Catalog No.S4282 Synonyms: Viracept, AG1343
Molecular Weight(MW): 663.89
Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.
Purity & Quality Control
Choose Selective HIV Protease Inhibitors
|Description||Nelfinavir Mesylate is a potent HIV protease inhibitor with Ki of 2 nM.|
|In vivo||In vivo studies indicate that AG1343 is well absorbed orally in a variety of species and possesses favorable pharmacokinetic properties in humans. Initial investigation of the compound in fed rats indicated an oral bioavailability of 43%. In contrast, the oral bioavailability was significantly reduced in fasted rats to 29%. Nelfinavir demonstrated significant oral bioavailabilability across a range of species including dogs (47%), marmosets (17%), and cynomolgus monkeys (26%). It has a long plasma half-life after oral dosing that is likely due to a combination of slow dissolution and absorption. nelfinavir is well absorbed in humans particularly when administered with food and possesses minimal and easily managed side effects.|
|In vitro||DMSO||100 mg/mL (150.62 mM)|
|Ethanol||100 mg/mL (150.62 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03050060||Not yet recruiting||Metastatic Renal Cell Cancer|Recurrent Melanoma|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Renal Cell Carcinoma|Stage IV Non-Small Cell Lung Cancer|Stage IV Renal Cell Cancer|Stage IV Skin Melanoma||University of Washington|National Cancer Institute (NCI)||April 2017||Phase 2|
|NCT01959672||Recruiting||Pancreatic Adenocarcinoma|Resectable Pancreatic Cancer|Stage IA Pancreatic Cancer|Stage IB Pancreatic Cancer|Stage IIA Pancreatic Cancer|Stage IIB Pancreatic Cancer|Stage III Pancreatic Cancer||University of Nebraska|National Cancer Institute (NCI)||September 2013||Phase 2|
|NCT01164709||Completed||Leukemia|Lymphoma|Mature T-cell and Nk-cell Neoplasms|Multiple Myeloma and Plasma Cell Neoplasm||Swiss Group for Clinical Cancer Research||July 2010||Phase 1|
|NCT00915694||Active, not recruiting||Brain and Central Nervous System Tumors||Abramson Cancer Center of the University of Pennsylvania|National Cancer Institute (NCI)||April 2009||Phase 1|
|NCT01068327||Unknown status||Adenocarcinoma of the Pancreas|Stage III Pancreatic Cancer||University of Nebraska|National Cancer Institute (NCI)||November 2007||Phase 1|
|NCT00589056||Active, not recruiting||Lung Cancer||Abramson Cancer Center of the University of Pennsylvania|National Cancer Institute (NCI)||June 2007||Phase 1|Phase 2|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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