Name: Edaravone
Brand: Selleck Chemicals
SKU: S1326
Availability: InStock
Rating: 5 (9 reviews)

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Quality Control

Batch: Purity: 99.89%

99.89

Related Targets	HSP JNK ROS eIF IRE1 PERK PDI PKR ASK ATF-6
Other Antioxidant Inhibitors	Elamipretide (SS-31, MTP-131) EGCG ((-)-Epigallocatechin Gallate) Tangeretin Silymarin Gipsoside (+)-Catechin Hydroxygenkwanin Rutin (trihydrate) Oleuropein (-)Epicatechin

Solubility

In vitro
Batch:

DMSO : 35 mg/mL (200.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (28.70mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.000mg/ml (5.74mM)	Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	174.2	Formula	C₁₀H₁₀N₂O	Storage (From the date of receipt)	3 years -20°C powder (seal)
CAS No.	89-25-8	Download SDF		Storage of Stock Solutions	Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.
Synonyms	MCI-186			SMILES	CC1=NN(C(=O)C1)C2=CC=CC=C2

Read more about storage stability CAS number SMILES

Mechanism of Action

In vitro	Edaravone exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. This compound provides the desirable features of NOS: it increases eNOS (beneficial NOS for rescuing ischemic stroke) and decreases nNOS and iNOS (detrimental NOS). This chemical, which inhibits oxidation and enhances NO production derived from increased eNOS expression, may improve and conserve cerebral blood flow without peroxynitrite generation during reperfusion.
In vivo	Edaravone significantly reduces the infarct volume and improves the neurological deficit scores at 24 hours after reperfusion in mice brain. This compound markedly suppresses the accumulation of HNE-modified protein and 8-OHdG at the penumbra area during the early period after reperfusion and reduces microglial activation, iNOS expression, and nitrotyrosine formation at the late period. It attenuates renal function and pathologic findings significantly in rat kidney. This chemical significantly reduces the generation of free radicals in the tubular cells indicated by dichlorodihydrofluorescein. Treated animals shows significantly improved neurological outcome. This treatment provides a significant reduction in the number of TUNEL-positive apoptotic cells, a decrease in Bax immunoreactivity and an increase in Bcl-2 expression within the peri-infarct area. It shows an excellent neuroprotective effect against ischemia/reperfusion brain injury through a Bax/Bcl-2 dependent anti-apoptotic mechanism.
References	[1] https://pubmed.ncbi.nlm.nih.gov/16834755/ [2] https://pubmed.ncbi.nlm.nih.gov/16166574/ [3] https://pubmed.ncbi.nlm.nih.gov/15086910/ [4] https://pubmed.ncbi.nlm.nih.gov/15921675/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07604350	NOT_YET_RECRUITING	Post-stroke Epilepsy; Post-stroke Seizure	First Affiliated Hospital of Wenzhou Medical University	2026-06	PHASE3
NCT07682922	NOT_YET_RECRUITING	Acute Ischemic Stroke	Xinqiao Hospital of Chongqing	2026-07-01	PHASE4
NCT07454473	RECRUITING	Chemo Brain	Chuansheng Zhao	2026-03-02	PHASE4
NCT07692399	NOT_YET_RECRUITING	CADASIL	Huashan Hospital	2026-07	PHASE2
NCT07801976	NOT_YET_RECRUITING	Healthy Volunteer	St. Jude Children's Research Hospital	2026-10	EARLY_PHASE1
NCT06674460	RECRUITING	Cerebral Small Vessel Disease; Ischemic Stroke	Peking Union Medical College Hospital	2025-08-01	PHASE3

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Edaravone Antioxidant chemical

Chemical Structure

Molecular Weight: 174.2