Home Metabolism Dehydrogenase inhibitor Ethyl potassium malonate

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Ethyl potassium malonate Dehydrogenase inhibitor

Cat.No.S6222

Ethyl potassium malonate (Potassium 3-ethoxy-3-oxopropanoate) is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate.
Ethyl potassium malonate Dehydrogenase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 170.2

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Quality Control

Batch: S622201 Water]34 mg/mL]false]DMSO]Insoluble]false]]]false Purity: 99%
99

Chemical Information, Storage & Stability

Molecular Weight 170.2 Formula

C5H7KO4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 6148-64-7 -- Storage of Stock Solutions

Synonyms Potassium 3-ethoxy-3-oxopropanoate, Malonic Acid Monoethyl Ester Potassium Salt Smiles CCOC(=O)CC(=O)[O-].[K+]

Solubility

In vitro
Batch:

Water : 34 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Dehydrogenase [1]

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