CAS No. 54143-57-6

Batch: Purity:99.96
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Metoclopramide hydrochloride hydrate Chemical Structure
Chemical Structure
Check the Metoclopramide hydrochloride hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 54143-57-6
Molecular Formula

C14H25Cl2N3O3
Molecular Weight (MW) 354.27
SMILES O.Cl.CCN(CC)CCNC(=O)C1=CC(=C(N)C=C1OC)Cl

Biological Activity

Metoclopramide hydrochloride hydrate is a dopamine receptor antagonist that also exhibits 5-HT3 receptor antagonist and 5-HT4 receptor agonist activities. By targeting dopamine D2 receptors in the chemoreceptor trigger zone and 5-HT receptors in the gastrointestinal tract, it modulates enteric neurotransmission and smooth muscle tone. These mechanisms promote upper gastrointestinal motility and exert potent antiemetic and gastroprokinetic phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (200.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 71 mg/mL
Ethanol 71 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.