Quinic acid

Catalog No.S3886 Batch:S388601

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Technical Data

Formula

C7H12O6
Molecular Weight 192.17 CAS No. 77-95-2
Solubility (25°C)* In vitro DMSO 38 mg/mL (197.74 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Quinic acid (Chinic acid, Kinic acid) is a crystalline acid obtained from cinchona bark, coffee beans, and other plant products and made synthetically by hydrolysis of chlorogenic acid.
In vitro Quinic acid inhibits NF-nB activity in cells grown in tissue culture in vitro[1]. Pre-incubation of MOVAS cells, the mouse vascular smooth muscle cell line for 2 h with Quinic acid (0.1, 1 and 10 μg/mL) dose-dependently inhibits TNF-α-induced mRNA and protein expression of VCAM-1 and monocyte adhesion. Quinic acid inhibits TNF-α-stimulated phosphorylation of MAP kinase and NK-κB activation. It inhibits the TNF-α-stimulated induction of VCAM-1 in VSMC by inhibiting the MAP kinase and NF-κB signaling pathways and the adhesion capacity of VSMC, which may explain the ability of Quinic acid to inhibit vascular inflammation such as atherosclerosis[2]. Quinic acids are capable of promoting neurite outgrowth. Treatment of PC12 cells with quinic acids instead of NGF induces neuronal differentiation[3].
In vivo Quinic acid increases splenic leukocyte numbers in vivo[1].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    Raji cell

  • Concentrations

    0-2.5mg/ml

  • Incubation Time

    48 h

  • Method

    Raji cells (2×105) are cultured in the presence of indicated concentrations of C-Med 100, QAA or QA. Growth rate is assayed after 48 h by counting triplicate samples of duplicate cultures in a Coulter cell counter.
Animal Study:[2]
  • Animal Models

    C57BL/6 mice

  • Dosages

    1, 2 and 4 mg/ml

  • Administration

    oral

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.