Catalog No.S1415 Synonyms: SR-25990C
Molecular Weight(MW): 419.9
Clopidogrel is an oral, thienopyridine class antiplatelet agent.
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|Description||Clopidogrel is an oral, thienopyridine class antiplatelet agent.|
Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes.  Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction).  Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. 
|In vivo||Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats.  Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS.  The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. |
-  Laine L, et al. Am J Gastroenterol, 2010, 105(1), 34-41.
-  Luo JC, et al. Eur J Pharmacol, 2012, 695(1-3), 112-119.
-  Coimbra LS, et al. J Clin Periodontol, 2014, 41(3), 295-302.
|In vitro||DMSO||83 mg/mL (197.66 mM)|
|Water||78 mg/mL (185.75 mM)|
|Ethanol||46 mg/mL (109.54 mM)|
* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02777580||Not yet recruiting||Myocardial Infarction||Katholieke Universiteit Leuven|Boehringer Ingelheim|Life Sciences Research Partners|Fund for Clinical Cardiovascular Research at LRD||September 2016||Phase 2|
|NCT02829151||Not yet recruiting||Critical Limb Ischemia||Yonsei University||July 2016||Phase 4|
|NCT02831218||Not yet recruiting||Percutaneous Transluminal Coronary Angioplasty||CHEOL WHAN LEE, M.D., Ph.D|CardioVascular Research Foundation, Korea|Asan Medical Center||July 2016||Phase 4|
|NCT02433587||Not yet recruiting||Peripheral Arterial Disease|Endovascular Procedures||University Hospital Case Medical Center||July 2016||Phase 3|
|NCT02776540||Recruiting||Ischemic Cerebrovascular Accident||Ain Shams University||May 2016||Phase 4|
|NCT02833948||Recruiting||Aortic Valve Stenosis|Cardiovascular Diseases|Heart Valve Diseases|Ventricular Outflow Obstruction|Thrombosis||ECRI bv|Rigshospitalet, Denmark|Bayer|Cardialysis BV||May 2016||Phase 3|
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