For research use only.
CAS No. 219861-08-2
Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
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|Description||Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.|
Escitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). It is used to treat the depression associated with mood disorders. It is also used on occassion in the treatment of body dysmorphic disorder and anxiety. The antidepressant, antiobsessive-compulsive, and antibulimic actions of escitalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. In vitro studies show that escitalopram is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of escitalopram is found to downregulate brain norepinephrine receptors, as has been observed with other drugs effective in the treatment of major depressive disorder. Escitalopram does not inhibit monoamine oxidase. 
|In vitro||DMSO||83 mg/mL (200.27 mM)|
|Water||25 mg/mL (60.32 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04239339||Recruiting||Drug: Escitalopram 20 mg|Drug: Placebo||Healthy||Rigshospitalet Denmark|University of Cambridge|Lundbeck Foundation||April 28 2020||Phase 4|
|NCT03912974||Completed||Drug: Escitalopram|Drug: Placebo oral capsule||Healthy||University Hospital Basel Switzerland||July 4 2019||Phase 1|
|NCT03460379||Recruiting||Drug: Escitalopram||Obesity Morbid||Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital||November 2 2016||--|
|NCT02865642||Recruiting||Drug: Serotonin Uptake Inhibitors|Drug: Placebo||Stroke||University Hospital Inselspital Berne|Cantonal Hospital of St. Gallen||August 2016||Phase 2|
|NCT04013464||Completed||Drug: Escitalopram||Depressive Disorder Major||Peking University Sixth Hospital|National Institute on Drug Dependence China||May 1 2016||Not Applicable|
|NCT02818751||Completed||Drug: Escitalopram|Other: Placebo||Anxiety||University of Cincinnati|National Institute of Mental Health (NIMH)||May 2015||Not Applicable|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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