Imipramine HCl

For research use only.

Catalog No.S4377 Synonyms: Melipramine HCl

Imipramine HCl Chemical Structure

Molecular Weight(MW): 316.87

Imipramine is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

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Biological Activity

Description Imipramine is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
In vitro

Imipramine in the microsomal incubation results in a predicted value for human clearance of 8.6 to 11 ml/min/kg, a slight underestimate of reported mean human blood clearance values (14–15 ml/min/kg). [1] Imipramine is metabolized into N-desmethylimipramine (84%), 2-hydroxyimipramine (10%), and 10-hydroxyimipramine (6%) in human hepatic microsomes. [2] Imipramine (3 μM) inhibits HERG-encoded potassium channels in a reversible manner in CHO cells. Imipramine (3 μM) inhibits HERG tail currents (IHERG) following test pulses to +20 mV with an IC50 of 3.4 μM and a Hill coefficient of 1.17 in CHO cells. Imipramine can completely block native cardiac IKr at 1μm in guinea-pig myocytes. [3]

In vivo Imipramine (10 mg/kg b.i.d.) reverses the decreased sucrose intake of rats exposed to chronic mild stress. Imipramine (10 mg/kg b.i.d.) completely reverses stress caused decrease in D2-receptor binding in the limbic forebrain (but not the striatum). [4] Imipramine (15 mg/kg, IP) exerts anxiolytic-like effects in the two elevated T-maze tasks in male Wistar rats. Imipramine (15 mg/kg, IP) enhances both avoidance and escape latencies in male Wistar rats. Imipramine (15 mg/kg, IP) decreases locomotor activity measured in a square arena in male Wistar rats. [5]

Protocol

Solubility (25°C)

In vitro DMSO 63 mg/mL (198.81 mM)
Water 63 mg/mL (198.81 mM)
Ethanol 63 mg/mL (198.81 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 316.87
Formula

C19H25ClN2

CAS No. 113-52-0
Storage powder
in solvent
Synonyms Melipramine HCl
Smiles Cl.CN(C)CCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID