DUB

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DUB Inhibitors (9)

water-soluble

Cat.No. Product Name Information Product Use Citation Customer Product Validation
S7130 PR-619 PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
S7132 P5091 (P005091) P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.
  • Trends Pharmacol Sci, 2014, 35(4):187-207
S7134 IU1 IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT.
  • Trends Pharmacol Sci, 2014, 35(4):187-207
S7140 TCID TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
S7135 LDN-57444 LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
S2243 Degrasyn (WP1130) Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT).
  • Trends Pharmacol Sci, 2014, 35(4):187-207
  • Oncogene, 2014, 10.1038/onc.2014.351
  • J Biol Chem, 2012, 288(4):2721-33
S7133 P22077 P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.
S4920 b-AP15 b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.
S7529 ML323 ML323 is a highly potent and selective USP1-UAF1 inhibitor with IC50 of 76 nM.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S7130 PR-619 <1 mg/mL 45 mg/mL <1 mg/mL
S7132 P5091 (P005091) <1 mg/mL 28 mg/mL <1 mg/mL
S7134 IU1 <1 mg/mL 60 mg/mL 60 mg/mL
S7140 TCID <1 mg/mL 23 mg/mL <1 mg/mL
S7135 LDN-57444 <1 mg/mL 11 mg/mL <1 mg/mL
S2243 Degrasyn (WP1130) <1 mg/mL 77 mg/mL 18 mg/mL
S7133 P22077 <1 mg/mL 63 mg/mL <1 mg/mL
S4920 b-AP15 <1 mg/mL 48 mg/mL <1 mg/mL
S7529 ML323 <1 mg/mL 76 mg/mL 38 mg/mL
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