Imipramine HCl

Synonyms: Melipramine HCl,G 22355

Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).

Imipramine HCl Chemical Structure

Imipramine HCl Chemical Structure

CAS: 113-52-0

Selleck's Imipramine HCl has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.95%
99.95

Imipramine HCl Related Products

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Biological Activity

Description Imipramine (Melipramine,G 22355) is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination).
In vitro
In vitro

Imipramine in the microsomal incubation results in a predicted value for human clearance of 8.6 to 11 ml/min/kg, a slight underestimate of reported mean human blood clearance values (14–15 ml/min/kg). [1] Imipramine is metabolized into N-desmethylimipramine (84%), 2-hydroxyimipramine (10%), and 10-hydroxyimipramine (6%) in human hepatic microsomes. [2] Imipramine (3 μM) inhibits HERG-encoded potassium channels in a reversible manner in CHO cells. Imipramine (3 μM) inhibits HERG tail currents (IHERG) following test pulses to +20 mV with an IC50 of 3.4 μM and a Hill coefficient of 1.17 in CHO cells. Imipramine can completely block native cardiac IKr at 1μm in guinea-pig myocytes. [3]

In Vivo
In vivo

Imipramine (10 mg/kg b.i.d.) reverses the decreased sucrose intake of rats exposed to chronic mild stress. Imipramine (10 mg/kg b.i.d.) completely reverses stress caused decrease in D2-receptor binding in the limbic forebrain (but not the striatum). [4] Imipramine (15 mg/kg, IP) exerts anxiolytic-like effects in the two elevated T-maze tasks in male Wistar rats. Imipramine (15 mg/kg, IP) enhances both avoidance and escape latencies in male Wistar rats. Imipramine (15 mg/kg, IP) decreases locomotor activity measured in a square arena in male Wistar rats. [5]

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04520217 Recruiting
Photosensitivity|Microvesicle Particle
Wright State University
June 6 2022 Phase 1
NCT00693680 Completed
Major Depression
Polish Academy of Sciences|Jagiellonian University
January 2005 Not Applicable

Chemical Information & Solubility

Molecular Weight 316.87 Formula

C19H25ClN2

CAS No. 113-52-0 SDF Download Imipramine HCl SDF
Smiles CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (198.81 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 63 mg/mL

Ethanol : 63 mg/mL


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In vivo
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