Home ER stress & UPR PDI

PDI

Other ER stress & UPR Related Inhibitors

PERK IRE1 PKR ATF-6 ER stress
Cat.No. Product Name Information Product Use Citations Product Validations
S8281 CCF642 CCF642 (AC1LYELL) is a novel PDI-inhibiting compound with antimyeloma activity.
Cell Mol Gastroenterol Hepatol, 2023, S2352-345X(23)00025-5
Int J Mol Sci, 2022, 23(24)15834
S0321 LOC14 LOC14 is a potent inhibitor of protein disulfide isomerase (PDI) with EC50 of 500 nM and Kd of 62 nM, respectively.
S2846 ML359 ML359 is a small molecule inhibitor of protein disulfide isomerase （PDI).
E6697New PACMA 31 PACMA 31 is an irreversible, orally active inhibitor of protein disulfide isomerase (PDI) with an IC50 of 10 μM. It covalently binds PDI's active-site cysteines, inhibiting reductase/isomerase activity in a dose- and time-dependent manner per insulin aggregation assays.