Ivermectin

Catalog No.S1351 Synonyms: MK933

Ivermectin Chemical Structure

Molecular Weight(MW): 875.09

Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.

Size Price Stock Quantity  
In DMSO USD 350 In stock
USD 97 In stock
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Biological Activity

Description Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug.
Targets
chloride channel [1] chloride channel [3]
In vitro

Ivermectin has potent antiviral activity towards both HIV-1 anddengue virus, both of which are strongly reliant on importin α/β nuclear import, with respect to the HIV-1 integrase and NS5 (non-structural protein 5) polymerase proteins respectively. [1] Ivermectin binds to a novel site on the GABAA receptor and allosterically enhances the affinity of the GABA binding site in mouse hippocampal embryonic neurons. [2] Ivermectin disrupts neurotransmission processes regulated by GluCl activity by binding to nematode glutamate-gated chloride channels (GluCls). Ivermectin decreases the amount of protein released from microfilariae. [3]

In vivo Ivermectin (1.25-10 mg/kg, intraperitoneal) significantly reduces 24-h alcohol consumption and intermittent limited access (4-hours) binge drinking, and operant alcohol self-administration (1-h). Ivermectin also produces a significant reduction in 24-h saccharin consumption, but does not alter operant sucrose self-administration. [4] Ivermectin improves mouse survival rate induced by a lethal dose of LPS. Ivermectin significantly decreases the production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro. Ivermectin suppresses NF-kB translocation induced by LPS. [5]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (114.27 mM)
Ethanol 28 mg/mL (31.99 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 875.09
Formula

C48H74O14

CAS No. 70288-86-7
Storage powder
Synonyms MK933

Bio Calculators

Molarity Calculator

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00339417 Completed Lymphatic Filariasis National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) February 22, 2006 Phase 2
NCT02841215 Not yet recruiting Gale|Severe Forms of Scabies|Oral Parasitic Drug|Ivermectin Assistance Publique - Hôpitaux de Paris March 2017 Phase 3
NCT03036059 Not yet recruiting Lymphatic Filariasis|Helminth Infection Noguchi Memorial Institute for Medical Research|Ghana Health Services March 2017 Phase 4
NCT02963324 Completed Malaria University Hospital, Basel, Switzerland November 2016 Phase 1
NCT02806414 Not yet recruiting Rosacea University of California, San Diego|Galderma July 2016 Phase 1|Phase 2
NCT02775617 Active, not recruiting Scabies|Yaws|Impetigo London School of Hygiene and Tropical Medicine|Atoifi Adventist Hospital, Solomon Islands|Kirby Institute|Murdoch Childrens Research Institute July 2016 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID