CAS No. 5081-48-1
Batch:
Purity:99.6
Chemical Structure
Check the
Ellipticine hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 5081-48-1 | |
|---|---|---|
| Molecular Formula |
C17H15ClN2 |
|
| Molecular Weight (MW) | 282.77 | |
| SMILES | CC1=C2C=CN=CC2=C(C3=C1NC4=CC=CC=C43)C.Cl |
Ellipticine hydrochloride is an antineoplastic plant alkaloid that acts as a potent inhibitor of DNA topoisomerase II and intercalates into DNA. Enzymatic oxidation by cytochromes P450 and peroxidases converts ellipticine into reactive species that form covalent DNA adducts. This dual mechanism disrupts DNA replication and transcription pathways, ultimately triggering cell cycle arrest and inducing apoptosis in cancer cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
3 mg/mL
(10.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | ˂1 mg/mL |
| Ethanol | ˂1 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Ellipticine hydrochloride Solubility in DMSO
- Ellipticine hydrochloride Stock Solution
- Ellipticine hydrochloride Storage
- Ellipticine hydrochloride Stability
- Ellipticine hydrochloride Molecular Weight
- Ellipticine hydrochloride SMILES
- Ellipticine hydrochloride Chemical Structure (2D and 3D)
- Ellipticine hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.