Home Metabolism PPAR agonist pemafibrate

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pemafibrate PPAR agonist

Cat.No.E2876

Pemafibrate(K-877) is a selective agonist of peroxisome proliferator-activated receptor (PPAR) α with an IC50 of 10 µM.
pemafibrate PPAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 490.55

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Quality Control

Batch: E287601 DMSO]98 mg/mL]false]Ethanol]98 mg/mL]false]Water]Insoluble]false Purity: 99.82%
99.82

Solubility

In vitro
Batch:

DMSO : 98 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 98 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 490.55 Formula

C28H30N2O6

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 848259-27-8 -- Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC50/Ki
PPARα
10 μM
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-03)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07562178 RECRUITING
Intracranial Atherosclerotic Disease (ICAD); Hypertriglyceridaemia; Stroke (CVA) or TIA
Tokyo Women's Medical University
 2026-05-26
NCT07634484 RECRUITING
Hypercholesterolemia
Kowa Company, Ltd.
 2026-07-01 PHASE4
NCT06247735 COMPLETED
Primary Biliary Cholangitis
Kowa Research Institute, Inc.
 2024-02-07 PHASE2
NCT06623539 ACTIVE_NOT_RECRUITING
Non Alcoholic Fatty Liver Disease
Yokohama City University
 2020-12-23 PHASE2
NCT06525311 COMPLETED
Primary Biliary Cholangitis; Compensated Cirrhosis
Kowa Research Institute, Inc.
 2024-10-01 PHASE1
NCT05923281 COMPLETED
Hypercholesterolemia
Kowa Company, Ltd.
 2023-05-01 PHASE3

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