRW5ITVJ?
SW982 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF30fGtKSzVyPUCuOFQ2OjhizszN M3LjdnNCVkeHUh?=
SCC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml62TWM2OD1yLkS0OVc6KM7:TR?= M{DxVXNCVkeHUh?=
C32 NXT1PVVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTxVYhKSzVyPUCuOFUzOjlizszN MWXTRW5ITVJ?
BFTC-909 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ixSGlEPTB;MD60OVI6QSEQvF2= NXPiVlVsW0GQR1XS
MEG-01 MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XOSmlEPTB;MD60OVM4OyEQvF2= M37BPXNCVkeHUh?=
M14 NFqzR3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNEW5O|kh|ryP M4roUnNCVkeHUh?=
MPP-89 NIPodW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLOTWM2OD1yLkS2NlU3KM7:TR?= MVXTRW5ITVJ?
HCC1937 Mk\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3e4[2lEPTB;MD60OlM5PCEQvF2= MoiwV2FPT0WU
SW837 NVLWc2ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXYN2Y2UUN3ME2wMlQ3PzJ{IN88US=> M1zXTXNCVkeHUh?=
DU-145 NUDUO|lMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjTVoFKSzVyPUCuOFY4OjlizszN NEDBbZRUSU6JRWK=
LB996-RCC M3fsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPXSZpKSzVyPUCuOFcxPTRizszN MnT5V2FPT0WU
C8166 M1;3eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3tdZJIUUN3ME2wMlQ4PCEQvF2= NXLnO5J[W0GQR1XS
MOLT-4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLXcpJKSzVyPUCuOFc4OzRizszN NGXTVHBUSU6JRWK=
DMS-53 NInxN5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLleGsyUUN3ME2wMlQ4QDB7IN88US=> NVHGVlVIW0GQR1XS
TE-5 NEn5RpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XLNWlEPTB;MD60PFMxPSEQvF2= M3XaU3NCVkeHUh?=
KYSE-520 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q2T2lEPTB;MD60PFM1OyEQvF2= Mm\LV2FPT0WU
Detroit562 MnziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDoSXZDUUN3ME2wMlQ5QDZizszN MUnTRW5ITVJ?
SIMA MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnXUYFKSzVyPUCuOFk1OTdizszN NI[wVmlUSU6JRWK=
NCI-H1651 M3n2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljBTWM2OD1yLkS5Olch|ryP NIPlPIJUSU6JRWK=
HCC1599 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy3bplKSzVyPUCuOFk6PTVizszN MlraV2FPT0WU
ABC-1 MlzXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTBwNUC0PVYh|ryP NH\sRm5USU6JRWK=
CAL-33 MnPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L3SmlEPTB;MD61NFg1PCEQvF2= M{DB[3NCVkeHUh?=
OPM-2 M{f5Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3WeW1wUUN3ME2wMlUxQTN5IN88US=> M4TDNHNCVkeHUh?=
RPMI-7951 NVP2SIJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jPRWlEPTB;MD61NFk2PyEQvF2= M1zqbHNCVkeHUh?=
HT-1080 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjWNXhKSzVyPUCuOVEyOTlizszN NEL6d5FUSU6JRWK=
LC4-1 NF\oNJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwNUG0NFMh|ryP MlTRV2FPT0WU
OVCAR-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTBwNUG1O{DPxE1? NXH5b4pWW0GQR1XS
CAPAN-1 NEDsUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwNUKyPFgh|ryP NVvkXZpIW0GQR1XS
SK-OV-3 NIC1PZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DC[GlEPTB;MD61NlQ{PCEQvF2= MV\TRW5ITVJ?
HuP-T3 M{eycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTBwNUK4Nlch|ryP MX\TRW5ITVJ?
