PKR

Other ER stress & UPR Related Inhibitors

PERK IRE1 PDI ATF-6 ER stress

Cat.No.	Product Name	Information	Product Use Citations
S6508	Mitapivat (AG-348)	Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.	Proc Natl Acad Sci U S A, 2022, 119(40):e2210779119
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). This compound prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.	Immunity, 2025, 58(10):2489-2504.e8 Exp Mol Med, 2024, 56(2):408-421. EMBO J, 2024, 43(5):780-805.
E2388	PKR-IN-2	PKR-IN-2 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160, which can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6508

Mitapivat (AG-348)

Mitapivat (AG-348) is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis.

Proc Natl Acad Sci U S A, 2022, 119(40):e2210779119

S9668

PKR-IN-C16

PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). This compound prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.

Immunity, 2025, 58(10):2489-2504.e8

Exp Mol Med, 2024, 56(2):408-421.

EMBO J, 2024, 43(5):780-805.

E2388

PKR-IN-2

PKR-IN-2 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160, which can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia.