HIV Protease

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No. Information Product Use Citations Product Validations
S1185

Ritonavir

Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases.

S1380

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S1457

Atazanavir Sulfate

Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S4662New

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.

Catalog No. Information Product Use Citations Product Validations
S1185

Ritonavir

Ritonavir is a Cytochrome P450 3A and Protease Inhibitor; Also inhibits Cytochrome P450 2D6, P-Glycoprotein and induces Cytochrome P450 2C19, Cytochrome P450 1A2, Cytochrome P450 2C9, Cytochrome P450 2B6 and UDP Glucuronosyltransferases.

S1380

Lopinavir

Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 pM in a cell-free assay.

S1457

Atazanavir Sulfate

Atazanavir Sulfate is a HIV protease inhibitor with Ki of 2.66 nM in a cell-free assay.

S1620

Darunavir Ethanolate

Darunavir Ethanolate (DRV) is a nonpeptidic HIV protease inhibitor, used to treat HIV infection.

S1639

Amprenavir

Amprenavir is a potent PXR-selective agonist, and an HIV protease inhibitor, used to treat HIV.

S4662New

Atazanavir

Atazanavir is an azapeptide and HIV-protease inhibitor that is used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.

S2319

Limonin

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

S4282

Nelfinavir Mesylate

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.