CAS No. 6148-64-7

Batch: Purity:99
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Ethyl potassium malonate Chemical Structure
Chemical Structure
Check the Ethyl potassium malonate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name potassium 3-ethoxy-3-oxopropanoate
CAS Number 6148-64-7
Molecular Formula

C5H7KO4
Molecular Weight (MW) 170.2
SMILES CCOC(=O)CC(=O)[O-].[K+]
InChIKey WVUCPRGADMCTBN-UHFFFAOYSA-M

Biological Activity

Ethyl potassium malonate acts as a competitive inhibitor of succinate dehydrogenase (Complex II), a key enzyme linking the tricarboxylic acid (TCA) cycle to the mitochondrial electron transport chain. By competing with succinate at the active site of the enzyme, it disrupts mitochondrial respiration, impairs oxidative phosphorylation, and suppresses downstream cellular ATP generation and metabolic homeostasis. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 34 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Sun F, et al. Cell. 2005;121(7):1043-57.

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Note: Technical data last updated: Sep 1, 2026.