CAS No. 692269-09-3
Batch:
Purity:99.28
Chemical Structure
Check the
CM10
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-prop-2-enyl-6-[[(1-propylbenzimidazol-2-yl)amino]methyl]phenol | |
|---|---|---|
| CAS Number | 692269-09-3 | |
| Molecular Formula |
C20H23N3O
|
|
| Molecular Weight (MW) | 321.42 | |
| SMILES | CCCN1C2=CC=CC=C2N=C1NCC3=CC=CC(=C3O)CC=C | |
| InChIKey | ZFHWEWJDCFGRBO-UHFFFAOYSA-N |
CM10 is a potent inhibitor of the aldehyde dehydrogenase 1A (ALDH1A) family, targeting ALDH1A1, ALDH1A2, and ALDH1A3 isoforms. By inhibiting ALDH1A enzymatic activity, CM10 disrupts retinoic acid signaling pathways and cellular detoxification mechanisms. This inhibition leads to the suppression of cancer stem cell self-renewal, reduced cell viability, and the induction of apoptotic cell death, thereby demonstrating robust anti-cancer activity. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.