CAS No. 23111-00-4
Batch:
Purity:99.98
Chemical Structure
Check the
Nicotinamide Riboside Chloride (NR-Cl)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide chloride | |
|---|---|---|
| CAS Number | 23111-00-4 | |
| Molecular Formula |
C11H15ClN2O5 |
|
| Molecular Weight (MW) | 290.7 | |
| InChIKey | YABIFCKURFRPPO-IVOJBTPCSA-N |
Nicotinamide riboside chloride is a pyridine-nucleoside precursor of nicotinamide adenine dinucleotide (NAD+). It increases intracellular NAD+ levels and activates the sirtuins SIRT1 and SIRT3. Elevation of NAD+ by nicotinamide riboside chloride enhances mitochondrial oxidative metabolism, promotes oxidative phosphorylation, and protects against high-fat diet-induced metabolic abnormalities and energy homeostasis impairment. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 58 mg/mL |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 58 mg/mL |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 58 mg/mL |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 58 mg/mL |
| Ethanol | Insoluble |
| DMSO |
58 mg/mL
(199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 58 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Nicotinamide Riboside Chloride (NR-Cl) Clinical Trials
- Nicotinamide Riboside Chloride (NR-Cl) Solubility in DMSO
- Nicotinamide Riboside Chloride (NR-Cl) Storage
- Nicotinamide Riboside Chloride (NR-Cl) Stability
- Nicotinamide Riboside Chloride (NR-Cl) Molecular Weight
- Nicotinamide Riboside Chloride (NR-Cl) Chemical Structure (2D and 3D)
- Nicotinamide Riboside Chloride (NR-Cl) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.