HIV Protease

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1185

Ritonavir

Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4).

S1380

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S1457

Atazanavir Sulfate

Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S4662New

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.

Catalog No. Information Product Use Citations Product Validations
S1185

Ritonavir

Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4).

S1380

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S1457

Atazanavir Sulfate

Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S4662New

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.