Prasugrel
Catalog No.S1258 Synonyms: CS-747, LY640315
Molecular Weight(MW): 373.44
Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.
Purity & Quality Control
Choose Selective P2 Receptor Inhibitors
Biological Activity
| Description | Prasugrel is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events. | |
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| Targets |
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| In vitro |
Prasugrel is a novel orally active thienopyridine with faster, higher and more reliable inhibition of platelet aggregation than clopidogrel reflecting its metabolism in vivo to an active metabolite with selective P2Y(12) antagonistic activity. [1] |
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| In vivo | Prasugrel shows platelet inhibition that was 8.2 times more potent than clopidogrel in WT mice. [1] Prasugrel (3 and 10 mg/kg) dose-relatedly and significantly reduces thrombus-mediated cerebral infarction 24 hours after the irradiation in rat models of cerebral and peripheral arterial occlusive diseases. Prasugrel (0.3-3 mg/kg) reduces incidence, total area, and total number of cerebral infarcts in a dose-related manner 24 hours after the vascular injury in an embolic infarction rats model. Prasugrel (0.03-3 mg/kg/day) administered from the day before the lauric acid injection for 11 successive days inhibits the progression of the disease in a dose-related manner in rats with lauric acid-induced peripheral arterial occlusive diseases. [2] Prasugrel administrated in dogs (0.03-0.3 mg/kg/day) and monkeys (0.1 and 0.3 mg/kg/day) once a day for 14 days results in potent, dose-related and cumulative inhibition of ADP-induced platelet aggregation. Prasugrel (0.1-1 mg/kg/day, p.o.) significantly prolongs the time to arterial occlusion and increases the duration of arterial patency in a rat model of electrically-induced arterial thrombosis. [3] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 30 mg/mL (80.33 mM) |
|---|---|---|
| Ethanol | 7 mg/mL (18.74 mM) | |
| Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 373.44 |
|---|---|
| Formula | C20H20FNO3S |
| CAS No. | 150322-43-3 |
| Storage | powder |
| Synonyms | CS-747, LY640315 |
Bio Calculators
Molarity Calculator
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03027934 | Not yet recruiting | Diabetes Mellitus | CirQuest Labs, LLC | February 28, 2017 | Phase 4 |
| NCT02978040 | Not yet recruiting | Coronary Artery Disease|STEMI - ST Elevation Myocardial Infarction | University Hospital Inselspital, Berne | February 2017 | Phase 4 |
| NCT03016611 | Not yet recruiting | Acute Coronary Syndrome|STEMI | Sheba Medical Center | February 2017 | Phase 4 |
| NCT02866175 | Not yet recruiting | Atrial Fibrillation | Daiichi Sankyo Inc.|European Cardiovascular Research Institute|Kompetenznetz Vorhofflimmern e.V.|Chiltern International Inc. | February 2017 | Phase 3 |
| NCT02944123 | Recruiting | Acute Coronary Syndrome | Dong-A University | September 2016 | Phase 3 |
| NCT02507323 | Withdrawn | Cardiovascular Disease | Yochai Birnbaum|AstraZeneca|Baylor College of Medicine | February 2016 | Phase 2 |
Tech Support
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