Fluvoxamine maleate

Catalog No.S1336 Synonyms: MK-264

Fluvoxamine maleate Chemical Structure

Molecular Weight(MW): 434.41

Fluvoxamine Maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.

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Biological Activity

Description Fluvoxamine Maleate is a selective serotonin (5-HT) reuptake inhibitor (SSRI), used in the treatment of obsessive-compulsive disorder.
Targets
5-HT [1]
In vitro

Fluvoxamine increases [5-HT]ex levels in rat the prefrontal cortex and thalamus, and also increases [DA]ex levels in the striatum. [1] Fluvoxamine maleate ameliorates tactile allodynia via spinal 5-HT2A/2C receptors, by acting on the receptors or 5-HT neurons. [2]

In vivo Fluvoxamine maleate also exhibits the antinociception in a dose-dependent manner in the paw pressure test in non-ligated mice. Fluvoxamine maleate also induces antinociceptive effect in the acute paw pressure test, and this effect is antagonized by the 5-HT3 receptor antagonist granisetron. [2] Fluvoxamine (10 and 30 mg/kg, i.p.) enhances synaptic efficacy in the hippocampo-mPFC pathway in a dose-dependent manner in the rat hippocampo-medial prefrontal cortex (mPFC). [3] Fluvoxamine (10 and 30 mg/kg, i.p.) suppresses long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP is completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 mg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 mg/rat, i.c.v.). [4] Fluvoxamine maleate reinforces the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibit the contraction induced by potassium ion on the isolated rat uterus preparation with IC50 of 3.99μM and 18.2μM, respectively. [5]

Protocol

Solubility (25°C)

In vitro DMSO 87 mg/mL (200.27 mM)
Ethanol 87 mg/mL (200.27 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 434.41
Formula

C14H18F3N2O2.C4H4O4

CAS No. 61718-82-9
Storage powder
in solvent
Synonyms MK-264

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01933919 Completed Obsessive Compulsive Disorder AbbVie|Meiji Seika Pharma Co. Ltd. August 14 2013 Phase 3
NCT01933919 Completed Obsessive Compulsive Disorder AbbVie|Meiji Seika Pharma Co. Ltd. August 14 2013 Phase 3
NCT00353028 Completed Major Depressive Disorder Solvay Pharmaceuticals October 2006 Phase 4
NCT00353028 Completed Major Depressive Disorder Solvay Pharmaceuticals October 2006 Phase 4
NCT00352768 Terminated Obsessive Compulsive Disorder Solvay Pharmaceuticals August 2006 Phase 4
NCT00352768 Terminated Obsessive Compulsive Disorder Solvay Pharmaceuticals August 2006 Phase 4

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID