Metoclopramide hydrochloride hydrate

Catalog No.S5949 Batch:S594901

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Technical Data

Formula

C14H25Cl2N3O3

Molecular Weight 354.27 CAS No. 54143-57-6
Solubility (25°C)* In vitro DMSO 71 mg/mL (200.41 mM)
Water 71 mg/mL (200.41 mM)
Ethanol 71 mg/mL (200.41 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Metoclopramide hydrochloride (Clorpa, Gimoti, Maxolon, Reglan) hydrate is primarily a Dopamine receptor antagonist, with 5HT3 receptor antagonist and 5HT4 receptor agonist activity, and used as an antiemetic and gastroprokinetic.
Targets
Dopamine receptor [1] 5HT3 receptor [1] 5HT4 receptor [1]
In vivo

Metoclopramide attenuates MSG-induced lying-on-belly behaviours of rats.[2]

Protocol (from reference)

Animal Study:

[2]

  • Animal Models

    Male and Female Sprague Dawley rats

  • Dosages

    5 mg/ml

  • Administration

    i.p.

Selleck's Metoclopramide hydrochloride hydrate has been cited by 2 publications

Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients [ Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344] PubMed: 36066384
The anti-cancer effect of metoclopramide on triple-negative breast cancer cells [ Pharmazie, 2021, 76(4):172-174] PubMed: 33849703

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.