NCI-H838 Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwNUK4OFkh|ryP MkftV2FPT0WU
K5 MnzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWe2coFIUUN3ME2wMlU{OjBzIN88US=> NH7yXmpUSU6JRWK=
CAL-72 NFe1XoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\ETWM2OD1yLkWzN|g4KM7:TR?= NUCyTFFSW0GQR1XS
NH-12 NWrGOo1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwNUO5OVkh|ryP NIHaZ4VUSU6JRWK=
SNB75 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrWU3B6UUN3ME2wMlU2PzNizszN M13USHNCVkeHUh?=
BPH-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwNU[zOFQh|ryP NX;QSXNyW0GQR1XS
NOMO-1 M3rUVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwNU[zO|Ih|ryP NETidmtUSU6JRWK=
G-402 MnO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzFTWM2OD1yLkW2OFk6KM7:TR?= NXz6Um5sW0GQR1XS
NCI-H2052 M2m1S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\vTWM2OD1yLkW2O|QyKM7:TR?= MmTyV2FPT0WU
RCM-1 Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwNUexOlYh|ryP NXnBW|d5W0GQR1XS
COR-L279 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrOR4lpUUN3ME2wMlU4OTh3IN88US=> NH3Lb|BUSU6JRWK=
A253 NXvxSop7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwNUe1NlUh|ryP NF;DW3BUSU6JRWK=
SK-MM-2 NWT0XIlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwNUe2O|kh|ryP MYHTRW5ITVJ?
NCI-H1703 M4PyRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXUOpNsUUN3ME2wMlU6PDJ5IN88US=> NFzYbXpUSU6JRWK=
UACC-257 NXexRoF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\COWlEPTB;MD61PVQ5PyEQvF2= M3jJUXNCVkeHUh?=
KALS-1 NXmxRYhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTpTWM2OD1yLk[wNFEyKM7:TR?= MX3TRW5ITVJ?
ES5 NUC5N3lpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfvTWM2OD1yLk[wOFgh|ryP MnHzV2FPT0WU
MHH-CALL-2 NV:4UXJOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;JPY5TUUN3ME2wMlYxQDh6IN88US=> MV;TRW5ITVJ?
ChaGo-K-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfqb4hKSzVyPUCuOlEzOjlizszN NH\0WZhUSU6JRWK=
TGBC1TKB NELn[4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwNkG5PEDPxE1? MlTtV2FPT0WU
KU-19-19 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnmyTWM2OD1yLk[0OVg3KM7:TR?= M2DmU3NCVkeHUh?=
COLO-684 NFnTWWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNkW2NVEh|ryP NULLRVI1W0GQR1XS
LS-1034 M3[wWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\JOWJKSzVyPUCuOlU5OTlizszN NXzxOnVjW0GQR1XS
RT-112 M4ezOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwNk[1PFch|ryP NEfXOY9USU6JRWK=
Capan-2 MnfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fD[WlEPTB;MD62OlYzOiEQvF2= NWe0c2FXW0GQR1XS
HSC-4 MmfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrSSnNKSzVyPUCuOlY3QThizszN MojrV2FPT0WU
COLO-824 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwNke4NlMh|ryP NYPhT4pbW0GQR1XS
NCI-H2170 NXPke3NmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjNTFZKSzVyPUCuOlgzPThizszN MVHTRW5ITVJ?
GDM-1 M3fscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwNki0PVQh|ryP NX;OUHd4W0GQR1XS
KP-4 NHX5e45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzpT2lKSzVyPUCuOlk2PzNizszN NUTh[lRLW0GQR1XS
VA-ES-BJ NHnwb|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DRUGlEPTB;MD62PVk5PiEQvF2= MojOV2FPT0WU
KM-H2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmSxTWM2OD1yLkewNFkyKM7:TR?= MX3TRW5ITVJ?
HH MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnQTWM2OD1yLkewOlYzKM7:TR?= MmnqV2FPT0WU
DK-MG NGTDOpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILtTFhKSzVyPUCuO|ExOTZizszN NUTSTHJDW0GQR1XS
VM-CUB-1 NYjCcJN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTBwN{GyOVkh|ryP NHS4VI1USU6JRWK=
COLO-829 MnLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG0WYpKSzVyPUCuO|E6QDVizszN MYfTRW5ITVJ?
OMC-1 NG[5[YRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwN{KxNFQh|ryP MormV2FPT0WU
NB12 Mnq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjoPFNKSzVyPUCuO|I2ODRizszN MVzTRW5ITVJ?
NCI-H28 NUfve3oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLxOnpKSzVyPUCuO|QxQDNizszN MYfTRW5ITVJ?
