Home Microbiology HIV Protease inhibitor Temsavir (BMS-626529)

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Temsavir (BMS-626529) HIV Protease inhibitor

Cat.No.S6625

Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses.
Temsavir (BMS-626529) HIV Protease inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 473.48

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Quality Control

Batch: S662501 DMSO]95 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.58%
99.58

Solubility

In vitro
Batch:

DMSO : 95 mg/mL (200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 473.48 Formula

C24H23N7O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 701213-36-7 -- Storage of Stock Solutions

Synonyms N/A Smiles CC1=NN(C=N1)C2=NC=C(C3=C2NC=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)OC

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04648280 Recruiting
HIV Infections With Multi Drug Resistant Virus
PENTA Foundation|ViiV Healthcare|PHPT Foundation|Hospital Universitario 12 de Octubre|Cromsource
 June 30 2022 Phase 1|Phase 2
NCT04757974 Completed
HIV Infections
ViiV Healthcare
 March 5 2021 Phase 1
NCT02805556 Completed
Infection Human Immunodeficiency Virus
ViiV Healthcare|GlaxoSmithKline
 March 15 2016 Phase 1
NCT02508064 Completed
Infection Human Immunodeficiency Virus
ViiV Healthcare|GlaxoSmithKline
 August 3 2015 Phase 1
NCT02480894 Completed
Infection Human Immunodeficiency Virus
ViiV Healthcare|GlaxoSmithKline
 July 7 2015 Phase 1

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