CAS No. 5369-03-9
Batch:
Purity:98.86
Chemical Structure
Check the
QX-314 chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride | |
|---|---|---|
| CAS Number | 5369-03-9 | |
| Molecular Formula |
C16H27ClN2O |
|
| Molecular Weight (MW) | 298.85 | |
| SMILES | [Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C | |
| InChIKey | LLPPOMUAOGMYQI-UHFFFAOYSA-N |
QX-314 chloride is a membrane-impermeant sodium channel inhibitor that permeates and activates human TRPV1 and TRPA1 channels. Entry of QX-314 into cells through open TRP channels enables selective blockade of intracellular sites on voltage-gated sodium channels. This inhibition abolishes sodium ion influx, suppressing action potential generation and downstream nociceptive signaling in sensory neurons. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 60 mg/mL |
| Ethanol | 60 mg/mL |
| DMSO |
60 mg/mL
(200.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 60 mg/mL |
| Ethanol | 60 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.