A673 NF21ZnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonOTWM2OD1yLke1NVc4KM7:TR?= MmSzV2FPT0WU
LB2241-RCC NIPJOm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnaWI9KSzVyPUCuO|YxQDdizszN NYXDOWF7W0GQR1XS
CCRF-CEM M{fuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzNO5RKSzVyPUCuO|cxPTJizszN M2SwbXNCVkeHUh?=
NCI-H510A MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTBwN{exPFYh|ryP NWfJPIszW0GQR1XS
SW48 M{jSOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrTTWM2OD1yLke3N|M{KM7:TR?= NF\H[W1USU6JRWK=
NCI-H2081 NEK3S|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1OzO2lEPTB;MD63PFE1PyEQvF2= NFPIRodUSU6JRWK=
RMG-I NEfDV3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzJeFNtUUN3ME2wMlc5OjF{IN88US=> M13IXXNCVkeHUh?=
LU-99A MoHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CwfmlEPTB;MD63PFQyOyEQvF2= NF3qeIVUSU6JRWK=
KP-N-YS M4n5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL0c2tUUUN3ME2wMlc5QTJzIN88US=> NVXjVVgzW0GQR1XS
MDA-MB-231 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwOECxN|Eh|ryP MYrTRW5ITVJ?
U031 NXrkN4ZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn5[mRKSzVyPUCuPFE1OjNizszN Mki1V2FPT0WU
EVSA-T Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwOEG2O|Ih|ryP MlnzV2FPT0WU
MDA-MB-157 NXO0coJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPPWopMUUN3ME2wMlgzOjdzIN88US=> MY\TRW5ITVJ?
EHEB NEXkTG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTlTWM2OD1yLkiyNlc3KM7:TR?= Mn3JV2FPT0WU
KINGS-1 NEjvRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO4OZhlUUN3ME2wMlgzPTV3IN88US=> MUXTRW5ITVJ?
23132-87 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33SS2lEPTB;MD64Nlg1OyEQvF2= MlnEV2FPT0WU
EFO-21 NEm1dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;PV3V[UUN3ME2wMlg1ODh7IN88US=> NUTmc4huW0GQR1XS
DOK NUT1eYhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrGRZBKSzVyPUCuPFQ5KM7:TR?= NIfNdXhUSU6JRWK=
NCI-H2171 M1WwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XGVWlEPTB;MD64OFk3KM7:TR?= NX\DR49tW0GQR1XS
NCI-SNU-5 MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjjTGk5UUN3ME2wMlg2PTdizszN NE\IW4RUSU6JRWK=
SK-N-DZ MmrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G5ZmlEPTB;MD64OVk1OyEQvF2= MYDTRW5ITVJ?
SNU-C2B MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULK[WFJUUN3ME2wMlg3QDBzIN88US=> MVXTRW5ITVJ?
CP66-MEL NFvBfG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LUTWlEPTB;MD64O|EyKM7:TR?= M{XJR3NCVkeHUh?=
SN12C M3;GXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\NTWM2OD1yLki4OlM4KM7:TR?= M4XpbXNCVkeHUh?=
A172 NEXVR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTMTWM2OD1yLki4Olk5KM7:TR?= MorQV2FPT0WU
NCI-H2347 Ml3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33ROWlEPTB;MD64PFc2OyEQvF2= MVjTRW5ITVJ?
NCI-H2228 M1fjVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3v5VWlEPTB;MD64PVM{QSEQvF2= MWPTRW5ITVJ?
SNU-387 NWn4XYd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n5T2lEPTB;MD65NFI3PCEQvF2= NGLZ[nlUSU6JRWK=
SK-MEL-24 NH\Rb2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn3d49SUUN3ME2wMlkyOzR2IN88US=> MoHIV2FPT0WU
MDA-MB-468 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;KXGlEPTB;MD65NVc{KM7:TR?= M2G1d3NCVkeHUh?=
NCI-H1694 NUTqPZhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LIOWlEPTB;MD65NVg4PiEQvF2= MYnTRW5ITVJ?
CCF-STTG1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDIPZJKSzVyPUCuPVI3OzdizszN MXvTRW5ITVJ?
