Home Metabolism Retinoid Receptor

Retinoid Receptor Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S1653 Retinoic acid (Tretinoin, Vitamin A acid) Retinoic acid (Tretinoin, Vitamin A acid) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), and can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells. Tretinoin (NSC 122758) can be used to induce animal models of osteoporosis.
Nat Commun, 2025, 16(1):616
Biomaterials, 2025, 314:122873
Theranostics, 2025, 15(6):2597-2623
Verified customer review of Retinoic acid (Tretinoin, Vitamin A acid)
S2098 Bexarotene Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.
Cell Mol Immunol, 2025, 10.1038/s41423-025-01268-9
Nucleic Acids Res, 2025, 53(14)gkaf669
J Immunother Cancer, 2024, 12(11)e009805
Verified customer review of Bexarotene
S4627 TTNPB (Arotinoid acid) TTNPB is a potent RAR agonist, and inhibits binding of [3H]tRA with IC50 of 5.1 nM, 4.5 nM, and 9.3 nM for human RARα, β, and γ, respectively.
Environ Int, 2025, 204:109820
Cancer Lett, 2025, 610:217339
Nan Fang Yi Ke Da Xue Xue Bao, 2025, 45(2):322-330
S4260 Tamibarotene Tamibarotene(Am 80) is a synthetic retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ.
iScience, 2024, 27(10):110862
Cancer Sci, 2024, 10.1111/cas.16280
Cancers (Basel), 2024, 16(7)1311
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ.
Cell, 2025, S0092-8674(25)00807-4
Cell Rep, 2023, 42(6):112566
Cell Res, 2022, 10.1038/s41422-022-00668-0
S1368 Acitretin Acitretin (Etretin, RO 10-1670) is a second generation retinoid used for psoriasis.
Int J Mol Sci, 2022, 23(16)9366
Sci Rep, 2021, 11(1):9601
Antimicrob Agents Chemother, 2017, 61(11). pii: e01368-17
Verified customer review of Acitretin
S1276 Adapalene Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne.
Int J Mol Sci, 2022, 23(16)9366
Cancer Discov, 2020, 10(7):1058-1077
PLoS Pathog, 2020, 16;16(3):e1008341
S1569 Tazarotene Tazarotene (AGN190168) is a retinoid prodrug of tazarotenic acid, which is a RAR agonist, used to treat psoriasis, acne, and sun damaged skin.
Int J Mol Sci, 2022, 23(16)9366
Mol Pharm, 2015, 12(9):3399-407
J Clin Invest, 2013, 123(9):3941-51
E2813 SR 11237 SR 11237, a retinoid X receptor (RXR)-specific agonist, can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
Nat Commun, 2024, 15(1):4108
J Am Heart Assoc, 2023, 12(15):e029415
E1627 BMS493 BMS493 is an inverse agonist of pan retinoic acid receptor (RAR). It increases nuclear corepressor interaction with RARs and can be used as an inhibitor for the dietary and pharmacologic manipulation of retinoic acid (RA) activity in vivo and in vitro.
bioRxiv, 2025, 2025.05.16.653860
S4699 Etretinate Etretinate (Tegison, Ethyl etrinoate, Retinoid, Etretinato,Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.
Viruses, 2021, 13(8)1533
E1445 Palovarotene Palovarotene (R 667; Ro 3300074) is a nuclear retinoic acid receptor γ (RAR-γ) agonist. It reduces heterotopic ossification (HO) in cultures and in murine and rat fibrodysplasia ossificans progressiva (FOP) models.
E6408New CD1530 CD1530 is a potent and selective agonist of RARγ receptor with Ki values of 150 nM. It is a potent inhibitor of heterotopic ossification (HO) and may be effective against congenital HO, with potential use in research on psoriasis, acne, photoaging, and cancer.
E4618 CD3254 CD3254 is a potent and selective agonist of retinoid X receptor (RXR). It may be utilized in cancer research and holds promise for the treatment of metabolic diseases.
S6132 All trans-Retinal All trans-Retinal (Retinaldehyde, Vitamin A aldehyde, Retinene), a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer.
S2520 CD437(AHPN) CD437(AHPN), a synthetic retinoid, is a selective Retinoic acid Receptor γ ( RARγ) agonist. It exhibits an antiproliferative effect and induces apoptosis via activation of AP-1 in vitro.
E1468 MSU-42011 MSU-42011 is an orally active agonist of retinoid X receptor (RXR). This compound inhibits the expression of iNOS and p-ERK protein. It exhibits immunomodulatory and antitumor activity. It can be used for cancer research.
E7548 Ch55 Ch55 is a synthetic analog of retinoic acid that acts as a potent agonist of RAR, binding with high affinity to retinoic acid receptors RAR-α, RAR-β, and RAR-γ, while showing no binding to cellular retinoic acid binding protein (CRABP). It demonstrates anti-fibrotic effects in preclinical models, reducing collagen deposition and hypertrophy in dermal tissues.