Imipramine HCl

Catalog No.S4377 Synonyms: Melipramine HCl

For research use only.

Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

Imipramine HCl Chemical Structure

CAS No. 113-52-0

Selleck's Imipramine HCl has been cited by 1 Publication

Purity & Quality Control

Choose Selective Serotonin Transporter Inhibitors

Biological Activity

Description Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
In vitro

Imipramine in the microsomal incubation results in a predicted value for human clearance of 8.6 to 11 ml/min/kg, a slight underestimate of reported mean human blood clearance values (14–15 ml/min/kg). [1] Imipramine is metabolized into N-desmethylimipramine (84%), 2-hydroxyimipramine (10%), and 10-hydroxyimipramine (6%) in human hepatic microsomes. [2] Imipramine (3 μM) inhibits HERG-encoded potassium channels in a reversible manner in CHO cells. Imipramine (3 μM) inhibits HERG tail currents (IHERG) following test pulses to +20 mV with an IC50 of 3.4 μM and a Hill coefficient of 1.17 in CHO cells. Imipramine can completely block native cardiac IKr at 1μm in guinea-pig myocytes. [3]

In vivo Imipramine (10 mg/kg b.i.d.) reverses the decreased sucrose intake of rats exposed to chronic mild stress. Imipramine (10 mg/kg b.i.d.) completely reverses stress caused decrease in D2-receptor binding in the limbic forebrain (but not the striatum). [4] Imipramine (15 mg/kg, IP) exerts anxiolytic-like effects in the two elevated T-maze tasks in male Wistar rats. Imipramine (15 mg/kg, IP) enhances both avoidance and escape latencies in male Wistar rats. Imipramine (15 mg/kg, IP) decreases locomotor activity measured in a square arena in male Wistar rats. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 63 mg/mL
(198.81 mM)
Water 63 mg/mL
(198.81 mM)
Ethanol ''63 mg/mL

Chemical Information

Molecular Weight 316.87


CAS No. 113-52-0
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04520217 Not yet recruiting Drug: 4% Imipramine Cream|Drug: Base Cream Photosensitivity|Microvesicle Particle Wright State Physicians December 2021 Phase 1
NCT00693680 Completed Dietary Supplement: Zincas Forte|Dietary Supplement: Placebo Major Depression Polish Academy of Sciences|Jagiellonian University January 2005 Not Applicable

(data from, updated on 2022-01-17)

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