K052 NGXDfoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm5[o1KSzVyPUCuPVQxPDdizszN NGeybGdUSU6JRWK=
NCI-H446 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPPTllmUUN3ME2wMlk2ODFizszN M3T2fnNCVkeHUh?=
MFE-280 NX7adW5ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ewUmlEPTB;MD65OlI6OSEQvF2= M{fF[HNCVkeHUh?=
KU812 M1vMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfpTFVbUUN3ME2wMlk6Ozh7IN88US=> MY\TRW5ITVJ?
MDA-MB-361 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUexNmR5UUN3ME2wMlk6Pzd5IN88US=> M4rsZ3NCVkeHUh?=
Raji MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfZfodiUUN3ME2xMlAzOjZ5IN88US=> MVHTRW5ITVJ?
TE-6 NFm4U4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj6fmVKSzVyPUGuNFM2PjZizszN NF;HSVZUSU6JRWK=
CAL-148 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnWxTWM2OD1zLkC0OFQ{KM7:TR?= NHPXdIRUSU6JRWK=
NCI-H1963 NETubGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Lx[mlEPTB;MT6wOFU2OyEQvF2= NFvBVpVUSU6JRWK=
SK-N-AS M{PCTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTFwMES2PFUh|ryP Mlz2V2FPT0WU
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NB6 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;OR5E{UUN3ME20MlQzPTB7IN88US=> M3nxN3NCVkeHUh?=
DSH1 NVTiRlJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[yZZllUUN3ME20MlQ4OTF4IN88US=> MlmwV2FPT0WU
BT-20 NYfTfIVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[0RWlEPTB;ND60PVAxOiEQvF2= MoTzV2FPT0WU
NCI-H1882 NX;HRWRZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTRwNUC1O{DPxE1? M1:4OXNCVkeHUh?=
WM-115 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1iyOGlEPTB;ND61NFg5OSEQvF2= MWHTRW5ITVJ?
SKG-IIIa M1Oxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;UblJKSzVyPUSuOlc4PyEQvF2= MoTTV2FPT0WU
NCI-H69 M162XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;0TWM2OD12LkewNlc2KM7:TR?= NWDhUWxiW0GQR1XS
MSTO-211H MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HremlEPTB;ND64N|U3PSEQvF2= NHLVcZFUSU6JRWK=
Mewo MnPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LEcGlEPTB;ND65OlMyOyEQvF2= NEjIWZhUSU6JRWK=
GI-ME-N MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fCS2lEPTB;NT6wNFUxQSEQvF2= NUDkSZVXW0GQR1XS
T98G MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTVwME[1NFgh|ryP NUXyb2hCW0GQR1XS
ECC4 NV\aSpJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HteWlEPTB;NT6wPVM4OiEQvF2= MlnaV2FPT0WU
EW-11 NUfVTFlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTVwMUiwPVkh|ryP M4nGfHNCVkeHUh?=
COLO-800 MkjNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTVwMUmzOFkh|ryP MkPqV2FPT0WU
NCI-H1755 M2f3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33ST2lEPTB;NT6yN|AzPyEQvF2= MkfmV2FPT0WU
KMS-12-PE Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HmZmlEPTB;NT6zOVA5PSEQvF2= MX;TRW5ITVJ?
HCC1954 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmruTWM2OD13Lki1PVcyKM7:TR?= NIfCRoxUSU6JRWK=
NCI-H187 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfRTWM2OD13LkmyPVg6KM7:TR?= MoftV2FPT0WU
LU-165 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;OTWM2OD13Lkm5NFAzKM7:TR?= NEPZU2NUSU6JRWK=
YAPC M4\jcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HEbWlEPTB;NT65PVA3QCEQvF2= M3K5ZXNCVkeHUh?=
LU-139 NHTDeXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTxT|lnUUN3ME22MlA5OzZ6IN88US=> M1LYN3NCVkeHUh?=
D-502MG NUT6b2N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTZwM{KwOFch|ryP M4Lk[nNCVkeHUh?=
IST-SL1 M1e5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn3TWM2OD14LkWzPVQ5KM7:TR?= NI\kfoVUSU6JRWK=
DG-75 NYHGTYNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTZwOEi3PFYh|ryP MXnTRW5ITVJ?
