Etoricoxib

Catalog No.S4651 Batch:S465101

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Technical Data

Formula

C18H15ClN2O2S
Molecular Weight 358.84 CAS No. 202409-33-4
Solubility (25°C)* In vitro DMSO 71 mg/mL (197.85 mM)
Ethanol 46 mg/mL (128.19 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Etoricoxib (Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia) is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
Targets
COX-2 [1]
In vivo The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2].

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    Human colon carcinoma cell line HCT-116

  • Concentrations

    200 μM

  • Incubation Time

    2 h

  • Method

    Human colon carcinoma cell line HCT-116 are treated with various coxibs for 2 h. Subsequently, the cells are harvested and the sphingolipids isolated and determined by LC-MS/MS.
Animal Study:

[1]
  • Animal Models

    Adult albino male mice

  • Dosages

    10 mg/kg

  • Administration

    p.o.

Selleck's Etoricoxib has been cited by 1 publication

The Establishment and Validation of the Human U937 Cell Line as a Cellular Model to Screen Immunomodulatory Agents Regulating Cytokine Release Induced by Influenza Virus Infection [ Virol Sin, 2019, 34(6):648-661] PubMed: 31286365

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.