A-438079 HCl
Catalog No.S7705
Molecular Weight(MW): 342.61
A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.
Purity & Quality Control
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Biological Activity
| Description | A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. | |||||||||||||||||||||||||||||||||||||
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| Targets |
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| In vitro |
In 1321N1 cells stably expressing rat P2X7 receptors, A-438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC50 of 321 nM. A-438079 is also selective for the P2X7 receptor, at concentrations up to 100 μM.[1] |
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| Cell Data |
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| In vivo | Intraperitoneal injection of A-438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A-438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg).[2] A-438079 partially but significantly prevents the 6-OHDA-induced depletion of striatal DA stores.[3] Pretreatment with A-438079 reduces nociceptive behaviour scores in the HC model.[4] A-438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A-438079 (100 and 300 μmol/kg, i.p.) significantly raises withdrawal thresh-olds in both the SNL and CCI models.[1] |
Protocol
| Animal Research:[3] |
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Solubility (25°C)
| In vitro | DMSO | 61 mg/mL (178.04 mM) |
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| Water | 61 mg/mL (178.04 mM) | |
| Ethanol | 20 mg/mL warmed (58.37 mM) | |
| In vivo | Add solvents individually and in order: Saline |
30mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 342.61 |
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| Formula | C13H10Cl3N5 |
| CAS No. | 899431-18-6 |
| Storage | powder |
| Synonyms | N/A |
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