Catalog No.S7140

TCID Chemical Structure

Molecular Weight(MW): 283.92

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Biological Activity

Description TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
Features TCID demonstrates selectivity for UCH-L3 over UCH-L1 by over 100-fold.
UCH-L3 [1] UCH-L1 [1]
0.6 μM 75 μM
In vitro

TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. [1] NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. [2] TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. [3]


Solubility (25°C)

In vitro DMSO 23 mg/mL (81.0 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 283.92


CAS No. 30675-13-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02240875 Recruiting Ebola|Ebola Zaire University of Oxford|Wellcome Trust|National Institute of Allergy and Infectious Diseases (NIAID) September 2014 Phase 1
NCT01466738 Completed Healthy Centocor Ortho Biotech Services, L.L.C. September 2011 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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DUB Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID