Clopidogrel Chemical Structure

Clopidogrel Chemical Structure
Molecular Weight: 419.9

Validation & Quality Control

Quality Control & MSDS

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Clopidogrel is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Description Clopidogrel is an oral, thienopyridine class antiplatelet agent.
Targets P2Y12 [1]
In vitro Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]
In vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]
Features

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesMouseRatRabbitGuinea pigHamsterDog
Weight (kg)0.020.151.80.40.0810
Body Surface Area (m2)0.0070.0250.150.050.020.5
Km factor36128520
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Laine L, et al. Am J Gastroenterol, 2010, 105(1), 34-41.

[2] Luo JC, et al. Eur J Pharmacol, 2012, 695(1-3), 112-119.

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Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2016-05-07)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02723981 Not yet recruiting Stable Angina|Unstable Angina|STEMI|NSTEMI|Coronary Disease IHF GmbH - Institut für Herzinfarktforschung|OrbusNeich April 2016 Phase 4
NCT02748330 Not yet recruiting Coronary Artery Disease|Diabetes Mellitus, Type 2 Peking Union Medical College Hospital April 2016 Phase 4
NCT02677545 Not yet recruiting Carotid Artery Stenosis University Hospital, Basel, Switzerland April 2016 Phase 2
NCT02689037 Not yet recruiting Intracranial Atherosclerosis The 476th Hospital of Peoples Liberation Army April 2016 Phase 3
NCT02663713 Not yet recruiting Myocardial Infarction|Diabetes Mellitus|Renal Disease|Coronary Artery Disease University of Patras|AstraZeneca March 2016 Phase 4

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Chemical Information

Download Clopidogrel SDF
Molecular Weight (MW) 419.9
Formula

C16H16ClNO2S.H2SO4

CAS No. 120202-66-6
Storage 3 years -20℃powder
6 months-80℃in solvent
Synonyms SR-25990C
Solubility (25°C) * In vitro DMSO 83 mg/mL (197.66 mM)
Water 78 mg/mL (185.75 mM)
Ethanol 46 mg/mL (109.54 mM)
In vivo
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, methyl ester, (αS)-, sulfate

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