Escitalopram Oxalate

Catalog No.S4064

Escitalopram Oxalate Chemical Structure

Molecular Weight(MW): 414.43

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
Targets
5-HT [2]
0.89 nM(Ki)
In vitro

Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.[1] In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. [2]

Protocol

Solubility (25°C)

In vitro DMSO 83 mg/mL (200.27 mM)
Water 25 mg/mL (60.32 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 414.43
Formula

C20H21FN2O.C2H2O4

CAS No. 219861-08-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03843463 Not yet recruiting Aphasia|Stroke Johns Hopkins University|University of South Carolina|Medical University of South Carolina|University of California Irvine February 2020 Phase 2
NCT03843463 Not yet recruiting Aphasia|Stroke Johns Hopkins University|University of South Carolina|Medical University of South Carolina|University of California Irvine February 2020 Phase 2
NCT03652870 Not yet recruiting Depression|Parkinson Disease University College London|London North West Healthcare NHS Trust|King''s College London|University Hospital Plymouth NHS Trust|NHS Lothian November 1 2019 Phase 3
NCT03652870 Not yet recruiting Depression|Parkinson Disease University College London|London North West Healthcare NHS Trust|King''s College London|University Hospital Plymouth NHS Trust|NHS Lothian November 1 2019 Phase 3
NCT03852160 Not yet recruiting Depressive Disorder Treatment-Resistant Janssen-Cilag International NV May 15 2019 Phase 3
NCT03852160 Not yet recruiting Depressive Disorder Treatment-Resistant Janssen-Cilag International NV May 15 2019 Phase 3

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID