Lopinavir (ABT-378)

Related HIV Protease Inhibitors

• Delanzomib (CEP-18770)

  CEP-18770 is a potent chymotrypsin-like proteasome inhibitor with IC50 of 3.8 nM.

• Danoprevir

  Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50 of 0.2-3.5 nM.

• BMS-708163 (Avagacestat)

  BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.

• VX-222

  VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM.

• Daclatasvir （BMS-790052）

  BMS-790052 is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM.

• LY2811376

  LY2811376 is a non-peptidic BACE1 inhibitor with IC50 of 239 nM/249 nM and also decreases the Aβ secretion with EC50 of ~300 nM.

• RO4929097

  RO4929097 is a γ secretase (GS) inhibitor with IC50 of 4 nM and also inhibits Aβ40 and ICN with EC50 of 14 nM and 5 nM, respectively.

• Semagacestat (LY450139)

  Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.

• MLN2238

  MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and K_i of 3.4 nM and 0.93 nM, respectively.

• MLN9708

  MLN9708 is a selective inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and K_i of 3.4 nM and 0.93 nM.