NCI-H1155 NXH6[IdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnpXmpFUUN3ME22Mlk2PThzIN88US=> M4jLcXNCVkeHUh?=
EFE-184 M1L5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH1T2ZKSzVyPUeuN|E3QTVizszN M3XrdXNCVkeHUh?=
AsPC-1 NUDPRYFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPzTWM2OD15LkS4PFA4KM7:TR?= M3zXeHNCVkeHUh?=
SW948 M4rSTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDROI9sUUN3ME23MlU5Ozl3IN88US=> MlG2V2FPT0WU
NCI-H524 NFnHZ5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrRZ2pKSzVyPUmuOVg3OjhizszN MVLTRW5ITVJ?
KOSC-2 M2frc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvEfldQUUN3ME25MlYzQDN2IN88US=> MXnTRW5ITVJ?
T-24 NFrq[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTlwOUS0NVUh|ryP MmjNV2FPT0WU
NCI-H748 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknFTWM2OD1zMD62N|k4KM7:TR?= NVu0cYpWW0GQR1XS
NCI-H23 NVixcIVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\iO5RuUUN3ME2xNE43PDR{IN88US=> M{i5S3NCVkeHUh?=
UACC-812 Mmj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXKXm9wUUN3ME2xNU44OTdizszN NXLOTW9XW0GQR1XS
SCLC-21H Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHGTWM2OD1zMj6xOVUyKM7:TR?= M3;LXHNCVkeHUh?=
NCI-SNU-16 NIDjeVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4raXWlEPTB;MUOuNVI2QCEQvF2= MULTRW5ITVJ?
HD-MY-Z NHi5fFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjodJM{UUN3ME2xOE43OzZ|IN88US=> M{\iVHNCVkeHUh?=
SK-N-FI MlzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M376ZWlEPTB;MUSuPFkyOiEQvF2= NFzsTVhUSU6JRWK=
LB647-SCLC M{C5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTF3LkexPVUh|ryP M3H0S3NCVkeHUh?=
NCI-H345 NInhOo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\GcGlEPTB;MUeuN|Q{KM7:TR?= MnHyV2FPT0WU
NCI-H1563 NVHvR2xOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTRb3lKSzVyPUG4Mlc3ODFizszN NWrLb5NRW0GQR1XS
RL Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nNSWlEPTB;MkGuNlY2PiEQvF2= NH:3NZBUSU6JRWK=
KY821 M{L4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHKTIlKSzVyPUKyMlA2PTNizszN MmixV2FPT0WU
JVM-3 M3zpUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXZWoFLUUN3ME2yOU4xPDF|IN88US=> MU\TRW5ITVJ?
NCI-H1793 NH20WJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDDd5BKSzVyPUK4MlU1QTlizszN MVfTRW5ITVJ?
LU-134-A NFvINo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fURWlEPTB;M{CuNlA{PyEQvF2= MWfTRW5ITVJ?
NCI-H1395 M2XLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn6XlJKSzVyPUOyMlI1OzFizszN M3;3cnNCVkeHUh?=
NCI-H1993 NEDXXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm2eGxKSzVyPUOyMlgzOThizszN NH\XUFdUSU6JRWK=
P31-FUJ MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2C0PWlEPTB;M{OuOFg6QSEQvF2= MVXTRW5ITVJ?
LS-513 MkTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\PenBMUUN3ME2zOU45QDd7IN88US=> Mnz0V2FPT0WU
SK-MEL-1 M4H6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTRyLkO0PVkh|ryP MXzTRW5ITVJ?
SW684 NFfKPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTjSGcyUUN3ME20N{46PjZzIN88US=> MU\TRW5ITVJ?
COR-L88 NWO4WGxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2njbmlEPTB;NESuNFY3PSEQvF2= NEmxOI5USU6JRWK=
NCI-H889 MnrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHySFlKSzVyPUS1MlAxQDdizszN MV7TRW5ITVJ?
TALL-1 M{HZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnae4ZJUUN3ME20Ok4yOTl7IN88US=> MVfTRW5ITVJ?
KARPAS-299 M2PSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rpRWlEPTB;NEeuNVk6OyEQvF2= MnX3V2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo Obatoclax also exhibits high antitumor activity in SCID mice bearing human C33A cerivical carcinoma tumors at a dose of 0.5 mg/kg. [1]

Protocol

Kinase Assay
+ Expand

Bcl-2 Binding affinity calculation:

A predicted binding affinity for Obatoclax binding to BCL-2 is calculated using the SIE scoring function. [4] As a control in determining the reliability of the calculation, predicted binding affinities Ki) are calculated for a set of 12 small molecules with experimentally measured binding affinities to BCL-2.
