Catalog No.S1351 Synonyms: MK933
Molecular Weight(MW): 875.09
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
Purity & Quality Control
Choose Selective Antifection Inhibitors
|Description||Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.|
Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively.  Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons.  Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. 
|In vivo||Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration.  Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. |
-  Wagstaff KM, et al. Biochem J, 2012, 443(3), 851-856.
-  Reiter RJ, et al. Prog Neurobiol, 1998, 56(3), 359-384.
-  Moreno Y, et al. Proc Natl Acad Sci U S A, 2010, 107(46), 20120-20125.
|In vitro||DMSO||100 mg/mL (114.27 mM)|
|Ethanol||28 mg/mL (31.99 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT00339417||Completed||Lymphatic Filariasis||National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC)||February 22, 2006||Phase 2|
|NCT02841215||Not yet recruiting||Gale|Severe Forms of Scabies|Oral Parasitic Drug|Ivermectin||Assistance Publique - Hôpitaux de Paris||March 2017||Phase 3|
|NCT03036059||Not yet recruiting||Lymphatic Filariasis|Helminth Infection||Noguchi Memorial Institute for Medical Research|Ghana Health Services||March 2017||Phase 4|
|NCT02963324||Completed||Malaria||University Hospital, Basel, Switzerland||November 2016||Phase 1|
|NCT02806414||Not yet recruiting||Rosacea||University of California, San Diego|Galderma||July 2016||Phase 1|Phase 2|
|NCT02775617||Active, not recruiting||Scabies|Yaws|Impetigo||London School of Hygiene and Tropical Medicine|Atoifi Adventist Hospital, Solomon Islands|Kirby Institute|Murdoch Childrens Research Institute||July 2016||Phase 4|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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