CAS No. 1038915-64-8

Batch: Purity:98.37
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Niraparib hydrochloride Chemical Structure
Chemical Structure
Check the Niraparib hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide;hydrochloride
CAS Number 1038915-64-8
Molecular Formula

C19H20N4O.ClH
Molecular Weight (MW) 356.85
InChIKey YXYDNYFWAFBCAN-PFEQFJNWSA-N

Ordering Information

Biological Activity

Niraparib hydrochloride is a potent poly(ADP-ribose) polymerase inhibitor targeting PARP1 (IC50 3.8 nM) and PARP2 (IC50 2.1 nM). By inhibiting PARP-mediated DNA repair pathways, the compound blocks the repair of radiation-induced DNA double-strand breaks, enhances DNA damage, and promotes apoptosis. Consequently, this compound suppresses cellular proliferation and exhibits marked anti-tumor activity in preclinical model systems. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 64 mg/mL (179.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 64 mg/mL
Ethanol 64 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.