Nelfinavir Mesylate

Catalog No.S4282

Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.

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Nelfinavir Mesylate Chemical Structure

Nelfinavir Mesylate Chemical Structure
Molecular Weight: 663.89

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Nelfinavir Mesylate is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.
Targets HIV protease [1]
IC50 2 nM(Ki)
In vitro
In vivo
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Kaldor SW, et al.J Med Chem, 1997,40(24):3979-85.

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-07-23)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01959672 Recruiting Pancreatic Adenocarcinoma|Resectable Pancreatic Cancer|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB  ...more Pancreatic Adenocarcinoma|Resectable Pancreatic Cancer|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer University of Nebraska|National Cancer Institute (NCI) September 2013 Phase 2
NCT01164709 Completed Leukemia|Lymphoma|Mature T-cell and Nk-cell Neoplasms|Multiple Myeloma and Plasma Cell Neoplasm Swiss Group for Clinical Cancer Research July 2010 Phase 1
NCT00915694 Active, not recruiting Brain and Central Nervous System Tumors Abramson Cancer Center of the University of Pennsylvania|  ...more Abramson Cancer Center of the University of Pennsylvania|National Cancer Institute (NCI) April 2009 Phase 1
NCT01068327 Active, not recruiting Adenocarcinoma of the Pancreas|Stage III Pancreatic Cancer University of Nebraska|National Cancer Institute (NCI) November 2007 Phase 1
NCT00589056 Recruiting Lung Cancer University of Pennsylvania|National Cancer Institute (NCI) June 2007 Phase 1|Phase 2

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Chemical Information

Download Nelfinavir Mesylate SDF
Molecular Weight (MW) 663.89
Formula

C33H49N3O7S2

CAS No. 159989-65-8
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms N/A
Solubility (25°C) * In vitro DMSO 100 mg/mL (150.62 mM)
Ethanol 100 mg/mL (150.62 mM)
Water <1 mg/mL (<1 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-(3S,4aS,8aS)-3-isoquinolinecarboxamide, methanesulfonate (1:1)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3

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