Imipramine HCl

Catalog No.S4377 Synonyms: Melipramine HCl

For research use only.

Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

Imipramine HCl Chemical Structure

CAS No. 113-52-0

Selleck's Imipramine HCl has been cited by 1 Publication

Purity & Quality Control

Choose Selective Serotonin Transporter Inhibitors

Biological Activity

Description Imipramine (Melipramine) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
In vitro

Imipramine in the microsomal incubation results in a predicted value for human clearance of 8.6 to 11 ml/min/kg, a slight underestimate of reported mean human blood clearance values (14–15 ml/min/kg). [1] Imipramine is metabolized into N-desmethylimipramine (84%), 2-hydroxyimipramine (10%), and 10-hydroxyimipramine (6%) in human hepatic microsomes. [2] Imipramine (3 μM) inhibits HERG-encoded potassium channels in a reversible manner in CHO cells. Imipramine (3 μM) inhibits HERG tail currents (IHERG) following test pulses to +20 mV with an IC50 of 3.4 μM and a Hill coefficient of 1.17 in CHO cells. Imipramine can completely block native cardiac IKr at 1μm in guinea-pig myocytes. [3]

In vivo Imipramine (10 mg/kg b.i.d.) reverses the decreased sucrose intake of rats exposed to chronic mild stress. Imipramine (10 mg/kg b.i.d.) completely reverses stress caused decrease in D2-receptor binding in the limbic forebrain (but not the striatum). [4] Imipramine (15 mg/kg, IP) exerts anxiolytic-like effects in the two elevated T-maze tasks in male Wistar rats. Imipramine (15 mg/kg, IP) enhances both avoidance and escape latencies in male Wistar rats. Imipramine (15 mg/kg, IP) decreases locomotor activity measured in a square arena in male Wistar rats. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 63 mg/mL
(198.81 mM)
Water 63 mg/mL
(198.81 mM)
Ethanol ''63 mg/mL

Chemical Information

Molecular Weight 316.87
Formula

C19H25ClN2

CAS No. 113-52-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04520217 Not yet recruiting Drug: 4% Imipramine Cream|Drug: Base Cream Photosensitivity|Microvesicle Particle Wright State Physicians December 2021 Phase 1
NCT00693680 Completed Dietary Supplement: Zincas Forte|Dietary Supplement: Placebo Major Depression Polish Academy of Sciences|Jagiellonian University January 2005 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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