Cell Research
+ Expand
  • Cell lines: Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs)
  • Concentrations: ~10 μM
  • Incubation Time: 48-72 hours
  • Method: Obatoclax is dissolved in DMSO at a stock concentration of 5 mM. Cell viability is assayed by MTT. Human MM cells (HMCLs), peripheral blood lymphocytes (PBLs), bone marrow stromal cells (BMSCs) are seeded in 96-well plates at a density of 2 × 104 per well for HMCLs or 5~10 × 103 for PBLs. Various concentrations of Obatoclax are added to the cells, with or without IGF-1 (50 ng/mL) or IL-6 (10 ng/mL). Cells are incubated for 48-72 hours and cell viability is determined.
    (Only for Reference)
Animal Research
+ Expand
  • Animal Models: Female BALB/c or CB17 SCID/SCID mice bearing SW480, C33A, PC3, and 4T1 cells are used.
  • Formulation: Obatoclax (tartrate salt) is formulated in 9.6% polyethylene glycol 300, 0.4% polysorbate 20, and 5% dextrose; while for the 4T1 tumor model, Obatoclax is formulated at a concentration of 0.6 mg/mL in 9.48% polyethylene glycol, 0.38% polysorbate 20, 1.2 m
  • Dosages: 0.0313, 0.25, 0.5 and 2 mg/kg
  • Administration: Administered intravenously (tail vein) once a day
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.73 mM)
Water <1 mg/mL
Ethanol <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 413.49
Formula

C20H19N3O.CH4O3S

CAS No. 803712-79-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
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    C3=C2/X C3: LOG(C3):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01563601 Withdrawn Extensive-stage Small Cell Lung Cancer Cephalon|Teva Pharmaceutical Industries August 2012 Phase 3
NCT01238146 Withdrawn Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue|Nodal Marginal Zone B-cell Lymphoma|Recurrent Grade 1 Follicular Lymphoma|Recurrent Grade 2 Follicular Lymphoma|Recurrent Mantle Cell Lymphoma|Recurrent Marginal Zone Lymphoma|Splenic Marginal Zone Lymphoma National Cancer Institute (NCI) October 2010 Phase 1|Phase 2
NCT00933985 Terminated Acute Leukemias of Ambiguous Lineage|Acute Undifferentiated Leukemia|Angioimmunoblastic T-cell Lymphoma|Blastic Phase Chronic Myelogenous Leukemia|Childhood Burkitt Lymphoma|Childhood Chronic Myelogenous Leukemia|Childhood Diffuse Large Cell Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Childhood Nasal Type Extranodal NK/T-cell Lymphoma|Cutaneous B-cell Non-Hodgkin Lymphoma|Hepatosplenic T-cell Lymphoma|Intraocular Lymphoma|Noncutaneous Extranodal Lymphoma|Peripheral T-cell Lymphoma|Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood Anaplastic Large Cell Lymphoma|Recurrent Childhood Grade III Lymphomatoid Granulomatosis|Recurrent Childhood Large Cell Lymphoma|Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Childhood Small Noncleaved Cell Lymphoma|Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma|Recurrent Mycosis Fungoides/Sezary Syndrome|Recurrent/Refractory Childhood Hodgkin Lymphoma|Refractory Chronic Lymphocytic Leukemia|Refractory Hairy Cell Leukemia|Relapsing Chronic Myelogenous Leukemia|Small Intestine Lymphoma|Unspecified Childhood Solid Tumor, Protocol Specific National Cancer Institute (NCI) June 2009 Phase 1
NCT00918931 Terminated Leukemia|Systemic Mastocytosis M.D. Anderson Cancer Center|Gemin X June 2009 Phase 2
NCT00719901 Terminated Refractory Multiple Myeloma|Stage I Multiple Myeloma|Stage II Multiple Myeloma|Stage III Multiple Myeloma National Cancer Institute (NCI) July 2008 Phase 1|Phase 2
NCT00724841 Terminated Metastatic Melanoma Gemin X|Teva Pharmaceutical Industries June 2008 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID