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Serotonin Transporter Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S5239 Paroxetine mesylate Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.
Am J Cancer Res, 2022, 12(4):1465-1483
Anal Methods, 2021, 10.1039/d0ay02027c
S5947 Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. This compound is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. It also inhibits histamine receptor H1, histamine receptor H4, 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid.
Cancer Cell, 2025, 43(4):776-796.e14
Cancers (Basel), 2019, 11(12)
S3140 Milnacipran HCl Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
S4112 Desvenlafaxine Succinate hydrate Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
Drug Metab Dispos, 2020, 48(10):1044-1052
S5693 Levomilnacipran Hydrochloride Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity.
E4887 Dapoxetine Dapoxetine ((S)-(+)-Dapoxetine; LY-210448) is a selective serotonin reuptake inhibitor (SSRI) with oral activity. This compound is a short-acting SSRI developed specifically for the treatment of premature ejaculation (PE).
S5655 Venlafaxine Venlafaxine (Wy 45030) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), used to treat major depressive disorder (MDD), generalised anxiety disorder (GAD), panic disorder and social phobia.
S5485 Desipramine Hydrochloride Desipramine hydrochloride (Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901) is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.
E4898 Escitalopram Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. This compound has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT).
S5071 Duloxetine Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
S1627 Nitazoxanide Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent(IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). This compound modulates autophagy and inhibits mTORC1 signaling.
iScience, 2025, 28(4):112218
Nat Commun, 2024, 15(1):8708
Mol Ther, 2024, S1525-0016(24)00340-X
S4749 Citalopram HBr Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective serotonin reuptake inhibitor (SSRI) with IC50 of 1.8 nM.
Cell Rep, 2024, 43(10):114818
Chem Biol Interact, 2024, 403:111246
Aging (Albany NY), 2021, 13(11):14729-14744
S4259 Vilazodone HCl Vilazodone HCl(EMD68843,SB659746A) is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors, used for the treatment of major depressive disorder.
Cell Rep Med, 2024, 5(10):101777
Eur J Pharmacol, 2024, 985:177058
J Pain, 2019, 20(1):16.e1-16.e16
S2282 Cinchonidine Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry.
CNS Neurosci Ther, 2023, 10.1111/cns.14403
J Med Virol, 2019, 91(8):1440-1447
S6301 MPP+ iodide MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
NPJ Parkinsons Dis, 2025, 11(1):3
Front Immunol, 2023, 14:1193081
E7756 Imipramine Imipramine is a tricyclic antidepressant that inhibits Fascin1 and the serotonin transporter with an IC50 of 32 nM. It also exhibits antitumor activity and induces autophagic cell death in U-87MG glioma cells.
J Extracell Vesicles, 2025, 14(2):e70042
S5858 Vilazodone Vilazodone (EMD-68843, SB-659746A) is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites.
J Pain, 2019, 20(1):16.e1-16.e16
S1869 Dapoxetine HCl Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.