CAS No. 2410796-79-9

Batch: Purity:99.92
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Sovilnesib (AMG 650) Chemical Structure
Chemical Structure
Check the Sovilnesib (AMG 650) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(6-azaspiro[2.5]octan-6-yl)-N-[2-(4,4-difluoropiperidin-1-yl)-6-methylpyrimidin-4-yl]-4-(2-hydroxyethylsulfonylamino)benzamide
CAS Number 2410796-79-9
Molecular Formula

C26H34F2N6O4S
Molecular Weight (MW) 564.65
SMILES CC1=CC(=NC(=N1)N2CCC(F)(F)CC2)NC(=O)C3=C(C=C(N[S;v6](=O)(=O)CCO)C=C3)N4CCC5(CC4)CC5
InChIKey KBDGEJDIHZDPHN-UHFFFAOYSA-N

Ordering Information

Biological Activity

Sovilnesib (AMG is an oral, first-in-class, selective kinesin-like protein KIF18A inhibitor. It binds at the interface of KIF18A and tubulin to disrupt microtubule motor activity and activate the mitotic spindle assembly checkpoint. This inhibition causes prolonged mitotic arrest and apoptosis selectively in chromosomally unstable cancer cells, showing minimal toxicity toward normal proliferating cells and inducing tumor regression in vivo. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (177.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.